JP2019518713A5 - - Google Patents
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- Publication number
- JP2019518713A5 JP2019518713A5 JP2018548878A JP2018548878A JP2019518713A5 JP 2019518713 A5 JP2019518713 A5 JP 2019518713A5 JP 2018548878 A JP2018548878 A JP 2018548878A JP 2018548878 A JP2018548878 A JP 2018548878A JP 2019518713 A5 JP2019518713 A5 JP 2019518713A5
- Authority
- JP
- Japan
- Prior art keywords
- trail
- polypeptide
- polypeptide chain
- amino acid
- monomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662309352P | 2016-03-16 | 2016-03-16 | |
| US62/309,352 | 2016-03-16 | ||
| US201662323501P | 2016-04-15 | 2016-04-15 | |
| US62/323,501 | 2016-04-15 | ||
| US201762445556P | 2017-01-12 | 2017-01-12 | |
| US62/445,556 | 2017-01-12 | ||
| PCT/US2017/022789 WO2017161173A1 (en) | 2016-03-16 | 2017-03-16 | Engineered trail for cancer therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019518713A JP2019518713A (ja) | 2019-07-04 |
| JP2019518713A5 true JP2019518713A5 (https=) | 2020-04-23 |
Family
ID=58413224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018548878A Pending JP2019518713A (ja) | 2016-03-16 | 2017-03-16 | 癌療法のための改変ｔｒａｉｌ |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20190077870A1 (https=) |
| EP (1) | EP3430034A1 (https=) |
| JP (1) | JP2019518713A (https=) |
| KR (1) | KR20180127407A (https=) |
| CN (1) | CN108884142A (https=) |
| AU (1) | AU2017234679A1 (https=) |
| CA (1) | CA3017622A1 (https=) |
| IL (1) | IL261267A (https=) |
| MX (1) | MX2018011219A (https=) |
| WO (1) | WO2017161173A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017066963A1 (zh) * | 2015-10-22 | 2017-04-27 | 成都华创生物技术有限公司 | 一种TRAIL双靶点突变蛋白MuR6S4TR、其制备方法及其应用 |
| AU2017283487A1 (en) * | 2016-06-13 | 2018-11-22 | Merrimack Pharmaceuticals, Inc. | Methods for selecting and treating patients with a trail-based therapeutic or death receptor agonist |
| CN109125709B (zh) * | 2018-08-23 | 2021-10-22 | 成都华创生物技术有限公司 | Trail突变体在制备治疗痤疮药物中的应用及一种制剂 |
| KR102764218B1 (ko) * | 2020-10-13 | 2025-02-11 | 신동준 | 반려견의 항암용 재조합 단백질 및 이를 포함하는 반려견을 위한 항암용 조성물 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1988007089A1 (en) | 1987-03-18 | 1988-09-22 | Medical Research Council | Altered antibodies |
| US5677425A (en) | 1987-09-04 | 1997-10-14 | Celltech Therapeutics Limited | Recombinant antibody |
| JPH0822239B2 (ja) * | 1988-07-07 | 1996-03-06 | 株式会社蛋白工学研究所 | 変異ヒト腫傷壊死因子 |
| WO1993022332A2 (en) | 1992-04-24 | 1993-11-11 | Board Of Regents, The University Of Texas System | Recombinant production of immunoglobulin-like domains in prokaryotic cells |
| AU691811B2 (en) | 1993-06-16 | 1998-05-28 | Celltech Therapeutics Limited | Antibodies |
| US6121022A (en) | 1995-04-14 | 2000-09-19 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
| US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
| JP4046354B2 (ja) | 1996-03-18 | 2008-02-13 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 増大した半減期を有する免疫グロブリン様ドメイン |
| US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| HU230769B1 (hu) | 1999-01-15 | 2018-03-28 | Genentech Inc. | Módosított effektor-funkciójú polipeptid-változatok |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| CN101633692A (zh) * | 1999-06-28 | 2010-01-27 | 杰南技术公司 | 利用二价金属离子制备Apo-2配体的方法 |
| HUP0204475A2 (en) | 2000-02-11 | 2003-04-28 | Merck Patent Gmbh | Enhancing the circulating half-life of antibody-based fusion proteins |
| US6725230B2 (en) | 2000-07-18 | 2004-04-20 | Aegis Analytical Corporation | System, method and computer program for assembling process data of multi-database origins using a hierarchical display |
| US20040002587A1 (en) | 2002-02-20 | 2004-01-01 | Watkins Jeffry D. | Fc region variants |
| US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
| US7317091B2 (en) | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
| EP1534335B9 (en) | 2002-08-14 | 2016-01-13 | Macrogenics, Inc. | Fcgammariib-specific antibodies and methods of use thereof |
| WO2004029207A2 (en) | 2002-09-27 | 2004-04-08 | Xencor Inc. | Optimized fc variants and methods for their generation |
| DE60334141D1 (de) | 2002-10-15 | 2010-10-21 | Facet Biotech Corp | VERÄNDERUNG VON FcRn-BINDUNGSAFFINITÄTEN ODER VON SERUMHALBWERTSZEITEN VON ANTIKÖRPERN MITTELS MUTAGENESE |
| JP2006524039A (ja) | 2003-01-09 | 2006-10-26 | マクロジェニクス，インコーポレーテッド | 変異型Ｆｃ領域を含む抗体の同定および作製ならびにその利用法 |
| US8101720B2 (en) | 2004-10-21 | 2012-01-24 | Xencor, Inc. | Immunoglobulin insertions, deletions and substitutions |
| GB0324368D0 (en) | 2003-10-17 | 2003-11-19 | Univ Cambridge Tech | Polypeptides including modified constant regions |
| GB0328261D0 (en) * | 2003-12-05 | 2004-01-07 | Univ Groningen | Improved cytokine design |
| CA2552788C (en) | 2004-01-12 | 2013-09-24 | Applied Molecular Evolution, Inc. | Fc region variants |
| EP1737890A2 (en) | 2004-03-24 | 2007-01-03 | Xencor, Inc. | Immunoglobulin variants outside the fc region |
| PL1776384T3 (pl) | 2004-08-04 | 2013-10-31 | Mentrik Biotech Llc | WARIANTY REGIONÓW Fc |
| GB0724532D0 (en) * | 2007-12-17 | 2008-01-30 | Nat Univ Ireland | Trail variants for treating cancer |
| DK2604693T3 (en) * | 2008-07-21 | 2016-05-30 | Apogenix Gmbh | Single-chain TNFSF molecules |
| CN102282168A (zh) | 2008-11-18 | 2011-12-14 | 梅里麦克制药股份有限公司 | 人血清白蛋白接头以及其结合物 |
| WO2010141329A1 (en) * | 2009-06-01 | 2010-12-09 | Medimmune, Llc | Molecules with extended half-lives and uses thereof |
| US8877687B2 (en) | 2010-04-26 | 2014-11-04 | Merrimack Pharmaceuticals | Assays for anti-drug antibodies in the presence of abundant endogenous protein counterpart of the drug |
| EP2468764A1 (en) * | 2010-12-24 | 2012-06-27 | Rijksuniversiteit te Groningen | TNF family ligand variants |
| US9822179B2 (en) * | 2011-04-01 | 2017-11-21 | Universitat Stuttgart | Recombinant TNF ligand family member polypeptides with antibody binding domain and uses therefor |
| CN111592601A (zh) * | 2011-07-06 | 2020-08-28 | 江苏靶标生物医药研究所有限公司 | 一种肿瘤靶向性肿瘤坏死因子相关凋亡配体变体及其应用 |
| NO2776305T3 (https=) * | 2014-04-23 | 2018-01-27 | ||
| US10428149B2 (en) * | 2015-03-18 | 2019-10-01 | Universitat Stuttgart | Single-chain tumor necrosis factor (TNF) ligand family molecules, fusion proteins and derivatives thereof |
-
2017
- 2017-03-16 CN CN201780016988.2A patent/CN108884142A/zh active Pending
- 2017-03-16 WO PCT/US2017/022789 patent/WO2017161173A1/en not_active Ceased
- 2017-03-16 MX MX2018011219A patent/MX2018011219A/es unknown
- 2017-03-16 EP EP17713861.7A patent/EP3430034A1/en not_active Withdrawn
- 2017-03-16 AU AU2017234679A patent/AU2017234679A1/en not_active Abandoned
- 2017-03-16 KR KR1020187029745A patent/KR20180127407A/ko not_active Withdrawn
- 2017-03-16 US US16/084,447 patent/US20190077870A1/en not_active Abandoned
- 2017-03-16 JP JP2018548878A patent/JP2019518713A/ja active Pending
- 2017-03-16 CA CA3017622A patent/CA3017622A1/en not_active Abandoned
-
2018
- 2018-08-21 IL IL261267A patent/IL261267A/en unknown
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