CY1112887T1 - Παραγωγα 4-κυκλοαλκυλ-υποκατεστημενης τετραϋδροκινολινης και η χρηση τους ως φαρμακα - Google Patents

Παραγωγα 4-κυκλοαλκυλ-υποκατεστημενης τετραϋδροκινολινης και η χρηση τους ως φαρμακα

Info

Publication number
CY1112887T1
CY1112887T1 CY20121100588T CY121100588T CY1112887T1 CY 1112887 T1 CY1112887 T1 CY 1112887T1 CY 20121100588 T CY20121100588 T CY 20121100588T CY 121100588 T CY121100588 T CY 121100588T CY 1112887 T1 CY1112887 T1 CY 1112887T1
Authority
CY
Cyprus
Prior art keywords
medicines
cycloalkyl
tetrahydroquinoline derivative
substituted tetrahydroquinoline
prevention
Prior art date
Application number
CY20121100588T
Other languages
English (en)
Inventor
Hilmar Bischoff
Heike Gielen-Haertwig
Volkhart Li
Carsten Schmeck
Michael Thutewohl
Alexandros Vakalopoulos
Olaf Weber
Martina Wuttke
Original Assignee
Bayer Pharma Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102004060997A external-priority patent/DE102004060997A1/de
Priority claimed from DE102004061000A external-priority patent/DE102004061000A1/de
Application filed by Bayer Pharma Aktiengesellschaft filed Critical Bayer Pharma Aktiengesellschaft
Publication of CY1112887T1 publication Critical patent/CY1112887T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Quinoline Compounds (AREA)

Abstract

Η παρούσα αίτηση αφορά ένα νέο παράγωγο τετραϋδροκινολίνης, μια μέθοδο για την παρασκευή του, τη χρήση του είτε από μόνο του ή σε συνδυασμούς για τη θεραπευτική αγωγή ή/και πρόληψη ασθενειών, επιπλέον της χρήσης του στην παρασκευή φαρμάκων, συγκεκριμένα ως αναστολέα της πρωτεΐνης μεταφοράς εστέρων χοληστερόλης (CΕΤΡ) για τη θεραπευτική αγωγή ή/και πρόληψη καρδιαγγειακών ασθενειών, συγκεκριμένα υπολιποπρωτεϊναιμιών, δυσλιπιδαιμιών, υπερτριγλυκεριδαιμιών, υπερλιπιδαιμιών, υπερχοληστερολαιμιών και αρτηριοσκλήρωσης.
CY20121100588T 2004-12-18 2012-06-29 Παραγωγα 4-κυκλοαλκυλ-υποκατεστημενης τετραϋδροκινολινης και η χρηση τους ως φαρμακα CY1112887T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102004060997A DE102004060997A1 (de) 2004-12-18 2004-12-18 Chemische Verbindung und ihre Verwendung
DE102004061000A DE102004061000A1 (de) 2004-12-18 2004-12-18 Chemische Verbindung und ihre Verwendung
EP05820528A EP1828137B1 (de) 2004-12-18 2005-12-15 4-cycloalkyl-substituierte tetrahydrochinolinderivate und deren verwendung als medikamente

Publications (1)

Publication Number Publication Date
CY1112887T1 true CY1112887T1 (el) 2016-04-13

Family

ID=35841894

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100588T CY1112887T1 (el) 2004-12-18 2012-06-29 Παραγωγα 4-κυκλοαλκυλ-υποκατεστημενης τετραϋδροκινολινης και η χρηση τους ως φαρμακα

Country Status (27)

Country Link
US (2) US8124775B2 (el)
EP (1) EP1828137B1 (el)
JP (1) JP5132317B2 (el)
KR (1) KR20070090248A (el)
AR (1) AR055011A1 (el)
AT (1) ATE555097T1 (el)
AU (1) AU2005315770B2 (el)
BR (1) BRPI0519602A2 (el)
CA (1) CA2591397A1 (el)
CU (1) CU23452B7 (el)
CY (1) CY1112887T1 (el)
DK (1) DK1828137T3 (el)
DO (1) DOP2005000259A (el)
ES (1) ES2384980T3 (el)
GT (1) GT200500377A (el)
IL (1) IL184008A (el)
MA (1) MA29100B1 (el)
MX (1) MX2007007188A (el)
NO (1) NO20073146L (el)
PE (1) PE20060767A1 (el)
PL (1) PL1828137T3 (el)
PT (1) PT1828137E (el)
RU (1) RU2393151C2 (el)
SI (1) SI1828137T1 (el)
TW (1) TW200635900A (el)
UY (1) UY29276A1 (el)
WO (1) WO2006063828A1 (el)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2007007187A (es) * 2004-12-18 2007-08-14 Bayer Healthcare Ag Derivados de (5s)-3-[(s)-fluoro-(4-trifluorometilfenil)metil]-5,6, 7,8-tetrahidroquinolin-5-ol y su uso como inhibidores de la proteina de transferencia de ester de colesterol.
DE102006012548A1 (de) * 2006-03-18 2007-09-20 Bayer Healthcare Ag Substituierte Chromanol-Derivate und ihre Verwendung
PL2268644T3 (pl) * 2008-03-05 2012-01-31 Boehringer Ingelheim Int Tricykliczne pochodne piperydyny, leki zawierające te związki, ich zastosowanie i sposoby ich wytwarzania
JP5780528B2 (ja) 2010-02-19 2015-09-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 三環式ピリジン誘導体、このような化合物を含有する医薬、それらの使用、およびそれらの調製方法
RU2572606C2 (ru) * 2010-07-09 2016-01-20 Дайити Санкио Компани, Лимитед Замещенное пиридиновое соединение
US20130053404A1 (en) 2011-02-17 2013-02-28 Boehringer Ingelheim International Gmbh Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation
AR087577A1 (es) 2011-08-17 2014-04-03 Boehringer Ingelheim Int Derivados de furo[3,4-c]quinolina, medicamentos que contienen dichos compuestos, su uso y proceso para su preparacion
ES2599757T3 (es) 2012-01-06 2017-02-03 Daiichi Sankyo Company, Limited Sales de aducto de ácido de un compuesto de piridina sustituido como inhibidores de la proteína de transferencia de ésteres de colesterilo (PTEC)
KR102456013B1 (ko) 2014-07-30 2022-10-18 에프. 호프만-라 로슈 아게 고밀도 지질단백질(hdl)-상승 제제 또는 hdl-모방 제제에 의한 치료법에 대한 반응성을 예측하기 위한 유전 표지

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19610932A1 (de) 1996-03-20 1997-09-25 Bayer Ag 2-Aryl-substituierte Pyridine
DE19627431A1 (de) 1996-07-08 1998-01-15 Bayer Ag Heterocyclisch kondensierte Pyridine
HRP970330B1 (en) * 1996-07-08 2004-06-30 Bayer Ag Cycloalkano pyridines
US6207671B1 (en) 1996-07-08 2001-03-27 Bayer Aktiengesellschaft Cycloalkano-pyridines
DE19627430A1 (de) 1996-07-08 1998-01-15 Bayer Ag Bicyclisch kondensierte Pyridine
DE19704244A1 (de) 1997-02-05 1998-08-06 Bayer Ag 5-Hydroxy-alkyl substituierte Phenyle
DE19709125A1 (de) 1997-03-06 1998-09-10 Bayer Ag Substituierte Chinoline
DE19741051A1 (de) * 1997-09-18 1999-03-25 Bayer Ag Hetero-Tetrahydrochinoline
MA24643A1 (fr) * 1997-09-18 1999-04-01 Bayer Ag Tetrahydro-naphtalenes substitues et composes analogues
DE19741399A1 (de) * 1997-09-19 1999-03-25 Bayer Ag Tetrahydrochinoline
DE19935966A1 (de) 1999-07-30 2001-02-01 Bayer Ag Verfahren zur Reduktion von Ketoalkoholen
DE10148436A1 (de) 2001-10-01 2003-04-17 Bayer Ag Tetrahydrochinoline
DE10250687A1 (de) 2002-10-31 2004-05-13 Bayer Ag 7H-Dibenzo(b,g)(1,5)dioxocin-5-on-Derivate und ihre Verwendung
MX2007007187A (es) * 2004-12-18 2007-08-14 Bayer Healthcare Ag Derivados de (5s)-3-[(s)-fluoro-(4-trifluorometilfenil)metil]-5,6, 7,8-tetrahidroquinolin-5-ol y su uso como inhibidores de la proteina de transferencia de ester de colesterol.

Also Published As

Publication number Publication date
AR055011A1 (es) 2007-08-01
US8124775B2 (en) 2012-02-28
JP5132317B2 (ja) 2013-01-30
ES2384980T3 (es) 2012-07-16
CA2591397A1 (en) 2006-06-22
AU2005315770A1 (en) 2006-06-22
US20120142728A1 (en) 2012-06-07
MX2007007188A (es) 2007-08-14
RU2393151C2 (ru) 2010-06-27
PE20060767A1 (es) 2006-09-10
IL184008A0 (en) 2007-10-31
DOP2005000259A (es) 2006-11-15
EP1828137B1 (de) 2012-04-25
EP1828137A1 (de) 2007-09-05
GT200500377A (es) 2006-11-09
UY29276A1 (es) 2006-07-31
JP2008524145A (ja) 2008-07-10
PL1828137T3 (pl) 2012-09-28
SI1828137T1 (sl) 2012-08-31
BRPI0519602A2 (pt) 2009-02-25
IL184008A (en) 2012-03-29
MA29100B1 (fr) 2007-12-03
PT1828137E (pt) 2012-07-04
AU2005315770B2 (en) 2011-12-08
RU2007127127A (ru) 2009-01-27
TW200635900A (en) 2006-10-16
KR20070090248A (ko) 2007-09-05
US20080255068A1 (en) 2008-10-16
NO20073146L (no) 2007-09-18
CU23452B7 (es) 2009-12-01
WO2006063828A1 (de) 2006-06-22
ATE555097T1 (de) 2012-05-15
DK1828137T3 (da) 2012-07-23

Similar Documents

Publication Publication Date Title
CY1112887T1 (el) Παραγωγα 4-κυκλοαλκυλ-υποκατεστημενης τετραϋδροκινολινης και η χρηση τους ως φαρμακα
CY1120996T1 (el) Αντισωματα anti-angptl3 και χρησεις αυτων
CY1118898T1 (el) Ανθρωπινα αντισωματα για πρωτεϊνη 4 τυπου ανθρωπινης αγγειοποιητινης
CY1122629T1 (el) Αιθυλεστερας εικοσαπενταενοϊκου οξεος για θεραπεια υπερτριγλυκεριδαιμιας
BRPI0519566A2 (pt) derivados de (5s)-3-[(s)-fléor(4-trifluormetilfenil)metil]-5,6,7,8-tet raidroquinolin-5-ol e seu uso como inibidores de cetp
CY1121070T1 (el) Φαρμακευτικες συνθεσεις για την αγωγη cftr μεσολαβουμενων παθησεων
EA200702674A1 (ru) Способ лечения атеросклероза, дислипидемий и связанных с ними состояний и фармацевтические композиции
BRPI0514133A (pt) compostos de fórmula i, processo para a sua fabricação, composições farmacêuticas, método para o tratamento e/ou profilaxia de doença que são mediadas por inibidores de cetp e uso dos compostos de fórmula i
CY1112813T1 (el) 4-(4-κυανο-2-θειοαρυλ)διϋδροπυριμιδινονες και η χρηση αυτων
EA200801580A1 (ru) Новые производные пирониндола и способ их получения
BRPI0413490A (pt) novos compostos
SE0303570L (sv) Fukt-känslig medicinsk produkt
LTC1725234I2 (lt) Sutrikimų arba ligų, susijusių su hiperlipidemija ir hipercholesterolemija, gydymo būdai, minimizuojant šalutinį poveikį
BRPI0821644A2 (pt) Compostos derivados de benzimidazol carboxila ou hidroxila substituídos, processo para a sua preparação, composições farmacêuticas que os contêm, método para o tratamento terapêutico ou profilático de enfermidades que são moduladas por agonistas fxr e usos dos compostos
ATE466925T1 (de) Duftverfahren und produkt
CY1115082T1 (el) Υποκατεστημενα παραγωγα 1,3-διφαινυλπροπανιου, παρασκευες και χρησεις αυτων
CL2007003209A1 (es) Composicion que comprende una vacuna de flavivirus vivos atenuados; composicion que comprende un producto farmaceutico derivado de virus o proteina; un metodo para la elaboracion de una composicion terapeutica que comprende liofilizar las composicion
DE602007013618D1 (de) Antikörper gegen das humane cytomegalie-virus (hcmv)
CY1108932T1 (el) Ενωσεις 4-(ετεροκυκλυλ)-βενζολοσουλφοξιμινης για την θεραπευτικη αγωγη φλεγμονωδων ασθενειων
CY1117504T1 (el) Παραγωγα 1-βενζυλ-3-υδροξυμεθυλινδαζολης και η χρηση τους στη θεραπευτικη αντιμετωπιση νοσων που βασιζονται στην εκφραση των mcp-1, και cx3cr1
DK1542729T3 (da) Stabilt immunogent produkt omfattende antigene heterokomplekser
EA200970398A1 (ru) Производные пиперидин или пиперазин замещенной тетрагидро-нафталин 1-карбоновой кислоты, ингибирующие мтр
EA202191244A1 (ru) Новые цитостатические конъюгаты с лигандами интегрина
CY1116840T1 (el) Χρηση 24-norudca
CY1113551T1 (el) Υποκατεστημενες ενωσεις νικοτιναμιδιου και η χρησιμοποιηση τους σε φαρμακα