DK168790D0 - - Google Patents
Info
- Publication number
- DK168790D0 DK168790D0 DK168790A DK168790A DK168790D0 DK 168790 D0 DK168790 D0 DK 168790D0 DK 168790 A DK168790 A DK 168790A DK 168790 A DK168790 A DK 168790A DK 168790 D0 DK168790 D0 DK 168790D0
- Authority
- DK
- Denmark
- Prior art keywords
- hgh
- divalent cation
- crystals
- derivatives
- growth factor
- Prior art date
Links
- 150000001768 cations Chemical class 0.000 abstract 3
- 239000013078 crystal Substances 0.000 abstract 2
- 239000003102 growth factor Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
- C30B29/54—Organic compounds
- C30B29/58—Macromolecular compounds
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Materials Engineering (AREA)
- Metallurgy (AREA)
- Endocrinology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Priority Applications (22)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK168790A DK168790D0 (pt) | 1990-07-13 | 1990-07-13 | |
NZ238904A NZ238904A (en) | 1990-07-13 | 1991-07-10 | Cation crystals of growth hormone and derivative; purification and pharmaceutical compositions |
PT98297A PT98297B (pt) | 1990-07-13 | 1991-07-11 | Processo para a preparacao de cristais cationicos da hormona de crescimento |
HU9300067A HU210323B (en) | 1990-07-13 | 1991-07-12 | Process for producing growth hormone crystals |
JP3512511A JP2524446B2 (ja) | 1990-07-13 | 1991-07-12 | 成長ホルモン結晶及びこのようなgh―結晶の製造方法 |
ZA915446A ZA915446B (en) | 1990-07-13 | 1991-07-12 | Growth hormone crystals and a process for production of these gh-crystals |
CA002086087A CA2086087C (en) | 1990-07-13 | 1991-07-12 | Growth hormone crystals and a process for production of these gh-crystals |
AU82846/91A AU666465B2 (en) | 1990-07-13 | 1991-07-12 | Growth hormone crystals and a process for production of these GH-crystals |
HU9300067A HUT64086A (en) | 1990-07-13 | 1991-07-12 | Process for producing gh-crystals |
AT91913240T ATE110745T1 (de) | 1990-07-13 | 1991-07-12 | Wachstumshormonkristalle und verfahren zu deren herstellung. |
DK91913240.7T DK0540582T3 (da) | 1990-07-13 | 1991-07-12 | Væksthormonkrystaller og fremgangsmåde til fremstilling af disse væksthormonkrystaller |
IE244491A IE67054B1 (en) | 1990-07-13 | 1991-07-12 | Growth hormone crystals and a process for production of these GH-crystals |
ES91913240T ES2060399T3 (es) | 1990-07-13 | 1991-07-12 | Cristales de la hormona del crecimiento y procedimiento para la produccion de estos cristales de la hormona del crecimiento. |
RU93005051/13A RU2108341C1 (ru) | 1990-07-13 | 1991-07-12 | Способ получения кристаллов гр или производных гр, кристаллы человеческих гр или производных человеческих гр и фармацевтический препарат |
PCT/DK1991/000203 WO1992000998A1 (en) | 1990-07-13 | 1991-07-12 | Growth hormone crystals and a process for production of these gh-crystals |
EP91913240A EP0540582B1 (en) | 1990-07-13 | 1991-07-12 | Growth hormone crystals and a process for production of these gh-crystals |
DE69103755T DE69103755T2 (de) | 1990-07-13 | 1991-07-12 | Wachstumshormonkristalle und verfahren zu deren herstellung. |
BG97281A BG61267B1 (en) | 1990-07-13 | 1993-01-12 | Growth hormone crystals and method for production thereof |
US08/350,758 US5780599A (en) | 1990-07-13 | 1994-12-07 | Growth hormone crystals and a process for production of growth hormone crystals |
US09/063,749 US6117984A (en) | 1990-07-13 | 1998-04-21 | Growth hormone crystals and a process for production of these GH-crystals |
US09/592,032 US6894023B1 (en) | 1990-07-13 | 2000-06-12 | Growth hormone crystals and a process for production of these GH-crystals |
US11/130,433 US20060116320A1 (en) | 1990-07-13 | 2005-05-16 | Growth hormone crystals and a process for production of these GH-crystals |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK168790A DK168790D0 (pt) | 1990-07-13 | 1990-07-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK168790D0 true DK168790D0 (pt) | 1990-07-13 |
Family
ID=8107212
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK168790A DK168790D0 (pt) | 1990-07-13 | 1990-07-13 | |
DK91913240.7T DK0540582T3 (da) | 1990-07-13 | 1991-07-12 | Væksthormonkrystaller og fremgangsmåde til fremstilling af disse væksthormonkrystaller |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK91913240.7T DK0540582T3 (da) | 1990-07-13 | 1991-07-12 | Væksthormonkrystaller og fremgangsmåde til fremstilling af disse væksthormonkrystaller |
Country Status (17)
Country | Link |
---|---|
US (1) | US6117984A (pt) |
EP (1) | EP0540582B1 (pt) |
JP (1) | JP2524446B2 (pt) |
AT (1) | ATE110745T1 (pt) |
AU (1) | AU666465B2 (pt) |
BG (1) | BG61267B1 (pt) |
CA (1) | CA2086087C (pt) |
DE (1) | DE69103755T2 (pt) |
DK (2) | DK168790D0 (pt) |
ES (1) | ES2060399T3 (pt) |
HU (2) | HU210323B (pt) |
IE (1) | IE67054B1 (pt) |
NZ (1) | NZ238904A (pt) |
PT (1) | PT98297B (pt) |
RU (1) | RU2108341C1 (pt) |
WO (1) | WO1992000998A1 (pt) |
ZA (1) | ZA915446B (pt) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6894023B1 (en) * | 1990-07-13 | 2005-05-17 | Novo Nordisk A/S | Growth hormone crystals and a process for production of these GH-crystals |
DK168790D0 (pt) * | 1990-07-13 | 1990-07-13 | Novo Nordisk As | |
ES2291264T3 (es) * | 1991-12-20 | 2008-03-01 | Novo Nordisk A/S | Formulacion farmaceutica estabilizada comprendiendo una hormona de crecimiento e histidina. |
SE9302278D0 (sv) * | 1992-10-28 | 1993-07-02 | Kabi Pharmacia Ab | Growth hormone |
EP0946169B1 (en) | 1996-12-20 | 2003-02-26 | Takeda Chemical Industries, Ltd. | Method of producing a sustained-release preparation |
US6541606B2 (en) | 1997-12-31 | 2003-04-01 | Altus Biologics Inc. | Stabilized protein crystals formulations containing them and methods of making them |
JP3723857B2 (ja) * | 1998-02-04 | 2005-12-07 | 日本ケミカルリサーチ株式会社 | ヒト成長ホルモン含有水性医薬組成物 |
US7101575B2 (en) | 1998-03-19 | 2006-09-05 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Production of nanocapsules and microcapsules by layer-wise polyelectrolyte self-assembly |
US6451347B1 (en) | 1999-03-01 | 2002-09-17 | Alkermes Controlled Therapeutics, Inc. | Method for purifying human growth hormone |
DE20023081U1 (de) | 1999-06-10 | 2003-01-16 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 80539 München | Eingekapselte Kristalle mit Mehrlagenbeschichtung |
US6566329B1 (en) | 1999-06-28 | 2003-05-20 | Novo Nordisk A/S | Freeze-dried preparation of human growth hormone |
TWI283182B (en) | 2000-08-07 | 2007-07-01 | Nektar Therapeutics | Inhalable spray dried 4-helix bundle protein powders having minimized aggregation |
SE517422C2 (sv) | 2000-10-06 | 2002-06-04 | Bioglan Ab | Farmaceutiskt acceptabel stärkelse |
SE517421C2 (sv) | 2000-10-06 | 2002-06-04 | Bioglan Ab | Mikropartiklar, lämpade för parenteral administration, väsentligen bestående av stärkelse med minst 85 % amylopektin och med reducerad molekylvikt, samt framställning därav |
JP2004510730A (ja) | 2000-10-06 | 2004-04-08 | ヤゴテック アーゲー | 非経口的投与可能な制御放出微粒子調製物 |
SE518007C2 (sv) | 2000-11-16 | 2002-08-13 | Bioglan Ab | Förfarande för framställning av mikropartiklar |
US7105181B2 (en) | 2001-10-05 | 2006-09-12 | Jagotec, Ag | Microparticles |
SE0201599D0 (sv) | 2002-03-21 | 2002-05-30 | Skyepharma Ab | Microparticles |
SE0202719D0 (sv) * | 2002-09-13 | 2002-09-13 | Pharmacia Ab | Process for mfg crystals of growth hormone |
KR20050090430A (ko) | 2002-12-31 | 2005-09-13 | 알투스 파마슈티컬스 인코포레이티드 | 인간 성장 호르몬 결정 및 이것의 제조 방법 |
NZ571243A (en) * | 2002-12-31 | 2010-04-30 | Altus Pharmaceuticals Inc | Complexes of protein crystals and ionic polymers comprising human growth hormone and protamine |
CN101659701B (zh) * | 2002-12-31 | 2019-03-26 | 阿尔特斯制药公司 | 人生长激素晶体和制备它们的方法 |
WO2005014034A1 (en) * | 2003-07-14 | 2005-02-17 | Nps Allelix Corp. | Stabilized formulation of parathyroid hormone |
EP1976551A4 (en) * | 2005-12-23 | 2009-12-30 | Altus Pharmaceuticals Inc | COMPOSITIONS COMPRISING COMPLEX PROTEIN CRYSTALS BY POLYCATIONS AND PROCESSING METHOD THEREOF |
EP2486916B1 (en) * | 2006-12-18 | 2015-04-01 | Ajinomoto Althea, Inc. | Human growth hormone formulations |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA653324A (en) * | 1962-12-04 | G. Brink Norman | Growth hormone and methods of preparing the same | |
US2143590A (en) * | 1936-09-26 | 1939-01-10 | Univ Alberta | Insulin preparation and process of producing crystals of insulin |
US2174862A (en) * | 1938-12-30 | 1939-10-03 | Frederick Stearns & Company | Process of producing crystalline insulin |
US2595278A (en) * | 1950-04-28 | 1952-05-06 | Armour & Co | Preparation of insulin from pancreas glands |
US3102077A (en) * | 1953-08-19 | 1963-08-27 | Christensen Henry Marinus | Preparation of insulin containing 2.75 to 8 percent zinc content |
US2897117A (en) * | 1955-02-10 | 1959-07-28 | Univ Alberta | Insulin process |
US3856771A (en) * | 1973-07-16 | 1974-12-24 | Lilly Co Eli | Process for manufacturing alkali metal or ammonium insulin |
ES8702440A1 (es) * | 1984-10-04 | 1986-12-16 | Monsanto Co | Un procedimiento para la preparacion de una composicion de polipeptido inyectable sustancialmente no acuosa. |
ATE62598T1 (de) * | 1984-10-04 | 1991-05-15 | Monsanto Co | Verzoegerte freisetzung biologisch aktiver somatotropine. |
IL79681A (en) * | 1985-08-12 | 1991-06-10 | Int Minerals & Chem Corp | Transition metal complexes of growth hormones and their prolonged release compositions |
HU203367B (en) * | 1987-01-30 | 1991-07-29 | Int Minerals & Chem Corp | Process for obtaining somatotpropins from weak aqueous solution |
US4764592A (en) * | 1987-04-23 | 1988-08-16 | Eli Lilly And Company | Crystalline human proinsulin and process for its production |
ATE198353T1 (de) * | 1988-08-24 | 2001-01-15 | American Cyanamid Co | Stabilisierung von somatotropinen durch modifikation von cystein-resten durch orts- spezifische mutagenese oder chemische derivatisierung |
US5109117A (en) * | 1990-06-26 | 1992-04-28 | Monsanto Company | Method of somatotropin naturation using urea and a soluble organic alcohol |
US5780599A (en) * | 1990-07-13 | 1998-07-14 | Novo Nordisk A/S | Growth hormone crystals and a process for production of growth hormone crystals |
DK168790D0 (pt) * | 1990-07-13 | 1990-07-13 | Novo Nordisk As |
-
1990
- 1990-07-13 DK DK168790A patent/DK168790D0/da active IP Right Grant
-
1991
- 1991-07-10 NZ NZ238904A patent/NZ238904A/xx unknown
- 1991-07-11 PT PT98297A patent/PT98297B/pt not_active IP Right Cessation
- 1991-07-12 HU HU9300067A patent/HU210323B/hu unknown
- 1991-07-12 WO PCT/DK1991/000203 patent/WO1992000998A1/en active IP Right Grant
- 1991-07-12 AT AT91913240T patent/ATE110745T1/de not_active IP Right Cessation
- 1991-07-12 IE IE244491A patent/IE67054B1/en not_active IP Right Cessation
- 1991-07-12 AU AU82846/91A patent/AU666465B2/en not_active Ceased
- 1991-07-12 EP EP91913240A patent/EP0540582B1/en not_active Expired - Lifetime
- 1991-07-12 DE DE69103755T patent/DE69103755T2/de not_active Expired - Fee Related
- 1991-07-12 JP JP3512511A patent/JP2524446B2/ja not_active Expired - Fee Related
- 1991-07-12 CA CA002086087A patent/CA2086087C/en not_active Expired - Fee Related
- 1991-07-12 RU RU93005051/13A patent/RU2108341C1/ru not_active IP Right Cessation
- 1991-07-12 ES ES91913240T patent/ES2060399T3/es not_active Expired - Lifetime
- 1991-07-12 DK DK91913240.7T patent/DK0540582T3/da active
- 1991-07-12 HU HU9300067A patent/HUT64086A/hu unknown
- 1991-07-12 ZA ZA915446A patent/ZA915446B/xx unknown
-
1993
- 1993-01-12 BG BG97281A patent/BG61267B1/bg unknown
-
1998
- 1998-04-21 US US09/063,749 patent/US6117984A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ATE110745T1 (de) | 1994-09-15 |
ZA915446B (en) | 1992-03-25 |
EP0540582B1 (en) | 1994-08-31 |
NZ238904A (en) | 1993-04-28 |
AU666465B2 (en) | 1996-02-15 |
WO1992000998A1 (en) | 1992-01-23 |
BG61267B1 (en) | 1997-04-30 |
CA2086087C (en) | 1999-09-14 |
DK0540582T3 (da) | 1995-01-30 |
RU2108341C1 (ru) | 1998-04-10 |
JPH05507497A (ja) | 1993-10-28 |
AU8284691A (en) | 1992-02-04 |
DE69103755D1 (de) | 1994-10-06 |
ES2060399T3 (es) | 1994-11-16 |
IE912444A1 (en) | 1992-01-15 |
IE67054B1 (en) | 1996-02-21 |
HU210323B (en) | 1995-03-28 |
EP0540582A1 (en) | 1993-05-12 |
CA2086087A1 (en) | 1992-01-14 |
DE69103755T2 (de) | 1995-02-23 |
HU9300067D0 (en) | 1993-04-28 |
PT98297B (pt) | 1999-01-29 |
JP2524446B2 (ja) | 1996-08-14 |
HUT64086A (en) | 1993-11-29 |
PT98297A (pt) | 1992-05-29 |
US6117984A (en) | 2000-09-12 |
BG97281A (bg) | 1994-03-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AHS | Application shelved for other reasons than non-payment | ||
B1 | Patent granted (law 1993) |