KR102685748B1 - 항암 융합 폴리펩타이드 - Google Patents

항암 융합 폴리펩타이드 Download PDF

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Publication number
KR102685748B1
KR102685748B1 KR1020177035641A KR20177035641A KR102685748B1 KR 102685748 B1 KR102685748 B1 KR 102685748B1 KR 1020177035641 A KR1020177035641 A KR 1020177035641A KR 20177035641 A KR20177035641 A KR 20177035641A KR 102685748 B1 KR102685748 B1 KR 102685748B1
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KR20180002855A (ko
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말론 히너
라시다 시함 벨 아이바
크리스틴 로테
쉐인 올윌
코리나 슐로서
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피어이스 파마슈티컬즈 게엠베하
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
KR1020177035641A 2015-05-18 2016-05-18 항암 융합 폴리펩타이드 Active KR102685748B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP15167927.1 2015-05-18
EP15167927 2015-05-18
EP16150508 2016-01-08
EP16150508.6 2016-01-08
PCT/EP2016/061071 WO2016184882A1 (en) 2015-05-18 2016-05-18 Anti-cancer fusion polypeptide

Publications (2)

Publication Number Publication Date
KR20180002855A KR20180002855A (ko) 2018-01-08
KR102685748B1 true KR102685748B1 (ko) 2024-07-18

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KR1020177035641A Active KR102685748B1 (ko) 2015-05-18 2016-05-18 항암 융합 폴리펩타이드

Country Status (22)

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US (2) US10913778B2 (https=)
EP (2) EP3298030B1 (https=)
JP (1) JP6947642B2 (https=)
KR (1) KR102685748B1 (https=)
CN (1) CN108112253B (https=)
AU (1) AU2016262845B2 (https=)
CA (1) CA2980838A1 (https=)
DK (1) DK3298030T5 (https=)
ES (1) ES2938525T3 (https=)
FI (1) FI3298030T3 (https=)
HR (1) HRP20230145T1 (https=)
HU (1) HUE061108T2 (https=)
LT (1) LT3298030T (https=)
MX (1) MX390894B (https=)
PL (1) PL3298030T3 (https=)
RS (1) RS64002B1 (https=)
RU (2) RU2754466C2 (https=)
SG (1) SG11201707426SA (https=)
SI (1) SI3298030T1 (https=)
SM (1) SMT202300026T1 (https=)
WO (1) WO2016184882A1 (https=)
ZA (1) ZA201706061B (https=)

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KR20180029238A (ko) 2015-07-15 2018-03-20 피어이스 파마슈티컬즈 게엠베하 Lag-3에 특이적인 신규 단백질
AR106188A1 (es) 2015-10-01 2017-12-20 Hoffmann La Roche Anticuerpos anti-cd19 humano humanizados y métodos de utilización
BR112019013189A2 (pt) * 2017-01-03 2019-12-10 Hoffmann La Roche moléculas de ligação ao antígeno biespecífica, polinucleotídeo, célula hospedeira, método de produção da molécula de ligação ao antígeno biespecífica, composição farmacêutica, uso, métodos para inibir o crescimento de células tumorais em um indivíduo e para tratar o câncer ou uma doença infecciosa
JP7183163B2 (ja) 2017-01-06 2022-12-05 クレシェンド・バイオロジックス・リミテッド プログラム細胞死（ｐｄ－１）に対するシングルドメイン抗体
WO2018134279A1 (en) * 2017-01-18 2018-07-26 Pieris Pharmaceuticals Gmbh Novel fusion polypeptides specific for lag-3 and pd-1
WO2018134274A1 (en) 2017-01-18 2018-07-26 Pieris Pharmaceuticals Gmbh Lipocalin muteins with binding affinity for lag-3
WO2019092452A1 (en) 2017-11-13 2019-05-16 Crescendo Biologics Limited Molecules that bind to cd137 and psma
GB201802573D0 (en) 2018-02-16 2018-04-04 Crescendo Biologics Ltd Therapeutic molecules that bind to LAG3
KR20200136949A (ko) 2018-03-26 2020-12-08 4에스체 악티엔게젤샤프트 암 치료를 위한 hdac 억제제 및 cd137 작용제를 포함하는 배합물
CA3100119A1 (en) * 2018-07-31 2020-02-06 Pieris Pharmaceuticals Gmbh Fusion protein specific for cd137 and pd-l1
MX2021010039A (es) * 2019-02-26 2021-09-21 Pieris Pharmaceuticals Gmbh Novedosas proteinas de fusion especificas para cd137 y gpc3.
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JP2022530216A (ja) * 2019-04-23 2022-06-28 エルジー・ケム・リミテッド 免疫グロブリンのＦｃ領域およびＧＤＦ１５を含む融合ポリペプチド
CR20210687A (es) * 2019-06-25 2022-03-03 Gilead Sciences Inc PROTEÍNAS DE FUSIÓN FLT3L-Fc Y MÉTODOS DE USO
TWI860386B (zh) * 2019-07-30 2024-11-01 英商拜西可泰克斯有限公司 異質雙環肽複合物
WO2023036043A1 (zh) * 2021-09-09 2023-03-16 广东东阳光药业有限公司 抗癌结合分子及其应用
KR20250071257A (ko) * 2022-09-21 2025-05-21 씨젠 인크. Cd137 및 cd228에 특이적인 신규한 융합 단백질

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Also Published As

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DK3298030T3 (en) 2023-02-06
JP2018519803A (ja) 2018-07-26
AU2016262845A1 (en) 2018-01-04
HUE061108T2 (hu) 2023-05-28
US10913778B2 (en) 2021-02-09
SI3298030T1 (sl) 2023-05-31
RS64002B1 (sr) 2023-03-31
MX2017014716A (es) 2018-06-28
ZA201706061B (en) 2022-05-25
PL3298030T3 (pl) 2023-05-08
KR20180002855A (ko) 2018-01-08
DK3298030T5 (en) 2024-10-07
RU2017135539A (ru) 2019-06-18
RU2754466C2 (ru) 2021-09-02
US11919931B2 (en) 2024-03-05
JP6947642B2 (ja) 2021-10-13
CN108112253B (zh) 2022-09-23
EP4219535A1 (en) 2023-08-02
EP3298030A1 (en) 2018-03-28
EP3298030B1 (en) 2023-01-18
ES2938525T3 (es) 2023-04-12
WO2016184882A1 (en) 2016-11-24
US20180148485A1 (en) 2018-05-31
FI3298030T3 (fi) 2023-02-22
SMT202300026T1 (it) 2023-03-17
RU2017135539A3 (https=) 2019-11-29
SG11201707426SA (en) 2017-10-30
MX390894B (es) 2025-03-21
RU2021119777A (ru) 2021-08-16
CA2980838A1 (en) 2016-11-24
CN108112253A (zh) 2018-06-01
AU2016262845B2 (en) 2020-07-23
HRP20230145T1 (hr) 2023-04-28
US20210403516A1 (en) 2021-12-30
LT3298030T (lt) 2023-02-27
BR112017020445A2 (pt) 2018-07-03

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