CN102552162A - 制备含有可压性差的治疗性化合物的组合物的挤压方法 - Google Patents
制备含有可压性差的治疗性化合物的组合物的挤压方法 Download PDFInfo
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- CN102552162A CN102552162A CN2011103445944A CN201110344594A CN102552162A CN 102552162 A CN102552162 A CN 102552162A CN 2011103445944 A CN2011103445944 A CN 2011103445944A CN 201110344594 A CN201110344594 A CN 201110344594A CN 102552162 A CN102552162 A CN 102552162A
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Landscapes
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- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024047555A1 (en) * | 2022-08-31 | 2024-03-07 | Sacmi Cooperativa Meccanici Imola Societa' Cooperativa | Method and apparatus for making solid medicines |
| CN118234387A (zh) * | 2021-11-16 | 2024-06-21 | 帝斯曼知识产权资产管理有限公司 | 包含封装的活性成分的颗粒 |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
| DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
| DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
| DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
| DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
| DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| GB2447898B (en) * | 2007-03-24 | 2011-08-17 | Reckitt Benckiser Healthcare | A tablet having improved stability with at least two actives |
| JP5774853B2 (ja) | 2008-01-25 | 2015-09-09 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 医薬投薬形 |
| EP2280681A1 (en) * | 2008-04-30 | 2011-02-09 | Novartis AG | Continuous process for making pharmaceutical compositions |
| CA2729596A1 (en) * | 2008-07-03 | 2010-01-07 | Novartis Ag | Melt granulation process |
| PL2997965T3 (pl) | 2009-07-22 | 2019-06-28 | Grünenthal GmbH | Odporna na manipulacje postać dawkowania opioidów wrażliwych na utlenianie |
| WO2011009602A1 (en) | 2009-07-22 | 2011-01-27 | Grünenthal GmbH | Hot-melt extruded controlled release dosage form |
| EP2611426B1 (en) | 2010-09-02 | 2014-06-25 | Grünenthal GmbH | Tamper resistant dosage form comprising inorganic salt |
| ES2487244T3 (es) | 2010-09-02 | 2014-08-20 | Grünenthal GmbH | Forma de dosificación resistente a la manipulación que comprende un polímero aniónico |
| CA2839123A1 (en) | 2011-07-29 | 2013-02-07 | Grunenthal Gmbh | Tamper-resistant tablet providing immediate drug release |
| US20130028972A1 (en) | 2011-07-29 | 2013-01-31 | Grunenthal Gmbh | Tamper-resistant tablet providing immediate drug release |
| JP6117249B2 (ja) | 2012-02-28 | 2017-04-19 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 薬理学的に活性な化合物および陰イオン性ポリマーを含むタンパーレジスタント剤形 |
| HRP20181716T1 (hr) | 2012-04-18 | 2018-12-28 | Grünenthal GmbH | Farmaceutski oblik doziranja otporan na zlonamjernu uporabu i naglo oslobađanje cjelokupne doze |
| US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
| GB201218012D0 (en) | 2012-10-08 | 2012-11-21 | Jagotec Ag | Dosage forms |
| WO2014191397A1 (en) | 2013-05-29 | 2014-12-04 | Grünenthal GmbH | Tamper-resistant dosage form containing one or more particles |
| US9737490B2 (en) | 2013-05-29 | 2017-08-22 | Grünenthal GmbH | Tamper resistant dosage form with bimodal release profile |
| WO2015004245A1 (en) | 2013-07-12 | 2015-01-15 | Grünenthal GmbH | Tamper-resistant dosage form containing ethylene-vinyl acetate polymer |
| WO2015023675A2 (en) | 2013-08-12 | 2015-02-19 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
| HK1224189A1 (zh) | 2013-11-26 | 2017-08-18 | Grünenthal GmbH | 通过低温研磨制备粉状药物组合物 |
| US10172797B2 (en) | 2013-12-17 | 2019-01-08 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| MX2016014738A (es) | 2014-05-12 | 2017-03-06 | Gruenenthal Gmbh | Formulacion en capsula de liberacion inmediata resistente a alteraciones que comprende tapentadol. |
| MX2016015417A (es) | 2014-05-26 | 2017-02-22 | Gruenenthal Gmbh | Multiparticulas protegidas contra vertido de dosis etanolico. |
| AU2015290098B2 (en) | 2014-07-17 | 2018-11-01 | Pharmaceutical Manufacturing Research Services, Inc. | Immediate release abuse deterrent liquid fill dosage form |
| AU2015336065A1 (en) | 2014-10-20 | 2017-05-04 | Pharmaceutical Manufacturing Research Services, Inc. | Extended release abuse deterrent liquid fill dosage form |
| JP2018513872A (ja) | 2015-04-24 | 2018-05-31 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 異なる粒子から２種の薬物の急速放出をもたらすタンパレジスタントな固定用量組合せ |
| WO2016170094A1 (en) | 2015-04-24 | 2016-10-27 | Grünenthal GmbH | Tamper-resistant fixed dose combination providing fast release of two drugs from particles |
| EA035434B1 (ru) | 2015-04-24 | 2020-06-15 | Грюненталь Гмбх | Защищенная от применения не по назначению лекарственная форма с немедленным высвобождением и устойчивостью к экстракции растворителями |
| WO2016170093A1 (en) | 2015-04-24 | 2016-10-27 | Grünenthal GmbH | Tamper-resistant fixed dose combination providing fast release of two drugs from particles and a matrix |
| EP3346991A1 (en) | 2015-09-10 | 2018-07-18 | Grünenthal GmbH | Protecting oral overdose with abuse deterrent immediate release formulations |
| DE102018010063A1 (de) | 2018-03-16 | 2019-09-19 | Ludwig-Maximilians-Universität München | Herstellung vesikulärer Phospholipid-Gele durch Schnecken-Extrusion |
| CN108888599B (zh) * | 2018-07-26 | 2021-06-08 | 国药集团致君（深圳）制药有限公司 | 双氯芬酸钠缓释组合物及其制备方法 |
| WO2022120194A1 (en) | 2020-12-03 | 2022-06-09 | Battelle Memorial Institute | Polymer nanoparticle and dna nanostructure compositions and methods for non-viral delivery |
| IL307454A (en) | 2021-04-07 | 2023-12-01 | Battelle Memorial Institute | Technologies for rapid design, construction, testing, learning to identify and use non-viral vectors |
| JP2024543839A (ja) * | 2021-11-16 | 2024-11-26 | ディーエスエム アイピー アセッツ ビー．ブイ． | 連続溶融造粒により取得できる高い効力の顆粒 |
| WO2023145869A1 (ja) * | 2022-01-31 | 2023-08-03 | 住友精化株式会社 | 製剤用組成物の製造方法及び製剤の製造方法 |
| WO2023145871A1 (ja) * | 2022-01-31 | 2023-08-03 | 住友精化株式会社 | 製剤用組成物の製造方法及び製剤の製造方法 |
| WO2025072751A1 (en) | 2023-09-29 | 2025-04-03 | Battelle Memorial Institute | Polymer nanoparticle compositions for in vivo expression of polypeptides |
| WO2025122954A1 (en) | 2023-12-08 | 2025-06-12 | Battelle Memorial Institute | Use of dna origami nanostructures for molecular information based data storage systems |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2571046B1 (fr) * | 1984-10-03 | 1987-10-16 | Roquette Freres | Procede de preparation de mannitol granulaire directement compressible |
| US5965161A (en) * | 1994-11-04 | 1999-10-12 | Euro-Celtique, S.A. | Extruded multi-particulates |
| DE19504831A1 (de) * | 1995-02-14 | 1996-09-05 | Basf Ag | Feste Wirkstoffzubereitungen enthaltend Hydroxypropylcellulose |
| DE19504832A1 (de) * | 1995-02-14 | 1996-08-22 | Basf Ag | Feste Wirkstoff-Zubereitungen |
| DE19509806A1 (de) * | 1995-03-21 | 1996-09-26 | Basf Ag | Lagerstabile Arzneiformen |
| DE19721467A1 (de) * | 1997-05-22 | 1998-11-26 | Basf Ag | Verfahren zur Herstellung kleinteiliger Zubereitungen biologisch aktiver Stoffe |
| HN1998000115A (es) * | 1997-08-21 | 1999-06-02 | Warner Lambert Co | Formas de dosificación farmacéuticas sólidas |
| DE19934610A1 (de) * | 1999-07-23 | 2001-01-25 | Bayer Ag | Schnellfreisetzende Extrudate und Verfahren zu ihrer Herstellung sowie daraus erhältliche Zubereitungen |
| PT1322158E (pt) * | 2000-10-02 | 2012-11-23 | Usv Ltd | Composições farmacêuticas de libertação prolongada contendo metformina e seu método de produção |
| WO2003004009A1 (en) * | 2001-07-02 | 2003-01-16 | Geneva Pharmaceuticals, Inc. | Pharmaceutical composition |
| PL370818A1 (en) * | 2001-09-28 | 2005-05-30 | Sun Pharmaceutical Industries Limited | Dosage form for treatment of diabetes mellitus |
| IN192180B (enExample) * | 2001-09-28 | 2004-03-06 | Ranbaxy Lab | |
| DE102005005446A1 (de) * | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
| FR2858556B1 (fr) * | 2003-08-06 | 2006-03-10 | Galenix Innovations | Composition pharmaceutique solide dispersible et/ou orodispersible non pelliculee contenant au moins le principe actif metformine, et procede de preparation |
| US20070098778A1 (en) * | 2004-03-02 | 2007-05-03 | Abeille Pharmaceuticals, Inc. | Co-formulations or kits of bioactive agents |
| JOP20180109A1 (ar) * | 2005-09-29 | 2019-01-30 | Novartis Ag | تركيبة جديدة |
| JP5284101B2 (ja) * | 2005-11-09 | 2013-09-11 | ノバルティス アーゲー | 一時可塑剤を用いる医薬組成物の製造法 |
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- 2006-05-08 JP JP2008511233A patent/JP5400377B2/ja not_active Expired - Fee Related
- 2006-05-08 AU AU2006244213A patent/AU2006244213B2/en not_active Ceased
- 2006-05-08 EP EP06759308A patent/EP1881819A1/en not_active Withdrawn
- 2006-05-08 RU RU2007145522/15A patent/RU2405539C2/ru not_active IP Right Cessation
- 2006-05-08 NZ NZ562304A patent/NZ562304A/en not_active IP Right Cessation
- 2006-05-08 NZ NZ585116A patent/NZ585116A/en not_active IP Right Cessation
- 2006-05-08 MX MX2007014041A patent/MX2007014041A/es active IP Right Grant
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- 2006-05-08 WO PCT/US2006/017708 patent/WO2006122021A1/en not_active Ceased
- 2006-05-08 US US11/909,509 patent/US20100152299A1/en not_active Abandoned
- 2006-05-08 KR KR1020137031633A patent/KR20130135403A/ko not_active Ceased
- 2006-05-08 CN CN2011103445944A patent/CN102552162A/zh active Pending
- 2006-05-08 CA CA002607624A patent/CA2607624A1/en not_active Abandoned
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118234387A (zh) * | 2021-11-16 | 2024-06-21 | 帝斯曼知识产权资产管理有限公司 | 包含封装的活性成分的颗粒 |
| WO2024047555A1 (en) * | 2022-08-31 | 2024-03-07 | Sacmi Cooperativa Meccanici Imola Societa' Cooperativa | Method and apparatus for making solid medicines |
Also Published As
| Publication number | Publication date |
|---|---|
| TNSN07415A1 (en) | 2009-03-17 |
| KR20130135403A (ko) | 2013-12-10 |
| NZ562304A (en) | 2010-06-25 |
| RU2405539C2 (ru) | 2010-12-10 |
| IL186456A0 (en) | 2008-01-20 |
| RU2007145522A (ru) | 2009-06-20 |
| AU2006244213B2 (en) | 2010-05-13 |
| AU2010212296B2 (en) | 2011-06-16 |
| AU2010212296A1 (en) | 2010-09-02 |
| CA2607624A1 (en) | 2006-11-16 |
| JP5400377B2 (ja) | 2014-01-29 |
| EP1881819A1 (en) | 2008-01-30 |
| US20120077879A1 (en) | 2012-03-29 |
| KR20080007357A (ko) | 2008-01-18 |
| WO2006122021A1 (en) | 2006-11-16 |
| BRPI0608609A2 (pt) | 2010-01-19 |
| AU2006244213A1 (en) | 2006-11-16 |
| MX2007014041A (es) | 2008-02-11 |
| US20100152299A1 (en) | 2010-06-17 |
| NO20076298L (no) | 2007-12-06 |
| NZ585116A (en) | 2011-12-22 |
| JP2008540540A (ja) | 2008-11-20 |
| MA29465B1 (fr) | 2008-05-02 |
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