RU2315764C2 - Производные дигидробензодиазепин-2-она для лечения неврологических нарушений - Google Patents
Производные дигидробензодиазепин-2-она для лечения неврологических нарушений Download PDFInfo
- Publication number
- RU2315764C2 RU2315764C2 RU2004126945/04A RU2004126945A RU2315764C2 RU 2315764 C2 RU2315764 C2 RU 2315764C2 RU 2004126945/04 A RU2004126945/04 A RU 2004126945/04A RU 2004126945 A RU2004126945 A RU 2004126945A RU 2315764 C2 RU2315764 C2 RU 2315764C2
- Authority
- RU
- Russia
- Prior art keywords
- dihydrobenzo
- ness
- mmol
- phenyl
- diazepin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02002012 | 2002-02-06 | ||
| EP02002012.9 | 2002-02-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2004126945A RU2004126945A (ru) | 2005-06-27 |
| RU2315764C2 true RU2315764C2 (ru) | 2008-01-27 |
Family
ID=27675598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2004126945/04A RU2315764C2 (ru) | 2002-02-06 | 2003-01-28 | Производные дигидробензодиазепин-2-она для лечения неврологических нарушений |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6949542B2 (https=) |
| EP (1) | EP1474416B1 (https=) |
| JP (1) | JP4077411B2 (https=) |
| KR (1) | KR20040081486A (https=) |
| CN (1) | CN100497333C (https=) |
| AR (1) | AR038481A1 (https=) |
| AT (1) | ATE374196T1 (https=) |
| AU (1) | AU2003205695B8 (https=) |
| BR (1) | BR0307474A (https=) |
| CA (1) | CA2474219C (https=) |
| DE (1) | DE60316538T2 (https=) |
| DK (1) | DK1474416T3 (https=) |
| ES (1) | ES2294264T3 (https=) |
| GT (1) | GT200300028A (https=) |
| HR (1) | HRP20040678A2 (https=) |
| IL (1) | IL163102A (https=) |
| MX (1) | MXPA04007516A (https=) |
| MY (1) | MY176608A (https=) |
| NO (1) | NO327697B1 (https=) |
| NZ (1) | NZ534122A (https=) |
| PA (1) | PA8565901A1 (https=) |
| PE (1) | PE20031011A1 (https=) |
| PL (1) | PL372425A1 (https=) |
| PT (1) | PT1474416E (https=) |
| RU (1) | RU2315764C2 (https=) |
| SI (1) | SI1474416T1 (https=) |
| TW (1) | TWI326599B (https=) |
| UY (1) | UY27654A1 (https=) |
| WO (1) | WO2003066623A1 (https=) |
| ZA (1) | ZA200406032B (https=) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2386980C (en) * | 1999-10-15 | 2010-03-16 | Geo Adam | Benzodiazepine derivatives for use in acute or chronic neurological disorders |
| AU2004262897B9 (en) * | 2003-07-25 | 2009-12-17 | F. Hoffmann-La Roche Ag | Combination of mGluR2 antagonist and ache inhibitor for treatment of acute and/or chronic neurological disorders |
| AU2006298829B2 (en) | 2005-09-27 | 2011-03-03 | F. Hoffmann-La Roche Ag | Oxadiazolyl pyrazolo-pyrimidines as mGluR2 antagonists |
| TWI417095B (zh) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途 |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| BRPI0810655A2 (pt) * | 2007-04-19 | 2014-11-04 | Hoffmann La Roche | Derivados de di-hidro-benzo[b][1,4] diazepin-2-ona sulfonamida |
| EP2188263B1 (en) | 2007-08-27 | 2012-06-27 | F. Hoffmann-La Roche AG | Benzimidazole derivatives used as fxr agonists |
| PL2203439T3 (pl) | 2007-09-14 | 2011-06-30 | Addex Pharmaceuticals Sa | 1',3'-dipodstawione-4-fenylo-3,4,5,6-tetrahydro-2H, 1'H-[1, 4']bipirydynylo-2'-ketony |
| US8252937B2 (en) | 2007-09-14 | 2012-08-28 | Janssen Pharmaceuticals, Inc. | 1,3-disubstituted 4-(aryl-X-phenyl)-1H-pyridin-2-ones |
| US8722894B2 (en) | 2007-09-14 | 2014-05-13 | Janssen Pharmaceuticals, Inc. | 1,3-disubstituted-4-phenyl-1H-pyridin-2-ones |
| RU2492170C9 (ru) | 2007-11-14 | 2013-12-27 | Орто-Макнейл-Янссен Фармасьютикалз, Инк. | Имидазо[1,2-а]пиридиновые производные и их применение в качестве положительных аллостерических модуляторов рецепторов mglur2 |
| JP5693452B2 (ja) | 2008-08-04 | 2015-04-01 | シーエイチディーアイ ファウンデーション，インコーポレーテッド | 特定のキヌレニン−３−モノオキシゲナーゼインヒビター、医薬組成物およびそれらの使用方法 |
| JP5547194B2 (ja) | 2008-09-02 | 2014-07-09 | ジャンセン ファーマシューティカルズ， インコーポレイテッド． | 代謝型グルタミン酸受容体の調節因子としての３−アザビシクロ［３．１．０］ヘキシル誘導体 |
| RU2517181C2 (ru) | 2008-10-16 | 2014-05-27 | Орто-Макнейл-Янссен Фармасьютикалз, Инк. | Производные индола и бензоморфолина в качестве модулятора метаботропных глутаматных рецепторов |
| WO2010060589A1 (en) | 2008-11-28 | 2010-06-03 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors |
| MY153912A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 1, 2, 4,-triazolo[4,3-a[pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| CN102439008B (zh) | 2009-05-12 | 2015-04-29 | 杨森制药有限公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途 |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| BR112012003871A2 (pt) | 2009-08-21 | 2015-09-08 | Otsuka Pharma Co Ltd | processo para a produção de composto de benzo[b][1,4]diazepina-2,4-diona |
| TWI481601B (zh) | 2009-08-21 | 2015-04-21 | Otsuka Pharma Co Ltd | 含氮化合物及藥學組成物 |
| MX2012008346A (es) | 2010-01-25 | 2012-11-12 | Chdi Foundation Inc | Determinados inhibidores de cinurenina-3-monooxigenasa, composiciones farmceuticas y metodos de uso de los mismos. |
| CN103261195B (zh) | 2010-11-08 | 2015-09-02 | 杨森制药公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
| EP2661435B1 (en) | 2010-11-08 | 2015-08-19 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
| PL2649069T3 (pl) | 2010-11-08 | 2016-01-29 | Janssen Pharmaceuticals Inc | Pochodne 1,2,4-triazolo[4,3-a]pirydyny i ich zastosowanie jako dodatnich allosterycznych modulatorów receptorów mGluR2 |
| EP2701699B1 (en) | 2011-04-28 | 2019-10-16 | The Broad Institute, Inc. | Inhibitors of histone deacetylase |
| US9193710B2 (en) | 2011-08-29 | 2015-11-24 | Sanford-Burnham Medical Research Institute | Benzodiazepinones as modulators of metabotropic glutamate receptor functions and neurological uses thereof |
| MX2014002459A (es) | 2011-08-30 | 2014-04-10 | Chdi Foundation Inc | Inhibidores de quinurenina-3-monooxigenasa, composiciones farmaceuticas y metodos de uso de los mismos. |
| SI2750677T1 (sl) | 2011-08-30 | 2017-10-30 | Chdi Foundation, Inc. | Inhibitorji kinurenin-3-monooksigenaze, farmacevtski sestavki in postopki njihove uporabe |
| JP6337255B2 (ja) | 2012-07-27 | 2018-06-06 | ザ ブロード インスティテュート, インコーポレーテッドThe Broad Institute, Inc. | ヒストンデアセチラーゼの阻害剤 |
| EP2925292A1 (en) | 2012-10-23 | 2015-10-07 | F. Hoffmann-La Roche AG | Mglu2/3 antagonists for the treatment of autistic disorders |
| US9914717B2 (en) | 2012-12-20 | 2018-03-13 | The Broad Institute, Inc. | Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| KR20220049612A (ko) | 2014-01-21 | 2022-04-21 | 얀센 파마슈티카 엔.브이. | 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도 |
| HUE053734T2 (hu) | 2014-01-21 | 2021-07-28 | Janssen Pharmaceutica Nv | 2-es altípusú metabotróp glutamáterg receptor pozitív allosztérikus modulátorait tartalmazó kombinációk és alkalmazásuk |
| KR20160143853A (ko) | 2014-04-23 | 2016-12-14 | 에프. 호프만-라 로슈 아게 | 지적 장애의 치료를 위한 mglu2/3 길항제 |
| CA2950952C (en) * | 2014-06-10 | 2023-01-10 | Sanford-Burnham Medical Research Institute | Metabotropic glutamate receptor negative allosteric modulators (nams) and uses thereof |
| CN106715421A (zh) | 2014-07-17 | 2017-05-24 | Chdi基金会股份有限公司 | 用于治疗hiv相关病症的方法和组合物 |
| JP2017206438A (ja) * | 2014-08-22 | 2017-11-24 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | テトラヒドロイミダゾ［１，５−ｄ］［１，４］オキサゼピン化合物（ＴＥＴＲＡＨＹＤＲＯＩＭＩＤＡＺＯ［１，５−ｄ］［１，４］ＯＸＡＺＥＰＩＮＥＣＯＭＰＯＵＮＤ） |
| WO2018019755A1 (en) | 2016-07-26 | 2018-02-01 | Basf Se | Herbicidal pyridine compounds |
| WO2018019721A1 (en) | 2016-07-26 | 2018-02-01 | Basf Se | Herbicidal pyridine compounds |
| CA3125731A1 (en) | 2018-01-12 | 2019-07-18 | KDAc Therapeutics, Inc. | Combination of a selective histone deacetylase 3 (hdac3) inhibitor and an immunotherapy agent for the treatment of cancer |
| CN110407740A (zh) * | 2019-09-04 | 2019-11-05 | 上海毕得医药科技有限公司 | 一种3-溴-2-乙基吡啶的合成方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE105839T1 (de) * | 1989-03-23 | 1994-06-15 | Pfizer | Antiallergische mittel auf der basis von diazepin. |
| CA2386980C (en) | 1999-10-15 | 2010-03-16 | Geo Adam | Benzodiazepine derivatives for use in acute or chronic neurological disorders |
| AU774451B2 (en) | 1999-10-15 | 2004-06-24 | F. Hoffmann-La Roche Ag | Benzodiazepine derivatives |
-
2003
- 2003-01-24 US US10/350,713 patent/US6949542B2/en not_active Expired - Lifetime
- 2003-01-28 PL PL03372425A patent/PL372425A1/xx not_active Application Discontinuation
- 2003-01-28 JP JP2003565996A patent/JP4077411B2/ja not_active Expired - Fee Related
- 2003-01-28 BR BR0307474-9A patent/BR0307474A/pt not_active Application Discontinuation
- 2003-01-28 DE DE60316538T patent/DE60316538T2/de not_active Expired - Lifetime
- 2003-01-28 NZ NZ534122A patent/NZ534122A/en not_active IP Right Cessation
- 2003-01-28 WO PCT/EP2003/000859 patent/WO2003066623A1/en not_active Ceased
- 2003-01-28 RU RU2004126945/04A patent/RU2315764C2/ru not_active IP Right Cessation
- 2003-01-28 MX MXPA04007516A patent/MXPA04007516A/es active IP Right Grant
- 2003-01-28 CN CNB038065452A patent/CN100497333C/zh not_active Expired - Fee Related
- 2003-01-28 ES ES03702549T patent/ES2294264T3/es not_active Expired - Lifetime
- 2003-01-28 PT PT03702549T patent/PT1474416E/pt unknown
- 2003-01-28 DK DK03702549T patent/DK1474416T3/da active
- 2003-01-28 HR HR20040678A patent/HRP20040678A2/hr not_active Application Discontinuation
- 2003-01-28 EP EP03702549A patent/EP1474416B1/en not_active Expired - Lifetime
- 2003-01-28 CA CA2474219A patent/CA2474219C/en not_active Expired - Fee Related
- 2003-01-28 SI SI200331034T patent/SI1474416T1/sl unknown
- 2003-01-28 KR KR10-2004-7012084A patent/KR20040081486A/ko not_active Ceased
- 2003-01-28 AT AT03702549T patent/ATE374196T1/de active
- 2003-01-28 AU AU2003205695A patent/AU2003205695B8/en not_active Ceased
- 2003-01-30 TW TW092102234A patent/TWI326599B/zh active
- 2003-02-03 GT GT200300028A patent/GT200300028A/es unknown
- 2003-02-03 PE PE2003000122A patent/PE20031011A1/es not_active Application Discontinuation
- 2003-02-04 AR ARP030100334A patent/AR038481A1/es unknown
- 2003-02-05 MY MYPI20030378A patent/MY176608A/en unknown
- 2003-02-05 UY UY27654A patent/UY27654A1/es not_active Application Discontinuation
- 2003-02-05 PA PA20038565901A patent/PA8565901A1/es unknown
-
2004
- 2004-07-19 IL IL163102A patent/IL163102A/en not_active IP Right Cessation
- 2004-07-28 ZA ZA200406032A patent/ZA200406032B/en unknown
- 2004-08-02 NO NO20043237A patent/NO327697B1/no not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20120129 |