MA29465B1 - Procede d'extrusion permettant de fabriquer des compositions renfermant des composes therapeutiques peu compressibles - Google Patents
Procede d'extrusion permettant de fabriquer des compositions renfermant des composes therapeutiques peu compressiblesInfo
- Publication number
- MA29465B1 MA29465B1 MA30393A MA30393A MA29465B1 MA 29465 B1 MA29465 B1 MA 29465B1 MA 30393 A MA30393 A MA 30393A MA 30393 A MA30393 A MA 30393A MA 29465 B1 MA29465 B1 MA 29465B1
- Authority
- MA
- Morocco
- Prior art keywords
- extrusion method
- therapeutic compounds
- manufacturing compositions
- compressible therapeutic
- low compressible
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'INVENTION CONCERNE UN PROCÉDÉ DE PRÉPARATION DE FORMES POSOLOGIQUES SOLIDES QUI CONTIENNENT UN COMPOSÉ THÉRAPEUTIQUE PEU COMPRESSIBLE. LE PROCÉDÉ CONCERNE PAR EXEMPLE L'UTILISATION D'UNE EXTRUDEUSE, NOTAMMENT D'UNE EXTRUDEUSE À DEUX VIS, POUR GRANULER À L'ÉTAT FONDU UN OU DES COMPOSÉ(S) THÉRAPEUTIQUE(S) À L'AIDE D'UN EXCIPIENT DE GRANULATION.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67958705P | 2005-05-10 | 2005-05-10 | |
US69315505P | 2005-06-23 | 2005-06-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA29465B1 true MA29465B1 (fr) | 2008-05-02 |
Family
ID=37022916
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA30393A MA29465B1 (fr) | 2005-05-10 | 2007-11-20 | Procede d'extrusion permettant de fabriquer des compositions renfermant des composes therapeutiques peu compressibles |
Country Status (16)
Country | Link |
---|---|
US (2) | US20100152299A1 (fr) |
EP (1) | EP1881819A1 (fr) |
JP (1) | JP5400377B2 (fr) |
KR (2) | KR20130135403A (fr) |
CN (1) | CN102552162A (fr) |
AU (2) | AU2006244213B2 (fr) |
BR (1) | BRPI0608609A2 (fr) |
CA (1) | CA2607624A1 (fr) |
IL (1) | IL186456A0 (fr) |
MA (1) | MA29465B1 (fr) |
MX (1) | MX2007014041A (fr) |
NO (1) | NO20076298L (fr) |
NZ (2) | NZ585116A (fr) |
RU (1) | RU2405539C2 (fr) |
TN (1) | TNSN07415A1 (fr) |
WO (1) | WO2006122021A1 (fr) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
GB2447898B (en) * | 2007-03-24 | 2011-08-17 | Reckitt Benckiser Healthcare | A tablet having improved stability with at least two actives |
US8383152B2 (en) | 2008-01-25 | 2013-02-26 | Gruenenthal Gmbh | Pharmaceutical dosage form |
WO2009134848A1 (fr) * | 2008-04-30 | 2009-11-05 | Novartis Ag | Procédé continu de fabrication de compositions pharmaceutiques |
ES2393949T3 (es) * | 2008-07-03 | 2013-01-02 | Novartis Ag | Proceso de granulación en estado fundido |
AR077420A1 (es) | 2009-07-22 | 2011-08-24 | Gruenenthal Gmbh | Forma de dosificacion resistente a la manipulacion para opiaceos sensibles a la oxidacion |
EP2456427B1 (fr) | 2009-07-22 | 2015-03-04 | Grünenthal GmbH | Formule de dosage pharmaceutique extrudée thermofusible à libération prolongée |
ES2486791T3 (es) | 2010-09-02 | 2014-08-19 | Grünenthal GmbH | Forma de dosificación resistente a la manipulación que comprende una sal inorgánica |
JP5933553B2 (ja) | 2010-09-02 | 2016-06-15 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | アニオン性ポリマーを含む不正使用抵抗性剤形 |
LT2736495T (lt) | 2011-07-29 | 2017-11-10 | Grünenthal GmbH | Sugadinimui atspari tabletė, pasižyminti greitu vaisto atpalaidavimu |
RS56527B1 (sr) | 2011-07-29 | 2018-02-28 | Gruenenthal Gmbh | Tableta za trenutno oslobađanje leka rezistentna na zloupotrebu |
CA2864949A1 (fr) | 2012-02-28 | 2013-09-06 | Grunenthal Gmbh | Forme pharmaceutique inviolable comprenant un compose pharmacologiquement actif et un polymere anionique |
EP2838512B1 (fr) | 2012-04-18 | 2018-08-22 | Grünenthal GmbH | Forme pharmaceutique inviolable et résistante au basculement de dose |
US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
GB201218012D0 (en) | 2012-10-08 | 2012-11-21 | Jagotec Ag | Dosage forms |
JP6466417B2 (ja) | 2013-05-29 | 2019-02-06 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 二峰性放出プロファイルを有する改変防止(tamper−resistant)剤形 |
MX371432B (es) | 2013-05-29 | 2020-01-30 | Gruenenthal Gmbh | Forma de dosificacion resistente al uso indebido que contiene una o mas particulas. |
MX368846B (es) | 2013-07-12 | 2019-10-18 | Gruenenthal Gmbh | Forma de dosificación resistente a la alteración que contiene polímero de acetato de etilen-vinilo. |
CA2919892C (fr) | 2013-08-12 | 2019-06-18 | Pharmaceutical Manufacturing Research Services, Inc. | Comprime extrude anti-abus a liberation immediate |
EP3073994A1 (fr) | 2013-11-26 | 2016-10-05 | Grünenthal GmbH | Préparation de composition pharmaceutique en poudre par cryo-broyage |
US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
WO2015095391A1 (fr) | 2013-12-17 | 2015-06-25 | Pharmaceutical Manufacturing Research Services, Inc. | Comprimé extrudé anti-abus à libération prolongée |
EP3142646A1 (fr) | 2014-05-12 | 2017-03-22 | Grünenthal GmbH | Formulation pour capsule à libération immédiate résistant aux manipulations illicites comprenant du tapentadol |
AU2015266117A1 (en) | 2014-05-26 | 2016-11-24 | Grunenthal Gmbh | Multiparticles safeguarded against ethanolic dose-dumping |
EP3169315B1 (fr) | 2014-07-17 | 2020-06-24 | Pharmaceutical Manufacturing Research Services, Inc. | Forme posologique remplie de liquide anti-abus à libération immédiate |
WO2016064873A1 (fr) | 2014-10-20 | 2016-04-28 | Pharmaceutical Manufacturing Research Services, Inc. | Forme galénique anti-abus de remplissage de liquide à libération prolongée |
US20160310428A1 (en) | 2015-04-24 | 2016-10-27 | Grunenthal Gmbh | Tamper-resistant fixed dose combination providing fast release of two drugs from different particles |
EA035434B1 (ru) | 2015-04-24 | 2020-06-15 | Грюненталь Гмбх | Защищенная от применения не по назначению лекарственная форма с немедленным высвобождением и устойчивостью к экстракции растворителями |
CA2983648A1 (fr) | 2015-04-24 | 2016-10-27 | Grunenthal Gmbh | Combinaison a dose fixe inalterable presentant une liberation rapide de deux medicaments de particules et d'une matrice |
JP2018515455A (ja) | 2015-04-24 | 2018-06-14 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 粒子から2種の薬物の急速放出をもたらすタンパレジスタントな固定用量組合せ |
JP2018526414A (ja) | 2015-09-10 | 2018-09-13 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 乱用抑止性の即放性製剤を用いた経口過剰摂取に対する保護 |
DE102018010063A1 (de) | 2018-03-16 | 2019-09-19 | Ludwig-Maximilians-Universität München | Herstellung vesikulärer Phospholipid-Gele durch Schnecken-Extrusion |
CN108888599B (zh) * | 2018-07-26 | 2021-06-08 | 国药集团致君(深圳)制药有限公司 | 双氯芬酸钠缓释组合物及其制备方法 |
WO2023088886A1 (fr) * | 2021-11-16 | 2023-05-25 | Dsm Ip Assets B.V. | Granules à haute puissance pouvant être obtenus par granulation en fusion continue |
WO2023088962A1 (fr) * | 2021-11-16 | 2023-05-25 | Dsm Ip Assets B.V. | Granulés comprenant des principes actifs encapsulés |
WO2023145871A1 (fr) * | 2022-01-31 | 2023-08-03 | 住友精化株式会社 | Procédé de fabrication de composition pour préparation pharmaceutique, et procédé de fabrication de préparation pharmaceutique |
WO2023145869A1 (fr) * | 2022-01-31 | 2023-08-03 | 住友精化株式会社 | Procédé de fabrication de composition pour préparation pharmaceutique, et procédé de fabrication de préparation pharmaceutique |
WO2024047555A1 (fr) * | 2022-08-31 | 2024-03-07 | Sacmi Cooperativa Meccanici Imola Societa' Cooperativa | Procédé et appareil de fabrication de médicaments solides |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2571046B1 (fr) * | 1984-10-03 | 1987-10-16 | Roquette Freres | Procede de preparation de mannitol granulaire directement compressible |
US5965161A (en) * | 1994-11-04 | 1999-10-12 | Euro-Celtique, S.A. | Extruded multi-particulates |
DE19504832A1 (de) * | 1995-02-14 | 1996-08-22 | Basf Ag | Feste Wirkstoff-Zubereitungen |
DE19504831A1 (de) * | 1995-02-14 | 1996-09-05 | Basf Ag | Feste Wirkstoffzubereitungen enthaltend Hydroxypropylcellulose |
DE19509806A1 (de) * | 1995-03-21 | 1996-09-26 | Basf Ag | Lagerstabile Arzneiformen |
DE19721467A1 (de) * | 1997-05-22 | 1998-11-26 | Basf Ag | Verfahren zur Herstellung kleinteiliger Zubereitungen biologisch aktiver Stoffe |
HN1998000115A (es) * | 1997-08-21 | 1999-06-02 | Warner Lambert Co | Formas de dosificación farmacéuticas sólidas |
DE19934610A1 (de) * | 1999-07-23 | 2001-01-25 | Bayer Ag | Schnellfreisetzende Extrudate und Verfahren zu ihrer Herstellung sowie daraus erhältliche Zubereitungen |
ES2392705T3 (es) * | 2000-10-02 | 2012-12-13 | Usv Ltd. | Composiciones farmacéuticas de liberación sostenida que contienen metformina y método para su producción |
WO2003004009A1 (fr) * | 2001-07-02 | 2003-01-16 | Geneva Pharmaceuticals, Inc. | Formulation a compression directe de medicaments faiblement compressibles tels que le chlorhydrate de metformine |
IN192180B (fr) * | 2001-09-28 | 2004-03-06 | Ranbaxy Lab | |
JP2005508331A (ja) * | 2001-09-28 | 2005-03-31 | サン・ファーマシューティカル・インダストリーズ・リミテッド | 糖尿病の処置のための投与製剤 |
DE102005005446A1 (de) * | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
FR2858556B1 (fr) * | 2003-08-06 | 2006-03-10 | Galenix Innovations | Composition pharmaceutique solide dispersible et/ou orodispersible non pelliculee contenant au moins le principe actif metformine, et procede de preparation |
JP2007526309A (ja) * | 2004-03-02 | 2007-09-13 | アベール ファーマシューティカルズ インコーポレイテッド | 生物活性剤の混合製剤またはキット |
JOP20180109A1 (ar) * | 2005-09-29 | 2019-01-30 | Novartis Ag | تركيبة جديدة |
JP5284101B2 (ja) * | 2005-11-09 | 2013-09-11 | ノバルティス アーゲー | 一時可塑剤を用いる医薬組成物の製造法 |
-
2006
- 2006-05-08 KR KR1020137031633A patent/KR20130135403A/ko not_active Application Discontinuation
- 2006-05-08 US US11/909,509 patent/US20100152299A1/en not_active Abandoned
- 2006-05-08 NZ NZ585116A patent/NZ585116A/en not_active IP Right Cessation
- 2006-05-08 BR BRPI0608609-8A patent/BRPI0608609A2/pt not_active IP Right Cessation
- 2006-05-08 NZ NZ562304A patent/NZ562304A/en not_active IP Right Cessation
- 2006-05-08 KR KR1020077026095A patent/KR20080007357A/ko not_active Application Discontinuation
- 2006-05-08 MX MX2007014041A patent/MX2007014041A/es active IP Right Grant
- 2006-05-08 RU RU2007145522/15A patent/RU2405539C2/ru not_active IP Right Cessation
- 2006-05-08 CN CN2011103445944A patent/CN102552162A/zh active Pending
- 2006-05-08 EP EP06759308A patent/EP1881819A1/fr not_active Withdrawn
- 2006-05-08 WO PCT/US2006/017708 patent/WO2006122021A1/fr active Application Filing
- 2006-05-08 JP JP2008511233A patent/JP5400377B2/ja not_active Expired - Fee Related
- 2006-05-08 CA CA002607624A patent/CA2607624A1/fr not_active Abandoned
- 2006-05-08 AU AU2006244213A patent/AU2006244213B2/en not_active Ceased
-
2007
- 2007-10-07 IL IL186456A patent/IL186456A0/en unknown
- 2007-11-09 TN TNP2007000415A patent/TNSN07415A1/en unknown
- 2007-11-20 MA MA30393A patent/MA29465B1/fr unknown
- 2007-12-06 NO NO20076298A patent/NO20076298L/no not_active Application Discontinuation
-
2010
- 2010-08-12 AU AU2010212296A patent/AU2010212296B2/en not_active Ceased
-
2011
- 2011-11-30 US US13/307,864 patent/US20120077879A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
NZ562304A (en) | 2010-06-25 |
TNSN07415A1 (en) | 2009-03-17 |
NZ585116A (en) | 2011-12-22 |
AU2006244213A1 (en) | 2006-11-16 |
US20100152299A1 (en) | 2010-06-17 |
JP2008540540A (ja) | 2008-11-20 |
IL186456A0 (en) | 2008-01-20 |
EP1881819A1 (fr) | 2008-01-30 |
MX2007014041A (es) | 2008-02-11 |
CA2607624A1 (fr) | 2006-11-16 |
NO20076298L (no) | 2007-12-06 |
RU2007145522A (ru) | 2009-06-20 |
CN102552162A (zh) | 2012-07-11 |
RU2405539C2 (ru) | 2010-12-10 |
KR20130135403A (ko) | 2013-12-10 |
AU2006244213B2 (en) | 2010-05-13 |
AU2010212296A1 (en) | 2010-09-02 |
AU2010212296B2 (en) | 2011-06-16 |
KR20080007357A (ko) | 2008-01-18 |
US20120077879A1 (en) | 2012-03-29 |
BRPI0608609A2 (pt) | 2010-01-19 |
JP5400377B2 (ja) | 2014-01-29 |
WO2006122021A1 (fr) | 2006-11-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA29465B1 (fr) | Procede d'extrusion permettant de fabriquer des compositions renfermant des composes therapeutiques peu compressibles | |
MA30807B1 (fr) | Compositions pharmaceutiques. | |
MXPA04004464A (es) | Compuestos de heteroarilo sustituido con azabiciclo para el tratamiento de enfermedades. | |
BR9808429A (pt) | Composição farmacêutica e processo para a sua preparação. | |
TN2009000059A1 (fr) | Formes de dosage pharmaceutiques orales anti-manipulation contenant un analgesique opioide | |
TW200722100A (en) | A therapeutic agent for a β related disorders | |
MXPA03011484A (es) | Heteroarilos multiciclicos sustituidos con quinuclidinas para el tratamiento de enfermedades. | |
MY138252A (en) | Azabicyclic-substitud fused-heteroaryl compounds for the treatment of disease | |
CL2011000450A1 (es) | Proceso para preparar una composicion farmaceutica que comprende a) mezclar un agonista del receptor s1p, seleccionado de 2-amino-2-[2-(4-octilfenil)etil]propano-1,3-diol y una sal del mismo, con un alcohol de azucar; b) moler y/o granular la mezcla; y c) mezclar la mezcla con un lubricante (divisional solicitud 745-2004). | |
MX2009001294A (es) | Granulo y tableta que se desintegra por vía oral que comprende oxicodona. | |
BR0213355A (pt) | composições farmacêuticas | |
TW200732321A (en) | Fast dissociating dopamine 2 receptor antagonists | |
MA31198B1 (fr) | Nouvelle forme dosifiee | |
TNSN08428A1 (fr) | NOUVELLE FORME d'ADMINISTRATION DU RACECADOTRIL | |
MA27206A1 (fr) | Azetidinones substituees par des groupements acides, procede pour leur preparation, medicaments contenant lesdits composes et utilisation de ceux-ci. | |
MA28093A1 (fr) | Forme polymorphe de 3-phenylsulfonyl-8-piperazine-1-yl-quinoleine | |
BRPI0518789A2 (pt) | formulaÇço farmacÊutica, processo para preparar uma formulaÇço farmacÊutica, produto, e, cÁpsula ou tablete | |
BRPI0518786A2 (pt) | formulaÇço farmacÊutica, processo para preparar uma formulaÇço farmacÊutica, produto, e, cÁpsula ou tablete | |
MXPA04003298A (es) | Compuestos de piperidina como antagonistas muscarinicos. | |
MA27133A1 (fr) | Nouvelles formes polymorphes cristallines d'hydrochlorure de lercanidipine et procede de fabrication associe | |
UA95274C2 (ru) | Твердый фармацевтический препарат, содержащий ирбесартан, и способы его изготовления | |
WO2005023833A3 (fr) | Traitement de maladies neurodegeneratives | |
TNSN05203A1 (fr) | Procede pour la fabrication d'une composition pharmaceutique sous la forme de comprimes contenant un fibrate et comprimes obtenus selon le procede | |
CA2455246A1 (fr) | Preparation de drogues comprenant de l'acide .alpha.-lipoique, de l'ambroxol et/ou des inhibiteurs de l'enzyme de conversion de l'angiotensine (ace) et leur utilisation pour le traitement de maladies neurodegeneratives | |
GT200600119A (es) | Composiciones farmaceuticas |