RU2108341C1 - Способ получения кристаллов гр или производных гр, кристаллы человеческих гр или производных человеческих гр и фармацевтический препарат - Google Patents

Способ получения кристаллов гр или производных гр, кристаллы человеческих гр или производных человеческих гр и фармацевтический препарат Download PDF

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Publication number
RU2108341C1
RU2108341C1 RU93005051/13A RU93005051A RU2108341C1 RU 2108341 C1 RU2108341 C1 RU 2108341C1 RU 93005051/13 A RU93005051/13 A RU 93005051/13A RU 93005051 A RU93005051 A RU 93005051A RU 2108341 C1 RU2108341 C1 RU 2108341C1
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RU
Russia
Prior art keywords
crystals
growth hormone
human
concentration
zinc cations
Prior art date
Application number
RU93005051/13A
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English (en)
Russian (ru)
Other versions
RU93005051A (ru
Inventor
Йункер Флемминг
Dk]
Фрис Тейсен Клаус
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Ново Нордиск А/С
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Publication of RU93005051A publication Critical patent/RU93005051A/ru
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Publication of RU2108341C1 publication Critical patent/RU2108341C1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
    • C30B29/54—Organic compounds
    • C30B29/58—Macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
RU93005051/13A 1990-07-13 1991-07-12 Способ получения кристаллов гр или производных гр, кристаллы человеческих гр или производных человеческих гр и фармацевтический препарат RU2108341C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK1687/90 1990-07-13
DK168790A DK168790D0 (enExample) 1990-07-13 1990-07-13
PCT/DK1991/000203 WO1992000998A1 (en) 1990-07-13 1991-07-12 Growth hormone crystals and a process for production of these gh-crystals

Publications (2)

Publication Number Publication Date
RU93005051A RU93005051A (ru) 1996-04-20
RU2108341C1 true RU2108341C1 (ru) 1998-04-10

Family

ID=8107212

Family Applications (1)

Application Number Title Priority Date Filing Date
RU93005051/13A RU2108341C1 (ru) 1990-07-13 1991-07-12 Способ получения кристаллов гр или производных гр, кристаллы человеческих гр или производных человеческих гр и фармацевтический препарат

Country Status (17)

Country Link
US (1) US6117984A (enExample)
EP (1) EP0540582B1 (enExample)
JP (1) JP2524446B2 (enExample)
AT (1) ATE110745T1 (enExample)
AU (1) AU666465B2 (enExample)
BG (1) BG61267B1 (enExample)
CA (1) CA2086087C (enExample)
DE (1) DE69103755T2 (enExample)
DK (2) DK168790D0 (enExample)
ES (1) ES2060399T3 (enExample)
HU (2) HUT64086A (enExample)
IE (1) IE67054B1 (enExample)
NZ (1) NZ238904A (enExample)
PT (1) PT98297B (enExample)
RU (1) RU2108341C1 (enExample)
WO (1) WO1992000998A1 (enExample)
ZA (1) ZA915446B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2357750C2 (ru) * 2002-12-31 2009-06-10 Элтус Фармасьютикалз Инк. Кристаллы человеческого гормона роста и способы их получения

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6894023B1 (en) * 1990-07-13 2005-05-17 Novo Nordisk A/S Growth hormone crystals and a process for production of these GH-crystals
DK168790D0 (enExample) * 1990-07-13 1990-07-13 Novo Nordisk As
DE10399015I1 (de) * 1991-12-20 2012-05-03 Novo Nordisk As Stabilisierte pharmazeutische formulierung, die wachstumshormon und histidin enthält
SE9302278D0 (sv) * 1992-10-28 1993-07-02 Kabi Pharmacia Ab Growth hormone
EP0946169B1 (en) * 1996-12-20 2003-02-26 Takeda Chemical Industries, Ltd. Method of producing a sustained-release preparation
US6541606B2 (en) 1997-12-31 2003-04-01 Altus Biologics Inc. Stabilized protein crystals formulations containing them and methods of making them
JP3723857B2 (ja) * 1998-02-04 2005-12-07 日本ケミカルリサーチ株式会社 ヒト成長ホルモン含有水性医薬組成物
US7101575B2 (en) 1998-03-19 2006-09-05 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Production of nanocapsules and microcapsules by layer-wise polyelectrolyte self-assembly
US6451347B1 (en) 1999-03-01 2002-09-17 Alkermes Controlled Therapeutics, Inc. Method for purifying human growth hormone
US6833192B1 (en) * 1999-06-10 2004-12-21 Max-Planck Gesellschaft Zur Forderrung Der Wissenschaften E.V. Encapsulation of crystals via multilayer coatings
US6566329B1 (en) 1999-06-28 2003-05-20 Novo Nordisk A/S Freeze-dried preparation of human growth hormone
MXPA03001092A (es) 2000-08-07 2003-09-25 Nektar Therapeutics Al Corp Polvos de proteina de haz de 4 helices secados por rocio, inhalables, que tienen agregacion minimizada.
SE517422C2 (sv) 2000-10-06 2002-06-04 Bioglan Ab Farmaceutiskt acceptabel stärkelse
CA2424896A1 (en) 2000-10-06 2002-04-11 Jagotec Ag A controlled-release, parenterally administrable microparticle preparation
SE517421C2 (sv) 2000-10-06 2002-06-04 Bioglan Ab Mikropartiklar, lämpade för parenteral administration, väsentligen bestående av stärkelse med minst 85 % amylopektin och med reducerad molekylvikt, samt framställning därav
SE518007C2 (sv) 2000-11-16 2002-08-13 Bioglan Ab Förfarande för framställning av mikropartiklar
US7105181B2 (en) 2001-10-05 2006-09-12 Jagotec, Ag Microparticles
SE0201599D0 (sv) 2002-03-21 2002-05-30 Skyepharma Ab Microparticles
SE0202719D0 (sv) * 2002-09-13 2002-09-13 Pharmacia Ab Process for mfg crystals of growth hormone
CN101659701B (zh) * 2002-12-31 2019-03-26 阿尔特斯制药公司 人生长激素晶体和制备它们的方法
KR20050094832A (ko) * 2002-12-31 2005-09-28 알투스 파마슈티컬스 인코포레이티드 단백질 결정과 이온성 중합체를 함유하는 복합체
WO2005014034A1 (en) * 2003-07-14 2005-02-17 Nps Allelix Corp. Stabilized formulation of parathyroid hormone
EP1976551A4 (en) * 2005-12-23 2009-12-30 Altus Pharmaceuticals Inc COMPOSITIONS COMPRISING COMPLEX PROTEIN CRYSTALS BY POLYCATIONS AND PROCESSING METHOD THEREOF
US8071544B2 (en) 2006-12-18 2011-12-06 Althea Technologies, Inc. Crystallized recombinant human growth factor formulations

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CA653324A (en) * 1962-12-04 G. Brink Norman Growth hormone and methods of preparing the same
US2143590A (en) * 1936-09-26 1939-01-10 Univ Alberta Insulin preparation and process of producing crystals of insulin
US2174862A (en) * 1938-12-30 1939-10-03 Frederick Stearns & Company Process of producing crystalline insulin
US2595278A (en) * 1950-04-28 1952-05-06 Armour & Co Preparation of insulin from pancreas glands
US3102077A (en) * 1953-08-19 1963-08-27 Christensen Henry Marinus Preparation of insulin containing 2.75 to 8 percent zinc content
US2897117A (en) * 1955-02-10 1959-07-28 Univ Alberta Insulin process
US3856771A (en) * 1973-07-16 1974-12-24 Lilly Co Eli Process for manufacturing alkali metal or ammonium insulin
EP0343696B1 (en) * 1984-10-04 1996-01-03 Monsanto Company Zinc-associated somatotropins
KR890002631B1 (ko) * 1984-10-04 1989-07-21 몬산토 캄파니 생물학적으로 활성인 소마토트로핀을 지속적으로 유리하는 조성물
IL79681A (en) * 1985-08-12 1991-06-10 Int Minerals & Chem Corp Transition metal complexes of growth hormones and their prolonged release compositions
EP0277043A3 (en) * 1987-01-30 1989-08-23 IMCERA Group Inc. Method for recovering somatotropins from dilute aqueous solution
US4764592A (en) * 1987-04-23 1988-08-16 Eli Lilly And Company Crystalline human proinsulin and process for its production
EP0355460B1 (en) * 1988-08-24 2000-12-27 American Cyanamid Company Stabilization of somatotropins by modification of cysteine residues utilizing site directed mutagenesis or chemical derivatization
US5109117A (en) * 1990-06-26 1992-04-28 Monsanto Company Method of somatotropin naturation using urea and a soluble organic alcohol
DK168790D0 (enExample) * 1990-07-13 1990-07-13 Novo Nordisk As
US5780599A (en) * 1990-07-13 1998-07-14 Novo Nordisk A/S Growth hormone crystals and a process for production of growth hormone crystals

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Am. Chem. Soc. 1958, р. 4429. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2357750C2 (ru) * 2002-12-31 2009-06-10 Элтус Фармасьютикалз Инк. Кристаллы человеческого гормона роста и способы их получения

Also Published As

Publication number Publication date
JPH05507497A (ja) 1993-10-28
WO1992000998A1 (en) 1992-01-23
BG61267B1 (en) 1997-04-30
CA2086087A1 (en) 1992-01-14
DE69103755T2 (de) 1995-02-23
HU9300067D0 (en) 1993-04-28
DE69103755D1 (de) 1994-10-06
EP0540582A1 (en) 1993-05-12
ZA915446B (en) 1992-03-25
HU210323B (en) 1995-03-28
HUT64086A (en) 1993-11-29
NZ238904A (en) 1993-04-28
JP2524446B2 (ja) 1996-08-14
ATE110745T1 (de) 1994-09-15
PT98297B (pt) 1999-01-29
DK168790D0 (enExample) 1990-07-13
IE67054B1 (en) 1996-02-21
EP0540582B1 (en) 1994-08-31
ES2060399T3 (es) 1994-11-16
US6117984A (en) 2000-09-12
CA2086087C (en) 1999-09-14
AU8284691A (en) 1992-02-04
IE912444A1 (en) 1992-01-15
DK0540582T3 (da) 1995-01-30
PT98297A (pt) 1992-05-29
AU666465B2 (en) 1996-02-15
BG97281A (bg) 1994-03-24

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20040713