RU2162468C2 - Моногидрат гидрохлорида 1-циклопропил-7-([s,s]-2,8-диазабицикло[4.3.0]нон-8-ил)-6-фтор-1,4-дигидро -8-метокси-4-оксо-3-хинолинкарбоновой кислоты и фармацевтическая композиция с антибактериальной активностью - Google Patents

Моногидрат гидрохлорида 1-циклопропил-7-([s,s]-2,8-диазабицикло[4.3.0]нон-8-ил)-6-фтор-1,4-дигидро -8-метокси-4-оксо-3-хинолинкарбоновой кислоты и фармацевтическая композиция с антибактериальной активностью Download PDF

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Publication number
RU2162468C2
RU2162468C2 RU96123410/04A RU96123410A RU2162468C2 RU 2162468 C2 RU2162468 C2 RU 2162468C2 RU 96123410/04 A RU96123410/04 A RU 96123410/04A RU 96123410 A RU96123410 A RU 96123410A RU 2162468 C2 RU2162468 C2 RU 2162468C2
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monohydrate
diazabicyclo
cyclopropyl
dihydro
oxo
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RU96123410/04A
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English (en)
Russian (ru)
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RU96123410A (ru
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ГРУНЕНБЕРГ Альфонс (DE)
Груненберг Альфонс
БОШЕ Патрик (DE)
Боше Патрик
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Байер Аг
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU96123410/04A 1995-12-12 1996-12-11 Моногидрат гидрохлорида 1-циклопропил-7-([s,s]-2,8-диазабицикло[4.3.0]нон-8-ил)-6-фтор-1,4-дигидро -8-метокси-4-оксо-3-хинолинкарбоновой кислоты и фармацевтическая композиция с антибактериальной активностью RU2162468C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19546249A DE19546249A1 (de) 1995-12-12 1995-12-12 Neue Kristallmodifikation des 1-Cyclopropyl-7-([S,S]-2,8-diazabicyclo[4,3,0]non-8-yl)-6-fluor-1,4-dihydro-8-methoxy-4-oxo-3-chinolincarbonsäure Hydrochlorid (CDCH), Verfahren zu dessen Herstellung und diese enthaltende pharmazeutische Zubereitungen
DE19546249.1 1995-12-12

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RU96123410A RU96123410A (ru) 1999-02-10
RU2162468C2 true RU2162468C2 (ru) 2001-01-27

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RU2383543C2 (ru) * 2004-04-01 2010-03-10 Байер Энимэл Хельс ГмбХ Тригидрат 8-циано-1-циклопропил-7-(1s, 6s-2,8-диазабицикло-[4.3.0]нонан-8-ил)-6-фтор-1, 4-дигидро-4-оксо-3-хинолинкарбоновой кислоты
RU2561037C2 (ru) * 2013-02-07 2015-08-20 Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") Антибактериальная фармацевтическая композиция и способ ее получения

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US6509327B1 (en) 1998-09-30 2003-01-21 Alcon Manufacturing, Ltd. Compositions and methods for treating otic, ophthalmic and nasal infections
US6395746B1 (en) 1998-09-30 2002-05-28 Alcon Manufacturing, Ltd. Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
US6716830B2 (en) 1998-09-30 2004-04-06 Alcon, Inc. Ophthalmic antibiotic compositions containing moxifloxacin
JP4809978B2 (ja) * 1998-11-10 2011-11-09 バイエル・シエリング・フアーマ・アクチエンゲゼルシヤフト 製薬学的モキシフロキサシン調製物
DE19854357A1 (de) * 1998-11-25 2000-05-31 Bayer Ag Semi-Hydrochlorid von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo/4.3.0/ -nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19854356A1 (de) * 1998-11-25 2000-05-31 Bayer Ag Kristallmodifikation A von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo-/4.3.0/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19854355A1 (de) * 1998-11-25 2000-05-31 Bayer Ag Kristallmodifikation B von 8-Cyan-1-cyclopropyl-7-(1S, 6S-2,8-diazabicyclo-/4.3.O/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19908449A1 (de) 1999-02-26 2000-08-31 Bayer Ag Kristallmodifikation C von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicylo-[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chino/incarbonsäure
EP1562942A1 (en) * 2002-10-31 2005-08-17 Ranbaxy Laboratories, Ltd. Amorphous moxifloxacin hydrochloride
EP2113505A1 (en) 2003-04-09 2009-11-04 Dr. Reddy's Laboratories, Ltd. A crystalline form III of anhydrous moxifloxacin hydrochloride and processes for the preparation thereof
EP1651630A1 (en) * 2003-08-05 2006-05-03 Matrix Laboratories Ltd An improved process for the preparation of moxifloxacin hydrochloride
ITMI20032259A1 (it) 2003-11-20 2005-05-21 Chemi Spa Nuovo polimorfo dell'acido 1-ciclopropil-7-(s,s-2,8-diazabciclo-4.3.0-non-8-il)-6-fluoro-1,4-diidro-8-metossi-4-oxo-chinolin carbossilico cloridrato e metodi per la sua preparazione
EP1685130B1 (en) * 2003-11-20 2008-12-10 CHEMI S.p.A. Polymorphs of 1-cyclopropyl-7-([s,s] - 2,8-diazadicyclo [4.3.0] non-8-yl) -6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid hydrochloride and methods for the preparation thereof
US7491725B2 (en) 2004-02-06 2009-02-17 Bristol-Myers Squibb Company Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors
DE102004063347A1 (de) * 2004-12-23 2006-07-13 Stada Arzneimittel Ag Gebrauchsfertige Gemcitabinlösungen und Gemcitabinlösungskonzentrate
WO2007033515A1 (fr) * 2005-09-21 2007-03-29 Shenzhen Tys R & D Co., Ltd. Formulation orale contenant de la moxifloxacine et son procédé de préparation
GB0612422D0 (en) * 2006-06-23 2006-08-02 Generics Uk Ltd Novel hydrate form
EP2145890B1 (en) 2006-06-27 2012-08-01 Sandoz AG Crystallization of hydrohalides of pharmaceutical compounds
ES2303768B1 (es) * 2006-09-08 2009-06-05 Quimica Sintetica, S.A. Nueva forma cristalina de moxifloxacino clorhidrato.
AU2007320997B2 (en) 2006-11-13 2012-11-08 Cipla Limited Process for the synthesis of moxifloxacin hydrochloride
EP1992626A1 (en) * 2007-05-10 2008-11-19 Sandoz AG Process for the preparation of moxifloxacin hydrochloride
EP2083010A1 (en) * 2008-01-08 2009-07-29 Chemo Ibérica, S.A. Polymorphic Forms of Moxifloxacin hydrochloride and processes for preparation thereof
EP2154137A1 (en) 2008-08-04 2010-02-17 Chemo Ibérica, S.A. Crystalline form of moxifloxacin base
JP5461565B2 (ja) * 2008-10-09 2014-04-02 アブディ イブラヒム イラク サナイ ベ ティカレット アノニム シルケティ 有機溶媒を使用したモキシフロキサシンの湿式造粒法
US20110212990A1 (en) * 2008-11-06 2011-09-01 Hetero Research Foundation Novel polymorph of moxifloxacin hydrochloride
ES2467105T5 (es) 2008-12-08 2017-12-05 Ratiopharm Gmbh Moxifloxacino compactado
KR20120025519A (ko) 2009-05-15 2012-03-15 레드엑스 파마 리미티드 산화환원 약물 유도체
WO2011121596A2 (en) * 2010-04-01 2011-10-06 Neuland Laboratories Ltd. Crystal modification of moxifloxacin hydrochloride
BRPI1106900A2 (pt) 2011-12-26 2013-11-05 Ems Sa Composição farmacêutica sólida compreendendo antibótico da familia das quinolonas e processo de sua obtenção
FR2992218B1 (fr) 2012-06-22 2015-01-23 Rivopharm Sa Composition pharmaceutique de chlorhydrate de moxifloxacine et procede de preparation
CN102924449B (zh) * 2012-10-30 2015-08-12 重庆福安药业集团庆余堂制药有限公司 盐酸莫西沙星h晶型及其制备方法和药物组合物
EP2928892B1 (en) 2012-12-04 2018-03-21 Mankind Pharma Ltd. An improved process for the preparation of moxifloxacin hydrochloride
MX388561B (es) 2013-03-15 2025-03-11 Melinta Subsidiary Corp Metodos para tratar infecciones en pacientes obesos y con sobrepeso usando antibioticos.

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2383543C2 (ru) * 2004-04-01 2010-03-10 Байер Энимэл Хельс ГмбХ Тригидрат 8-циано-1-циклопропил-7-(1s, 6s-2,8-диазабицикло-[4.3.0]нонан-8-ил)-6-фтор-1, 4-дигидро-4-оксо-3-хинолинкарбоновой кислоты
RU2561037C2 (ru) * 2013-02-07 2015-08-20 Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") Антибактериальная фармацевтическая композиция и способ ее получения

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NZ299905A (en) 1998-09-24
KR100525146B1 (ko) 2006-01-27
ES2179910T3 (es) 2003-02-01
MY117492A (en) 2004-07-31
US5849752A (en) 1998-12-15
DK0780390T3 (da) 2002-11-11
CA2192418A1 (en) 1997-06-13
ZA9610405B (en) 1997-06-23
IL119795A (en) 1998-12-27
JPH09169757A (ja) 1997-06-30
SG47201A1 (en) 1998-03-20
HRP960558B1 (en) 2002-04-30
DE59609501D1 (de) 2002-09-05
NO965298D0 (no) 1996-12-11
MX9606325A (es) 1997-10-31
YU49485B (sh) 2006-08-17
CN1061348C (zh) 2001-01-31
IN185805B (cg-RX-API-DMAC10.html) 2001-05-05
MA24342A1 (fr) 1998-07-01
NL300109I1 (nl) 2003-02-03
SV1996000109A (es) 1997-10-23
ID22625A (id) 1999-12-02
EE9600201A (et) 1997-06-16
PL184885B1 (pl) 2003-01-31
AR005009A1 (es) 1999-04-07
HUP9603428A2 (en) 1997-08-28
EP0780390B1 (de) 2002-07-31
HUP9603428A3 (en) 1997-10-28
HU226521B1 (en) 2009-03-30
EE03474B1 (et) 2001-08-15
JP4104687B2 (ja) 2008-06-18
CZ288657B6 (cs) 2001-08-15
ATE221531T1 (de) 2002-08-15
UA35638C2 (uk) 2001-04-16
AU7421696A (en) 1997-06-19
PL317415A1 (en) 1997-06-23
IL119795A0 (en) 1997-03-18
RO119782B1 (ro) 2005-03-30
SK159196A3 (en) 1997-10-08
HRP960558A2 (en) 1998-02-28
KR970042550A (ko) 1997-07-24
BG101043A (en) 1998-04-30
CA2192418C (en) 2001-06-12
TW411340B (en) 2000-11-11
BR9605968A (pt) 1998-08-18
CO4480105A1 (es) 1997-07-09
SK282805B6 (sk) 2002-12-03
NO965298L (no) 1997-06-13
SA96170492B1 (ar) 2006-05-23
YU65096A (sh) 1998-12-23
BG62258B1 (bg) 1999-06-30
TR199600970A2 (tr) 1997-06-21
NO306725B1 (no) 1999-12-13
DE19546249A1 (de) 1997-06-19
PT780390E (pt) 2002-11-29
CU22774A3 (es) 2002-07-24
AU708006B2 (en) 1999-07-29
EP0780390A1 (de) 1997-06-25
CZ364696A3 (en) 1997-07-16
CN1160052A (zh) 1997-09-24
HU9603428D0 (en) 1997-01-28
SI0780390T1 (en) 2002-10-31

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Effective date: 20050120

HK4A Changes in a published invention
PD4A Correction of name of patent owner
PC41 Official registration of the transfer of exclusive right

Effective date: 20130806