RU2107682C1 - Кристаллическая форма n-[4-[5-(циклопентилоксикарбонил) амино-1-метил-индол-3-илметил]-3-метоксибензоил]-2-метилбензолсульфонамида, способ ее получения и фармацевтическая композиция, обладающая активностью антагониста лейкотриенов - Google Patents
Кристаллическая форма n-[4-[5-(циклопентилоксикарбонил) амино-1-метил-индол-3-илметил]-3-метоксибензоил]-2-метилбензолсульфонамида, способ ее получения и фармацевтическая композиция, обладающая активностью антагониста лейкотриенов Download PDFInfo
- Publication number
- RU2107682C1 RU2107682C1 SU5010266A SU5010266A RU2107682C1 RU 2107682 C1 RU2107682 C1 RU 2107682C1 SU 5010266 A SU5010266 A SU 5010266A SU 5010266 A SU5010266 A SU 5010266A RU 2107682 C1 RU2107682 C1 RU 2107682C1
- Authority
- RU
- Russia
- Prior art keywords
- methyl
- methoxybenzoyl
- cyclopentyloxycarbonyl
- amino
- ylmethyl
- Prior art date
Links
- -1 cyclopentyloxycarbonyl Chemical group 0.000 title claims description 6
- 239000005557 antagonist Substances 0.000 title 1
- 238000002329 infrared spectrum Methods 0.000 claims abstract description 11
- 150000001875 compounds Chemical class 0.000 claims abstract description 7
- 239000000843 powder Substances 0.000 claims description 25
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 24
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 14
- 239000008194 pharmaceutical composition Substances 0.000 claims description 13
- 239000002245 particle Substances 0.000 claims description 9
- YEEZWCHGZNKEEK-UHFFFAOYSA-N Zafirlukast Chemical compound COC1=CC(C(=O)NS(=O)(=O)C=2C(=CC=CC=2)C)=CC=C1CC(C1=C2)=CN(C)C1=CC=C2NC(=O)OC1CCCC1 YEEZWCHGZNKEEK-UHFFFAOYSA-N 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 238000005096 rolling process Methods 0.000 claims description 6
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims description 5
- 239000004615 ingredient Substances 0.000 claims description 5
- 239000003380 propellant Substances 0.000 claims description 5
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims description 5
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- DDMOUSALMHHKOS-UHFFFAOYSA-N 1,2-dichloro-1,1,2,2-tetrafluoroethane Chemical compound FC(F)(Cl)C(F)(F)Cl DDMOUSALMHHKOS-UHFFFAOYSA-N 0.000 claims description 4
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Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB909027018A GB9027018D0 (en) | 1990-12-12 | 1990-12-12 | Heterocyclic compounds |
| GB9027018.2 | 1990-12-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2107682C1 true RU2107682C1 (ru) | 1998-03-27 |
Family
ID=10686919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU5010266A RU2107682C1 (ru) | 1990-12-12 | 1991-12-11 | Кристаллическая форма n-[4-[5-(циклопентилоксикарбонил) амино-1-метил-индол-3-илметил]-3-метоксибензоил]-2-метилбензолсульфонамида, способ ее получения и фармацевтическая композиция, обладающая активностью антагониста лейкотриенов |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US5294636A (enExample) |
| EP (1) | EP0490649B1 (enExample) |
| JP (1) | JP2650807B2 (enExample) |
| KR (1) | KR100194479B1 (enExample) |
| CN (2) | CN1032469C (enExample) |
| AP (1) | AP286A (enExample) |
| AT (1) | ATE145199T1 (enExample) |
| AU (1) | AU656344B2 (enExample) |
| CA (1) | CA2056067C (enExample) |
| CZ (1) | CZ288151B6 (enExample) |
| DE (1) | DE69123123T2 (enExample) |
| DK (1) | DK0490649T3 (enExample) |
| ES (1) | ES2094797T3 (enExample) |
| FI (1) | FI101296B1 (enExample) |
| GB (2) | GB9027018D0 (enExample) |
| GR (1) | GR3021605T3 (enExample) |
| HK (1) | HK81497A (enExample) |
| HU (2) | HU213109B (enExample) |
| IE (1) | IE914316A1 (enExample) |
| IL (1) | IL100090A (enExample) |
| MX (1) | MX9102475A (enExample) |
| MY (1) | MY108629A (enExample) |
| NZ (1) | NZ240940A (enExample) |
| PH (1) | PH30041A (enExample) |
| RU (1) | RU2107682C1 (enExample) |
| SK (1) | SK279018B6 (enExample) |
| TW (1) | TW222264B (enExample) |
| ZA (1) | ZA919772B (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2236404C2 (ru) * | 1999-01-09 | 2004-09-20 | Астразенека Аб | Кристаллическая гидратированная форма кальциевой соли бис[(е)-7-[4-(4-фторфенил)-6-изопропил-2-[метил(метилсульфонил)амино]-пири мидин-5-ил]-(3r,5s)-3,5-дигидроксигепт-6-еновой кислоты], способ ее получения, фармацевтическая композиция, способ ее получения и способ лечения |
| RU2265599C2 (ru) * | 2000-02-15 | 2005-12-10 | Астразенека Аб | Кристаллические соли 7-[4-(4-фторфенил)-6-изопропил-2-[метил (метилсульфонил) амино]пиримидин-5-ил]-(3r,5s)-3,5-дигидроксигепт-6-еновой кислоты, способ их получения и фармацевтическая композиция |
| RU2505531C2 (ru) * | 2008-12-22 | 2014-01-27 | Оно Фармасьютикал Ко., Лтд. | Этинилиндольные соединения |
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| DK0455596T3 (da) * | 1990-05-04 | 1994-11-28 | Ciba Geigy Ag | Substituerede indoler |
| IL100091A (en) * | 1990-12-12 | 1998-08-16 | Zeneca Ltd | Pharmaceutical compositions containing a physical form of n-[4-[5-(cyclopentyloxycarbonyl)amino-1-methyl indol-3-yl-methyl]-2-methylbenzenesulpho-namide and process for their preparation |
| GB9119001D0 (en) * | 1991-09-05 | 1991-10-23 | Ici Plc | Pharmaceutical agents |
| GR1001368B (el) * | 1992-10-08 | 1993-10-29 | Ici Plc | Φαρμακευτικοί φορείς. |
| DE4235133A1 (de) * | 1992-10-19 | 1994-04-21 | Bayer Ag | Kristallines (R)-(-)-2-Cycloheptyl-N-methylsulfonyl-[4-(2-chinolinyl-methoxy)-phenyl]-acetamid |
| JP3732508B2 (ja) * | 1993-10-01 | 2006-01-05 | アストラ・アクチエボラーグ | 粉末状薬剤の製造方法 |
| IS1736B (is) | 1993-10-01 | 1999-12-30 | Astra Ab | Aðferð og tæki sem stuðla að aukinni samloðun agna |
| GB9723985D0 (en) * | 1997-11-14 | 1998-01-14 | Zeneca Ltd | Pharmaceutical compositions |
| GB9726735D0 (en) * | 1997-12-18 | 1998-02-18 | Zeneca Ltd | Pharmaceutical compositions |
| IL139243A0 (en) * | 2000-10-24 | 2001-11-25 | Internat Specialty Products Is | Ethanolate of zafirlukast, process for manufacture and pharmaceutical compositions thereof |
| TWI353979B (en) * | 2002-04-10 | 2011-12-11 | Nippon Zoki Pharmaceutical Co | Novel crystal form of 5-hydroxy-1-methylhydantoin |
| US20090317476A1 (en) * | 2003-07-31 | 2009-12-24 | Robinson Cynthia B | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a leukotriene receptor antagonist for treatment of asthma or chronic obstructive pulmonary disease |
| US20050026882A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a leukotriene receptor antagonist for treatment of asthma or chronic obstructive pulmonary disease |
| US20050113410A1 (en) * | 2003-11-03 | 2005-05-26 | Mark Tawa | Pharmaceutical salts of zafirlukast |
| JP2008531721A (ja) * | 2005-03-03 | 2008-08-14 | エラン・ファルマ・インターナショナル・リミテッド | 複素環式アミド誘導体のナノ粒子状組成物 |
| US20070197467A1 (en) * | 2006-02-06 | 2007-08-23 | Srinivasulu Rangineni | Zafirlukast compositions |
| US20090012146A1 (en) * | 2007-07-02 | 2009-01-08 | Giridhar Reddy Buggana | Solubility-enhanced pharmaceutical compositions comprising zafirlukast |
| US20090191183A1 (en) * | 2007-07-30 | 2009-07-30 | Auspex Pharmaceuticals, Inc. | Substituted indoles |
| WO2014012954A1 (en) | 2012-07-18 | 2014-01-23 | Takeda Gmbh | Treatment of partly controlled or uncontrolled severe asthma |
| CN103396353B (zh) * | 2013-08-23 | 2015-05-20 | 海南通用三洋药业有限公司 | 一种扎鲁司特无定型态及其制备方法 |
| WO2015110394A1 (en) | 2014-01-22 | 2015-07-30 | Takeda Gmbh | Treatment of partly controlled or uncontrolled severe asthma with a pde4 inhibitor (and in combination with a leukotriene modifier) |
| PT109030B (pt) * | 2015-12-15 | 2019-09-25 | Hovione Farmaciência, S.A. | Preparação de partículas inaláveis de zafirlucaste |
| CA3052071A1 (en) | 2017-01-30 | 2018-08-02 | Western New England University | Thiol isomerases inhibitors and use thereof |
| JP2024521736A (ja) | 2021-05-19 | 2024-06-04 | クエルシス ファーマ エージー | 筋萎縮性側索硬化症の治療に使用するためのケルセチン含有組成物 |
| US20250275936A1 (en) | 2022-05-06 | 2025-09-04 | Quercis Pharma AG | Method for treating cancers and neurological diseases using quercetin-containing compositions |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0199543B1 (en) * | 1985-04-17 | 1991-12-04 | Ici Americas Inc. | Heterocyclic amide derivatives |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4161516A (en) * | 1975-07-25 | 1979-07-17 | Fisons Limited | Composition for treating airway disease |
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1990
- 1990-12-12 GB GB909027018A patent/GB9027018D0/en active Pending
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1991
- 1991-11-19 IL IL10009091A patent/IL100090A/en active IP Right Grant
- 1991-11-22 CA CA002056067A patent/CA2056067C/en not_active Expired - Fee Related
- 1991-12-06 TW TW080109583A patent/TW222264B/zh active
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- 1991-12-11 AU AU88995/91A patent/AU656344B2/en not_active Ceased
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- 1991-12-11 DK DK91311505.1T patent/DK0490649T3/da active
- 1991-12-11 SK SK3758-91A patent/SK279018B6/sk unknown
- 1991-12-11 IE IE431691A patent/IE914316A1/en not_active IP Right Cessation
- 1991-12-11 ZA ZA919772A patent/ZA919772B/xx unknown
- 1991-12-11 RU SU5010266A patent/RU2107682C1/ru not_active IP Right Cessation
- 1991-12-11 ES ES91311505T patent/ES2094797T3/es not_active Expired - Lifetime
- 1991-12-11 AT AT91311505T patent/ATE145199T1/de not_active IP Right Cessation
- 1991-12-11 NZ NZ240940A patent/NZ240940A/en not_active IP Right Cessation
- 1991-12-11 DE DE69123123T patent/DE69123123T2/de not_active Expired - Lifetime
- 1991-12-11 FI FI915825A patent/FI101296B1/fi not_active IP Right Cessation
- 1991-12-11 US US07/805,426 patent/US5294636A/en not_active Expired - Lifetime
- 1991-12-11 GB GB9126353A patent/GB2250743B/en not_active Expired - Lifetime
- 1991-12-11 KR KR1019910022609A patent/KR100194479B1/ko not_active Expired - Fee Related
- 1991-12-11 PH PH43618A patent/PH30041A/en unknown
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1995
- 1995-06-15 HU HU95P/P00208P patent/HU211125A9/hu unknown
- 1995-08-30 CN CN95115922A patent/CN1074411C/zh not_active Expired - Fee Related
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1996
- 1996-11-14 GR GR960402814T patent/GR3021605T3/el unknown
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1997
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| EP0199543B1 (en) * | 1985-04-17 | 1991-12-04 | Ici Americas Inc. | Heterocyclic amide derivatives |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2236404C2 (ru) * | 1999-01-09 | 2004-09-20 | Астразенека Аб | Кристаллическая гидратированная форма кальциевой соли бис[(е)-7-[4-(4-фторфенил)-6-изопропил-2-[метил(метилсульфонил)амино]-пири мидин-5-ил]-(3r,5s)-3,5-дигидроксигепт-6-еновой кислоты], способ ее получения, фармацевтическая композиция, способ ее получения и способ лечения |
| RU2265599C2 (ru) * | 2000-02-15 | 2005-12-10 | Астразенека Аб | Кристаллические соли 7-[4-(4-фторфенил)-6-изопропил-2-[метил (метилсульфонил) амино]пиримидин-5-ил]-(3r,5s)-3,5-дигидроксигепт-6-еновой кислоты, способ их получения и фармацевтическая композиция |
| RU2505531C2 (ru) * | 2008-12-22 | 2014-01-27 | Оно Фармасьютикал Ко., Лтд. | Этинилиндольные соединения |
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Legal Events
| Date | Code | Title | Description |
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| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20051212 |