RU2405539C2 - Экструзионный способ приготовления композиций, содержащих плохо прессующиеся лекарственные соединения - Google Patents
Экструзионный способ приготовления композиций, содержащих плохо прессующиеся лекарственные соединения Download PDFInfo
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- RU2405539C2 RU2405539C2 RU2007145522/15A RU2007145522A RU2405539C2 RU 2405539 C2 RU2405539 C2 RU 2405539C2 RU 2007145522/15 A RU2007145522/15 A RU 2007145522/15A RU 2007145522 A RU2007145522 A RU 2007145522A RU 2405539 C2 RU2405539 C2 RU 2405539C2
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- 229940084026 sodium valproate Drugs 0.000 description 1
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- FJPYVLNWWICYDW-UHFFFAOYSA-M sodium;5,5-diphenylimidazolidin-1-ide-2,4-dione Chemical compound [Na+].O=C1[N-]C(=O)NC1(C=1C=CC=CC=1)C1=CC=CC=C1 FJPYVLNWWICYDW-UHFFFAOYSA-M 0.000 description 1
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- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 description 1
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- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67958705P | 2005-05-10 | 2005-05-10 | |
| US60/679,587 | 2005-05-10 | ||
| US69315505P | 2005-06-23 | 2005-06-23 | |
| US60/693,155 | 2005-06-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2007145522A RU2007145522A (ru) | 2009-06-20 |
| RU2405539C2 true RU2405539C2 (ru) | 2010-12-10 |
Family
ID=37022916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007145522/15A RU2405539C2 (ru) | 2005-05-10 | 2006-05-08 | Экструзионный способ приготовления композиций, содержащих плохо прессующиеся лекарственные соединения |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20100152299A1 (enExample) |
| EP (1) | EP1881819A1 (enExample) |
| JP (1) | JP5400377B2 (enExample) |
| KR (2) | KR20080007357A (enExample) |
| CN (1) | CN102552162A (enExample) |
| AU (2) | AU2006244213B2 (enExample) |
| BR (1) | BRPI0608609A2 (enExample) |
| CA (1) | CA2607624A1 (enExample) |
| IL (1) | IL186456A0 (enExample) |
| MA (1) | MA29465B1 (enExample) |
| MX (1) | MX2007014041A (enExample) |
| NO (1) | NO20076298L (enExample) |
| NZ (2) | NZ585116A (enExample) |
| RU (1) | RU2405539C2 (enExample) |
| TN (1) | TNSN07415A1 (enExample) |
| WO (1) | WO2006122021A1 (enExample) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
| US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
| DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
| DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
| DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
| DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| GB2447898B (en) * | 2007-03-24 | 2011-08-17 | Reckitt Benckiser Healthcare | A tablet having improved stability with at least two actives |
| EP2249811A1 (en) | 2008-01-25 | 2010-11-17 | Grünenthal GmbH | Pharmaceutical dosage form |
| RU2010148536A (ru) * | 2008-04-30 | 2012-06-10 | Новартис АГ (CH) | Способ непрерывного изготовления фармацевтических композиций |
| MX2010014566A (es) * | 2008-07-03 | 2011-02-15 | Novartis Ag | Proceso de granulacion de fundido. |
| AR077493A1 (es) | 2009-07-22 | 2011-08-31 | Gruenenthal Gmbh | Composicion farmaceutica extruida en caliente con liberacion controlada. procedimiento de preparacion |
| SI2456424T1 (sl) | 2009-07-22 | 2013-10-30 | Gruenenthal Gmbh | Oksidacijsko stabilizirana odmerna oblika, varna pred zlorabo |
| PL2611425T3 (pl) | 2010-09-02 | 2014-09-30 | Gruenenthal Gmbh | Odporna na ingerencję postać dawki zawierająca polimer anionowy |
| MX2013002377A (es) | 2010-09-02 | 2013-04-29 | Gruenenthal Gmbh | Forma de dosificacion resistente a manipulacion que comprende una sal inorganica. |
| JP2014524925A (ja) | 2011-07-29 | 2014-09-25 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 即時薬剤放出を提供するタンパーレジスタント錠剤 |
| EP2736497B1 (en) | 2011-07-29 | 2017-08-23 | Grünenthal GmbH | Tamper-resistant tablet providing immediate drug release |
| MX356421B (es) | 2012-02-28 | 2018-05-29 | Gruenenthal Gmbh | Forma de dosificacion resistente a la manipulacion indebida que comprende un compuesto farmacologicamente activo y un polimero anionico. |
| AR090695A1 (es) | 2012-04-18 | 2014-12-03 | Gruenenthal Gmbh | Forma de dosificacion farmaceutica resistente a la adulteracion y resistente a la liberacion inmediata de la dosis |
| US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
| GB201218012D0 (en) | 2012-10-08 | 2012-11-21 | Jagotec Ag | Dosage forms |
| US9737490B2 (en) | 2013-05-29 | 2017-08-22 | Grünenthal GmbH | Tamper resistant dosage form with bimodal release profile |
| MX371432B (es) | 2013-05-29 | 2020-01-30 | Gruenenthal Gmbh | Forma de dosificacion resistente al uso indebido que contiene una o mas particulas. |
| EA032465B1 (ru) | 2013-07-12 | 2019-05-31 | Грюненталь Гмбх | Защищенная от применения не по назначению пероральная фармацевтическая лекарственная форма, содержащая этиленвинилацетатный полимер, и способ ее изготовления |
| CA2919892C (en) | 2013-08-12 | 2019-06-18 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
| BR112016010482B1 (pt) | 2013-11-26 | 2022-11-16 | Grünenthal GmbH | Preparação de uma composição farmacêutica em pó por meio de criomoagem |
| US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
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- 2006-05-08 KR KR1020077026095A patent/KR20080007357A/ko not_active Ceased
- 2006-05-08 US US11/909,509 patent/US20100152299A1/en not_active Abandoned
- 2006-05-08 MX MX2007014041A patent/MX2007014041A/es active IP Right Grant
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- 2006-05-08 AU AU2006244213A patent/AU2006244213B2/en not_active Ceased
- 2006-05-08 RU RU2007145522/15A patent/RU2405539C2/ru not_active IP Right Cessation
- 2006-05-08 KR KR1020137031633A patent/KR20130135403A/ko not_active Ceased
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- 2006-05-08 CN CN2011103445944A patent/CN102552162A/zh active Pending
- 2006-05-08 BR BRPI0608609-8A patent/BRPI0608609A2/pt not_active IP Right Cessation
- 2006-05-08 JP JP2008511233A patent/JP5400377B2/ja not_active Expired - Fee Related
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2007
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Also Published As
| Publication number | Publication date |
|---|---|
| CN102552162A (zh) | 2012-07-11 |
| AU2010212296A1 (en) | 2010-09-02 |
| EP1881819A1 (en) | 2008-01-30 |
| JP2008540540A (ja) | 2008-11-20 |
| MA29465B1 (fr) | 2008-05-02 |
| IL186456A0 (en) | 2008-01-20 |
| JP5400377B2 (ja) | 2014-01-29 |
| KR20130135403A (ko) | 2013-12-10 |
| US20100152299A1 (en) | 2010-06-17 |
| AU2006244213B2 (en) | 2010-05-13 |
| KR20080007357A (ko) | 2008-01-18 |
| NZ585116A (en) | 2011-12-22 |
| US20120077879A1 (en) | 2012-03-29 |
| AU2006244213A1 (en) | 2006-11-16 |
| CA2607624A1 (en) | 2006-11-16 |
| AU2010212296B2 (en) | 2011-06-16 |
| TNSN07415A1 (en) | 2009-03-17 |
| WO2006122021A1 (en) | 2006-11-16 |
| BRPI0608609A2 (pt) | 2010-01-19 |
| MX2007014041A (es) | 2008-02-11 |
| NZ562304A (en) | 2010-06-25 |
| NO20076298L (no) | 2007-12-06 |
| RU2007145522A (ru) | 2009-06-20 |
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