JP5400377B2 - 圧縮性に乏しい治療用化合物を有する組成物の製造法 - Google Patents
圧縮性に乏しい治療用化合物を有する組成物の製造法 Download PDFInfo
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- JP5400377B2 JP5400377B2 JP2008511233A JP2008511233A JP5400377B2 JP 5400377 B2 JP5400377 B2 JP 5400377B2 JP 2008511233 A JP2008511233 A JP 2008511233A JP 2008511233 A JP2008511233 A JP 2008511233A JP 5400377 B2 JP5400377 B2 JP 5400377B2
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Classifications
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
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- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
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| US67958705P | 2005-05-10 | 2005-05-10 | |
| US60/679,587 | 2005-05-10 | ||
| US69315505P | 2005-06-23 | 2005-06-23 | |
| US60/693,155 | 2005-06-23 | ||
| PCT/US2006/017708 WO2006122021A1 (en) | 2005-05-10 | 2006-05-08 | Extrusion process for making compositions with poorly compressible therapeutic compounds |
Publications (3)
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| JP2008540540A JP2008540540A (ja) | 2008-11-20 |
| JP2008540540A5 JP2008540540A5 (enExample) | 2009-07-02 |
| JP5400377B2 true JP5400377B2 (ja) | 2014-01-29 |
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| JP2008511233A Expired - Fee Related JP5400377B2 (ja) | 2005-05-10 | 2006-05-08 | 圧縮性に乏しい治療用化合物を有する組成物の製造法 |
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| US (2) | US20100152299A1 (enExample) |
| EP (1) | EP1881819A1 (enExample) |
| JP (1) | JP5400377B2 (enExample) |
| KR (2) | KR20130135403A (enExample) |
| CN (1) | CN102552162A (enExample) |
| AU (2) | AU2006244213B2 (enExample) |
| BR (1) | BRPI0608609A2 (enExample) |
| CA (1) | CA2607624A1 (enExample) |
| IL (1) | IL186456A0 (enExample) |
| MA (1) | MA29465B1 (enExample) |
| MX (1) | MX2007014041A (enExample) |
| NO (1) | NO20076298L (enExample) |
| NZ (2) | NZ585116A (enExample) |
| RU (1) | RU2405539C2 (enExample) |
| TN (1) | TNSN07415A1 (enExample) |
| WO (1) | WO2006122021A1 (enExample) |
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| US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
| DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
| DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
| US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
| DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
| DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| GB2447898B (en) * | 2007-03-24 | 2011-08-17 | Reckitt Benckiser Healthcare | A tablet having improved stability with at least two actives |
| TWI454288B (zh) | 2008-01-25 | 2014-10-01 | Gruenenthal Chemie | 藥物劑型 |
| BRPI0910545A2 (pt) * | 2008-04-30 | 2015-09-29 | Novartis Ag | processo contínuo para fazer composições farmacêuticas |
| PT2309987E (pt) * | 2008-07-03 | 2012-12-13 | Novartis Ag | Processo para granulação por fusão |
| ES2534908T3 (es) | 2009-07-22 | 2015-04-30 | Grünenthal GmbH | Forma de dosificación de liberación controlada extruida por fusión en caliente |
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- 2006-05-08 CA CA002607624A patent/CA2607624A1/en not_active Abandoned
- 2006-05-08 RU RU2007145522/15A patent/RU2405539C2/ru not_active IP Right Cessation
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- 2006-05-08 EP EP06759308A patent/EP1881819A1/en not_active Withdrawn
- 2006-05-08 CN CN2011103445944A patent/CN102552162A/zh active Pending
- 2006-05-08 US US11/909,509 patent/US20100152299A1/en not_active Abandoned
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|---|---|
| WO2006122021A1 (en) | 2006-11-16 |
| NZ562304A (en) | 2010-06-25 |
| EP1881819A1 (en) | 2008-01-30 |
| MA29465B1 (fr) | 2008-05-02 |
| BRPI0608609A2 (pt) | 2010-01-19 |
| RU2405539C2 (ru) | 2010-12-10 |
| CN102552162A (zh) | 2012-07-11 |
| RU2007145522A (ru) | 2009-06-20 |
| AU2006244213B2 (en) | 2010-05-13 |
| IL186456A0 (en) | 2008-01-20 |
| AU2006244213A1 (en) | 2006-11-16 |
| AU2010212296A1 (en) | 2010-09-02 |
| US20100152299A1 (en) | 2010-06-17 |
| CA2607624A1 (en) | 2006-11-16 |
| TNSN07415A1 (en) | 2009-03-17 |
| KR20130135403A (ko) | 2013-12-10 |
| NZ585116A (en) | 2011-12-22 |
| KR20080007357A (ko) | 2008-01-18 |
| AU2010212296B2 (en) | 2011-06-16 |
| NO20076298L (no) | 2007-12-06 |
| US20120077879A1 (en) | 2012-03-29 |
| JP2008540540A (ja) | 2008-11-20 |
| MX2007014041A (es) | 2008-02-11 |
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