NO20003057L - Indolderivater som inhibitorer av faktor Xa - Google Patents

Indolderivater som inhibitorer av faktor Xa

Info

Publication number
NO20003057L
NO20003057L NO20003057A NO20003057A NO20003057L NO 20003057 L NO20003057 L NO 20003057L NO 20003057 A NO20003057 A NO 20003057A NO 20003057 A NO20003057 A NO 20003057A NO 20003057 L NO20003057 L NO 20003057L
Authority
NO
Norway
Prior art keywords
inhibitors
factor
indole derivatives
indole
derivatives
Prior art date
Application number
NO20003057A
Other languages
English (en)
Other versions
NO316912B1 (no
NO20003057D0 (no
Inventor
Elisabeth Defossa
Uwe Heinelt
Otmar Klingler
Gerhard Zoller
Fahad Al-Obeidi
Armin Walser
Peter Wildgoose
Hans Matter
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of NO20003057D0 publication Critical patent/NO20003057D0/no
Publication of NO20003057L publication Critical patent/NO20003057L/no
Publication of NO316912B1 publication Critical patent/NO316912B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO20003057A 1997-12-24 2000-06-14 Indolderivater som inhibitorer av faktor Xa NO316912B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97122901 1997-12-24
PCT/EP1998/008030 WO1999033800A1 (en) 1997-12-24 1998-12-10 Indole derivatives as inhibitors or factor xa

Publications (3)

Publication Number Publication Date
NO20003057D0 NO20003057D0 (no) 2000-06-14
NO20003057L true NO20003057L (no) 2000-08-18
NO316912B1 NO316912B1 (no) 2004-06-21

Family

ID=8227884

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20003057A NO316912B1 (no) 1997-12-24 2000-06-14 Indolderivater som inhibitorer av faktor Xa

Country Status (29)

Country Link
US (1) US6337344B1 (no)
EP (1) EP1042287B1 (no)
JP (1) JP4589529B2 (no)
KR (1) KR100608472B1 (no)
CN (1) CN1220681C (no)
AR (1) AR018031A1 (no)
AT (1) ATE293599T1 (no)
AU (1) AU743881B2 (no)
BR (1) BR9814340B1 (no)
CA (1) CA2316172C (no)
CZ (1) CZ298827B6 (no)
DE (1) DE69829879T2 (no)
DK (1) DK1042287T3 (no)
ES (1) ES2241194T3 (no)
HK (1) HK1033795A1 (no)
HU (1) HU227568B1 (no)
ID (1) ID27044A (no)
IL (1) IL136954A0 (no)
MY (1) MY120064A (no)
NO (1) NO316912B1 (no)
NZ (1) NZ505370A (no)
PL (1) PL195682B1 (no)
PT (1) PT1042287E (no)
RU (1) RU2225397C2 (no)
SI (1) SI1042287T1 (no)
TR (1) TR200001954T2 (no)
TW (1) TWI241294B (no)
WO (1) WO1999033800A1 (no)
ZA (1) ZA9811759B (no)

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CA2358578A1 (en) 1999-01-02 2000-07-13 Aventis Pharma Deutschland Gmbh Novel malonic acid derivatives, processes for their preparation, their use and pharmaceutical compositions containing them (inhibition of factor xa activity)
BR9916733A (pt) 1999-01-02 2001-09-25 Aventis Pharma Gmbh Derivados de arilalcanoìla, processos para sua preparação, seu uso e composições farmacêuticas que os contêm
GB9902459D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902455D0 (en) * 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902461D0 (en) * 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902453D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902452D0 (en) * 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
CO5370679A1 (es) * 1999-06-01 2004-02-27 Smithkline Beecham Corp Inhibidores fab 1
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GB0000625D0 (en) 2000-01-13 2000-03-01 Zeneca Ltd Chemical compounds
EP1127884A1 (en) 2000-02-26 2001-08-29 Aventis Pharma Deutschland GmbH Novel malonic acid derivatives, processes for their preparation, their use as inhibitor of factor XA activity and pharmaceutical compositions containing them
GB0005366D0 (en) * 2000-03-06 2000-04-26 Xenova Ltd Pharmaceutical compounds
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EP1314733A1 (en) * 2001-11-22 2003-05-28 Aventis Pharma Deutschland GmbH Indole-2-carboxamides as factor Xa inhibitors
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CA2570365A1 (en) * 2004-06-18 2005-12-29 Biolipox Ab Indoles useful in the treatment of inflammation
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EP3454945B1 (en) 2016-05-12 2022-01-19 The Regents Of The University Of Michigan Ash1l inhibitors and methods of treatment therewith
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Also Published As

Publication number Publication date
RU2225397C2 (ru) 2004-03-10
TR200001954T2 (tr) 2000-12-21
CN1220681C (zh) 2005-09-28
ES2241194T3 (es) 2005-10-16
PL341400A1 (en) 2001-04-09
HU227568B1 (en) 2011-08-29
WO1999033800A1 (en) 1999-07-08
TWI241294B (en) 2005-10-11
NO316912B1 (no) 2004-06-21
PT1042287E (pt) 2005-08-31
DE69829879T2 (de) 2006-03-02
EP1042287A1 (en) 2000-10-11
KR20010033573A (ko) 2001-04-25
DE69829879D1 (de) 2005-05-25
CN1283186A (zh) 2001-02-07
NZ505370A (en) 2002-06-28
AU743881B2 (en) 2002-02-07
AU2052899A (en) 1999-07-19
PL195682B1 (pl) 2007-10-31
HUP0100723A3 (en) 2002-12-28
ATE293599T1 (de) 2005-05-15
HK1033795A1 (en) 2001-09-21
AR018031A1 (es) 2001-10-31
SI1042287T1 (en) 2005-10-31
DK1042287T3 (da) 2005-08-15
BR9814340A (pt) 2000-10-03
US6337344B1 (en) 2002-01-08
KR100608472B1 (ko) 2006-08-09
JP2001527066A (ja) 2001-12-25
CZ20002310A3 (cs) 2000-10-11
MY120064A (en) 2005-08-30
HUP0100723A2 (hu) 2001-08-28
ID27044A (id) 2001-02-22
CZ298827B6 (cs) 2008-02-20
CA2316172A1 (en) 1999-07-08
ZA9811759B (en) 1999-07-28
EP1042287B1 (en) 2005-04-20
NO20003057D0 (no) 2000-06-14
CA2316172C (en) 2010-02-02
JP4589529B2 (ja) 2010-12-01
IL136954A0 (en) 2001-06-14
BR9814340B1 (pt) 2010-07-13

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