PT98297A - Processo para a preparacao de cristais cationicos da hormona de crescimento - Google Patents

Processo para a preparacao de cristais cationicos da hormona de crescimento

Info

Publication number
PT98297A
PT98297A PT98297A PT9829791A PT98297A PT 98297 A PT98297 A PT 98297A PT 98297 A PT98297 A PT 98297A PT 9829791 A PT9829791 A PT 9829791A PT 98297 A PT98297 A PT 98297A
Authority
PT
Portugal
Prior art keywords
crystals
cationic
preparation
growth hormone
hgh
Prior art date
Application number
PT98297A
Other languages
English (en)
Other versions
PT98297B (pt
Inventor
Flemming Junker
Claus Friis Theisen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of PT98297A publication Critical patent/PT98297A/pt
Publication of PT98297B publication Critical patent/PT98297B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
    • C30B29/54—Organic compounds
    • C30B29/58—Macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Metallurgy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
PT98297A 1990-07-13 1991-07-11 Processo para a preparacao de cristais cationicos da hormona de crescimento PT98297B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK168790A DK168790D0 (pt) 1990-07-13 1990-07-13

Publications (2)

Publication Number Publication Date
PT98297A true PT98297A (pt) 1992-05-29
PT98297B PT98297B (pt) 1999-01-29

Family

ID=8107212

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98297A PT98297B (pt) 1990-07-13 1991-07-11 Processo para a preparacao de cristais cationicos da hormona de crescimento

Country Status (17)

Country Link
US (1) US6117984A (pt)
EP (1) EP0540582B1 (pt)
JP (1) JP2524446B2 (pt)
AT (1) ATE110745T1 (pt)
AU (1) AU666465B2 (pt)
BG (1) BG61267B1 (pt)
CA (1) CA2086087C (pt)
DE (1) DE69103755T2 (pt)
DK (2) DK168790D0 (pt)
ES (1) ES2060399T3 (pt)
HU (2) HUT64086A (pt)
IE (1) IE67054B1 (pt)
NZ (1) NZ238904A (pt)
PT (1) PT98297B (pt)
RU (1) RU2108341C1 (pt)
WO (1) WO1992000998A1 (pt)
ZA (1) ZA915446B (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK168790D0 (pt) * 1990-07-13 1990-07-13 Novo Nordisk As
US6894023B1 (en) * 1990-07-13 2005-05-17 Novo Nordisk A/S Growth hormone crystals and a process for production of these GH-crystals
ES2291264T3 (es) * 1991-12-20 2008-03-01 Novo Nordisk A/S Formulacion farmaceutica estabilizada comprendiendo una hormona de crecimiento e histidina.
SE9302278D0 (sv) * 1992-10-28 1993-07-02 Kabi Pharmacia Ab Growth hormone
KR20000057693A (ko) 1996-12-20 2000-09-25 다케다 야쿠힌 고교 가부시키가이샤 지효성 제제의 제조 방법
US6541606B2 (en) 1997-12-31 2003-04-01 Altus Biologics Inc. Stabilized protein crystals formulations containing them and methods of making them
JP3723857B2 (ja) * 1998-02-04 2005-12-07 日本ケミカルリサーチ株式会社 ヒト成長ホルモン含有水性医薬組成物
US7101575B2 (en) 1998-03-19 2006-09-05 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Production of nanocapsules and microcapsules by layer-wise polyelectrolyte self-assembly
US6451347B1 (en) 1999-03-01 2002-09-17 Alkermes Controlled Therapeutics, Inc. Method for purifying human growth hormone
ES2184716T3 (es) 1999-06-10 2003-04-16 Max Planck Gesellschaft Encapsulacion de cristales por medio de recubrimientos multicapa.
US6566329B1 (en) 1999-06-28 2003-05-20 Novo Nordisk A/S Freeze-dried preparation of human growth hormone
JP2004515467A (ja) 2000-08-07 2004-05-27 ネクター セラピューティックス 吸入可能な、噴霧乾燥した、最少の凝集物を有する４−ヘリックスバンドルタンパク質粉末
CA2424896A1 (en) 2000-10-06 2002-04-11 Jagotec Ag A controlled-release, parenterally administrable microparticle preparation
SE517422C2 (sv) 2000-10-06 2002-06-04 Bioglan Ab Farmaceutiskt acceptabel stärkelse
SE517421C2 (sv) 2000-10-06 2002-06-04 Bioglan Ab Mikropartiklar, lämpade för parenteral administration, väsentligen bestående av stärkelse med minst 85 % amylopektin och med reducerad molekylvikt, samt framställning därav
SE518007C2 (sv) 2000-11-16 2002-08-13 Bioglan Ab Förfarande för framställning av mikropartiklar
US7105181B2 (en) 2001-10-05 2006-09-12 Jagotec, Ag Microparticles
SE0201599D0 (sv) 2002-03-21 2002-05-30 Skyepharma Ab Microparticles
SE0202719D0 (sv) * 2002-09-13 2002-09-13 Pharmacia Ab Process for mfg crystals of growth hormone
ZA200505305B (en) * 2002-12-31 2007-07-25 Altus Pharmaceuticals Inc Human growth hormone crystals and methods for preparing them
ZA200505306B (en) * 2002-12-31 2006-09-27 Altus Pharmaceuticals Inc Complexes of protein crystals and ionic polymers
KR20050090430A (ko) 2002-12-31 2005-09-13 알투스 파마슈티컬스 인코포레이티드 인간 성장 호르몬 결정 및 이것의 제조 방법
WO2005014034A1 (en) * 2003-07-14 2005-02-17 Nps Allelix Corp. Stabilized formulation of parathyroid hormone
US20090023629A1 (en) * 2005-12-23 2009-01-22 Altus Pharmaceuticals Inc. Compositions comprising polycation-complexed protein crystals and methods of treatment using them
AU2007333959A1 (en) * 2006-12-18 2008-06-26 Altus Pharmaceuticals Inc. Human growth hormone formulations

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA653324A (en) * 1962-12-04 G. Brink Norman Growth hormone and methods of preparing the same
US2143590A (en) * 1936-09-26 1939-01-10 Univ Alberta Insulin preparation and process of producing crystals of insulin
US2174862A (en) * 1938-12-30 1939-10-03 Frederick Stearns & Company Process of producing crystalline insulin
US2595278A (en) * 1950-04-28 1952-05-06 Armour & Co Preparation of insulin from pancreas glands
US3102077A (en) * 1953-08-19 1963-08-27 Christensen Henry Marinus Preparation of insulin containing 2.75 to 8 percent zinc content
US2897117A (en) * 1955-02-10 1959-07-28 Univ Alberta Insulin process
US3856771A (en) * 1973-07-16 1974-12-24 Lilly Co Eli Process for manufacturing alkali metal or ammonium insulin
KR890002631B1 (ko) * 1984-10-04 1989-07-21 몬산토 캄파니 생물학적으로 활성인 소마토트로핀을 지속적으로 유리하는 조성물
EP0343696B1 (en) * 1984-10-04 1996-01-03 Monsanto Company Zinc-associated somatotropins
IL79681A (en) * 1985-08-12 1991-06-10 Int Minerals & Chem Corp Transition metal complexes of growth hormones and their prolonged release compositions
JPS63216898A (ja) * 1987-01-30 1988-09-09 インターナシヨナル・ミネラルズ・アンド・ケミカル・コーポレイシヨン 希薄水溶液からソマトトロビンを回収する方法
US4764592A (en) * 1987-04-23 1988-08-16 Eli Lilly And Company Crystalline human proinsulin and process for its production
EP0355460B1 (en) * 1988-08-24 2000-12-27 American Cyanamid Company Stabilization of somatotropins by modification of cysteine residues utilizing site directed mutagenesis or chemical derivatization
US5109117A (en) * 1990-06-26 1992-04-28 Monsanto Company Method of somatotropin naturation using urea and a soluble organic alcohol
US5780599A (en) * 1990-07-13 1998-07-14 Novo Nordisk A/S Growth hormone crystals and a process for production of growth hormone crystals
DK168790D0 (pt) * 1990-07-13 1990-07-13 Novo Nordisk As

Also Published As

Publication number Publication date
AU666465B2 (en) 1996-02-15
PT98297B (pt) 1999-01-29
ATE110745T1 (de) 1994-09-15
CA2086087A1 (en) 1992-01-14
EP0540582B1 (en) 1994-08-31
NZ238904A (en) 1993-04-28
US6117984A (en) 2000-09-12
DK168790D0 (pt) 1990-07-13
EP0540582A1 (en) 1993-05-12
JP2524446B2 (ja) 1996-08-14
AU8284691A (en) 1992-02-04
HUT64086A (en) 1993-11-29
CA2086087C (en) 1999-09-14
DE69103755T2 (de) 1995-02-23
DK0540582T3 (da) 1995-01-30
RU2108341C1 (ru) 1998-04-10
IE912444A1 (en) 1992-01-15
WO1992000998A1 (en) 1992-01-23
HU210323B (en) 1995-03-28
BG97281A (bg) 1994-03-24
HU9300067D0 (en) 1993-04-28
BG61267B1 (en) 1997-04-30
IE67054B1 (en) 1996-02-21
DE69103755D1 (de) 1994-10-06
JPH05507497A (ja) 1993-10-28
ES2060399T3 (es) 1994-11-16
ZA915446B (en) 1992-03-25

Similar Documents

Publication Publication Date Title
PT98297A (pt) Processo para a preparacao de cristais cationicos da hormona de crescimento
ZA885192B (en) Pharmaceutical preparations
AU6780687A (en) Benzamido-aromatic derivatives, process for their preparation and their use in human or veterinary medicine and in cosmetics
AU7383687A (en) Pharmaceutical preparations containing formoterol or its salts, and a method of treating skin diseases
NZ228564A (en) Corticosteroid-containing skin care composition for use as moisturiser: preparation thereof
FI102969B1 (fi) Lämpö- ja pH-stabiileja subtilisiinianalogeja ja menetelmä niiden valmistamiseksi
DE3772521D1 (de) Insulinzubereitung fuer nicht-parenterale verabreichung.
AU577595B2 (en) Crystalline calcium pseudomonate
HU893408D0 (en) Process for the production of glycosamino-glucane salts and medical preparations containing them
NZ228632A (en) Topical otopathic preparations containing ofloxacin
BR8803293A (pt) Amidas de acido 6,7-dihidro-pirazolo(1,5-a arroba(1,3,5 arroba triazin-2-sulfonico,processo para sua preparacao,composicao herbicida e reguladora do crescimento de plantas,aplicacao e processo para preparacao da composicao
NZ236058A (en) Expression vector for hbeta-ngf (human beta nerve growth factor), product and composition
GB8828694D0 (en) Preparation for introducing active substance for regulating tanning into skin production & use thereof
IL90056A0 (en) Topical pharmaceutical compositions containing 4-quinoline carboxylic acid derivatives
DE69015910D1 (de) Pharmazeutische Verwendung von Fettsäuren.
HU908361D0 (en) Process for the production of oxazole derivatives and medical preparations containing them as active agents
AR240917A1 (es) "procedimiento para preparar derivados del acido 2-(4-hidroxi-2-oxopirrolidin-acetico:intermediarios de aplicacion exclusiva en dicho procedimiento y la preparacion de dichos intermediarios".
AU7336387A (en) Aromatic naphthyl compounds, a process for their preparation and their use in human and veterinary medicine and in cosmetic compositions
HUT44770A (en) Process for producing 6-phenoxymethyl-4-hydroxy-tetrahydropyran-2-one derivatives and pharmaceutical preparations comprising them as active substance
NO902104D0 (no) Kosmetisk blanding.
IT8748117A0 (it) Derivati di glicina quali agenti preventivi e terapeutici per le complicanze diabetiche
ES2006121A6 (es) Procedimiento para la preparacion de una composicion farmaceutica destinada al tratamiento de enfermedades cutaneas.
HUT40791A (en) Process for preparing optically active azolyl-carbinol derivatives and pharmaceutical preparations comprising such compounds
EP0248736A3 (en) Substituted benzimidazolylthiomethyl benzothiazole derivatives and their salts, process for their preparation, their medical application and compositions containing them
IL83495A0 (en) Oxirane pseudooligosaccharides,a process for their preparation,and pharmaceutical preparations containing them

Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19920110

FG3A Patent granted, date of granting

Effective date: 19981002

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20040430