RU2225397C2 - Производные индола как ингибиторы фактора Ха - Google Patents

Производные индола как ингибиторы фактора Ха Download PDF

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RU2225397C2
RU2225397C2 RU2000119774/04A RU2000119774A RU2225397C2 RU 2225397 C2 RU2225397 C2 RU 2225397C2 RU 2000119774/04 A RU2000119774/04 A RU 2000119774/04A RU 2000119774 A RU2000119774 A RU 2000119774A RU 2225397 C2 RU2225397 C2 RU 2225397C2
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alkyl
formula
residue
phenyl
compound
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RU2000119774/04A
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English (en)
Russian (ru)
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RU2000119774A (ru
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Элизабет ДЕФОССА (DE)
Элизабет ДЕФОССА
Уве ХАЙНЕЛЬТ (DE)
Уве ХАЙНЕЛЬТ
Отмар КЛИНГЛЕР (DE)
Отмар КЛИНГЛЕР
Герхард ЦОЛЛЕР (DE)
Герхард ЦОЛЛЕР
Фахад АЛЬ-ОБАЙДИ (US)
Фахад АЛЬ-ОБАЙДИ
Армин ВАЛЬЗЕР (US)
Армин ВАЛЬЗЕР
Питер ВАЙЛДГУЗ (DE)
Питер ВАЙЛДГУЗ
Ханс МАТТЕР (DE)
Ханс МАТТЕР
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Авентис Фарма Дойчланд Гмбх
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
RU2000119774/04A 1997-12-24 1998-12-10 Производные индола как ингибиторы фактора Ха RU2225397C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97122901.8 1997-12-24
EP97122901 1997-12-24

Publications (2)

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RU2000119774A RU2000119774A (ru) 2002-09-27
RU2225397C2 true RU2225397C2 (ru) 2004-03-10

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US (1) US6337344B1 (https=)
EP (1) EP1042287B1 (https=)
JP (1) JP4589529B2 (https=)
KR (1) KR100608472B1 (https=)
CN (1) CN1220681C (https=)
AR (1) AR018031A1 (https=)
AT (1) ATE293599T1 (https=)
AU (1) AU743881B2 (https=)
BR (1) BR9814340B1 (https=)
CA (1) CA2316172C (https=)
CZ (1) CZ298827B6 (https=)
DE (1) DE69829879T2 (https=)
DK (1) DK1042287T3 (https=)
ES (1) ES2241194T3 (https=)
HU (1) HU227568B1 (https=)
ID (1) ID27044A (https=)
IL (1) IL136954A0 (https=)
MY (1) MY120064A (https=)
NO (1) NO316912B1 (https=)
NZ (1) NZ505370A (https=)
PL (1) PL195682B1 (https=)
PT (1) PT1042287E (https=)
RU (1) RU2225397C2 (https=)
SI (1) SI1042287T1 (https=)
TR (1) TR200001954T2 (https=)
TW (1) TWI241294B (https=)
WO (1) WO1999033800A1 (https=)
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2382778C2 (ru) * 2004-06-21 2010-02-27 Ф.Хоффманн-Ля Рош Аг Производные индола в качестве антагонистов гистаминовых рецепторов
RU2412182C2 (ru) * 2005-11-30 2011-02-20 Ф.Хоффманн-Ля Рош Аг Производные 1,1-диоксотиоморфолинилиндолилметанона для применения в качестве модуляторов гистамина 3 (н3)
RU2446157C2 (ru) * 2006-09-13 2012-03-27 Санофи-Авентис Изосериновые производные для применения в качестве ингибиторов фактора свертывания крови ixa

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2382778C2 (ru) * 2004-06-21 2010-02-27 Ф.Хоффманн-Ля Рош Аг Производные индола в качестве антагонистов гистаминовых рецепторов
RU2412182C2 (ru) * 2005-11-30 2011-02-20 Ф.Хоффманн-Ля Рош Аг Производные 1,1-диоксотиоморфолинилиндолилметанона для применения в качестве модуляторов гистамина 3 (н3)
RU2446157C2 (ru) * 2006-09-13 2012-03-27 Санофи-Авентис Изосериновые производные для применения в качестве ингибиторов фактора свертывания крови ixa

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BR9814340A (pt) 2000-10-03
JP4589529B2 (ja) 2010-12-01
NO20003057L (no) 2000-08-18
US6337344B1 (en) 2002-01-08
PL195682B1 (pl) 2007-10-31
TWI241294B (en) 2005-10-11
IL136954A0 (en) 2001-06-14
NO20003057D0 (no) 2000-06-14
DE69829879D1 (de) 2005-05-25
ID27044A (id) 2001-02-22
DK1042287T3 (da) 2005-08-15
AU2052899A (en) 1999-07-19
CN1220681C (zh) 2005-09-28
CA2316172A1 (en) 1999-07-08
SI1042287T1 (en) 2005-10-31
NO316912B1 (no) 2004-06-21
KR20010033573A (ko) 2001-04-25
CZ298827B6 (cs) 2008-02-20
MY120064A (en) 2005-08-30
EP1042287A1 (en) 2000-10-11
DE69829879T2 (de) 2006-03-02
CZ20002310A3 (cs) 2000-10-11
TR200001954T2 (tr) 2000-12-21
CN1283186A (zh) 2001-02-07
ZA9811759B (en) 1999-07-28
HUP0100723A2 (hu) 2001-08-28
AR018031A1 (es) 2001-10-31
HK1033795A1 (en) 2001-09-21
HU227568B1 (en) 2011-08-29
PT1042287E (pt) 2005-08-31
HUP0100723A3 (en) 2002-12-28
JP2001527066A (ja) 2001-12-25
NZ505370A (en) 2002-06-28
EP1042287B1 (en) 2005-04-20
KR100608472B1 (ko) 2006-08-09
WO1999033800A1 (en) 1999-07-08
ATE293599T1 (de) 2005-05-15
BR9814340B1 (pt) 2010-07-13
AU743881B2 (en) 2002-02-07
ES2241194T3 (es) 2005-10-16
CA2316172C (en) 2010-02-02
PL341400A1 (en) 2001-04-09

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