RU2021119777A - Слитый полипептид, способный связывать cd137 и gpc3, молекула нуклеиновой кислоты, содержащая нуклеотидную последовательность, кодирующую такой слитый полипептид, способ его получения и пути применения - Google Patents

Слитый полипептид, способный связывать cd137 и gpc3, молекула нуклеиновой кислоты, содержащая нуклеотидную последовательность, кодирующую такой слитый полипептид, способ его получения и пути применения Download PDF

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RU2021119777A
RU2021119777A RU2021119777A RU2021119777A RU2021119777A RU 2021119777 A RU2021119777 A RU 2021119777A RU 2021119777 A RU2021119777 A RU 2021119777A RU 2021119777 A RU2021119777 A RU 2021119777A RU 2021119777 A RU2021119777 A RU 2021119777A
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RU2021119777A
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Марлон Хиннер
Рачида Сихам Бел Айба
Кристине Роте
Шейн Ольвилль
Коринна ШЛОССЕР
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ПИЕРИС ФАРМАСЬЮТИКАЛС ГмбХ
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Publication of RU2021119777A publication Critical patent/RU2021119777A/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
RU2021119777A 2015-05-18 2016-05-18 Слитый полипептид, способный связывать cd137 и gpc3, молекула нуклеиновой кислоты, содержащая нуклеотидную последовательность, кодирующую такой слитый полипептид, способ его получения и пути применения RU2021119777A (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP15167927.1 2015-05-18
EP15167927 2015-05-18
EP16150508 2016-01-08
EP16150508.6 2016-01-08

Related Parent Applications (1)

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RU2017135539A Division RU2754466C2 (ru) 2015-05-18 2016-05-18 Слитый полипептид с противораковой активностью

Publications (1)

Publication Number Publication Date
RU2021119777A true RU2021119777A (ru) 2021-08-16

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RU2021119777A RU2021119777A (ru) 2015-05-18 2016-05-18 Слитый полипептид, способный связывать cd137 и gpc3, молекула нуклеиновой кислоты, содержащая нуклеотидную последовательность, кодирующую такой слитый полипептид, способ его получения и пути применения
RU2017135539A RU2754466C2 (ru) 2015-05-18 2016-05-18 Слитый полипептид с противораковой активностью

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US (2) US10913778B2 (https=)
EP (2) EP3298030B1 (https=)
JP (1) JP6947642B2 (https=)
KR (1) KR102685748B1 (https=)
CN (1) CN108112253B (https=)
AU (1) AU2016262845B2 (https=)
CA (1) CA2980838A1 (https=)
DK (1) DK3298030T5 (https=)
ES (1) ES2938525T3 (https=)
FI (1) FI3298030T3 (https=)
HR (1) HRP20230145T1 (https=)
HU (1) HUE061108T2 (https=)
LT (1) LT3298030T (https=)
MX (1) MX390894B (https=)
PL (1) PL3298030T3 (https=)
RS (1) RS64002B1 (https=)
RU (2) RU2021119777A (https=)
SG (1) SG11201707426SA (https=)
SI (1) SI3298030T1 (https=)
SM (1) SMT202300026T1 (https=)
WO (1) WO2016184882A1 (https=)
ZA (1) ZA201706061B (https=)

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Publication number Publication date
DK3298030T3 (en) 2023-02-06
EP4219535A1 (en) 2023-08-02
MX2017014716A (es) 2018-06-28
AU2016262845A1 (en) 2018-01-04
RU2017135539A3 (https=) 2019-11-29
PL3298030T3 (pl) 2023-05-08
JP2018519803A (ja) 2018-07-26
SI3298030T1 (sl) 2023-05-31
DK3298030T5 (en) 2024-10-07
RU2017135539A (ru) 2019-06-18
KR102685748B1 (ko) 2024-07-18
CN108112253B (zh) 2022-09-23
EP3298030A1 (en) 2018-03-28
FI3298030T3 (fi) 2023-02-22
HRP20230145T1 (hr) 2023-04-28
SMT202300026T1 (it) 2023-03-17
US20180148485A1 (en) 2018-05-31
CN108112253A (zh) 2018-06-01
MX390894B (es) 2025-03-21
AU2016262845B2 (en) 2020-07-23
US10913778B2 (en) 2021-02-09
ES2938525T3 (es) 2023-04-12
US11919931B2 (en) 2024-03-05
JP6947642B2 (ja) 2021-10-13
SG11201707426SA (en) 2017-10-30
HUE061108T2 (hu) 2023-05-28
RU2754466C2 (ru) 2021-09-02
RS64002B1 (sr) 2023-03-31
WO2016184882A1 (en) 2016-11-24
EP3298030B1 (en) 2023-01-18
US20210403516A1 (en) 2021-12-30
KR20180002855A (ko) 2018-01-08
CA2980838A1 (en) 2016-11-24
BR112017020445A2 (pt) 2018-07-03
ZA201706061B (en) 2022-05-25
LT3298030T (lt) 2023-02-27

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