RU2393151C2 - 4-циклоалкилзамещенные производные тетрагидрохинолина и их применение в качестве лекарств - Google Patents
4-циклоалкилзамещенные производные тетрагидрохинолина и их применение в качестве лекарств Download PDFInfo
- Publication number
- RU2393151C2 RU2393151C2 RU2007127127/04A RU2007127127A RU2393151C2 RU 2393151 C2 RU2393151 C2 RU 2393151C2 RU 2007127127/04 A RU2007127127/04 A RU 2007127127/04A RU 2007127127 A RU2007127127 A RU 2007127127A RU 2393151 C2 RU2393151 C2 RU 2393151C2
- Authority
- RU
- Russia
- Prior art keywords
- compound
- formula
- cetp
- administered
- cholesterol
- Prior art date
Links
- ZFGMQLLHHKPTNJ-UHFFFAOYSA-N CC(C)(Cc1nc(C2CCCC2)c(C(c2ccc(C(F)(F)F)cc2)=O)c(C2CCCCC2)c11)CC1=O Chemical compound CC(C)(Cc1nc(C2CCCC2)c(C(c2ccc(C(F)(F)F)cc2)=O)c(C2CCCCC2)c11)CC1=O ZFGMQLLHHKPTNJ-UHFFFAOYSA-N 0.000 description 1
- 0 CC(C)c1c([C@](c2ccc(C(F)(F)F)cc2)F)c(C2CCCC2)c([C@](CC(C)(C)C2)O*)c2n1 Chemical compound CC(C)c1c([C@](c2ccc(C(F)(F)F)cc2)F)c(C2CCCC2)c([C@](CC(C)(C)C2)O*)c2n1 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004060997A DE102004060997A1 (de) | 2004-12-18 | 2004-12-18 | Chemische Verbindung und ihre Verwendung |
| DE102004061000.2 | 2004-12-18 | ||
| DE102004061000A DE102004061000A1 (de) | 2004-12-18 | 2004-12-18 | Chemische Verbindung und ihre Verwendung |
| DE102004060997.7 | 2004-12-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2007127127A RU2007127127A (ru) | 2009-01-27 |
| RU2393151C2 true RU2393151C2 (ru) | 2010-06-27 |
Family
ID=35841894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007127127/04A RU2393151C2 (ru) | 2004-12-18 | 2005-12-15 | 4-циклоалкилзамещенные производные тетрагидрохинолина и их применение в качестве лекарств |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US8124775B2 (https=) |
| EP (1) | EP1828137B1 (https=) |
| JP (1) | JP5132317B2 (https=) |
| KR (1) | KR20070090248A (https=) |
| AR (1) | AR055011A1 (https=) |
| AT (1) | ATE555097T1 (https=) |
| AU (1) | AU2005315770B2 (https=) |
| BR (1) | BRPI0519602A2 (https=) |
| CA (1) | CA2591397A1 (https=) |
| CU (1) | CU23452B7 (https=) |
| CY (1) | CY1112887T1 (https=) |
| DK (1) | DK1828137T3 (https=) |
| DO (1) | DOP2005000259A (https=) |
| ES (1) | ES2384980T3 (https=) |
| GT (1) | GT200500377A (https=) |
| IL (1) | IL184008A (https=) |
| MA (1) | MA29100B1 (https=) |
| MX (1) | MX2007007188A (https=) |
| NO (1) | NO20073146L (https=) |
| PE (1) | PE20060767A1 (https=) |
| PL (1) | PL1828137T3 (https=) |
| PT (1) | PT1828137E (https=) |
| RU (1) | RU2393151C2 (https=) |
| SI (1) | SI1828137T1 (https=) |
| TW (1) | TW200635900A (https=) |
| UY (1) | UY29276A1 (https=) |
| WO (1) | WO2006063828A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2572606C2 (ru) * | 2010-07-09 | 2016-01-20 | Дайити Санкио Компани, Лимитед | Замещенное пиридиновое соединение |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0519566A2 (pt) * | 2004-12-18 | 2009-01-27 | Bayer Healthcare Ag | derivados de (5s)-3-[(s)-fléor(4-trifluormetilfenil)metil]-5,6,7,8-tet raidroquinolin-5-ol e seu uso como inibidores de cetp |
| DE102006012548A1 (de) * | 2006-03-18 | 2007-09-20 | Bayer Healthcare Ag | Substituierte Chromanol-Derivate und ihre Verwendung |
| BRPI0909105A2 (pt) * | 2008-03-05 | 2015-08-25 | Boehringer Ingelheim Int | Derivados de piridina tricíclicos, composição farmacêutica e uso dos mesmos, bem como processos para preparar os ditos compostos e a dita composição farmacêutica |
| UY33229A (es) * | 2010-02-19 | 2011-09-30 | Boehringer Ingelheim Int | Derivados de piridina tricíclicos, medicamentos que contienen tales compuestos, su uso y proceso pa ra su preparación |
| EP2675811A1 (en) | 2011-02-17 | 2013-12-25 | Boehringer Ingelheim International GmbH | Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation |
| EP2760868B1 (en) | 2011-08-17 | 2018-04-25 | Boehringer Ingelheim International GmbH | Furo[3,4-c]quinoline derivatives, medicaments containing such compounds, their use and process for their preparation |
| TWI570118B (zh) | 2012-01-06 | 2017-02-11 | 第一三共股份有限公司 | 經取代之吡啶化合物的酸加成鹽 |
| MX384679B (es) | 2014-07-30 | 2025-03-14 | Hoffmann La Roche | Marcadores genéticos para predecir la reactividad a terapia con agente que eleva la lipoproteína de alta densidad (hdl) o que imita la lipoproteína de alta densidad (hdl). |
| WO2025185022A1 (zh) * | 2024-03-05 | 2025-09-12 | 维康平生(北京)生物科技有限公司 | 一种脂肪体的制备方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2066315C1 (ru) * | 1991-08-29 | 1996-09-10 | Байер Аг | Замещенные производные миндальной кислоты и способ их получения |
| US6069148A (en) * | 1996-07-08 | 2000-05-30 | Bayer Aktiengesellschaft | Cycloalkano-pyridines |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19610932A1 (de) | 1996-03-20 | 1997-09-25 | Bayer Ag | 2-Aryl-substituierte Pyridine |
| DE19627431A1 (de) | 1996-07-08 | 1998-01-15 | Bayer Ag | Heterocyclisch kondensierte Pyridine |
| DE19627430A1 (de) | 1996-07-08 | 1998-01-15 | Bayer Ag | Bicyclisch kondensierte Pyridine |
| US6207671B1 (en) | 1996-07-08 | 2001-03-27 | Bayer Aktiengesellschaft | Cycloalkano-pyridines |
| DE19704244A1 (de) | 1997-02-05 | 1998-08-06 | Bayer Ag | 5-Hydroxy-alkyl substituierte Phenyle |
| DE19709125A1 (de) | 1997-03-06 | 1998-09-10 | Bayer Ag | Substituierte Chinoline |
| MA24643A1 (fr) * | 1997-09-18 | 1999-04-01 | Bayer Ag | Tetrahydro-naphtalenes substitues et composes analogues |
| DE19741051A1 (de) | 1997-09-18 | 1999-03-25 | Bayer Ag | Hetero-Tetrahydrochinoline |
| DE19741399A1 (de) | 1997-09-19 | 1999-03-25 | Bayer Ag | Tetrahydrochinoline |
| DE19935966A1 (de) | 1999-07-30 | 2001-02-01 | Bayer Ag | Verfahren zur Reduktion von Ketoalkoholen |
| DE10148436A1 (de) | 2001-10-01 | 2003-04-17 | Bayer Ag | Tetrahydrochinoline |
| DE10250687A1 (de) | 2002-10-31 | 2004-05-13 | Bayer Ag | 7H-Dibenzo(b,g)(1,5)dioxocin-5-on-Derivate und ihre Verwendung |
| BRPI0519566A2 (pt) * | 2004-12-18 | 2009-01-27 | Bayer Healthcare Ag | derivados de (5s)-3-[(s)-fléor(4-trifluormetilfenil)metil]-5,6,7,8-tet raidroquinolin-5-ol e seu uso como inibidores de cetp |
-
2005
- 2005-12-15 ES ES05820528T patent/ES2384980T3/es not_active Expired - Lifetime
- 2005-12-15 PL PL05820528T patent/PL1828137T3/pl unknown
- 2005-12-15 EP EP05820528A patent/EP1828137B1/de not_active Expired - Lifetime
- 2005-12-15 WO PCT/EP2005/013490 patent/WO2006063828A1/de not_active Ceased
- 2005-12-15 SI SI200531547T patent/SI1828137T1/sl unknown
- 2005-12-15 CA CA002591397A patent/CA2591397A1/en not_active Abandoned
- 2005-12-15 AT AT05820528T patent/ATE555097T1/de active
- 2005-12-15 DK DK05820528.7T patent/DK1828137T3/da active
- 2005-12-15 AU AU2005315770A patent/AU2005315770B2/en not_active Ceased
- 2005-12-15 MX MX2007007188A patent/MX2007007188A/es active IP Right Grant
- 2005-12-15 RU RU2007127127/04A patent/RU2393151C2/ru not_active IP Right Cessation
- 2005-12-15 PT PT05820528T patent/PT1828137E/pt unknown
- 2005-12-15 JP JP2007545948A patent/JP5132317B2/ja not_active Expired - Fee Related
- 2005-12-15 BR BRPI0519602-7A patent/BRPI0519602A2/pt not_active IP Right Cessation
- 2005-12-15 KR KR1020077016219A patent/KR20070090248A/ko not_active Ceased
- 2005-12-15 US US11/793,482 patent/US8124775B2/en not_active Expired - Fee Related
- 2005-12-16 PE PE2005001475A patent/PE20060767A1/es not_active Application Discontinuation
- 2005-12-16 DO DO2005P000259A patent/DOP2005000259A/es unknown
- 2005-12-16 AR ARP050105313A patent/AR055011A1/es not_active Application Discontinuation
- 2005-12-16 TW TW094144588A patent/TW200635900A/zh unknown
- 2005-12-19 GT GT200500377A patent/GT200500377A/es unknown
- 2005-12-20 UY UY29276A patent/UY29276A1/es not_active Application Discontinuation
-
2007
- 2007-06-18 CU CU20070140A patent/CU23452B7/es not_active IP Right Cessation
- 2007-06-18 MA MA30003A patent/MA29100B1/fr unknown
- 2007-06-18 IL IL184008A patent/IL184008A/en not_active IP Right Cessation
- 2007-06-19 NO NO20073146A patent/NO20073146L/no not_active Application Discontinuation
-
2012
- 2012-02-16 US US13/398,290 patent/US20120142728A1/en not_active Abandoned
- 2012-06-29 CY CY20121100588T patent/CY1112887T1/el unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2066315C1 (ru) * | 1991-08-29 | 1996-09-10 | Байер Аг | Замещенные производные миндальной кислоты и способ их получения |
| US6069148A (en) * | 1996-07-08 | 2000-05-30 | Bayer Aktiengesellschaft | Cycloalkano-pyridines |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2572606C2 (ru) * | 2010-07-09 | 2016-01-20 | Дайити Санкио Компани, Лимитед | Замещенное пиридиновое соединение |
Also Published As
| Publication number | Publication date |
|---|---|
| US20080255068A1 (en) | 2008-10-16 |
| US20120142728A1 (en) | 2012-06-07 |
| AU2005315770B2 (en) | 2011-12-08 |
| US8124775B2 (en) | 2012-02-28 |
| DOP2005000259A (es) | 2006-11-15 |
| IL184008A0 (en) | 2007-10-31 |
| PE20060767A1 (es) | 2006-09-10 |
| CA2591397A1 (en) | 2006-06-22 |
| RU2007127127A (ru) | 2009-01-27 |
| SI1828137T1 (sl) | 2012-08-31 |
| JP5132317B2 (ja) | 2013-01-30 |
| NO20073146L (no) | 2007-09-18 |
| AU2005315770A1 (en) | 2006-06-22 |
| IL184008A (en) | 2012-03-29 |
| ATE555097T1 (de) | 2012-05-15 |
| MA29100B1 (fr) | 2007-12-03 |
| EP1828137A1 (de) | 2007-09-05 |
| KR20070090248A (ko) | 2007-09-05 |
| TW200635900A (en) | 2006-10-16 |
| UY29276A1 (es) | 2006-07-31 |
| PL1828137T3 (pl) | 2012-09-28 |
| DK1828137T3 (da) | 2012-07-23 |
| ES2384980T3 (es) | 2012-07-16 |
| GT200500377A (es) | 2006-11-09 |
| CY1112887T1 (el) | 2016-04-13 |
| MX2007007188A (es) | 2007-08-14 |
| EP1828137B1 (de) | 2012-04-25 |
| JP2008524145A (ja) | 2008-07-10 |
| BRPI0519602A2 (pt) | 2009-02-25 |
| CU23452B7 (es) | 2009-12-01 |
| PT1828137E (pt) | 2012-07-04 |
| WO2006063828A1 (de) | 2006-06-22 |
| AR055011A1 (es) | 2007-08-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20120142728A1 (en) | Chemical compound and its use | |
| US8227511B2 (en) | Substituted chromanol derivatives and their use | |
| JP6856614B2 (ja) | １，４−二置換ピリダジン誘導体およびｓｍｎ欠損に関連する状態を処置するためのその使用 | |
| JP4157178B2 (ja) | 複素環式−縮合ピリジン類 | |
| JP2008524137A (ja) | （５ｓ）−３−［（ｓ）−フルオロ（４−トリフルオロメチルフェニル）メチル−５，６，７，８−テトラヒドロキノリン−５−オール誘導体およびｃｅｔｐ阻害剤としてのそれらの使用 | |
| EA010656B1 (ru) | Тетрагидрохинолиноны и их применение в качестве антагонистов метаботропных глутаматных рецепторов | |
| HUP0102307A2 (hu) | Biszpidinszármazékok, eljárás előállításukra, ezeket tartalmazó gyógyszerkészítmények, valamint intermedierjeik | |
| EA017093B1 (ru) | Хинолины и их терапевтическое применение | |
| KR20160072252A (ko) | 신규 dgat2 억제제 | |
| JP2005508341A (ja) | ３−ヒドロキシ−（４−トリフルオロメチルフェニル）−メチル−７−スピロシクロブチル−５，６，７，８−テトラヒドロキノリン−５−オール誘導体およびコレステロールエステル転送タンパク質（ｃｅｔｐ）阻害剤としてのその使用 | |
| TW201627302A (zh) | 經取代之醯胺化合物 | |
| JP2005530691A (ja) | 新規なチロインジシンとその関連プロセス、薬学的組成物および方法 | |
| CN101124206B (zh) | 4-环烷基取代的四氢喹啉衍生物及其作为药物的用途 | |
| JP2001302669A (ja) | 三環性フタラジノン誘導体 | |
| HK1117832A (en) | 4-cycloalkyl-substituted tetrahydrochinoline derivatives and use thereof as medicaments | |
| DE102004061001A1 (de) | Chemische Verbindung und ihre Verwendung | |
| DE102004061002A1 (de) | Chemische Verbindung und ihre Verwendung | |
| DE102004060998A1 (de) | Chemische Verbindung und ihre Verwendung | |
| DE102004061003A1 (de) | Chemische Verbindung und ihre Verwendung | |
| DE102004061000A1 (de) | Chemische Verbindung und ihre Verwendung | |
| DE102004060999A1 (de) | Chemische Verbindung und ihre Verwendung |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TK4A | Correction to the publication in the bulletin (patent) |
Free format text: AMENDMENT TO CHAPTER -FG4A- IN JOURNAL: 18-2010 |
|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20131216 |