JP2005530691A - 新規なチロインジシンとその関連プロセス、薬学的組成物および方法 - Google Patents
新規なチロインジシンとその関連プロセス、薬学的組成物および方法 Download PDFInfo
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- JP2005530691A JP2005530691A JP2003569126A JP2003569126A JP2005530691A JP 2005530691 A JP2005530691 A JP 2005530691A JP 2003569126 A JP2003569126 A JP 2003569126A JP 2003569126 A JP2003569126 A JP 2003569126A JP 2005530691 A JP2005530691 A JP 2005530691A
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Classifications
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Abstract
Description
Ali,M.;et al.,Tylophora indica.Phytochemistry1989,28,3513−3517.
Faber,L.;et al.,Stereospecific synthesis of a 9,11,12,13,13a,14−hexahydrodibenzo(f,h)−pyrrolo(1,2−[b]isoquinoline alkaloid.Helv.Chim.Acta1973,56,2882−2884;7)Comins,D.L.;Chern,X.;Morgan,L.A.Enantiopure N−acyldihydropyridones as synthetic intermediates:Asymmetric synthesis of−septicine and−tylophorine.J.Org.Chem.1997,62,7435−7438.
XはHまたはORbであり、RbはH、アルキル、置換アルキル、アリル、置換アリル、複素環または置換複素環である。
Ihara,M.;et al.,Stereocontrolled Synthesis of Quinolizidines and Indolizidines Using Trialkylsilyl Triflurormethanesulphonate:Total Synthesis of−Tylophorine.J.Chem.Soc.,Chem.Commun.1985,1159−1160
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Claims (62)
- 構造式
- 構造式
- 薬学的に受容可能なキャリアーと請求項1または2の化合物の治療有効量を含んだことを特徴とする薬学的組成物。
- 薬学的に受容可能なキャリアーと請求項3〜15または55〜58の化合物の治療有効量を含んだことを特徴とする薬学的組成物。
- 必要とする腫瘍罹病哺乳動物に請求項1または2の化合物の1種以上の治療有効量を投与することを特徴とする哺乳動物の治療方法。
- 必要とする腫瘍罹病哺乳動物に請求項3〜15または55〜58の化合物の1種以上の治療有効量を投与することを特徴とする哺乳動物の治療方法。
- 必要とする癌罹病哺乳動物に請求項1または2の化合物の1種以上の治療有効量を投与することを特徴とする哺乳動物の治療方法。
- 必要とする癌罹病哺乳動物に請求項3〜15または55〜58の化合物の1種以上の治療有効量を投与することを特徴とする哺乳動物の治療方法。
- 癌が胃癌、結腸癌、直腸癌、肝臓癌、膵臓癌、肺癌、乳癌、子宮頚管癌、子宮癌、卵巣癌、前立腺癌、精巣癌、嚢癌、腎臓癌、脳または中枢神経系癌、頭部および頚部癌、咽喉癌、ホジキン病癌、非ホジキン白血病、多発性骨髄腫白血病、皮膚黒色素細胞腫、急性リンパ細胞白血病、急性骨髄性白血病、ユーイング肉腫、小細胞肺癌、絨毛癌、平滑筋組織腫瘍、ウイルムス腫瘍、神経芽細胞腫、毛状細胞白血病、口腔/咽喉癌、食道癌、咽頭癌、黒色素細胞腫、腎臓およびリンパ腫の1種以上であることを特徴とする請求項30または31に記載の方法。
- 癌が抗薬性癌であることを特徴とする請求項30に記載の方法。
- 癌が、アルキル化剤、DNA−相互作用化合物およびトポイソメラーゼ活性剤からなる群から選ばれる少なくとも1種の薬剤に対して、抵抗性であることを特徴とする請求項33に記載の方法。
- 癌が、エトポサイド、ゲムシタビン、ヒドロキシウレア、トポI薬およびトポII薬からなる群から選ばれた少なくとも1種の薬剤に対して、抵抗性であることを特徴とする請求項33に記載の方法。
- 請求項1または2の化合物が腫瘍成長の抑制のために投与されることを特徴とする請求項28に記載の方法。
- 請求項3〜15または55〜58の化合物が腫瘍成長の抑制のために投与されることを特徴とする請求項29に記載の方法。
- 請求項1の化合物が、エトポサイド、シス−プラチン、カルボプラチン、ロバプラチン、オルマプラチン、オキサプラチン、ヘキサメチルマラミン、NLCQ−1、メファラン、ジヒドロキシブスルファン、シクロフォスフアミド、ダウノルビシン、ドキソルビシン、ミトミシン、アドリアミシン、カンプトセシン、ビンクリスチン、ビンブラスチン、ヒドロキシウレア、ゲミシタビン、トポ−Iおよびトポ−II薬、ポリヌクレオチド、オリゴヌクレオチド、タキソール、メタサイクリン、抗血管形成薬、アザインドール誘導体、ジベンゾフルオレン誘導体、テモゾロマイド、AP/AMPおよびそれらのプロドラッグ形態からなる群から選ばれた1種または化合物、と一緒に投与されることを特徴とする請求項28に記載の方法。
- 腫瘍が良性腫瘍であることを特徴とする請求項28または29に記載の方法。
- 癌が悪性腫瘍であることを特徴とする請求項30または31に記載の方法。
- 癌が薬剤抵抗性を発展させたことを特徴とする請求項30〜32のいずれかひとつに記載の方法。
- 癌が多重薬剤抵抗性乳癌であることを特徴とする請求項30〜32のいずれかひとつに記載の方法。
- 腫瘍の成長、拡散を抑制するかまたは縮小すべく請求項1または2の1種以上の化合物が哺乳動物に投与されることを特徴とする請求項28または29に記載の方法。
- 腫瘍の成長、拡散を抑制するかまたは縮小すべく請求項3〜15または55〜58の1種以上の化合物が哺乳動物に投与されることを特徴とする請求項28または29に記載の方法。
- 哺乳動物が人間であることを特徴とする請求項28〜44のいずれかひとつに記載の方法。
- 炎症または自己免疫障害罹病哺乳動物の治療方法であって、投与を必要とする哺乳動物に請求項1または2の化合物、エピマー、薬学的に受容可能な塩、溶媒和物またはその多形体の1種以上の治療有効量を投与することを特徴とする治療方法。
- 炎症または自己免疫障害罹病哺乳動物の治療方法であって、投与を必要とする哺乳動物に請求項3〜15または55〜58の化合物、エピマー、薬学的に受容可能な塩、溶媒和物またはその多形体の1種以上の治療有効量を投与することを特徴とする治療方法。
- 炎症または自己免疫障害がNF−κBの活性化を伴うことを特徴とする請求項46または47に記載の方法。
- 炎症または自己免疫障害が移植拒否症、移植併発血管障害、急性糸球体腎炎、ループス腎炎および尿細管間質性腎炎、喘息、呼吸障害症、胃炎、リューマチ性関節炎、紅斑性狼瘡、血管炎、糖尿病、AIDS、敗血症、血栓症、冠状動脈病、血管形成またはバイパス手術後の再狭窄、虚血症であることを特徴とする請求項46または47に記載の方法。
- 炎症または自己免疫障害がリューマチ性関節炎、炎症腸病、喘息、皮膚炎、乾癬およびアトピー性皮膚炎、自己免疫病、組織および器官拒否、アルツハイマー病、ホジキン病、AIDS、運動失調毛細血管拡張症であることを特徴とする請求項46または47に記載の方法。
- 必要とする患者に請求項1〜15または55〜58の化合物の治療有効量を投与することを特徴とするEBV感染の治療方法。
- 必要とする患者に請求項1〜15または55〜58の化合物の治療有効量を投与することを特徴とするEBV関連リンパ腫または癌の治療方法。
- 患者がEBV感染に罹病する可能性を防止または低減する方法であって、EBV感染に罹病する危険のある患者に請求項1〜15および55〜58の化合物の治療有効量を投与することを特徴とする方法。
- 患者がEBV関連リンパ腫または癌に罹病する可能性を防止または低減する方法であって、治療を必要とする患者に請求項1〜15および55〜58の化合物の治療有効量を投与することを特徴とする方法。
- 構造式
- 腫瘍治療用の薬剤の製造のための請求項1〜15および55〜58の化合物の使用方法。
- 癌治療用の薬剤の製造のための請求項1〜15および55〜58の化合物の使用方法。
- 患者におけるEBV感染治療用の薬剤の製造のための請求項1〜15および55〜58の化合物の使用方法。
- 炎症または自己免疫障害治療用の薬剤の製造のための請求項1〜15および55〜58の化合物の使用方法。
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WO2010047127A1 (ja) * | 2008-10-23 | 2010-04-29 | 株式会社ヤクルト本社 | フェナンスロインドリジジン化合物及びこれを有効成分とするNFκB阻害剤 |
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WO2005018638A1 (en) * | 2003-08-13 | 2005-03-03 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
EP1604990A1 (en) * | 2004-06-11 | 2005-12-14 | National Health Research Institutes | Phenanthroindolizidine alkaloids |
WO2007081540A2 (en) * | 2006-01-05 | 2007-07-19 | University Of North Carolina At Chapel Hill | Tylophorine analogs as antitumor agents |
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CN105924380B (zh) * | 2015-02-27 | 2019-03-05 | 顺天乡大学校产学协力团 | 菲类化合物或其衍生物、以及含有该菲类化合物或其衍生物的治疗结核病用药物组合物 |
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WO2001023384A1 (fr) * | 1999-09-27 | 2001-04-05 | Japan As Represented By Director General Of Agency Of National Cancer Center | Agents antitumoraux |
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2003
- 2003-02-12 JP JP2003569126A patent/JP2005530691A/ja active Pending
- 2003-02-12 CA CA002474848A patent/CA2474848A1/en not_active Abandoned
- 2003-02-12 US US10/502,074 patent/US20050222418A1/en not_active Abandoned
- 2003-02-12 AU AU2003217373A patent/AU2003217373B2/en not_active Ceased
- 2003-02-12 WO PCT/US2003/004072 patent/WO2003070166A2/en active Application Filing
- 2003-02-12 EP EP03713417A patent/EP1482937A4/en not_active Withdrawn
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2001023384A1 (fr) * | 1999-09-27 | 2001-04-05 | Japan As Represented By Director General Of Agency Of National Cancer Center | Agents antitumoraux |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010047126A1 (ja) * | 2008-10-23 | 2010-04-29 | 株式会社ヤクルト本社 | フェナンスロインドリジジン誘導体及びこれを有効成分とするNFκB阻害剤 |
WO2010047127A1 (ja) * | 2008-10-23 | 2010-04-29 | 株式会社ヤクルト本社 | フェナンスロインドリジジン化合物及びこれを有効成分とするNFκB阻害剤 |
EA019927B1 (ru) * | 2008-10-23 | 2014-07-30 | Кабусики Кайся Якулт Хонса | ФЕНАНТРОИНДОЛИЗИДИНОВОЕ СОЕДИНЕНИЕ И ИНГИБИТОР NFκB, СОДЕРЖАЩИЙ ЕГО В КАЧЕСТВЕ ДЕЙСТВУЮЩЕГО ИНГРЕДИЕНТА |
JP5583589B2 (ja) * | 2008-10-23 | 2014-09-03 | 株式会社ヤクルト本社 | フェナンスロインドリジジン誘導体及びこれを有効成分とするNFκB阻害剤 |
US9174979B2 (en) | 2008-10-23 | 2015-11-03 | Kabushiki Kaisha Yakult Honsha | Phenanthroindolizidine compound and NFκB inhibitor containing same as active ingredient |
EA023622B1 (ru) * | 2008-10-23 | 2016-06-30 | Кабусики Кайся Якулт Хонса | ПРОИЗВОДНОЕ ФЕНАНТРОИНДОЛИЗИДИНА И ИНГИБИТОР NFκB, СОДЕРЖАЩИЙ ЕГО В КАЧЕСТВЕ АКТИВНОГО ИНГРЕДИЕНТА |
Also Published As
Publication number | Publication date |
---|---|
WO2003070166A2 (en) | 2003-08-28 |
AU2003217373B2 (en) | 2009-04-30 |
AU2003217373A1 (en) | 2003-09-09 |
CA2474848A1 (en) | 2003-08-28 |
EP1482937A4 (en) | 2007-02-21 |
US20050222418A1 (en) | 2005-10-06 |
EP1482937A2 (en) | 2004-12-08 |
WO2003070166A3 (en) | 2004-01-08 |
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