RU2191021C2 - Пролекарство для терапии опухолей и воспалительных заболеваний - Google Patents

Пролекарство для терапии опухолей и воспалительных заболеваний Download PDF

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Publication number
RU2191021C2
RU2191021C2 RU97103585/14A RU97103585A RU2191021C2 RU 2191021 C2 RU2191021 C2 RU 2191021C2 RU 97103585/14 A RU97103585/14 A RU 97103585/14A RU 97103585 A RU97103585 A RU 97103585A RU 2191021 C2 RU2191021 C2 RU 2191021C2
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compound
active principle
prodrug
amino
formula
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RU97103585/14A
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English (en)
Russian (ru)
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RU97103585A (ru
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Клаус БОСЛЕТ (DE)
Клаус БОСЛЕТ
Ерг ЧЕХ (DE)
Ерг ЧЕХ
Манфред ГЕРКЕН (DE)
Манфред ГЕРКЕН
Райнер ШТРАУБ (DE)
Райнер ШТРАУБ
Клод МОННЕРЕ (FR)
Клод Моннере
Жан-Клод ФЛОРЭН (FR)
Жан-Клод ФЛОРЭН
Фредерик ШМИДТ (FR)
Фредерик ШМИДТ
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Авентис Фарма Дойчланд Гмбх
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
RU97103585/14A 1996-03-12 1997-03-06 Пролекарство для терапии опухолей и воспалительных заболеваний RU2191021C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96103866 1996-03-12
EP96103866.8 1996-03-12

Publications (2)

Publication Number Publication Date
RU97103585A RU97103585A (ru) 1999-04-20
RU2191021C2 true RU2191021C2 (ru) 2002-10-20

Family

ID=8222555

Family Applications (1)

Application Number Title Priority Date Filing Date
RU97103585/14A RU2191021C2 (ru) 1996-03-12 1997-03-06 Пролекарство для терапии опухолей и воспалительных заболеваний

Country Status (24)

Country Link
US (1) US5935995A (https=)
EP (1) EP0795334B1 (https=)
JP (1) JP4392065B2 (https=)
KR (1) KR100466467B1 (https=)
CN (1) CN1168733C (https=)
AT (1) ATE316799T1 (https=)
AU (1) AU708202B2 (https=)
BG (1) BG61900B1 (https=)
BR (1) BRPI9701248B1 (https=)
CA (1) CA2199664C (https=)
CZ (1) CZ297994B6 (https=)
DE (1) DE59712561D1 (https=)
DK (1) DK0795334T3 (https=)
ES (1) ES2257756T3 (https=)
HU (1) HU228764B1 (https=)
NO (1) NO320322B1 (https=)
NZ (1) NZ314368A (https=)
PL (1) PL189604B1 (https=)
RO (1) RO120951B1 (https=)
RU (1) RU2191021C2 (https=)
SG (1) SG50011A1 (https=)
SI (1) SI0795334T1 (https=)
TR (1) TR199700178A2 (https=)
UA (1) UA50719C2 (https=)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2414475C2 (ru) * 2005-06-29 2011-03-20 Трешолд Фармасьютикалз, Инк. Пролекарства фосфорамидатных алкилаторов
RU2527531C2 (ru) * 2007-04-06 2014-09-10 Зайофарм Онколоджи, Инк. Соли изофосфорамидного иприта и его аналогов
RU2568639C2 (ru) * 2009-09-02 2015-11-20 Окленд Юнисервисиз Лимитед Ингибиторы киназы, их пролекарственные формы и их применение в терапии
US10383949B2 (en) 2014-05-28 2019-08-20 Legochem Biosciences, Inc. Compounds comprising self-immolative group
RU2705548C2 (ru) * 2009-05-01 2019-11-08 Юниверсити Корт Оф Дзе Юниверсити Оф Данди Лечение или профилактика пролиферативных состояний
US11167040B2 (en) 2015-11-25 2021-11-09 Legochem Biosciences, Inc. Conjugates comprising peptide groups and methods related thereto
US11173214B2 (en) 2015-11-25 2021-11-16 Legochem Biosciences, Inc. Antibody-drug conjugates comprising branched linkers and methods related thereto
US11413353B2 (en) 2015-11-25 2022-08-16 Legochem Biosciences, Inc. Conjugates comprising self-immolative groups and methods related thereto
US11654197B2 (en) 2017-03-29 2023-05-23 Legochem Biosciences, Inc. Pyrrolobenzodiazepine dimer prodrug and ligand-linker conjugate compound of the same
US11707533B2 (en) 2019-09-04 2023-07-25 Legochem Biosciences, Inc. Antibody-drug conjugate comprising antibody against human ROR1 and use for the same
US11760773B2 (en) 2018-02-02 2023-09-19 Maverix Oncology, Inc. Small molecule drug conjugates of gemcitabine monophosphate
US11827703B2 (en) 2018-05-09 2023-11-28 Legochem Biosciences, Inc. Compositions and methods related to anti-CD19 antibody drug conjugates

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US5525606A (en) 1994-08-01 1996-06-11 The United States Of America As Represented By The Department Of Health And Human Services Substituted 06-benzylguanines and 6(4)-benzyloxypyrimidines
DE19720312A1 (de) * 1997-05-15 1998-11-19 Hoechst Ag Zubereitung mit erhöhter in vivo Verträglichkeit
IL138990A0 (en) * 1999-02-12 2001-11-25 Biostream Inc Matrices for drug delivery and methods for making and using the same
US6716452B1 (en) * 2000-08-22 2004-04-06 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
ES2246234T3 (es) 1999-05-04 2006-02-16 Strakan International Limited Glicosidos de androgenos y actividad androgenica de los mismos.
US6191119B1 (en) * 1999-10-15 2001-02-20 Supergen, Inc. Combination therapy including 9-nitro-20(S)-camptothecin
US8394813B2 (en) 2000-11-14 2013-03-12 Shire Llc Active agent delivery systems and methods for protecting and administering active agents
DE10058596A1 (de) * 2000-11-25 2002-06-06 Aventis Pharma Gmbh Verfahren zum Screening von chemischen Verbindungen zur Modulierung der Wechselwirkung einer EVH1-Domäne oder eines Proteins mit einer EVH1-Domäne mit einer EVH1-Bindedomäne oder einem Protein mit einer EVH1-Bindedomäne sowie ein Verfahren zum Nachweis besagter Wechselwirkung
US20060014697A1 (en) 2001-08-22 2006-01-19 Travis Mickle Pharmaceutical compositions for prevention of overdose or abuse
US7169752B2 (en) 2003-09-30 2007-01-30 New River Pharmaceuticals Inc. Compounds and compositions for prevention of overdose of oxycodone
WO2003018549A2 (en) * 2001-08-30 2003-03-06 Chemocentryx, Inc. Bicyclic compounds as inhibitors of chemokine binding to us28
EP1541579A1 (en) * 2002-06-20 2005-06-15 Nippon Suisan Kaisha, Ltd. Produrg, medicinal utilization thereof and process for producing the same
US8133881B2 (en) 2003-01-13 2012-03-13 Shire Llc Carbohydrate conjugates to prevent abuse of controlled substances
US7160867B2 (en) * 2003-05-16 2007-01-09 Isotechnika, Inc. Rapamycin carbohydrate derivatives
EP1734962A4 (en) * 2004-03-30 2010-07-14 Painceptor Pharma Corp COMPOSITIONS AND METHOD FOR MODULATING CONTROLLED ION CHANNELS
US7825096B2 (en) * 2004-09-08 2010-11-02 The United States Of America As Represented By The Department Of Health And Human Services O6-alkylguanine-DNA alkyltransferase inactivators and beta-glucuronidase cleavable prodrugs
KR101253399B1 (ko) 2010-10-26 2013-04-11 영남대학교 산학협력단 아포지단백질 ａ－ｉ 및 그 변이체를 포함한 재조합 고밀도지단백질을 이용한 라파마이신 제형
CN108367043A (zh) 2015-12-04 2018-08-03 西雅图基因公司 季铵化的微管溶素化合物的缀合物
US11793880B2 (en) 2015-12-04 2023-10-24 Seagen Inc. Conjugates of quaternized tubulysin compounds

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EP0511917A1 (fr) * 1991-04-30 1992-11-04 Laboratoires Hoechst S.A. Prodrogues glycosylées, leur procédé de préparation et leurs utilisations

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WO1992019639A1 (fr) * 1991-04-30 1992-11-12 Laboratoires Hoechst Prodrogues glycosylees, leur procede de preparation et leurs utilisations

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Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2414475C2 (ru) * 2005-06-29 2011-03-20 Трешолд Фармасьютикалз, Инк. Пролекарства фосфорамидатных алкилаторов
RU2527531C2 (ru) * 2007-04-06 2014-09-10 Зайофарм Онколоджи, Инк. Соли изофосфорамидного иприта и его аналогов
RU2705548C2 (ru) * 2009-05-01 2019-11-08 Юниверсити Корт Оф Дзе Юниверсити Оф Данди Лечение или профилактика пролиферативных состояний
RU2568639C2 (ru) * 2009-09-02 2015-11-20 Окленд Юнисервисиз Лимитед Ингибиторы киназы, их пролекарственные формы и их применение в терапии
US10383949B2 (en) 2014-05-28 2019-08-20 Legochem Biosciences, Inc. Compounds comprising self-immolative group
RU2712744C2 (ru) * 2014-05-28 2020-01-30 Легокем Байосайенсез, Инк. Соединения, включающие саморасщепляющуюся группу
US10980890B2 (en) 2014-05-28 2021-04-20 Legochem Biosciences, Inc. Compounds comprising self-immolative group
US11173214B2 (en) 2015-11-25 2021-11-16 Legochem Biosciences, Inc. Antibody-drug conjugates comprising branched linkers and methods related thereto
US11167040B2 (en) 2015-11-25 2021-11-09 Legochem Biosciences, Inc. Conjugates comprising peptide groups and methods related thereto
US11413353B2 (en) 2015-11-25 2022-08-16 Legochem Biosciences, Inc. Conjugates comprising self-immolative groups and methods related thereto
US11975076B2 (en) 2015-11-25 2024-05-07 Legochem Biosciences, Inc. Antibody-drug conjugates comprising branched linkers and methods related thereto
US11654197B2 (en) 2017-03-29 2023-05-23 Legochem Biosciences, Inc. Pyrrolobenzodiazepine dimer prodrug and ligand-linker conjugate compound of the same
US12398124B2 (en) 2017-03-29 2025-08-26 Ligachem Biosciences Inc. Pyrrolobenzodiazepine dimer prodrug and ligand-linker conjugate compound of the same
US11760773B2 (en) 2018-02-02 2023-09-19 Maverix Oncology, Inc. Small molecule drug conjugates of gemcitabine monophosphate
US11827703B2 (en) 2018-05-09 2023-11-28 Legochem Biosciences, Inc. Compositions and methods related to anti-CD19 antibody drug conjugates
US11707533B2 (en) 2019-09-04 2023-07-25 Legochem Biosciences, Inc. Antibody-drug conjugate comprising antibody against human ROR1 and use for the same

Also Published As

Publication number Publication date
HU228764B1 (en) 2013-05-28
CN1168733C (zh) 2004-09-29
HU9700579D0 (en) 1997-04-28
AU708202B2 (en) 1999-07-29
CN1163895A (zh) 1997-11-05
SG50011A1 (en) 1998-06-15
NZ314368A (en) 1998-10-28
HUP9700579A2 (en) 1997-12-29
CA2199664A1 (en) 1997-09-12
TR199700178A2 (tr) 1997-09-21
SI0795334T1 (sl) 2006-06-30
BG101290A (en) 1997-09-30
CZ297994B6 (cs) 2007-05-16
CZ74297A3 (en) 1997-09-17
DE59712561D1 (de) 2006-04-13
EP0795334B1 (de) 2006-02-01
MX9701832A (es) 1998-07-31
NO971116D0 (no) 1997-03-11
BG61900B1 (bg) 1998-09-30
BR9701248A (pt) 1999-10-13
ATE316799T1 (de) 2006-02-15
JP4392065B2 (ja) 2009-12-24
BR9701248A8 (pt) 2013-06-18
EP0795334A2 (de) 1997-09-17
UA50719C2 (uk) 2002-11-15
CA2199664C (en) 2008-05-20
PL189604B1 (pl) 2005-08-31
US5935995A (en) 1999-08-10
NO320322B1 (no) 2005-11-21
EP0795334A3 (de) 1997-09-24
JPH101495A (ja) 1998-01-06
ES2257756T3 (es) 2006-08-01
HUP9700579A3 (en) 1999-05-28
KR100466467B1 (ko) 2005-06-29
AU1620597A (en) 1997-09-18
DK0795334T3 (da) 2006-06-06
PL318878A1 (en) 1997-09-15
BRPI9701248B1 (pt) 2022-01-18
NO971116L (no) 1997-09-15
RO120951B1 (ro) 2006-10-30
KR970065550A (ko) 1997-10-13

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