ES2097423T3 - Analogos de vitamina d3. - Google Patents

Analogos de vitamina d3.

Info

Publication number
ES2097423T3
ES2097423T3 ES93117951T ES93117951T ES2097423T3 ES 2097423 T3 ES2097423 T3 ES 2097423T3 ES 93117951 T ES93117951 T ES 93117951T ES 93117951 T ES93117951 T ES 93117951T ES 2097423 T3 ES2097423 T3 ES 2097423T3
Authority
ES
Spain
Prior art keywords
analogs
vitamin
diseases
hyperproliferactive
acil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93117951T
Other languages
English (en)
Inventor
Thomas I Doran
John Arthur Mclane
Masami Okabe
Michelangelo Scalone
Milan Radoje Uskokovic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2097423T3 publication Critical patent/ES2097423T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE DESCRIBEN UNOS COMPUESTOS DE FORMULA (I) DONDE R1 Y R2 SON H O ACILO; CON LA PREVISION DE QUE O R1 O R2 SEA H, UTIL EN EL TRATAMIENTO DE ENFERMEDADES DE LA PIEL HIPERPROLIFERACTIVA Y ENFERMEDADES DE LAS GLANDULAS SEBACEAS
ES93117951T 1992-11-20 1993-11-05 Analogos de vitamina d3. Expired - Lifetime ES2097423T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US97913392A 1992-11-20 1992-11-20

Publications (1)

Publication Number Publication Date
ES2097423T3 true ES2097423T3 (es) 1997-04-01

Family

ID=25526724

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93117951T Expired - Lifetime ES2097423T3 (es) 1992-11-20 1993-11-05 Analogos de vitamina d3.

Country Status (25)

Country Link
US (3) US5342833A (es)
EP (1) EP0599114B1 (es)
JP (2) JP2502931B2 (es)
KR (1) KR940011443A (es)
CN (1) CN1051762C (es)
AT (1) ATE147728T1 (es)
AU (1) AU669222B2 (es)
BR (1) BR9304780A (es)
CA (1) CA2108848A1 (es)
CZ (1) CZ284415B6 (es)
DE (1) DE69307478T2 (es)
DK (1) DK0599114T3 (es)
ES (1) ES2097423T3 (es)
FI (1) FI935092A (es)
GR (1) GR3022691T3 (es)
HU (1) HU213609B (es)
IL (1) IL107614A (es)
NO (1) NO304022B1 (es)
NZ (1) NZ250194A (es)
PH (1) PH30991A (es)
PL (1) PL176017B1 (es)
RU (1) RU2126385C1 (es)
TW (1) TW267161B (es)
UY (1) UY23678A1 (es)
ZA (1) ZA938478B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA95906B (en) * 1994-02-07 1996-08-06 Res Developments Foundation Non-viral vector
EP0897300A4 (en) * 1995-10-10 2000-07-05 Marilyn Strube TREATMENT OF PRURITUS WITH VITAMIN D AND ITS ANALOGS
TW403735B (en) * 1995-11-22 2000-09-01 Hoffmann La Roche 25-hydroxy-16-ene-26, 27-bishomo-cholecalciferol
US5691328A (en) * 1996-02-02 1997-11-25 Clarion Pharmaceuticals Inc. Phosphoethanolamine conjugates of vitamin D compounds
NO971934L (no) * 1996-05-23 1997-11-24 Hoffmann La Roche Flourinerte vitamin D3 -analoger
US5939408A (en) 1996-05-23 1999-08-17 Hoffman-La Roche Inc. Vitamin D3 analogs
DE69813380T2 (de) * 1997-05-02 2003-12-04 Duphar International Research B.V., Weesp Verfahren zur Herstellung von 16-Dehydro Vitamin D Verbindungen
US8404667B2 (en) * 2006-12-29 2013-03-26 Wisconsin Alumni Research Foundation Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog
WO2006051106A1 (en) 2004-11-12 2006-05-18 Bioxell Spa Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
EP3101025A4 (en) 2014-01-29 2017-07-12 Humedix Co. Ltd. Pegylated 7-dehydrocholesterol derivative
KR101702076B1 (ko) 2015-02-25 2017-02-02 주식회사 휴메딕스 지방산 컨쥬게이션된 7-데하이드로콜레스테롤 유도체

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3970676A (en) * 1974-10-29 1976-07-20 The Upjohn Company Novel process and intermediate compounds used is preparation of -Δ5,7- steroid dienes
US4116985A (en) * 1976-07-26 1978-09-26 The Upjohn Company Novel method for preparing cholesta-5,7-diene 3β,25-diol and derivatives thereof
US4360471A (en) * 1981-12-11 1982-11-23 Wisconsin Alumni Research Foundation 23-Dehydro-25-hydroxyvitamin D3
US4456553A (en) * 1982-05-07 1984-06-26 Teijin Limited Vitamin D3 derivatives, process for preparation thereof, and antigens comprising said derivatives to be used for preparation of antibodies for immunochemical assay and antibodies prepared therefrom
US4448721A (en) * 1982-09-20 1984-05-15 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 compounds and process for preparing same
JPS63264452A (ja) * 1986-10-20 1988-11-01 Sumitomo Pharmaceut Co Ltd フッ素化ビタミンｄ↓３誘導体
DE3881665T2 (de) * 1987-03-30 1993-10-07 Kuraray Co Pregnanabkömmlinge und verfahren zur herstellung.
US5087619A (en) * 1988-01-20 1992-02-11 Hoffman-La Roche Inc. Vitamin D3 analogs
ZA8923B (en) * 1988-01-20 1989-09-27 Hoffmann La Roche 16-dehydro-vitamin d3-derivatives
US5145846A (en) * 1988-01-20 1992-09-08 Hoffmann-La Roche Inc. Vitamin D3 analogs
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
ATE124416T1 (de) * 1988-07-05 1995-07-15 Kuraray Co Steroid-verbindungen.
US4973584A (en) * 1989-03-09 1990-11-27 Deluca Hector F Novel 1α-hydroxyvitamin D2 epimer and derivatives
CA1333616C (en) * 1989-03-09 1994-12-20 Hector F. Deluca 19-nor-vitamin d compounds
NZ232734A (en) * 1989-03-09 1991-11-26 Wisconsin Alumni Res Found 19-nor vitamin d derivatives and pharmaceutical compositions
ATE99942T1 (de) * 1989-05-18 1994-01-15 Hoffmann La Roche Dehydrocholecalciferolderivate.
EP0443021A1 (en) * 1989-09-11 1991-08-28 Wisconsin Alumni Research Foundation Novel use of vitamin d compounds to inhibit replication of the aids virus
IL97158A (en) * 1990-02-06 1994-12-29 Schering Ag Homologous histories of vitamin D in the side chain, processes for their preparation and pharmaceutical preparations containing them
DE4101953A1 (de) * 1991-01-19 1992-07-23 Schering Ag 23-oxa-derivate in der vitamin-d-reihe, verfahren zu ihrer herstellung diese derivate enthaltende pharmazeutische praeparate sowie deren verwendung als arzneimittel
DE4105503A1 (de) * 1991-02-19 1992-08-20 Jenapharm Gmbh Ausgangsverbindungen zur herstellung von calcitriol sowie dessen abkoemmlingen, verfahren zur herstellung dieser ausgangsverbindungen sowie zwischenprodukte fuer dieses verfahren
US5206230A (en) * 1991-06-05 1993-04-27 Daikin Industries, Ltd. Fluorine-containing vitamin D3 analogues and pharmaceutical composition containing the same
ATE143007T1 (de) * 1991-07-05 1996-10-15 Duphar Int Res Vitamin-d derivat, verfahren zu dessen herstellung sowie zwischenprodukte dafür

Also Published As

Publication number Publication date
JPH06199777A (ja) 1994-07-19
IL107614A (en) 1999-09-22
RU2126385C1 (ru) 1999-02-20
IL107614A0 (en) 1994-02-27
BR9304780A (pt) 1994-07-05
HU213609B (en) 1997-08-28
PH30991A (en) 1997-12-23
AU669222B2 (en) 1996-05-30
US5342833A (en) 1994-08-30
JPH08109191A (ja) 1996-04-30
JP2502931B2 (ja) 1996-05-29
ZA938478B (en) 1994-05-20
NO304022B1 (no) 1998-10-12
KR940011443A (ko) 1994-06-21
FI935092A0 (fi) 1993-11-17
CN1090573A (zh) 1994-08-10
HUT66022A (en) 1994-08-29
NO934197D0 (no) 1993-11-19
DE69307478T2 (de) 1997-05-28
PL176017B1 (pl) 1999-03-31
US5747478A (en) 1998-05-05
CZ284415B6 (cs) 1998-11-11
NZ250194A (en) 1996-01-26
EP0599114B1 (en) 1997-01-15
HU9303227D0 (en) 1994-03-28
NO934197L (no) 1994-05-24
FI935092A (fi) 1994-05-21
PL301103A1 (en) 1994-05-30
CA2108848A1 (en) 1994-05-21
US5393900A (en) 1995-02-28
DE69307478D1 (de) 1997-02-27
CN1051762C (zh) 2000-04-26
ATE147728T1 (de) 1997-02-15
EP0599114A1 (en) 1994-06-01
DK0599114T3 (da) 1997-04-14
AU5069793A (en) 1994-06-02
TW267161B (es) 1996-01-01
GR3022691T3 (en) 1997-05-31
UY23678A1 (es) 1994-05-20
CZ248993A3 (en) 1994-06-15

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