KR20040081486A - 신경학적 장애의 치료를 위한다이하이드로벤조다이아제핀-2-온 유도체 - Google Patents

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Publication number

KR20040081486A

KR20040081486A KR10-2004-7012084A KR20047012084A KR20040081486A KR 20040081486 A KR20040081486 A KR 20040081486A KR 20047012084 A KR20047012084 A KR 20047012084A KR 20040081486 A KR20040081486 A KR 20040081486A

Authority

KR

South Korea

Prior art keywords

phenyl

pyridin

methyl

mmol

trifluoromethyl

Prior art date

2002-02-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Ceased

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• 208000012902 Nervous system disease Diseases 0.000 title claims abstract description 7
• 208000025966 Neurological disease Diseases 0.000 title claims abstract description 7
• 238000000034 method Methods 0.000 claims abstract description 827
• 150000001875 compounds Chemical class 0.000 claims abstract description 691
• 238000002360 preparation method Methods 0.000 claims abstract description 25
• 239000003814 drug Substances 0.000 claims abstract description 12
• 230000001154 acute effect Effects 0.000 claims abstract description 7
• 230000001684 chronic effect Effects 0.000 claims abstract description 7
• 238000004519 manufacturing process Methods 0.000 claims abstract description 7
• 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract description 5
• -1 pyrrole-1-yl Chemical group 0.000 claims description 272
• 125000000217 alkyl group Chemical group 0.000 claims description 77
• 125000003545 alkoxy group Chemical group 0.000 claims description 52
• 125000003282 alkyl amino group Chemical group 0.000 claims description 31
• 239000001257 hydrogen Substances 0.000 claims description 31
• 229910052739 hydrogen Inorganic materials 0.000 claims description 31
• 229910052736 halogen Inorganic materials 0.000 claims description 30
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 27
• 150000002367 halogens Chemical class 0.000 claims description 27
• 150000002431 hydrogen Chemical class 0.000 claims description 26
• 150000003839 salts Chemical class 0.000 claims description 22
• 125000001153 fluoro group Chemical group F* 0.000 claims description 21
• 125000001424 substituent group Chemical group 0.000 claims description 19
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 18
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 14
• 125000004414 alkyl thio group Chemical group 0.000 claims description 12
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 12
• 125000004566 azetidin-1-yl group Chemical group N1(CCC1)* 0.000 claims description 9
• 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 8
• 125000004076 pyridyl group Chemical group 0.000 claims description 8
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
• 239000002253 acid Substances 0.000 claims description 6
• ILVXOBCQQYKLDS-UHFFFAOYSA-N pyridine N-oxide Chemical compound [O-][N+]1=CC=CC=C1 ILVXOBCQQYKLDS-UHFFFAOYSA-N 0.000 claims description 6
• 208000028017 Psychotic disease Diseases 0.000 claims description 5
• 125000003277 amino group Chemical group 0.000 claims description 5
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 5
• RRJHUDLALLDKRL-UHFFFAOYSA-N 8-chloro-4-[3-(2,6-dimethylpyridin-4-yl)phenyl]-7-methyl-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound CC1=NC(C)=CC(C=2C=C(C=CC=2)C=2CC(=O)NC3=CC(Cl)=C(C)C=C3N=2)=C1 RRJHUDLALLDKRL-UHFFFAOYSA-N 0.000 claims description 4
• CWZIXKLALYDKHJ-UHFFFAOYSA-N 8-chloro-7-methyl-4-[3-(2-methylpyridin-4-yl)phenyl]-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C=2CC(=O)NC3=CC(Cl)=C(C)C=C3N=2)=C1 CWZIXKLALYDKHJ-UHFFFAOYSA-N 0.000 claims description 4
• 208000024827 Alzheimer disease Diseases 0.000 claims description 4
• 208000026139 Memory disease Diseases 0.000 claims description 4
• 208000010877 cognitive disease Diseases 0.000 claims description 4
• 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 4
• 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims description 4
• 230000002265 prevention Effects 0.000 claims description 4
• 238000007363 ring formation reaction Methods 0.000 claims description 4
• 201000000980 schizophrenia Diseases 0.000 claims description 4
• XTQHVAXLUHGINO-UHFFFAOYSA-N 4-(3-pyridin-3-ylphenyl)-7-(2,2,2-trifluoroethoxy)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound N=1C2=CC(OCC(F)(F)F)=CC=C2NC(=O)CC=1C(C=1)=CC=CC=1C1=CC=CN=C1 XTQHVAXLUHGINO-UHFFFAOYSA-N 0.000 claims description 3
• XFCBAUSXXGLTIP-UHFFFAOYSA-N 4-(3-pyridin-3-ylphenyl)-7-(2,2,2-trifluoroethoxy)-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(C(F)(F)F)C(OCC(F)(F)F)=CC=2N=C1C(C=1)=CC=CC=1C1=CC=CN=C1 XFCBAUSXXGLTIP-UHFFFAOYSA-N 0.000 claims description 3
• NBKPYZLFZCYJJE-UHFFFAOYSA-N 4-(3-pyridin-4-ylphenyl)-7-(2,2,2-trifluoroethoxy)-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(C(F)(F)F)C(OCC(F)(F)F)=CC=2N=C1C(C=1)=CC=CC=1C1=CC=NC=C1 NBKPYZLFZCYJJE-UHFFFAOYSA-N 0.000 claims description 3
• JYTRCRINABXASK-UHFFFAOYSA-N 4-(3-pyridin-4-ylphenyl)-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC2=CC(C(F)(F)F)=CC=C2N=C1C(C=1)=CC=CC=1C1=CC=NC=C1 JYTRCRINABXASK-UHFFFAOYSA-N 0.000 claims description 3
• PQWNWLVSPGJPAF-UHFFFAOYSA-N 4-[3-(2,6-dimethylpyridin-4-yl)phenyl]-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound CC1=NC(C)=CC(C=2C=C(C=CC=2)C=2CC(=O)NC3=CC(=CC=C3N=2)C(F)(F)F)=C1 PQWNWLVSPGJPAF-UHFFFAOYSA-N 0.000 claims description 3
• DFWDFOZNVALGES-UHFFFAOYSA-N 4-[3-(2-methylpyridin-4-yl)phenyl]-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C=2CC(=O)NC3=CC(=CC=C3N=2)C(F)(F)F)=C1 DFWDFOZNVALGES-UHFFFAOYSA-N 0.000 claims description 3
• CUBHTWLIWFXCKK-UHFFFAOYSA-N 7,8-dichloro-4-(3-pyridin-3-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound N=1C=2C=C(Cl)C(Cl)=CC=2NC(=O)CC=1C(C=1)=CC=CC=1C1=CC=CN=C1 CUBHTWLIWFXCKK-UHFFFAOYSA-N 0.000 claims description 3
• VMEZSFFCHLCBBK-UHFFFAOYSA-N 7,8-dichloro-4-(3-pyridin-4-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound N=1C=2C=C(Cl)C(Cl)=CC=2NC(=O)CC=1C(C=1)=CC=CC=1C1=CC=NC=C1 VMEZSFFCHLCBBK-UHFFFAOYSA-N 0.000 claims description 3
• CMLVJJVYIVBZNH-UHFFFAOYSA-N 7,8-dichloro-4-[3-(2-methylpyridin-4-yl)phenyl]-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C=2CC(=O)NC3=CC(Cl)=C(Cl)C=C3N=2)=C1 CMLVJJVYIVBZNH-UHFFFAOYSA-N 0.000 claims description 3
• DZCFLWXSUXKAJI-UHFFFAOYSA-N 7-(dimethylamino)-4-(3-pyridin-3-ylphenyl)-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(C(F)(F)F)C(N(C)C)=CC=2N=C1C(C=1)=CC=CC=1C1=CC=CN=C1 DZCFLWXSUXKAJI-UHFFFAOYSA-N 0.000 claims description 3
• YQKASQGOPRPMLH-UHFFFAOYSA-N 7-(dimethylamino)-4-(3-pyridin-4-ylphenyl)-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(C(F)(F)F)C(N(C)C)=CC=2N=C1C(C=1)=CC=CC=1C1=CC=NC=C1 YQKASQGOPRPMLH-UHFFFAOYSA-N 0.000 claims description 3
• CCOJJDFNFUBNKN-UHFFFAOYSA-N 7-(dimethylamino)-4-[3-(2-methylpyridin-4-yl)phenyl]-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(C(F)(F)F)C(N(C)C)=CC=2N=C1C(C=1)=CC=CC=1C1=CC=NC(C)=C1 CCOJJDFNFUBNKN-UHFFFAOYSA-N 0.000 claims description 3
• OPUCFSUMZCYZKN-UHFFFAOYSA-N 7-chloro-4-(3-pyridin-4-ylphenyl)-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound N=1C=2C=C(Cl)C(C(F)(F)F)=CC=2NC(=O)CC=1C(C=1)=CC=CC=1C1=CC=NC=C1 OPUCFSUMZCYZKN-UHFFFAOYSA-N 0.000 claims description 3
• AHDAHZZDQMCLJT-UHFFFAOYSA-N 7-chloro-4-[3-(2,6-dimethylpyridin-4-yl)phenyl]-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound CC1=NC(C)=CC(C=2C=C(C=CC=2)C=2CC(=O)NC3=CC(=C(Cl)C=C3N=2)C(F)(F)F)=C1 AHDAHZZDQMCLJT-UHFFFAOYSA-N 0.000 claims description 3
• QFBDRSIFOKYSDY-UHFFFAOYSA-N 7-ethoxy-4-(3-pyridin-4-ylphenyl)-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(C(F)(F)F)C(OCC)=CC=2N=C1C(C=1)=CC=CC=1C1=CC=NC=C1 QFBDRSIFOKYSDY-UHFFFAOYSA-N 0.000 claims description 3
• JNFNUQBEVWFFJC-UHFFFAOYSA-N 7-methyl-4-(3-pyrazin-2-ylphenyl)-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(C(F)(F)F)C(C)=CC=2N=C1C(C=1)=CC=CC=1C1=CN=CC=N1 JNFNUQBEVWFFJC-UHFFFAOYSA-N 0.000 claims description 3
• OQTSPIQICMTNOL-UHFFFAOYSA-N 7-methyl-4-(3-pyridazin-4-ylphenyl)-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(C(F)(F)F)C(C)=CC=2N=C1C(C=1)=CC=CC=1C1=CC=NN=C1 OQTSPIQICMTNOL-UHFFFAOYSA-N 0.000 claims description 3
• ZYGZDPKEZBLAHD-UHFFFAOYSA-N 7-methyl-4-(3-pyridin-4-ylphenyl)-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(C(F)(F)F)C(C)=CC=2N=C1C(C=1)=CC=CC=1C1=CC=NC=C1 ZYGZDPKEZBLAHD-UHFFFAOYSA-N 0.000 claims description 3
• ZTMGYWMZJBHXBD-UHFFFAOYSA-N 7-methyl-4-[3-(2-methylpyridin-4-yl)phenyl]-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C=2CC(=O)NC3=CC(=C(C)C=C3N=2)C(F)(F)F)=C1 ZTMGYWMZJBHXBD-UHFFFAOYSA-N 0.000 claims description 3
• NZWUYDARLBVUAZ-UHFFFAOYSA-N 8-(2-fluorophenyl)-4-(3-pyridin-3-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound FC1=CC=CC=C1C1=CC=C(N=C(CC(=O)N2)C=3C=C(C=CC=3)C=3C=NC=CC=3)C2=C1 NZWUYDARLBVUAZ-UHFFFAOYSA-N 0.000 claims description 3
• DEOUQGPUEWWMNC-UHFFFAOYSA-N 8-(2-fluorophenyl)-4-(3-pyridin-4-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound FC1=CC=CC=C1C1=CC=C(N=C(CC(=O)N2)C=3C=C(C=CC=3)C=3C=CN=CC=3)C2=C1 DEOUQGPUEWWMNC-UHFFFAOYSA-N 0.000 claims description 3
• VBTRNVBPGJSEAM-UHFFFAOYSA-N 8-(2-fluorophenyl)-4-(3-pyrimidin-5-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound FC1=CC=CC=C1C1=CC=C(N=C(CC(=O)N2)C=3C=C(C=CC=3)C=3C=NC=NC=3)C2=C1 VBTRNVBPGJSEAM-UHFFFAOYSA-N 0.000 claims description 3
• QHWRKFWOOXWYMW-UHFFFAOYSA-N 8-(2-fluorophenyl)-4-[3-(2-methylpyridin-3-yl)phenyl]-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound CC1=NC=CC=C1C1=CC=CC(C=2CC(=O)NC3=CC(=CC=C3N=2)C=2C(=CC=CC=2)F)=C1 QHWRKFWOOXWYMW-UHFFFAOYSA-N 0.000 claims description 3
• PQMAJJWGJPOQQE-UHFFFAOYSA-N 8-chloro-4-(3-pyridin-3-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC2=CC(Cl)=CC=C2N=C1C(C=1)=CC=CC=1C1=CC=CN=C1 PQMAJJWGJPOQQE-UHFFFAOYSA-N 0.000 claims description 3
• QWFYXUVFCJKYON-UHFFFAOYSA-N 8-chloro-4-(3-pyridin-4-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC2=CC(Cl)=CC=C2N=C1C(C=1)=CC=CC=1C1=CC=NC=C1 QWFYXUVFCJKYON-UHFFFAOYSA-N 0.000 claims description 3
• JLXAVOQTRVUYKG-UHFFFAOYSA-N 8-chloro-4-[3-(2-methylpyridin-3-yl)phenyl]-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound CC1=NC=CC=C1C1=CC=CC(C=2CC(=O)NC3=CC(Cl)=CC=C3N=2)=C1 JLXAVOQTRVUYKG-UHFFFAOYSA-N 0.000 claims description 3
• PRPOBZJPAWDSGQ-UHFFFAOYSA-N 8-chloro-4-[3-(2-methylpyridin-4-yl)phenyl]-7-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C=2CC(=O)NC3=CC(Cl)=C(C=C3N=2)C(F)(F)F)=C1 PRPOBZJPAWDSGQ-UHFFFAOYSA-N 0.000 claims description 3
• VOUQMUWKUYFRJK-UHFFFAOYSA-N 8-chloro-4-[3-(6-methylpyridin-3-yl)phenyl]-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1=NC(C)=CC=C1C1=CC=CC(C=2CC(=O)NC3=CC(Cl)=CC=C3N=2)=C1 VOUQMUWKUYFRJK-UHFFFAOYSA-N 0.000 claims description 3
• HRSCABPISYBZJE-UHFFFAOYSA-N 8-chloro-7-methyl-4-(3-pyrazin-2-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(Cl)C(C)=CC=2N=C1C(C=1)=CC=CC=1C1=CN=CC=N1 HRSCABPISYBZJE-UHFFFAOYSA-N 0.000 claims description 3
• ITPMBZMJFFOBBB-UHFFFAOYSA-N 8-chloro-7-methyl-4-(3-pyridazin-4-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(Cl)C(C)=CC=2N=C1C(C=1)=CC=CC=1C1=CC=NN=C1 ITPMBZMJFFOBBB-UHFFFAOYSA-N 0.000 claims description 3
• ODSWASRHKDESDR-UHFFFAOYSA-N 8-chloro-7-methyl-4-(3-pyridin-3-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(Cl)C(C)=CC=2N=C1C(C=1)=CC=CC=1C1=CC=CN=C1 ODSWASRHKDESDR-UHFFFAOYSA-N 0.000 claims description 3
• QPHSKVNFGZIDPN-UHFFFAOYSA-N 8-chloro-7-methyl-4-(3-pyridin-4-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(Cl)C(C)=CC=2N=C1C(C=1)=CC=CC=1C1=CC=NC=C1 QPHSKVNFGZIDPN-UHFFFAOYSA-N 0.000 claims description 3
• YYEKPNNSPXLPJC-UHFFFAOYSA-N 8-methyl-4-(3-pyridin-3-ylphenyl)-7-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound N=1C=2C=C(C(F)(F)F)C(C)=CC=2NC(=O)CC=1C(C=1)=CC=CC=1C1=CC=CN=C1 YYEKPNNSPXLPJC-UHFFFAOYSA-N 0.000 claims description 3
• QRDOMCFVXRYHRK-UHFFFAOYSA-N 8-methyl-4-(3-pyridin-4-ylphenyl)-7-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound N=1C=2C=C(C(F)(F)F)C(C)=CC=2NC(=O)CC=1C(C=1)=CC=CC=1C1=CC=NC=C1 QRDOMCFVXRYHRK-UHFFFAOYSA-N 0.000 claims description 3
• YCFKJJCPSFWCPF-UHFFFAOYSA-N 8-methyl-4-[3-(2-methylpyridin-4-yl)phenyl]-7-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C=2CC(=O)NC3=CC(C)=C(C=C3N=2)C(F)(F)F)=C1 YCFKJJCPSFWCPF-UHFFFAOYSA-N 0.000 claims description 3
• 208000028698 Cognitive impairment Diseases 0.000 claims description 3
• 125000003342 alkenyl group Chemical group 0.000 claims description 3
• 125000001207 fluorophenyl group Chemical group 0.000 claims description 3
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 3
• 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 3
• LYTVXCQQTLUEQR-UHFFFAOYSA-N ro4491533 Chemical compound CC1=NC(C)=CC(C=2C=C(C=CC=2)C=2CC(=O)NC3=CC(=C(C)C=C3N=2)C(F)(F)F)=C1 LYTVXCQQTLUEQR-UHFFFAOYSA-N 0.000 claims description 3
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 3
• 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims description 2
• PXNOUTUNFINTTA-UHFFFAOYSA-N 4-[3-(2,6-dimethylpyridin-4-yl)phenyl]-7-(2,2,2-trifluoroethoxy)-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound CC1=NC(C)=CC(C=2C=C(C=CC=2)C=2CC(=O)NC3=CC(=C(OCC(F)(F)F)C=C3N=2)C(F)(F)F)=C1 PXNOUTUNFINTTA-UHFFFAOYSA-N 0.000 claims description 2
• GGCAJGPNBPIIQA-UHFFFAOYSA-N 4-[3-(2,6-dimethylpyridin-4-yl)phenyl]-7-ethoxy-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(C(F)(F)F)C(OCC)=CC=2N=C1C(C=1)=CC=CC=1C1=CC(C)=NC(C)=C1 GGCAJGPNBPIIQA-UHFFFAOYSA-N 0.000 claims description 2
• UVNQIBJKZJJBQK-UHFFFAOYSA-N 4-[3-(2,6-dimethylpyridin-4-yl)phenyl]-7-ethyl-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(C(F)(F)F)C(CC)=CC=2N=C1C(C=1)=CC=CC=1C1=CC(C)=NC(C)=C1 UVNQIBJKZJJBQK-UHFFFAOYSA-N 0.000 claims description 2
• AFSJGBXRHLXBHV-UHFFFAOYSA-N 4-[3-(2-ethyl-6-methylpyridin-4-yl)phenyl]-7-methyl-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound CC1=NC(CC)=CC(C=2C=C(C=CC=2)C=2CC(=O)NC3=CC(=C(C)C=C3N=2)C(F)(F)F)=C1 AFSJGBXRHLXBHV-UHFFFAOYSA-N 0.000 claims description 2
• CHTAULFZQPVWNJ-UHFFFAOYSA-N 4-[3-(2-ethylpyridin-4-yl)phenyl]-7-methyl-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1=NC(CC)=CC(C=2C=C(C=CC=2)C=2CC(=O)NC3=CC(=C(C)C=C3N=2)C(F)(F)F)=C1 CHTAULFZQPVWNJ-UHFFFAOYSA-N 0.000 claims description 2
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• PQKSSPVBXWJJSY-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-ethyl-6-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC1=NC(CC)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(OCC(F)(F)F)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 PQKSSPVBXWJJSY-UHFFFAOYSA-N 0.000 description 1
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• SYEIZHUWSGRKFK-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-ethylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-5-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl]carbamate Chemical compound CCC1=NC=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC(OCC(F)(F)F)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 SYEIZHUWSGRKFK-UHFFFAOYSA-N 0.000 description 1
• DMNNYLAWBHITAY-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-ethylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-5-methyl-4-(trifluoromethyl)phenyl]carbamate Chemical compound CCC1=NC=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC(C)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 DMNNYLAWBHITAY-UHFFFAOYSA-N 0.000 description 1
• HGYGFXAKIKAXAE-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-ethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(CC)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 HGYGFXAKIKAXAE-UHFFFAOYSA-N 0.000 description 1
• IVFHMVFVALEIHP-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-ethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(CC)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(OCC(F)(F)F)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 IVFHMVFVALEIHP-UHFFFAOYSA-N 0.000 description 1
• SFFCGMUSTDBPCP-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-methylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC1=NC=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 SFFCGMUSTDBPCP-UHFFFAOYSA-N 0.000 description 1
• GAWGVGIFJHIAJX-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethoxy)phenyl]carbamate Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC=C(OC(F)(F)F)C=2)NC(=O)OC(C)(C)C)=C1 GAWGVGIFJHIAJX-UHFFFAOYSA-N 0.000 description 1
• LHRQEQNDWOPMMP-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 LHRQEQNDWOPMMP-UHFFFAOYSA-N 0.000 description 1
• BQIUGFNNXUEOFE-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(OCC(F)(F)F)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 BQIUGFNNXUEOFE-UHFFFAOYSA-N 0.000 description 1
• RQXCITFSHPMRBM-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-(oxan-2-yloxymethyl)-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(COC3OCCCC3)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 RQXCITFSHPMRBM-UHFFFAOYSA-N 0.000 description 1
• LJPOWYOWRSUDQN-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-morpholin-4-yl-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(=C(C=2)C(F)(F)F)N2CCOCC2)NC(=O)OC(C)(C)C)=C1 LJPOWYOWRSUDQN-UHFFFAOYSA-N 0.000 description 1
• MJFGHEKMNSCRHL-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-propyl-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(CCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(C)N=CC=2)=C1 MJFGHEKMNSCRHL-UHFFFAOYSA-N 0.000 description 1
• RFETYSQXWCJAIG-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-pyrrolidin-1-yl-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(=C(C=2)C(F)(F)F)N2CCCC2)NC(=O)OC(C)(C)C)=C1 RFETYSQXWCJAIG-UHFFFAOYSA-N 0.000 description 1
• PWIVUWJXCISGCI-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-morpholin-4-ylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(OCC(F)(F)F)=C(C(F)(F)F)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(N=CC=2)N2CCOCC2)=C1 PWIVUWJXCISGCI-UHFFFAOYSA-N 0.000 description 1
• CRTUHSYQMXJIFJ-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(4,6-dimethylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(C)=CC(C)=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 CRTUHSYQMXJIFJ-UHFFFAOYSA-N 0.000 description 1
• JIKGTETTXZRCNJ-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(4,6-dimethylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-5-ethoxy-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(OCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C(=CC(C)=NC=2)C)=C1 JIKGTETTXZRCNJ-UHFFFAOYSA-N 0.000 description 1
• IATKLHBGWSDXMA-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(4,6-dimethylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-5-methyl-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(C)=CC(C)=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC(C)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 IATKLHBGWSDXMA-UHFFFAOYSA-N 0.000 description 1
• NLRWJCQEWRBCLW-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(4-methylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC1=CC=NC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 NLRWJCQEWRBCLW-UHFFFAOYSA-N 0.000 description 1
• ZRBCNWHQJILXSH-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(4-methylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-5-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC1=CC=NC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC(OCC(F)(F)F)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 ZRBCNWHQJILXSH-UHFFFAOYSA-N 0.000 description 1
• MSXXVUXYPBYBGT-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(5-cyclopropylpyridin-2-yl)phenyl]-3-oxopropanoyl]amino]-5-(2,2,2-trifluoroethoxy)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(OCC(F)(F)F)=CC=C1NC(=O)CC(=O)C1=CC=CC(C=2N=CC(=CC=2)C2CC2)=C1 MSXXVUXYPBYBGT-UHFFFAOYSA-N 0.000 description 1
• AELPPHIHALNNHE-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(5-ethyl-2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound CCC1=CN=C(C)C=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 AELPPHIHALNNHE-UHFFFAOYSA-N 0.000 description 1
• VYJSUUDJBHZGSC-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(5-ethyl-2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl]carbamate Chemical compound CCC1=CN=C(C)C=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC(OCC(F)(F)F)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 VYJSUUDJBHZGSC-UHFFFAOYSA-N 0.000 description 1
• YCGPWHQHVGUNPW-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(6-cyanopyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=C(C(F)(F)F)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC(=CC=2)C#N)=C1 YCGPWHQHVGUNPW-UHFFFAOYSA-N 0.000 description 1
• UHMRJWDQGKUAOU-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(6-cyclopropyl-4-methylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC1=CC(C2CC2)=NC=C1C(C=1)=CC=CC=1C(=O)CC(=O)NC1=CC(C(F)(F)F)=CC=C1NC(=O)OC(C)(C)C UHMRJWDQGKUAOU-UHFFFAOYSA-N 0.000 description 1
• DPSHXKPDMHZNBN-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(6-cyclopropyl-4-methylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-5-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC1=CC(C2CC2)=NC=C1C(C=1)=CC=CC=1C(=O)CC(=O)NC1=CC(C(F)(F)F)=C(OCC(F)(F)F)C=C1NC(=O)OC(C)(C)C DPSHXKPDMHZNBN-UHFFFAOYSA-N 0.000 description 1
• WIICREGHTXRKNA-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(6-cyclopropyl-4-methylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-5-ethoxy-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(OCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C(=CC(=NC=2)C2CC2)C)=C1 WIICREGHTXRKNA-UHFFFAOYSA-N 0.000 description 1
• GKNSNJFCORUWLK-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(6-cyclopropyl-4-methylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-5-methyl-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC1=CC(C2CC2)=NC=C1C(C=1)=CC=CC=1C(=O)CC(=O)NC1=CC(C(F)(F)F)=C(C)C=C1NC(=O)OC(C)(C)C GKNSNJFCORUWLK-UHFFFAOYSA-N 0.000 description 1
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• AFOLXTOSCNMGRD-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(6-cyclopropylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=C(C(F)(F)F)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC(=CC=2)C2CC2)=C1 AFOLXTOSCNMGRD-UHFFFAOYSA-N 0.000 description 1
• GMMVRTFSFAIIOK-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(6-cyclopropylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-5-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(OCC(F)(F)F)=C(C(F)(F)F)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC(=CC=2)C2CC2)=C1 GMMVRTFSFAIIOK-UHFFFAOYSA-N 0.000 description 1
• SITLVXPWWJTEJH-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(6-cyclopropylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-5-ethyl-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(CC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC(=CC=2)C2CC2)=C1 SITLVXPWWJTEJH-UHFFFAOYSA-N 0.000 description 1
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• FZBDRJQHDYVBSO-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(6-cyclopropylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-5-propyl-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(CCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC(=CC=2)C2CC2)=C1 FZBDRJQHDYVBSO-UHFFFAOYSA-N 0.000 description 1
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• CVHKXRLYSLKIBI-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(6-ethyl-4-methylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-5-methyl-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(CC)=CC(C)=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC(C)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 CVHKXRLYSLKIBI-UHFFFAOYSA-N 0.000 description 1
• WVHLIYCNSRXLJD-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(6-ethylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(CC)=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 WVHLIYCNSRXLJD-UHFFFAOYSA-N 0.000 description 1
• HJDOMPIKQRIMFX-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(6-ethylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-5-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(CC)=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC(OCC(F)(F)F)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 HJDOMPIKQRIMFX-UHFFFAOYSA-N 0.000 description 1
• FSWZDQAVJFSKHX-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(6-ethylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-5-methyl-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(CC)=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC(C)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 FSWZDQAVJFSKHX-UHFFFAOYSA-N 0.000 description 1
• XXJWPPQNUFTAOZ-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(6-methoxypyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethoxy)phenyl]carbamate Chemical compound C1=NC(OC)=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC=C(OC(F)(F)F)C=2)NC(=O)OC(C)(C)C)=C1 XXJWPPQNUFTAOZ-UHFFFAOYSA-N 0.000 description 1
• YANKMUFDYVMPGQ-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(6-methoxypyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(OC)=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 YANKMUFDYVMPGQ-UHFFFAOYSA-N 0.000 description 1
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• QZSDRYHGXIVLGD-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(6-methoxypyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-5-(2,2,2-trifluoroethoxy)phenyl]carbamate Chemical compound C1=NC(OC)=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC(OCC(F)(F)F)=CC=2)NC(=O)OC(C)(C)C)=C1 QZSDRYHGXIVLGD-UHFFFAOYSA-N 0.000 description 1
• CHKRNPNGLRWUMS-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(6-methoxypyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-5-methyl-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(OC)=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC(C)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 CHKRNPNGLRWUMS-UHFFFAOYSA-N 0.000 description 1
• CRVCIZPQXNRXCZ-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(6-methylpyridazin-3-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound N1=NC(C)=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 CRVCIZPQXNRXCZ-UHFFFAOYSA-N 0.000 description 1
• MQOPROVXZLTCGB-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(6-methylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(C)=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 MQOPROVXZLTCGB-UHFFFAOYSA-N 0.000 description 1
• MOUMIOAJPKVWCP-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(6-methylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-5-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(C)=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC(OCC(F)(F)F)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 MOUMIOAJPKVWCP-UHFFFAOYSA-N 0.000 description 1
• BGMPCWMMZDQUEO-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-[2-(2-methylpropyl)pyridin-4-yl]phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(CC(C)C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 BGMPCWMMZDQUEO-UHFFFAOYSA-N 0.000 description 1
• ZCELBRNWROWOAG-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-[2-(2-methylpropyl)pyridin-4-yl]phenyl]-3-oxopropanoyl]amino]-5-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(CC(C)C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(OCC(F)(F)F)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 ZCELBRNWROWOAG-UHFFFAOYSA-N 0.000 description 1
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• YYJLLPCWOXPZHF-UHFFFAOYSA-N tert-butyl n-[2-[[3-oxo-3-(3-pyridazin-3-ylphenyl)propanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=C(C(F)(F)F)C=C1NC(=O)CC(=O)C1=CC=CC(C=2N=NC=CC=2)=C1 YYJLLPCWOXPZHF-UHFFFAOYSA-N 0.000 description 1
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• MVSGJABTQYPSHP-UHFFFAOYSA-N tert-butyl n-[2-[[3-oxo-3-(3-pyridin-2-ylphenyl)propanoyl]amino]-4-(trifluoromethoxy)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=C(OC(F)(F)F)C=C1NC(=O)CC(=O)C1=CC=CC(C=2N=CC=CC=2)=C1 MVSGJABTQYPSHP-UHFFFAOYSA-N 0.000 description 1
• KEBHZTNBBTUQPP-UHFFFAOYSA-N tert-butyl n-[2-[[3-oxo-3-(3-pyridin-2-ylphenyl)propanoyl]amino]-5-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(OCC(F)(F)F)=C(C(F)(F)F)C=C1NC(=O)CC(=O)C1=CC=CC(C=2N=CC=CC=2)=C1 KEBHZTNBBTUQPP-UHFFFAOYSA-N 0.000 description 1
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• DWDNHYOQWHZEAX-UHFFFAOYSA-N tert-butyl n-[2-[[3-oxo-3-(3-pyridin-3-ylphenyl)propanoyl]amino]-4-(trifluoromethoxy)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=C(OC(F)(F)F)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC=CC=2)=C1 DWDNHYOQWHZEAX-UHFFFAOYSA-N 0.000 description 1
• MMSOUSOYYNDHGP-UHFFFAOYSA-N tert-butyl n-[2-[[3-oxo-3-(3-pyridin-3-ylphenyl)propanoyl]amino]-5-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(OCC(F)(F)F)=C(C(F)(F)F)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC=CC=2)=C1 MMSOUSOYYNDHGP-UHFFFAOYSA-N 0.000 description 1
• ZPYDTMSSNAYDNW-UHFFFAOYSA-N tert-butyl n-[2-[[3-oxo-3-(3-pyridin-3-ylphenyl)propanoyl]amino]-5-(2,2,2-trifluoroethoxy)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(OCC(F)(F)F)=CC=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC=CC=2)=C1 ZPYDTMSSNAYDNW-UHFFFAOYSA-N 0.000 description 1
• MYUUDPKSWJXRIT-UHFFFAOYSA-N tert-butyl n-[2-[[3-oxo-3-(3-pyridin-3-ylphenyl)propanoyl]amino]-5-propoxy-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(OCCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC=CC=2)=C1 MYUUDPKSWJXRIT-UHFFFAOYSA-N 0.000 description 1
• PQJBIQCBKXIKHU-UHFFFAOYSA-N tert-butyl n-[2-[[3-oxo-3-(3-pyridin-3-ylphenyl)propanoyl]amino]-5-propyl-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(CCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC=CC=2)=C1 PQJBIQCBKXIKHU-UHFFFAOYSA-N 0.000 description 1
• KIWJJFBOGUDHQA-UHFFFAOYSA-N tert-butyl n-[2-[[3-oxo-3-(3-pyridin-3-ylphenyl)propanoyl]amino]-5-pyrrolidin-1-yl-4-(trifluoromethyl)phenyl]carbamate Chemical compound FC(F)(F)C=1C=C(NC(=O)CC(=O)C=2C=C(C=CC=2)C=2C=NC=CC=2)C(NC(=O)OC(C)(C)C)=CC=1N1CCCC1 KIWJJFBOGUDHQA-UHFFFAOYSA-N 0.000 description 1
• XGCMLPMAAYEMRS-UHFFFAOYSA-N tert-butyl n-[2-[[3-oxo-3-(3-pyridin-4-ylphenyl)propanoyl]amino]-5-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(OCC(F)(F)F)=C(C(F)(F)F)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=CN=CC=2)=C1 XGCMLPMAAYEMRS-UHFFFAOYSA-N 0.000 description 1
• NKAPFYHGQINYMV-UHFFFAOYSA-N tert-butyl n-[2-[[3-oxo-3-(3-pyridin-4-ylphenyl)propanoyl]amino]-5-(2,2,2-trifluoroethoxy)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(OCC(F)(F)F)=CC=C1NC(=O)CC(=O)C1=CC=CC(C=2C=CN=CC=2)=C1 NKAPFYHGQINYMV-UHFFFAOYSA-N 0.000 description 1
• STLZQVBAKLSDDP-UHFFFAOYSA-N tert-butyl n-[2-[[3-oxo-3-[3-(2-propan-2-ylpyridin-4-yl)phenyl]propanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(C(C)C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 STLZQVBAKLSDDP-UHFFFAOYSA-N 0.000 description 1
• PPOBYHJKOFAPJC-UHFFFAOYSA-N tert-butyl n-[2-[[3-oxo-3-[3-(2-propan-2-ylpyridin-4-yl)phenyl]propanoyl]amino]-5-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(C(C)C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(OCC(F)(F)F)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 PPOBYHJKOFAPJC-UHFFFAOYSA-N 0.000 description 1
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• CAPZREDDLIZZHY-UHFFFAOYSA-N tert-butyl n-[2-[[3-oxo-3-[3-(6-propan-2-ylpyridin-3-yl)phenyl]propanoyl]amino]-5-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(C(C)C)=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC(OCC(F)(F)F)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 CAPZREDDLIZZHY-UHFFFAOYSA-N 0.000 description 1
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• IKWPHCMXIKWDMJ-UHFFFAOYSA-N tert-butyl n-[2-nitro-5-(oxan-2-yloxymethyl)-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C([N+]([O-])=O)C(NC(=O)OC(C)(C)C)=CC(COC2OCCCC2)=C1C(F)(F)F IKWPHCMXIKWDMJ-UHFFFAOYSA-N 0.000 description 1
• WGLJJWTWJCBCRU-UHFFFAOYSA-N tert-butyl n-[4-(2-fluorophenyl)-2-[[3-[3-(2-methylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]phenyl]carbamate Chemical compound CC1=NC=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC=C(C=2)C=2C(=CC=CC=2)F)NC(=O)OC(C)(C)C)=C1 WGLJJWTWJCBCRU-UHFFFAOYSA-N 0.000 description 1
• JLQVKKVHDWNIAP-UHFFFAOYSA-N tert-butyl n-[4-(2-fluorophenyl)-2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]phenyl]carbamate Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC=C(C=2)C=2C(=CC=CC=2)F)NC(=O)OC(C)(C)C)=C1 JLQVKKVHDWNIAP-UHFFFAOYSA-N 0.000 description 1
• YFGINBUYENXRIR-UHFFFAOYSA-N tert-butyl n-[4-(2-fluorophenyl)-2-[[3-[3-(6-methylpyridazin-3-yl)phenyl]-3-oxopropanoyl]amino]phenyl]carbamate Chemical compound N1=NC(C)=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC=C(C=2)C=2C(=CC=CC=2)F)NC(=O)OC(C)(C)C)=C1 YFGINBUYENXRIR-UHFFFAOYSA-N 0.000 description 1
• DOTUXDOIWXTKBF-UHFFFAOYSA-N tert-butyl n-[4-(2-fluorophenyl)-2-[[3-[3-(6-methylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]phenyl]carbamate Chemical compound C1=NC(C)=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC=C(C=2)C=2C(=CC=CC=2)F)NC(=O)OC(C)(C)C)=C1 DOTUXDOIWXTKBF-UHFFFAOYSA-N 0.000 description 1
• DJCJNJXPFYMGCV-UHFFFAOYSA-N tert-butyl n-[4-(2-fluorophenyl)-2-[[3-oxo-3-(3-pyrimidin-5-ylphenyl)propanoyl]amino]phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=C(C=2C(=CC=CC=2)F)C=C1NC(=O)CC(=O)C(C=1)=CC=CC=1C1=CN=CN=C1 DJCJNJXPFYMGCV-UHFFFAOYSA-N 0.000 description 1
• VVZPMMLFELNELO-UHFFFAOYSA-N tert-butyl n-[4-[2-(4-fluorophenyl)ethynyl]-2-[[3-oxo-3-(3-pyridin-2-ylphenyl)propanoyl]amino]phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=C(C#CC=2C=CC(F)=CC=2)C=C1NC(=O)CC(=O)C(C=1)=CC=CC=1C1=CC=CC=N1 VVZPMMLFELNELO-UHFFFAOYSA-N 0.000 description 1
• FCEZDMQMHSZRDH-UHFFFAOYSA-N tert-butyl n-[4-[2-(4-fluorophenyl)ethynyl]-2-[[3-oxo-3-(3-pyridin-3-ylphenyl)propanoyl]amino]phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=C(C#CC=2C=CC(F)=CC=2)C=C1NC(=O)CC(=O)C(C=1)=CC=CC=1C1=CC=CN=C1 FCEZDMQMHSZRDH-UHFFFAOYSA-N 0.000 description 1
• VMCZDVOUDACLSE-UHFFFAOYSA-N tert-butyl n-[4-chloro-2-[[3-[3-(2,6-dimethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-(trifluoromethyl)phenyl]carbamate Chemical compound CC1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(=C(Cl)C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 VMCZDVOUDACLSE-UHFFFAOYSA-N 0.000 description 1
• QDPXRPKRTHLBGR-UHFFFAOYSA-N tert-butyl n-[4-chloro-2-[[3-[3-(2,6-dimethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-[methyl(2-methylpropyl)amino]phenyl]carbamate Chemical compound C1=C(Cl)C(N(C)CC(C)C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(C)N=C(C)C=2)=C1 QDPXRPKRTHLBGR-UHFFFAOYSA-N 0.000 description 1
• UNLONZXJUYAWEQ-UHFFFAOYSA-N tert-butyl n-[4-chloro-2-[[3-[3-(2,6-dimethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]phenyl]carbamate Chemical compound CC1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC=C(Cl)C=2)NC(=O)OC(C)(C)C)=C1 UNLONZXJUYAWEQ-UHFFFAOYSA-N 0.000 description 1
• IMWWDTSOVIAWKG-UHFFFAOYSA-N tert-butyl n-[4-chloro-2-[[3-[3-(2-cyanopyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-(2,2,2-trifluoroethoxy)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(OCC(F)(F)F)=C(Cl)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(N=CC=2)C#N)=C1 IMWWDTSOVIAWKG-UHFFFAOYSA-N 0.000 description 1
• NQMNOPBAIYEGMC-UHFFFAOYSA-N tert-butyl n-[4-chloro-2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(=C(Cl)C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 NQMNOPBAIYEGMC-UHFFFAOYSA-N 0.000 description 1
• ZWDAKLYLAGRHKC-UHFFFAOYSA-N tert-butyl n-[4-chloro-2-[[3-[3-(6-cyclopropylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-5-methylphenyl]carbamate Chemical compound C1=C(Cl)C(C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC(=CC=2)C2CC2)=C1 ZWDAKLYLAGRHKC-UHFFFAOYSA-N 0.000 description 1
• LSWJZVKAMCSWKO-UHFFFAOYSA-N tert-butyl n-[4-chloro-2-[[3-[3-(6-ethylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-5-methylphenyl]carbamate Chemical compound C1=NC(CC)=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC(C)=C(Cl)C=2)NC(=O)OC(C)(C)C)=C1 LSWJZVKAMCSWKO-UHFFFAOYSA-N 0.000 description 1
• PKXCYFWUTLHLOW-UHFFFAOYSA-N tert-butyl n-[4-chloro-2-[[3-oxo-3-(3-pyridin-3-ylphenyl)propanoyl]amino]-5-(2,2,2-trifluoroethoxy)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(OCC(F)(F)F)=C(Cl)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC=CC=2)=C1 PKXCYFWUTLHLOW-UHFFFAOYSA-N 0.000 description 1
• ZLTHQALFCFVKDR-UHFFFAOYSA-N tert-butyl n-[4-chloro-2-[[3-oxo-3-(3-pyrimidin-5-ylphenyl)propanoyl]amino]-5-(trifluoromethyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(C(F)(F)F)=C(Cl)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC=NC=2)=C1 ZLTHQALFCFVKDR-UHFFFAOYSA-N 0.000 description 1
• QRNUUOLMGOOOSO-UHFFFAOYSA-N tert-butyl n-[4-chloro-2-nitro-5-(2,2,2-trifluoroethoxy)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(OCC(F)(F)F)=C(Cl)C=C1[N+]([O-])=O QRNUUOLMGOOOSO-UHFFFAOYSA-N 0.000 description 1
• WKBDTTDZYIUVRS-UHFFFAOYSA-N tert-butyl n-[4-chloro-5-(2-methylpropylamino)-2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]phenyl]carbamate Chemical compound C1=C(Cl)C(NCC(C)C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(C)N=CC=2)=C1 WKBDTTDZYIUVRS-UHFFFAOYSA-N 0.000 description 1
• OBGLZAPWHPTKGG-UHFFFAOYSA-N tert-butyl n-[4-chloro-5-[methyl(2-methylpropyl)amino]-2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]phenyl]carbamate Chemical compound C1=C(Cl)C(N(C)CC(C)C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(C)N=CC=2)=C1 OBGLZAPWHPTKGG-UHFFFAOYSA-N 0.000 description 1
• DLTLNXMXDWXBQK-UHFFFAOYSA-N tert-butyl n-[4-chloro-5-[methyl(2-methylpropyl)amino]-2-[[3-[3-[2-(oxan-2-yloxymethyl)pyridin-4-yl]phenyl]-3-oxopropanoyl]amino]phenyl]carbamate Chemical compound C1=C(Cl)C(N(C)CC(C)C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(COC3OCCCC3)N=CC=2)=C1 DLTLNXMXDWXBQK-UHFFFAOYSA-N 0.000 description 1
• VBJGARLWJVZWJI-UHFFFAOYSA-N tert-butyl n-[4-chloro-5-[methyl(propan-2-yl)amino]-2-[[3-[3-[2-(oxan-2-yloxymethyl)pyridin-4-yl]phenyl]-3-oxopropanoyl]amino]phenyl]carbamate Chemical compound C1=C(Cl)C(N(C)C(C)C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(COC3OCCCC3)N=CC=2)=C1 VBJGARLWJVZWJI-UHFFFAOYSA-N 0.000 description 1
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• SUMNZNKVOSLXAB-UHFFFAOYSA-N tert-butyl n-[4-chloro-5-ethoxy-2-[[3-oxo-3-(3-pyridin-3-ylphenyl)propanoyl]amino]phenyl]carbamate Chemical compound C1=C(Cl)C(OCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC=CC=2)=C1 SUMNZNKVOSLXAB-UHFFFAOYSA-N 0.000 description 1
• XMIUEPJSUSFUQD-UHFFFAOYSA-N tert-butyl n-[4-chloro-5-fluoro-2-[[3-[3-(6-methylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]phenyl]carbamate Chemical compound C1=NC(C)=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC(F)=C(Cl)C=2)NC(=O)OC(C)(C)C)=C1 XMIUEPJSUSFUQD-UHFFFAOYSA-N 0.000 description 1
• WVMRVVSOSSLCAN-UHFFFAOYSA-N tert-butyl n-[4-chloro-5-methyl-2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]phenyl]carbamate Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(C)=C(Cl)C=2)NC(=O)OC(C)(C)C)=C1 WVMRVVSOSSLCAN-UHFFFAOYSA-N 0.000 description 1
• ZMFJJJYNYCIREL-UHFFFAOYSA-N tert-butyl n-[4-chloro-5-methyl-2-[[3-[3-(6-methylpyrazin-2-yl)phenyl]-3-oxopropanoyl]amino]phenyl]carbamate Chemical compound CC1=CN=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(C)=C(Cl)C=2)NC(=O)OC(C)(C)C)=N1 ZMFJJJYNYCIREL-UHFFFAOYSA-N 0.000 description 1
• MYZABYHOAJHNGF-UHFFFAOYSA-N tert-butyl n-[4-chloro-5-methyl-2-[[3-[3-[2-(oxan-2-yloxymethyl)pyridin-4-yl]phenyl]-3-oxopropanoyl]amino]phenyl]carbamate Chemical compound C1=C(Cl)C(C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(COC3OCCCC3)N=CC=2)=C1 MYZABYHOAJHNGF-UHFFFAOYSA-N 0.000 description 1
• ICIISWNNUBLESU-UHFFFAOYSA-N tert-butyl n-[4-chloro-5-methyl-2-[[3-[3-[2-methyl-6-(oxan-2-yloxymethyl)pyridin-4-yl]phenyl]-3-oxopropanoyl]amino]phenyl]carbamate Chemical compound N=1C(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(C)=C(Cl)C=2)NC(=O)OC(C)(C)C)=CC=1COC1CCCCO1 ICIISWNNUBLESU-UHFFFAOYSA-N 0.000 description 1
• PIERZSOCQXGZKD-UHFFFAOYSA-N tert-butyl n-[4-chloro-5-methyl-2-[[3-oxo-3-[3-(6-propan-2-ylpyridin-3-yl)phenyl]propanoyl]amino]phenyl]carbamate Chemical compound C1=NC(C(C)C)=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC(C)=C(Cl)C=2)NC(=O)OC(C)(C)C)=C1 PIERZSOCQXGZKD-UHFFFAOYSA-N 0.000 description 1
• ZCPLTGWQXIPJPL-UHFFFAOYSA-N tert-butyl n-[4-chloro-5-methyl-2-[[3-oxo-3-[3-[2-(trifluoromethyl)pyridin-4-yl]phenyl]propanoyl]amino]phenyl]carbamate Chemical compound C1=C(Cl)C(C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(N=CC=2)C(F)(F)F)=C1 ZCPLTGWQXIPJPL-UHFFFAOYSA-N 0.000 description 1
• GOLMVUOFGGPYQG-UHFFFAOYSA-N tert-butyl n-[4-methyl-2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(=C(C)C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 GOLMVUOFGGPYQG-UHFFFAOYSA-N 0.000 description 1
• QBTMCRKXPQESSF-UHFFFAOYSA-N tert-butyl n-[4-methyl-2-[[3-[3-(6-methylpyrazin-2-yl)phenyl]-3-oxopropanoyl]amino]-5-(trifluoromethyl)phenyl]carbamate Chemical compound CC1=CN=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(=C(C)C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=N1 QBTMCRKXPQESSF-UHFFFAOYSA-N 0.000 description 1
• MVAPUEXZUCAICG-UHFFFAOYSA-N tert-butyl n-[4-methyl-2-[[3-oxo-3-(3-pyrimidin-5-ylphenyl)propanoyl]amino]-5-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(C)=CC(NC(=O)CC(=O)C=2C=C(C=CC=2)C=2C=NC=NC=2)=C1NC(=O)OC(C)(C)C MVAPUEXZUCAICG-UHFFFAOYSA-N 0.000 description 1
• VWIIAKIRBQBGBZ-UHFFFAOYSA-N tert-butyl n-[5-(2-methoxyethoxy)-2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(OCCOC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(C)N=CC=2)=C1 VWIIAKIRBQBGBZ-UHFFFAOYSA-N 0.000 description 1
• LMHVQSUVLTZVGO-UHFFFAOYSA-N tert-butyl n-[5-(2-methylpropylamino)-2-[[3-oxo-3-(3-pyridin-4-ylphenyl)propanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(NCC(C)C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=CN=CC=2)=C1 LMHVQSUVLTZVGO-UHFFFAOYSA-N 0.000 description 1
• BJEUMHJPDGOPEB-UHFFFAOYSA-N tert-butyl n-[5-(cyclopropylmethoxy)-2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(OCC3CC3)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 BJEUMHJPDGOPEB-UHFFFAOYSA-N 0.000 description 1
• UGYMLBBXUDNUEI-UHFFFAOYSA-N tert-butyl n-[5-(cyclopropylmethoxy)-2-[[3-[3-(6-cyclopropylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound FC(F)(F)C=1C=C(NC(=O)CC(=O)C=2C=C(C=CC=2)C=2C=NC(=CC=2)C2CC2)C(NC(=O)OC(C)(C)C)=CC=1OCC1CC1 UGYMLBBXUDNUEI-UHFFFAOYSA-N 0.000 description 1
• TZEACKVNBPGUOX-UHFFFAOYSA-N tert-butyl n-[5-(cyclopropylmethoxy)-2-[[3-oxo-3-(3-pyridin-3-ylphenyl)propanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound FC(F)(F)C=1C=C(NC(=O)CC(=O)C=2C=C(C=CC=2)C=2C=NC=CC=2)C(NC(=O)OC(C)(C)C)=CC=1OCC1CC1 TZEACKVNBPGUOX-UHFFFAOYSA-N 0.000 description 1
• XSJNVTIIPMNDRR-UHFFFAOYSA-N tert-butyl n-[5-(dimethylamino)-2-[[3-[3-(2,6-dimethylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(N(C)C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C(=NC(C)=CC=2)C)=C1 XSJNVTIIPMNDRR-UHFFFAOYSA-N 0.000 description 1
• QQKHNGOWTLVSJO-UHFFFAOYSA-N tert-butyl n-[5-(dimethylamino)-2-[[3-[3-(2,6-dimethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(N(C)C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(C)N=C(C)C=2)=C1 QQKHNGOWTLVSJO-UHFFFAOYSA-N 0.000 description 1
• QEZOLOLBNJYXCI-UHFFFAOYSA-N tert-butyl n-[5-(dimethylamino)-2-[[3-[3-(6-methoxypyridazin-3-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound N1=NC(OC)=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC(=C(C=2)C(F)(F)F)N(C)C)NC(=O)OC(C)(C)C)=C1 QEZOLOLBNJYXCI-UHFFFAOYSA-N 0.000 description 1
• SAQONGYYTBDYNR-UHFFFAOYSA-N tert-butyl n-[5-(dimethylamino)-2-[[3-[3-(6-methylpyridazin-3-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(N(C)C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2N=NC(C)=CC=2)=C1 SAQONGYYTBDYNR-UHFFFAOYSA-N 0.000 description 1
• CYHKYIHNWZMSTE-UHFFFAOYSA-N tert-butyl n-[5-(dimethylamino)-2-[[3-[3-[2-(oxan-2-yloxymethyl)pyridin-4-yl]phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(N(C)C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(COC3OCCCC3)N=CC=2)=C1 CYHKYIHNWZMSTE-UHFFFAOYSA-N 0.000 description 1
• QEDOJLBFIFQZMO-UHFFFAOYSA-N tert-butyl n-[5-(dimethylamino)-2-[[3-oxo-3-(3-pyrazin-2-ylphenyl)propanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(N(C)C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2N=CC=NC=2)=C1 QEDOJLBFIFQZMO-UHFFFAOYSA-N 0.000 description 1
• ZNIWARGZPPIEQD-UHFFFAOYSA-N tert-butyl n-[5-(dimethylamino)-2-[[3-oxo-3-(3-pyridin-2-ylphenyl)propanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(N(C)C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2N=CC=CC=2)=C1 ZNIWARGZPPIEQD-UHFFFAOYSA-N 0.000 description 1
• NLOIEOPPMRZMCT-UHFFFAOYSA-N tert-butyl n-[5-(dimethylamino)-2-[[3-oxo-3-(3-pyridin-3-ylphenyl)propanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(N(C)C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC=CC=2)=C1 NLOIEOPPMRZMCT-UHFFFAOYSA-N 0.000 description 1
• YJTVVLXUYKAHBA-UHFFFAOYSA-N tert-butyl n-[5-(dimethylamino)-2-[[3-oxo-3-(3-pyrimidin-5-ylphenyl)propanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(N(C)C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC=NC=2)=C1 YJTVVLXUYKAHBA-UHFFFAOYSA-N 0.000 description 1
• LXESDSJTWCYMCF-UHFFFAOYSA-N tert-butyl n-[5-(dimethylamino)-4-(2-fluorophenyl)-2-[[3-oxo-3-(3-pyridin-4-ylphenyl)propanoyl]amino]phenyl]carbamate Chemical compound C1=C(C=2C(=CC=CC=2)F)C(N(C)C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C(C=1)=CC=CC=1C1=CC=NC=C1 LXESDSJTWCYMCF-UHFFFAOYSA-N 0.000 description 1
• OQSOMGNCWKWTNU-UHFFFAOYSA-N tert-butyl n-[5-(hydroxymethyl)-2-nitro-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(CO)=C(C(F)(F)F)C=C1[N+]([O-])=O OQSOMGNCWKWTNU-UHFFFAOYSA-N 0.000 description 1
• ZXELKRCHWGUXOM-UHFFFAOYSA-N tert-butyl n-[5-[cyclopropyl(methyl)amino]-2-[[3-oxo-3-(3-pyridin-3-ylphenyl)propanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C=1C(NC(=O)OC(C)(C)C)=C(NC(=O)CC(=O)C=2C=C(C=CC=2)C=2C=NC=CC=2)C=C(C(F)(F)F)C=1N(C)C1CC1 ZXELKRCHWGUXOM-UHFFFAOYSA-N 0.000 description 1
• DFACHXTWSXOIER-UHFFFAOYSA-N tert-butyl n-[5-[methyl(2-methylpropyl)amino]-2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(N(C)CC(C)C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(C)N=CC=2)=C1 DFACHXTWSXOIER-UHFFFAOYSA-N 0.000 description 1
• YUFKUZUHQXWZRI-UHFFFAOYSA-N tert-butyl n-[5-[methyl(2-methylpropyl)amino]-2-[[3-[3-[2-(oxan-2-yloxymethyl)pyridin-4-yl]phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(N(C)CC(C)C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(COC3OCCCC3)N=CC=2)=C1 YUFKUZUHQXWZRI-UHFFFAOYSA-N 0.000 description 1
• CZPDQHYOZKYZKK-UHFFFAOYSA-N tert-butyl n-[5-[methyl(propan-2-yl)amino]-2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(N(C)C(C)C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(C)N=CC=2)=C1 CZPDQHYOZKYZKK-UHFFFAOYSA-N 0.000 description 1
• YPTOGHWMHINNLF-UHFFFAOYSA-N tert-butyl n-[5-[methyl(propan-2-yl)amino]-2-[[3-[3-[2-(oxan-2-yloxymethyl)pyridin-4-yl]phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(N(C)C(C)C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(COC3OCCCC3)N=CC=2)=C1 YPTOGHWMHINNLF-UHFFFAOYSA-N 0.000 description 1
• OVHHMYBZOZDCIJ-UHFFFAOYSA-N tert-butyl n-[5-[methyl(propyl)amino]-2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(N(C)CCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(C)N=CC=2)=C1 OVHHMYBZOZDCIJ-UHFFFAOYSA-N 0.000 description 1
• BPMURVIOBACFFO-UHFFFAOYSA-N tert-butyl n-[5-[methyl(propyl)amino]-2-[[3-[3-[2-(oxan-2-yloxymethyl)pyridin-4-yl]phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(N(C)CCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(COC3OCCCC3)N=CC=2)=C1 BPMURVIOBACFFO-UHFFFAOYSA-N 0.000 description 1
• OMXQDZGLFAFFMG-UHFFFAOYSA-N tert-butyl n-[5-[methyl(propyl)amino]-2-[[3-oxo-3-(3-pyrazin-2-ylphenyl)propanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(N(C)CCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2N=CC=NC=2)=C1 OMXQDZGLFAFFMG-UHFFFAOYSA-N 0.000 description 1
• DHRPZVAAUNBRBI-UHFFFAOYSA-N tert-butyl n-[5-[methyl(propyl)amino]-2-[[3-oxo-3-(3-pyridin-4-ylphenyl)propanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(N(C)CCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=CN=CC=2)=C1 DHRPZVAAUNBRBI-UHFFFAOYSA-N 0.000 description 1
• IEHXFXJFTUBGTJ-UHFFFAOYSA-N tert-butyl n-[5-[methyl(propyl)amino]-2-[[3-oxo-3-(3-pyrimidin-5-ylphenyl)propanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(N(C)CCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC=NC=2)=C1 IEHXFXJFTUBGTJ-UHFFFAOYSA-N 0.000 description 1
• JEJOABWZPOUSTK-UHFFFAOYSA-N tert-butyl n-[5-chloro-2-[[3-[3-(2,3-dimethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC1=NC=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(Cl)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1C JEJOABWZPOUSTK-UHFFFAOYSA-N 0.000 description 1
• ZJQAGBSNOVCCRC-UHFFFAOYSA-N tert-butyl n-[5-chloro-2-[[3-[3-(2,5-dimethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(Cl)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1C ZJQAGBSNOVCCRC-UHFFFAOYSA-N 0.000 description 1
• PJIWZZUXQDIICJ-UHFFFAOYSA-N tert-butyl n-[5-chloro-2-[[3-[3-(2,6-dimethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(Cl)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 PJIWZZUXQDIICJ-UHFFFAOYSA-N 0.000 description 1
• JQALVDYZZKDKBC-UHFFFAOYSA-N tert-butyl n-[5-chloro-2-[[3-[3-(2-ethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(CC)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(Cl)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 JQALVDYZZKDKBC-UHFFFAOYSA-N 0.000 description 1
• DPTDZVLRBMCJEJ-UHFFFAOYSA-N tert-butyl n-[5-chloro-2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(Cl)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 DPTDZVLRBMCJEJ-UHFFFAOYSA-N 0.000 description 1
• FAFVIQRAMQAMOH-UHFFFAOYSA-N tert-butyl n-[5-chloro-2-[[3-[3-[2-(2-methylpropyl)pyridin-4-yl]phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(CC(C)C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(Cl)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 FAFVIQRAMQAMOH-UHFFFAOYSA-N 0.000 description 1
• UMTLAMPZCNPWLG-UHFFFAOYSA-N tert-butyl n-[5-chloro-2-[[3-[3-[2-methyl-6-(oxan-2-yloxymethyl)pyridin-4-yl]phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound N=1C(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(Cl)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=CC=1COC1CCCCO1 UMTLAMPZCNPWLG-UHFFFAOYSA-N 0.000 description 1
• VGBZSTZEVUARLR-UHFFFAOYSA-N tert-butyl n-[5-chloro-2-[[3-oxo-3-(3-pyridin-3-ylphenyl)propanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(Cl)=C(C(F)(F)F)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC=CC=2)=C1 VGBZSTZEVUARLR-UHFFFAOYSA-N 0.000 description 1
• ZDUKAULYNYPEQL-UHFFFAOYSA-N tert-butyl n-[5-chloro-2-[[3-oxo-3-(3-pyrimidin-5-ylphenyl)propanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(Cl)=C(C(F)(F)F)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC=NC=2)=C1 ZDUKAULYNYPEQL-UHFFFAOYSA-N 0.000 description 1
• TWVMUYWBEQVMAP-UHFFFAOYSA-N tert-butyl n-[5-chloro-2-[[3-oxo-3-[3-(2-propan-2-ylpyridin-4-yl)phenyl]propanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(C(C)C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(Cl)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 TWVMUYWBEQVMAP-UHFFFAOYSA-N 0.000 description 1
• DBRLMEJJMQUJIN-UHFFFAOYSA-N tert-butyl n-[5-chloro-2-[[3-oxo-3-[3-[2-(trifluoromethyl)pyridin-4-yl]phenyl]propanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(Cl)=C(C(F)(F)F)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(N=CC=2)C(F)(F)F)=C1 DBRLMEJJMQUJIN-UHFFFAOYSA-N 0.000 description 1
• HPOFWGSBPYENNC-UHFFFAOYSA-N tert-butyl n-[5-chloro-4-methyl-2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]phenyl]carbamate Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(Cl)=C(C)C=2)NC(=O)OC(C)(C)C)=C1 HPOFWGSBPYENNC-UHFFFAOYSA-N 0.000 description 1
• KSOYVPMGIZSKDD-UHFFFAOYSA-N tert-butyl n-[5-chloro-4-methyl-2-[[3-[3-(6-methylpyrazin-2-yl)phenyl]-3-oxopropanoyl]amino]phenyl]carbamate Chemical compound CC1=CN=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(Cl)=C(C)C=2)NC(=O)OC(C)(C)C)=N1 KSOYVPMGIZSKDD-UHFFFAOYSA-N 0.000 description 1
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