DOP2005000259A - Compuesto químico y su uso. - Google Patents

Compuesto químico y su uso.

Info

Publication number
DOP2005000259A
DOP2005000259A DO2005P000259A DO2005000259A DOP2005000259A DO P2005000259 A DOP2005000259 A DO P2005000259A DO 2005P000259 A DO2005P000259 A DO 2005P000259A DO 2005000259 A DO2005000259 A DO 2005000259A DO P2005000259 A DOP2005000259 A DO P2005000259A
Authority
DO
Dominican Republic
Prior art keywords
chemical compound
prevention
preparation
treatment
diseases
Prior art date
Application number
DO2005P000259A
Other languages
English (en)
Inventor
Hilmar Bischoff
Heike Gielenhaertwig
Volkhart Li
Carsten Schmeck
Michael Thutewohl
Alexandros Vakalopoulos
Olaf Weber
Martina Wuttke
Original Assignee
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102004060997A external-priority patent/DE102004060997A1/de
Priority claimed from DE102004061000A external-priority patent/DE102004061000A1/de
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Publication of DOP2005000259A publication Critical patent/DOP2005000259A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

LA PRESENTE SOLICITUD SE REFIERE A UN NUEVO DERIVADO DE TETRAHIDROQUINOLINA, A UN PROCEDIMIENTO PARA SU PREPARACION, A SU USO SOLO O EN COMBINACIONES PARA EL TRATAMIENTO Y/O LA PREVENCION DE ENFERMEDADES, ASI COMO A SU USO PARA LA PREPARACIÓN DE FARMACOS, ESPECIALMENTE COMO INHIBIDOR DE LA PROTEINA DE TRANSFERENCIA DE ESTER DE COLESTEROL (CETP) PARA EL TRATAMIENTO Y/O LA PREVENCION DE ENFERMEDADES CARDIOVASCULARES, ESPECIALMENTE DE HIPOLIPOPROTEINEMIAS, DISLIPIDEMIAS, HIPERTRIGLICERIDEMIAS, HIPERLIPIDEMIAS, HIPERCOLESTEROLEMIAS Y ARTERIOSCLEROSIS.
DO2005P000259A 2004-12-18 2005-12-16 Compuesto químico y su uso. DOP2005000259A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004060997A DE102004060997A1 (de) 2004-12-18 2004-12-18 Chemische Verbindung und ihre Verwendung
DE102004061000A DE102004061000A1 (de) 2004-12-18 2004-12-18 Chemische Verbindung und ihre Verwendung

Publications (1)

Publication Number Publication Date
DOP2005000259A true DOP2005000259A (es) 2006-11-15

Family

ID=35841894

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2005P000259A DOP2005000259A (es) 2004-12-18 2005-12-16 Compuesto químico y su uso.

Country Status (27)

Country Link
US (2) US8124775B2 (es)
EP (1) EP1828137B1 (es)
JP (1) JP5132317B2 (es)
KR (1) KR20070090248A (es)
AR (1) AR055011A1 (es)
AT (1) ATE555097T1 (es)
AU (1) AU2005315770B2 (es)
BR (1) BRPI0519602A2 (es)
CA (1) CA2591397A1 (es)
CU (1) CU23452B7 (es)
CY (1) CY1112887T1 (es)
DK (1) DK1828137T3 (es)
DO (1) DOP2005000259A (es)
ES (1) ES2384980T3 (es)
GT (1) GT200500377A (es)
IL (1) IL184008A (es)
MA (1) MA29100B1 (es)
MX (1) MX2007007188A (es)
NO (1) NO20073146L (es)
PE (1) PE20060767A1 (es)
PL (1) PL1828137T3 (es)
PT (1) PT1828137E (es)
RU (1) RU2393151C2 (es)
SI (1) SI1828137T1 (es)
TW (1) TW200635900A (es)
UY (1) UY29276A1 (es)
WO (1) WO2006063828A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008524137A (ja) * 2004-12-18 2008-07-10 バイエル・ヘルスケア・アクチェンゲゼルシャフト （５ｓ）−３−［（ｓ）−フルオロ（４−トリフルオロメチルフェニル）メチル−５，６，７，８−テトラヒドロキノリン−５−オール誘導体およびｃｅｔｐ阻害剤としてのそれらの使用
DE102006012548A1 (de) * 2006-03-18 2007-09-20 Bayer Healthcare Ag Substituierte Chromanol-Derivate und ihre Verwendung
BRPI0909105A2 (pt) * 2008-03-05 2015-08-25 Boehringer Ingelheim Int Derivados de piridina tricíclicos, composição farmacêutica e uso dos mesmos, bem como processos para preparar os ditos compostos e a dita composição farmacêutica
MX2012009149A (es) 2010-02-19 2012-09-28 Boehringer Ingelheim Int Derivados de piridina triciclicos, medicamentos que contienen tales compuestos, su uso y proceso para su preparacion.
KR101764458B1 (ko) * 2010-07-09 2017-08-02 다이이찌 산쿄 가부시키가이샤 치환 피리딘 화합물
JP2014506887A (ja) 2011-02-17 2014-03-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 三環式ピリジン誘導体、このような化合物を含有する医薬、それらの使用およびそれらの調製のためのプロセス
US9150583B2 (en) 2011-08-17 2015-10-06 Boehringer Ingelheim International Gmbh Furo[3,4-c]quinoline derivatives, medicaments containing such compounds, their use and process for their preparation
JP6097225B2 (ja) * 2012-01-06 2017-03-15 第一三共株式会社 置換ピリジン化合物の酸付加塩
EP3174995B1 (en) 2014-07-30 2020-08-19 F.Hoffmann-La Roche Ag Genetic markers for predicting responsiveness to therapy with hdl-raising or hdl mimicking agent

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19610932A1 (de) 1996-03-20 1997-09-25 Bayer Ag 2-Aryl-substituierte Pyridine
HRP970330B1 (en) 1996-07-08 2004-06-30 Bayer Ag Cycloalkano pyridines
US6207671B1 (en) 1996-07-08 2001-03-27 Bayer Aktiengesellschaft Cycloalkano-pyridines
DE19627430A1 (de) 1996-07-08 1998-01-15 Bayer Ag Bicyclisch kondensierte Pyridine
DE19627431A1 (de) 1996-07-08 1998-01-15 Bayer Ag Heterocyclisch kondensierte Pyridine
DE19704244A1 (de) 1997-02-05 1998-08-06 Bayer Ag 5-Hydroxy-alkyl substituierte Phenyle
DE19709125A1 (de) 1997-03-06 1998-09-10 Bayer Ag Substituierte Chinoline
MA24643A1 (fr) 1997-09-18 1999-04-01 Bayer Ag Tetrahydro-naphtalenes substitues et composes analogues
DE19741051A1 (de) * 1997-09-18 1999-03-25 Bayer Ag Hetero-Tetrahydrochinoline
DE19741399A1 (de) * 1997-09-19 1999-03-25 Bayer Ag Tetrahydrochinoline
DE19935966A1 (de) 1999-07-30 2001-02-01 Bayer Ag Verfahren zur Reduktion von Ketoalkoholen
DE10148436A1 (de) * 2001-10-01 2003-04-17 Bayer Ag Tetrahydrochinoline
DE10250687A1 (de) 2002-10-31 2004-05-13 Bayer Ag 7H-Dibenzo(b,g)(1,5)dioxocin-5-on-Derivate und ihre Verwendung
JP2008524137A (ja) * 2004-12-18 2008-07-10 バイエル・ヘルスケア・アクチェンゲゼルシャフト （５ｓ）−３−［（ｓ）−フルオロ（４−トリフルオロメチルフェニル）メチル−５，６，７，８−テトラヒドロキノリン−５−オール誘導体およびｃｅｔｐ阻害剤としてのそれらの使用

Also Published As

Publication number Publication date
EP1828137B1 (de) 2012-04-25
IL184008A0 (en) 2007-10-31
RU2007127127A (ru) 2009-01-27
TW200635900A (en) 2006-10-16
MA29100B1 (fr) 2007-12-03
UY29276A1 (es) 2006-07-31
KR20070090248A (ko) 2007-09-05
NO20073146L (no) 2007-09-18
CY1112887T1 (el) 2016-04-13
IL184008A (en) 2012-03-29
EP1828137A1 (de) 2007-09-05
WO2006063828A1 (de) 2006-06-22
BRPI0519602A2 (pt) 2009-02-25
US20120142728A1 (en) 2012-06-07
ATE555097T1 (de) 2012-05-15
CA2591397A1 (en) 2006-06-22
CU23452B7 (es) 2009-12-01
JP5132317B2 (ja) 2013-01-30
US20080255068A1 (en) 2008-10-16
DK1828137T3 (da) 2012-07-23
PL1828137T3 (pl) 2012-09-28
ES2384980T3 (es) 2012-07-16
PT1828137E (pt) 2012-07-04
GT200500377A (es) 2006-11-09
JP2008524145A (ja) 2008-07-10
AU2005315770A1 (en) 2006-06-22
MX2007007188A (es) 2007-08-14
PE20060767A1 (es) 2006-09-10
AU2005315770B2 (en) 2011-12-08
SI1828137T1 (sl) 2012-08-31
US8124775B2 (en) 2012-02-28
RU2393151C2 (ru) 2010-06-27
AR055011A1 (es) 2007-08-01

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