RU2126385C1 - Аналоги витамина d3, способ их получения, фармацевтическая композиция - Google Patents

Аналоги витамина d3, способ их получения, фармацевтическая композиция Download PDF

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Publication number
RU2126385C1
RU2126385C1 RU93052149A RU93052149A RU2126385C1 RU 2126385 C1 RU2126385 C1 RU 2126385C1 RU 93052149 A RU93052149 A RU 93052149A RU 93052149 A RU93052149 A RU 93052149A RU 2126385 C1 RU2126385 C1 RU 2126385C1
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RU
Russia
Prior art keywords
compound
formula
compounds
vitamin
solution
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RU93052149A
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English (en)
Russian (ru)
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RU93052149A (ru
Inventor
И.Доран Томас
Артур Маклейн Джон
Окабе Масами
СКАЛОНЕ Микельанджело
Радое Ускокович Милан
Original Assignee
Ф.Хоффманн-Ля Рош Аг
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Publication of RU93052149A publication Critical patent/RU93052149A/ru
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Publication of RU2126385C1 publication Critical patent/RU2126385C1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
RU93052149A 1992-11-20 1993-11-15 Аналоги витамина d3, способ их получения, фармацевтическая композиция RU2126385C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97913392A 1992-11-20 1992-11-20
US979.133 1992-11-20
US979133 1992-11-20

Publications (2)

Publication Number Publication Date
RU93052149A RU93052149A (ru) 1996-12-27
RU2126385C1 true RU2126385C1 (ru) 1999-02-20

Family

ID=25526724

Family Applications (1)

Application Number Title Priority Date Filing Date
RU93052149A RU2126385C1 (ru) 1992-11-20 1993-11-15 Аналоги витамина d3, способ их получения, фармацевтическая композиция

Country Status (25)

Country Link
US (3) US5342833A (OSRAM)
EP (1) EP0599114B1 (OSRAM)
JP (2) JP2502931B2 (OSRAM)
KR (1) KR940011443A (OSRAM)
CN (1) CN1051762C (OSRAM)
AT (1) ATE147728T1 (OSRAM)
AU (1) AU669222B2 (OSRAM)
BR (1) BR9304780A (OSRAM)
CA (1) CA2108848A1 (OSRAM)
CZ (1) CZ284415B6 (OSRAM)
DE (1) DE69307478T2 (OSRAM)
DK (1) DK0599114T3 (OSRAM)
ES (1) ES2097423T3 (OSRAM)
FI (1) FI935092A7 (OSRAM)
GR (1) GR3022691T3 (OSRAM)
HU (1) HU213609B (OSRAM)
IL (1) IL107614A (OSRAM)
NO (1) NO304022B1 (OSRAM)
NZ (1) NZ250194A (OSRAM)
PH (1) PH30991A (OSRAM)
PL (1) PL176017B1 (OSRAM)
RU (1) RU2126385C1 (OSRAM)
TW (1) TW267161B (OSRAM)
UY (1) UY23678A1 (OSRAM)
ZA (1) ZA938478B (OSRAM)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA95906B (en) * 1994-02-07 1996-08-06 Res Developments Foundation Non-viral vector
JPH11514999A (ja) * 1995-10-10 1999-12-21 ストルーブ，マリリン ビタミンｄおよびその誘導体による掻痒症治療
TW403735B (en) * 1995-11-22 2000-09-01 Hoffmann La Roche 25-hydroxy-16-ene-26, 27-bishomo-cholecalciferol
US5691328A (en) * 1996-02-02 1997-11-25 Clarion Pharmaceuticals Inc. Phosphoethanolamine conjugates of vitamin D compounds
US5939408A (en) 1996-05-23 1999-08-17 Hoffman-La Roche Inc. Vitamin D3 analogs
NO971934L (no) * 1996-05-23 1997-11-24 Hoffmann La Roche Flourinerte vitamin D3 -analoger
JPH10316652A (ja) * 1997-05-02 1998-12-02 Duphar Internatl Res Bv １６−デヒドロビタミンｄ化合物の製造方法
US8404667B2 (en) * 2006-12-29 2013-03-26 Wisconsin Alumni Research Foundation Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog
EP1812011A1 (en) 2004-11-12 2007-08-01 Bioxell S.p.a. Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
WO2015115796A1 (ko) 2014-01-29 2015-08-06 주식회사 휴메딕스 페길레이션된 7-디하이드로콜레스테롤 유도체
KR101702076B1 (ko) 2015-02-25 2017-02-02 주식회사 휴메딕스 지방산 컨쥬게이션된 7-데하이드로콜레스테롤 유도체
GB202016614D0 (en) 2020-10-20 2020-12-02 King S College London Compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2159520B (en) * 1984-05-31 1987-12-16 Wisconsin Alumni Res Found 1, 24-dihydroxy- 22-vitamin d3 and process for preparing same

Family Cites Families (22)

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Publication number Priority date Publication date Assignee Title
US3970676A (en) * 1974-10-29 1976-07-20 The Upjohn Company Novel process and intermediate compounds used is preparation of -Δ5,7- steroid dienes
US4116985A (en) * 1976-07-26 1978-09-26 The Upjohn Company Novel method for preparing cholesta-5,7-diene 3β,25-diol and derivatives thereof
US4360471A (en) * 1981-12-11 1982-11-23 Wisconsin Alumni Research Foundation 23-Dehydro-25-hydroxyvitamin D3
US4456553A (en) * 1982-05-07 1984-06-26 Teijin Limited Vitamin D3 derivatives, process for preparation thereof, and antigens comprising said derivatives to be used for preparation of antibodies for immunochemical assay and antibodies prepared therefrom
US4448721A (en) * 1982-09-20 1984-05-15 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 compounds and process for preparing same
JPS63264452A (ja) * 1986-10-20 1988-11-01 Sumitomo Pharmaceut Co Ltd フッ素化ビタミンｄ↓３誘導体
DE3881665T2 (de) * 1987-03-30 1993-10-07 Kuraray Co Pregnanabkömmlinge und verfahren zur herstellung.
US5087619A (en) * 1988-01-20 1992-02-11 Hoffman-La Roche Inc. Vitamin D3 analogs
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
ZA8923B (en) * 1988-01-20 1989-09-27 Hoffmann La Roche 16-dehydro-vitamin d3-derivatives
US5145846A (en) * 1988-01-20 1992-09-08 Hoffmann-La Roche Inc. Vitamin D3 analogs
DE3854089T2 (de) * 1988-07-05 1995-11-02 Kuraray Co Steroid-verbindungen.
US4973584A (en) * 1989-03-09 1990-11-27 Deluca Hector F Novel 1α-hydroxyvitamin D2 epimer and derivatives
CA1333616C (en) * 1989-03-09 1994-12-20 Hector F. Deluca 19-nor-vitamin d compounds
NZ232734A (en) * 1989-03-09 1991-11-26 Wisconsin Alumni Res Found 19-nor vitamin d derivatives and pharmaceutical compositions
EP0398217B1 (de) * 1989-05-18 1994-01-12 F. Hoffmann-La Roche Ag Dehydrocholecalciferolderivate
EP0443021A1 (en) * 1989-09-11 1991-08-28 Wisconsin Alumni Research Foundation Novel use of vitamin d compounds to inhibit replication of the aids virus
JPH05501718A (ja) * 1990-02-06 1993-04-02 シェーリング　アクチェンゲゼルシャフト 側鎖同族体ビタミン―ｄ―誘導体、その製造法ならびに該誘導体を含有する、過増殖を示す疾病を治療するための製薬学的調製剤
DE4101953A1 (de) * 1991-01-19 1992-07-23 Schering Ag 23-oxa-derivate in der vitamin-d-reihe, verfahren zu ihrer herstellung diese derivate enthaltende pharmazeutische praeparate sowie deren verwendung als arzneimittel
DE4105503A1 (de) * 1991-02-19 1992-08-20 Jenapharm Gmbh Ausgangsverbindungen zur herstellung von calcitriol sowie dessen abkoemmlingen, verfahren zur herstellung dieser ausgangsverbindungen sowie zwischenprodukte fuer dieses verfahren
US5206230A (en) * 1991-06-05 1993-04-27 Daikin Industries, Ltd. Fluorine-containing vitamin D3 analogues and pharmaceutical composition containing the same
ES2093180T3 (es) * 1991-07-05 1996-12-16 Duphar Int Res Compuesto de vitamina d, metodo de preparar este compuesto y producto intermedio de dicho metodo.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2159520B (en) * 1984-05-31 1987-12-16 Wisconsin Alumni Res Found 1, 24-dihydroxy- 22-vitamin d3 and process for preparing same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Машковский М.Д. Лекарственные препараты.-М.: Медицина, 1985, ч.2, с.34-36. *

Also Published As

Publication number Publication date
DE69307478T2 (de) 1997-05-28
NZ250194A (en) 1996-01-26
CN1051762C (zh) 2000-04-26
GR3022691T3 (en) 1997-05-31
PL176017B1 (pl) 1999-03-31
US5747478A (en) 1998-05-05
US5342833A (en) 1994-08-30
EP0599114B1 (en) 1997-01-15
UY23678A1 (es) 1994-05-20
FI935092A0 (fi) 1993-11-17
ATE147728T1 (de) 1997-02-15
ZA938478B (en) 1994-05-20
HUT66022A (en) 1994-08-29
NO304022B1 (no) 1998-10-12
KR940011443A (ko) 1994-06-21
JPH06199777A (ja) 1994-07-19
IL107614A0 (en) 1994-02-27
DE69307478D1 (de) 1997-02-27
CZ248993A3 (en) 1994-06-15
JPH08109191A (ja) 1996-04-30
AU669222B2 (en) 1996-05-30
PL301103A1 (en) 1994-05-30
EP0599114A1 (en) 1994-06-01
TW267161B (OSRAM) 1996-01-01
AU5069793A (en) 1994-06-02
US5393900A (en) 1995-02-28
CA2108848A1 (en) 1994-05-21
FI935092L (fi) 1994-05-21
DK0599114T3 (da) 1997-04-14
NO934197D0 (no) 1993-11-19
NO934197L (no) 1994-05-24
ES2097423T3 (es) 1997-04-01
IL107614A (en) 1999-09-22
FI935092A7 (fi) 1994-05-21
JP2502931B2 (ja) 1996-05-29
HU213609B (en) 1997-08-28
BR9304780A (pt) 1994-07-05
HU9303227D0 (en) 1994-03-28
PH30991A (en) 1997-12-23
CZ284415B6 (cs) 1998-11-11
CN1090573A (zh) 1994-08-10

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