RU2015150263A - Способы лечения бактериальных инфекций - Google Patents
Способы лечения бактериальных инфекций Download PDFInfo
- Publication number
- RU2015150263A RU2015150263A RU2015150263A RU2015150263A RU2015150263A RU 2015150263 A RU2015150263 A RU 2015150263A RU 2015150263 A RU2015150263 A RU 2015150263A RU 2015150263 A RU2015150263 A RU 2015150263A RU 2015150263 A RU2015150263 A RU 2015150263A
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- Russia
- Prior art keywords
- mycobacterium
- staphylococcus
- streptococcus
- leptospira
- mycoplasma
- Prior art date
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- 229940115932 legionella pneumophila Drugs 0.000 claims 1
- 244000144972 livestock Species 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229940041009 monobactams Drugs 0.000 claims 1
- 229940055036 mycobacterium phlei Drugs 0.000 claims 1
- 206010033072 otitis externa Diseases 0.000 claims 1
- 229940051027 pasteurella multocida Drugs 0.000 claims 1
- 244000052769 pathogen Species 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 150000002960 penicillins Chemical class 0.000 claims 1
- 208000008494 pericarditis Diseases 0.000 claims 1
- 206010034674 peritonitis Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 150000002989 phenols Chemical class 0.000 claims 1
- 229940041153 polymyxins Drugs 0.000 claims 1
- 229940007042 proteus vulgaris Drugs 0.000 claims 1
- 208000020029 respiratory tract infectious disease Diseases 0.000 claims 1
- 229940046939 rickettsia prowazekii Drugs 0.000 claims 1
- 201000001223 septic arthritis Diseases 0.000 claims 1
- 229940007046 shigella dysenteriae Drugs 0.000 claims 1
- 229940115939 shigella sonnei Drugs 0.000 claims 1
- 229940037648 staphylococcus simulans Drugs 0.000 claims 1
- 229940115922 streptococcus uberis Drugs 0.000 claims 1
- 229940041030 streptogramins Drugs 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
- 229960003165 vancomycin Drugs 0.000 claims 1
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 claims 1
- MYPYJXKWCTUITO-LYRMYLQWSA-O vancomycin(1+) Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C([O-])=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)[NH2+]C)[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-O 0.000 claims 1
- 210000003905 vulva Anatomy 0.000 claims 1
- 229940098232 yersinia enterocolitica Drugs 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Claims (37)
1. Способ лечения или профилактики бактериальной колонизации или инфекции у субъекта, включающий стадию: введения субъекту терапевтически эффективного количества робенидина или его терапевтически приемлемой соли, причем указанная бактериальная колонизация или инфекция вызвана бактериальным агентом.
2. Способ по п. 1, отличающийся тем, что субъект выбран из группы, включающей: человека, животных, принадлежащих видам семейства псовых, кошачьих, крупного рогатого скота, овец, коз, свиней, птиц, рыб и лошадей.
3. Способ по п. 1, отличающийся тем, что робенидин вводят субъекту в дозе в диапазоне от 0,1 до 250 мг/кг массы тела.
4. Способ по любому из пп. 1-3, отличающийся тем, что бактериальный агент является грамположительным.
5. Способ по п. 4, отличающийся тем, что бактериальный агент выбран из группы, включающей: Abiotrophia defective, Acholeplasma spp., Actinobaculum suis, Actinomyces bovis, Actinomyces europaeus, Actinomyces georgiae, Actinomyces gerencseriae, Actinomyces graevenitzii, Actinomyces hordeovulneris, Actinomyces israelii серотип II, Actinomyces israelii, Actinomyces meyeri, A ctinomyces naeslundii, Actinomyces neuii, Actinomyces odontolyticus, Actinomyces radingae, Actinomyces spp, Actinomyces turicensis, Actinomyces viscosus, Alloscardovia omnicolens, Anaerococcus hydrogenalis, Anaerococcus lactolyticus, Anaerococcus murdochii, Anaerococcus octavius, Anaerococcus prevotii, Anaerococcus tetradius, Anaerococcus vaginalis, Arcanobacterium (Actinomyces) bernardiae, Arcanobacterium (Actinomyces) pyogenes, Arcanobacterium bernardiae, Arcanobacterium cardiffensis, Arcanobacterium funkei, Arcanobacterium haemolyticum, Arcanobacterium houstonensis, Arcanobacterium lingnae, Arcanobacterium pyogenes (Actinomyces pyogenes), Arthrobacter, Atopobium minutum, Atopobium parvulum, Atopobium rimae, Atopobium spp, Atopobium vaginae, Bacillus anthracis, Bacillus cereus, Bacillus circulans, Bacillus licheniformis, Bacillus megaterium, Bacillus melaninogenicus, Bacillus pumilus, Bacillus sphaericus, Bacillus subtilis, beta haemolytic Steptococcus spp, Bifidobacteria adolescentis, Bifidobacteria dentium, Bifidobacteria scardovii, Bifidobacteria, Brevibacillus brevis, Brevibacillus laterosporus, Brevibacterium, Bulleidia extructa, Catabacter hongkongensis, коринеформные бактерии CDC групп F-1 и G, Clostridium tetani, Clostridium baratii, Clostridium bifermentans, Clostridium botulinum (типы А, В, C, D, E, F, G), Clostridium botulinum, Clostridium butyricum, Clostridium chauvoei, Clostridium colinum, Clostridium difficile, Clostridium haemolyticum, Clostridium histolyticum, Clostridium novyi тип A, Clostridium novyi тип В, Clostridium novyi, Clostridium perfringens тип A, Clostridium perfringens типы A-E, Clostridium perfringens, Clostridium piliforme, Clostridium ramosum, Clostridium septicum, Clostridium sordelli, Clostridium sphenoides, Clostridium spiroforme, Clostridium spp, Clostridium tertium, Clostridium tetani, Collinsella aerofaciens, Corynebacterium accolens, Corynebacterium afermentans afermentans, Corynebacterium afermentans lipophilum, Corynebacterium amycolatum, Corynebacterium argentoratense, Corynebacterium aurimucosum, Corynebacterium auris, Corynebacterium bovis, Corynebacterium confusum, Corynebacterium cystidis, Corynebacterium diphtheria, Corynebacterium freneyi, Corynebacterium glucuronolyticum, Corynebacterium jeikeium, Corynebacterium kroppenstedtii, Corynebacterium kutscheri, Corynebacterium lipophiloflavum, Corynebacterium macginleyi, Corynebacterium matruchotii, orynebacterium minutissimum, Corynebacterium pilosum, Corynebacterium propinquum, Corynebacterium pseudodiphtheriticum, Corynebacterium pseudotuberculosis, Corynebacterium renale, Corynebacterium riegelii, Corynebacterium simulans, Corynebacterium striatum, Corynebacterium sundvallense, Corynebacterium thomssensii, Corynebacterium tuberculostearum, Corynebacterium ulcerans, Corynebacterium urealyticum, Corynebacterium xerosis, Crossiella equi, Dermabacter, Dermatophilus congolense, Dermatophilus congolensis, Eggerthella brachy, Eggerthella hongkongensis, Eggerthella infirmum, Eggerthella lenta, Eggerthella minutum, Eggerthella nodatum, Eggerthella saphenum, Eggerthella sinensis, Eggerthella sulci, Eggerthella tenue, Eggerthella, Enterococcus avium, Enterococcus bovis, Enterococcus casseliflavus/flavescens, Enterococcus cecorum, Enterococcus dispar, Enterococcus durans, Enterococcus faecalis, Enterococcus faecium, Enterococcus gallinarum, Enterococcus gilvus, Enterococcus hirae, Enterococcus italicus, Enterococcus malodoratus, Enterococcus mundtii, Enterococcus pallens, Enterococcus pseudoavium, Enterococcus raffinosus, Enterococcus sanguinicola, Enterococcus spp, Erysipelothrix rhusiopathiae, Eubacterium, Filifactor alocis, Finegoldia magna, Gallicola bamesae, Gemella asaccharolytica, Gemella bergeri, Gemella cuniculi, Gemella haemolysans, Gemella morbillorum, Gemella palaticanis, Gemella sanguinis, Gordonia spp., Granulicatella adiacens, Granulicatella elegans, Granulicatella para-adiacens, Kytococcus schroeteri, Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus fermentum, Lactobacillus gasseri, Lactobacillus iners, Lactobacillus plantarum, Lactobacillus rhamnosus, Lactobacillus species, Lactobacillus ultunensis, Leifsonia aquatic, Leuconostoc citreum, Leuconostoc lactis, Leuconostoc mesenteroides, Leuconostoc paramesenteroides, Leuconostoc pseudomesenteroides, Listeria grayi, Listeria innocua, Listeria ivanovii, Listeria monocytogenes, Listeria seeligeri, Listeria welshimeri, Microbacterium, M obiluncus curtisii, Mobiluncus mulieris, Mobiluncus spp, Mogibacterium timidum, Mogibacterium vescum, Moryella indoligenes, Mycobacterium senegalense, Mycobacterium abscessus, Mycobacterium africanum, Mycobacterium arupense, Mycobacterium asiaticum, Mycobacterium aubagnense, Mycobacterium avium complex, Mycobacterium avium subsp paratuberculosis, Mycobacterium avium, Mycobacterium bolletii, Mycobacterium bovis, Mycobacterium branderi, Mycobacterium canettii, Mycobacterium caprae, Mycobacterium celatum, Mycobacterium chelonae, Mycobacterium chimaera, Mycobacterium colombiense, Mycobacterium conceptionense, Mycobacterium conspicuum, Mycobacterium elephantis, Mycobacterium farcinogenes, Mycobacterium florentinum, группа Mycobacterium fortuitum, Mycobacterium genavense, Mycobacterium goodii, Mycobacterium haemophilum, Mycobacterium heckeshornense, Mycobacterium heidelbergense, Mycobacterium houstonense, Mycobacterium immunogenum, Mycobacterium interjectum, Mycobacterium intracellulars, Mycobacterium kansasii, Mycobacterium lacus, Mycobacterium lentiflavum, Mycobacterium leprae, Mycobacterium lepraemurium, Mycobacterium mageritense, Mycobacterium malmoense, Mycobacterium marinum, Mycobacterium massiliense, Mycobacterium microti, Mycobacterium montefiorense (угри), Mycobacterium moracense, Mycobacterium mucogenicum, Mycobacterium nebraskense, Mycobacterium neoaurum, Mycobacterium novocastrense, Mycobacterium palustre, Mycobacterium paratuberculosis (болезнь Джона,), Mycobacterium parmense, Mycobacterium phlei, Mycobacterium phocaicum, Mycobacterium pinnipedii, Mycobacterium porcinum, Mycobacterium pseudoshottsii (рыбы,), Mycobacterium pseudotuberculosis, Mycobacterium saskatchewanense, Mycobacterium scrofulaceum, Mycobacterium senuense, Mycobacterium septicum, Mycobacterium simiae, Mycobacterium smegmatis, Mycobacterium spp, Mycobacterium szulgai, Mycobacterium terrae/chromogenicum complex, Mycobacterium triplex, Mycobacterium tuberculosis, Mycobacterium tusciae, Mycobacterium ulcerans, Mycobacterium wolinskyi, Mycobacterium xenopi, Mycobacterium, Nocardia asteroides, Nocardia brasiliensis, Nocardia farcinica, Nocardia nova, Nocardia otitidiscaviarum, Nocardia spp, Nocardia transvalensis, Oerskovia, Olsenella oral spp, Olsenella profuse, Olsenella uli, Oribacterium sinus, Paenibacillus alvei, Parvimonas micra, Pediococcus, Peptococcus indolicus, Peptococcus niger, Peptoniphilus asaccharolyticus, Peptoniphilus gorbachii, Peptoniphilus harei, Peptoniphilus indolicus, Peptoniphilus ivorii, Peptoniphilus lacrimalis, Peptoniphilus olsenii, Peptostreptococcus anaerobius, Peptostreptococcus stomatis, Propionibacterium acnes, Propionibacterium granulosum, Propionibacterium propionicum, Propionibacterium, Pseudoramibacter alactolyticus, Rhodococcus equi, Rhodococcus erythropolis, Rhodococcus fasciens, Rhodococcus rhodochrous, Rothia, Ruminococcus productus, Slackia exigua, Slackia heliotrinireducens, Solobacterium moorei, Staphylococcus ariettae, Staphylococcus aureus subsp.anaerobius, Staphylococcus aureus, Staphylococcus auricularis, Staphylococcus capitis subsp.capitis, Staphylococcus capitis subsp. urealyticus, Staphylococcus capitis, Staphylococcus caprae, Staphylococcus camosus, Staphylococcus caseolyticus, Staphylococcus chromogenes, Staphylococcus cohnii subsp.cohnii, Staphylococcus cohnii subsp. urealyticus, Staphylococcus cohnii, Staphylococcus condimenti, Staphylococcus delphini, Staphylococcus epidermidis, Staphylococcus equorum, Staphylococcus felis, Staphylococcus fleurettii, Staphylococcus gallinarum, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus hyicus, Staphylococcus intermedius, Staphylococcus kloosii, Staphylococcus lentus, Staphylococcus lugdunensis, Staphylococcus lutrae, Staphylococcus muscae, Staphylococcus nepalensis, Staphylococcus pasteuri, Staphylococcus pettenkoferi, Staphylococcus piscifermentans, Staphylococcus pseudintermedius, Staphylococcus pulvereri, Staphylococcus saccharolyticus, Staphylococcus saprophytics, Staphylococcus schleiferi subsp.coagulans, Staphylococcus schleiferi, Staphylococcus sciuri, Staphylococcus simiae, Staphylococcus simulans, Staphylococcus spp, Staphylococcus succinus, Staphylococcus vitulinus, Staphylococcus wameri, Staphylococcus xylosus, Staphylococcus vitulinus, Stomatococcus mucilaginosus (в соответствии с новой классификацией - Rothia mucilaginosa), Streptococcus agalactiae, видовая группа Streptococcus anginosus (Streptococcus intermedius, Streptococcus constellatus и Streptococcus anginosus), видовая группа Streptococcus bovis (S. gallolyticus subsp.gallolyticus (ранее S. Bovis биотип I), Streptococcus bovis, Streptococcus canis, Streptococcus dysgalactiae subsp.dysgalactiae, S. equi subsp. equi, S. equi subsp. zooepidemicus, S. porcinus, S. canis, S. suis, S. iniae), Streptococcus dysgalactiae subsp. equisimilis, Streptococcus dysgalactiae, Streptococcus equi (Streptococcus equi subsp equi), Streptococcus equi subsp. zooepidemicus, Streptococcus equi, Streptococcus equinus, Streptococcus equisimilis (Streptococcus dysgalactiae subsp equisimilis), Streptococcus gallolyticus subsp.pasteurianus (formerly S. bovis биотип II/2), Streptococcus infantarius subsp Infantarius, Streptococcus lutetiensis (ранее S. bovis биотип II/1), видовая группа Streptococcus mitis (S. cristatus, S. infantis, S. mitis, S. oralis, S. peroris, S. orisratti) и видовая группа Streptococcus mutans (S. cricetus, S. downei, S. ferus, S. hyovaginalis, S. macaccae, S. mutans, S. ratti, S. sobrinus, Sanguinis Group, S. gordonii, S. parasanguinis, S. sanguinis), Streptococcus pneumoniae, Streptococcus porcinus, Streptococcus pyogenes, видовая группа Streptococcus salivarius (S. alactolyticus, S. hyointestinalis, S. infantarius, S. salivarius, S. thermophilus, S. vestibularis), Streptococcus spp, Streptococcus suis, Streptococcus uberis, Streptococcus zooepidemicus (Streptococcus equi subsp zooepidemicus), Streptococcus zooepidemicus, Trueperella abortisuis, Trueperella bernardiae, Trueperella bialowiezensis, Trueperella bonasi, Trueperella pyogenes (Arcanobacterium pyogenes), Tsukamurella spp., Turicellan Turicibacter sanguine.
6. Способ по п. 5, отличающийся тем, что бактериальный агент выбран из группы, включающей: Staphylococcus aureus, Staphylococcus pseudintermedius, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Enterococcus faecium, Enterococcus faecalis, and Clostridium difficile.
7. Способ по любому из пп. 1-3, отличающийся тем, что бактериальный агент является грамотрицательным.
8. Способ по п. 7, отличающийся тем, что бактериальный агент выбран из группы, включающей: Acetobacteraceae: -- Roseomonas cervicalis; Roseomonas faunae; Roseomonas gilardii. -Aeromonadaceae: - Aeromonas allosaccharophila; Aeromonas aquariomm; Aeromonas caviae; Aeromonas hydrophila (и подвиды); Aeromonas salmonicida; Aeromonas shubertii; Aeromonas veronii biovar sobria (Aeromonas sobria). - Alcaligenaceae: - Achromobacter xylosoxidans; Alcaligenes faecalis; Bordetella ansorpii; Bordetella avium; Bordetella bronchiseptica; Bordetella hinzii; Bordetella holmesii; Bordetella parapertussis; Bordetella pertussis; Bordetella petrii; Bordetella trematum; Oligella ureolytica; Oligella urethralis. -- Anaplasmataceae: - Anaplasma phagocytophilum; Anaplasma platys; Anaplasma bovis; Anaplasma centrale; Anaplasma marginale; Anaplasma odocoilei; Anaplasma ovis; Ehrlichia canis; Ehrlichia chaffeensis; Ehrlichia ewingii; Ehrlichia muris; Ehrlichia ovina; Ehrlichia ruminantium; Neoehrlichia lotoris; Neoehhichia mikurensis; Neorickettsia helminthoeca; Neorickettsia risticii; Neorickettsia sennetsu; Wolbachia pipientis. -- Armatimonadaceae: - Armatimonas rosea. -- Bacteroidaceae: - Bacteroides forsythus; Bacteroides fragilis; Bacteroides melaninogenicus; Bacteroides ruber; Bacteroides urealtyicus. -- Bartonellaceae: - Bartonella alsatica; Bartonella australis; Bartonella bacilliformis; Bartonella birtlesii; Bartonella bovis; Bartonella capreoli; Bartonella chomelii; Bartonella clarridgeiae; Bartonella doshiae; Bartonella elizabethae; Bartonella grahamii; Bartonella henselae; Bartonella koehlerae; Bartonella peromysci; Bartonella phoceensis; Bartonella quintana; Bartonella rattimassiliensis; Bartonella rochalimae; Bartonella schoenbuchensis; Bartonella talpae; Bartonella tamiae; Bartonella taylorii; Bartonella tribocorum; Bartonella vinsonii subsp.berkhoffii; Bartonella vinsonii subsp.arupensis; Bartonella vinsonii subsp.vinsonii. - Bdellovibrionaceae: - Bdellovibrio spp. -- Brachyspiraceae: -Brachyspira spp including Brachyspira hampsonii, Brachyspira hyodysenteriae, Brachyspira murdochii, Brachyspira pilosicoli. -- Brucellaceae: - Brucella abortus; Brucella canis; Brucella ceti; Brucella melitensis; Brucella ovis; Brucella pinnipedialis; Brucella suis; Ochrobactrum anthropi; Ochrobactrum intermedium. -- Burkholderiaceae: - Burkholderia aborts; Burkholderia ambifaria (genomovar VII); Burkholderia anthina (геномовар VIII); Burkholderia cenocepacia (геномовар III); Burkholderia cepacia (genomovar I); Burkholderia diffusa; Burkholderia dolosa (геномовар VI); Burkholderia latens; Burkholderia mallei; Burkholderia metallica; Burkholderia multivorans (геномовар II); Burkholderia pseudomallei; Burkholderia pyrrocinia (геномовар IX); Burkholderia seminalis; Burkholderia stabilis (геномовар IV); Burkholderia ubonensis (геномовар X); Burkholderia vietnamiensis (геномовар V); Cupriavidus pauculus; Cupriavidus gilardii; Ralstonia pickettii; Ralstonia mannitolilytica; Sphaerotilus hippei; Sphaerotilus montanus; Sphaerotilus natans. -- Campylobacteraceae: - Arcobacter spp includng Arcobacter skirrowii; Campylobacter coli; Campylobacter concisus; Campylobacter curvus; Campylobacter fetus; Campylobacter gracilis; Campylobacter helveticus; Campylobacter hominis; Campylobacter hyointestinalis; Campylobacter insulaenigrae; Campylobacter jejuni; Campylobacter lanienae; Campylobacter Ian; Campylobacter laridis; Campylobacter mucosalis; Campylobacter rectus; Campylobacter showae; Campylobacter sputorum; Campylobacter upsaliensis. -- Candidatus: - Piscichlamydia salmonis. --Cardiobacteiiaceae: - Cardiobacterium hominis; Cardiobacterium valvarum; Dichelobacter nodosus. -- Chlamydiaceae: - Chlamydia spp, в том числе Chlamydia avium, Chlamydia gallinacea, Chlamydia muridarum, Chlamydia suis, Chlamydia trachomatis; Chlamydophila spp, в том числе Chlamydophila pneumoniae, Chlamydophila pecorum, Chlamydophila psittaci, Chlamydophila abortus, Chlamydophila caviae и Chlamydophila felis. -- Chthonomonadaceae: - Chthonomonas calidirosea. -- Comamonadaceae: - Comamonas testosteroni; Verminephrobacter spp. --Coxiellaceae: - Coxiella burnetii. -- Cytophagaceae: - Cytophaga columnaris; Cytophaga hutchinsonii; Flexibacter echinicida; Flexibacter elegans; Flexibacter flexilis; Flexibacter litoralis; Flexibacter polymorphus; Flexibacter roseolus; Flexibacter ruber. - Desulfovibrionaceae: - Bilophila wadsworthia; Lawsonia intracellularis. -- Enterobacteriaceae: - Cedecea davisae; Cedecea lapagei; Cedecea neteri; amalonaticus; Citrobacter diversus; Citrobacter freundii; Citrobacter koseri; Cronobacter condimenti; Cronobacter dublinensis; Cronobacter helveticus; Cronobacter malonaticus; Cronobacter muytjensii; Cronobacter pulveris; Cronobacter sakazakii; Cronobacter turicensis; Cronobacter universalis; Cronobacter zurichensis; Edwardsiella ictaluri; Edwardsiella tarda; Enterobacter aerogenes; Enterobacter agglomerans; Enterobacter cloacae; Enterobacter cowanii; Escherichia albertii; Escherichia coli, в том числе AIEC = адгезивно-инвазивные E. coli, EaggEC = энтероагрегативные E. coli; EHEC = энтерогеморрагические E. coli; EIEC = энтероинвазивные E. coli; EPEC = энтеропатогенные E. coli; ETEC=энтеротоксигенные E. coli; ExPEC = внекишечные патогенные E. coli, NMEC = E. coli неонатального менингита, NTEC = некротоксигенные E. coli, UPEC = уропатогенные E. coli.; Escherichia fergusonii; Ewingella americana; Hafnia atvei; Hafnia paralvei; Klebsiella granulomatis; Klebsiella oxytoca; Klebsiella pneumoniae; Kluyvera ascorbata; Kluyvera cryocrescens; Morganella morganii; Pantoea (ранее Enterobacter) agglomerans; Photorhabdus asymbiotica; Plesiomonas shigelloides; Proteus mirabilis; Proteus penneri; Proteus vulgaris; Providencia alcalifaciens; Providencia rettgeri; Providencia stuartii; Raoultella electrica; Raoultella ornithinolytica; Raoultella planticola; Raoultella terrigena; Salmonella bongori, Salmonella enterica subspecies enterica (многие серотипы); Serratia liquifaciens; Serratia marcesans; Shigella boydii; Shigella dysenteriae; Shigella flexneri; Shigella sonnei; Yersinia enterocolitica; Yersinia pestis; Yersinia pseudotuberculosis; Yersinia ruckeri. -- Fimbriimonadaceae: - Fimbriimonas ginsengisoli. -- Flavobactehaceae: - Bergeyella zoohelcum; Capnocytophaga canimorsus; Capnocytophaga cynodegmi; Capnocytophaga gingivalis; Capnocytophaga granulosa; Capnocytophaga haemolytica; Capnocytophaga leadbetteh; Capnocytophaga ochracea; Capnocytophaga sputigena; Chryseobacterium indologenes; Chryseobacterium piscicola; Elizabethkingia meningoseptica; Flavobacterium branchiophilum; Flavobacterium columnare; Flavobacterium oncorhynchi; Flavobacterium piscicida; Flavobacterium psychrophilum; Myroides odoratus; Myroides odoratimimus; Ornithobacterium rhinotracheale; Riemerella anatipestifer; Riemerella columbina; Riemerella columbipharyngis; Tenacibaculum dicentrarchi; Tenacibaculum discolour; Tenacibaculum gallaicum; Tenacibaculum maritimum; Tenacibaculum soleae; Weeksella virosa. -- Francisellaceae: - Francisella tularensis subsp. tularensis; Francisella tularensis subsp. holarctica; Francisella tularensis subsp.novicida; Francisella philomiragia; Francisella noatunensis; Francisella noatunensis subsp.orientalis (также известный как Francisella asiatica). -- Fusobacteriaceae; - Fusobacterium spp., в том числе Fusobacterium necrophorum, Fusobacterium nucleatum, Fuso-bacterium polymorphum. -- Helicobacteraceae: - Helicobacter cinaedi; Helicobacter fennelliae; Helicobacter pylori. -- Legionellaceae: - Legionella pneumophila и другие виды, в том числе Legionella anisa; Legionella birminghamensis; Legionella bozemannii; Legionella cincinnatiensis; Legionella dumoffii; Legionella feeleii; Legionella gormanii; Legionella hackeliae; Legionella jordanis; Legionella lansingensis; Legionella longbeachae; Legionella maceachemii; Legionella micdadei; Legionella oakridgensis; Legionella parisiensis; Legionella sainthelens; Legionella tusconensis; Legionella wadsworthii; Legionella waltersii. -- Leptospiraceae: - Leptospira alexanderi (в том числе Leptospira alexanderi серовар Hebdomadis, Leptospira alexanderi серовар Manhao 3); Leptospira alstoni (в том числе Leptospira alstoni серовар Pingchang, Leptospira alstoni серовар Sichuan); Leptospira biflexa (в том числе Leptospira biflexa серовар Ancona, Leptospira biflexa серовар Canela); Leptospira borgpetersenii (в том числе Leptospira borgpetersenii серовар Hardjo, Leptospira borgpetersenii серовар Hardjo-bovis, Leptospira borgpetersenii серовар Pomona, Leptospira borgpetersenii серовар Tarassovi); Leptospira broomii (в том числе Leptospira broomii серовар Hurstbridge); Leptospira fainei (в том числе Leptospira fainei серовар Hurstbridge); Leptospira idonii; Leptospira inadai (в том числе Leptospira inadai серовар Lyme, Leptospira inadai серовар Malaya); Leptospira interrogans (в том числе Leptospira interrogans серовар Australis, Leptospira interrogans серовар Autumnalis, Leptospira interrogans серовар Bratislava, Leptospira interrogans серовар Canicola, Leptospira interrogans серовар Grippotyphosa, Leptospira interrogans серовар Hardjo, Leptospira interrogans серовар Hardjo-bovis, Leptospira interrogans серовар Icterohaemorrhagiae, Leptospira interrogans серовар Pomona, Leptospira interrogans серовар Pyrogenes, Leptospira interrogans серовар Tarassovi); Leptospira kirschneri (including Leptospira kirschneri serovar Bulgarica, Leptospira kirschneri serovar Cynopteri, Leptospira kirschneri serovar Grippotyphosa); Leptospira kmetyi; Leptospira licerasiae; Leptospira meyeri (в том числе Leptospira meyeri серовар Sofia); Leptospira noguchii (в том числе Leptospira noguchii серовар Panama, Leptospira noguchii серовар Pomona); Leptospira santarosai; Leptospira terpstrae; Leptospira vanthielii; Leptospira weilii (в том числе Leptospira weilii серовар Celledoni, Leptospira weilii серовар Sarmin); Leptospira wolbachii; Leptospira wolffii; Leptospira yanagawae. -- Leptotrichiaceae: - Leptotrichia buccalis; Streptobacillus moniliformis. -- Methylobacteriaceae: - группа Methylobacterium extorquens; Methylobacterium fujisawaense; Methylobacterium mesophilicum; Methylobacterium zatmanii. -- Moraxellaceae: -Acinetobacter baumannii (геномный вид 2); Acinetobacter baylyi; Acinetobacter bouvetii; Acinetobacter calcoaceticus (геномный вид 1); Acinetobacter gerneri; Acinetobacter grimontii; Acinetobacter haemolyticus (геномный вид 4); Acinetobacter johnsonii (геномный вид 7); Acinetobacter junii (геномный вид 5); Acinetobacter Iwoffi (геномный вид 8/9); Acinetobacter parvus; Acinetobacter radioresistens (геномный вид 12); Acinetobacter schindleri; Acinetobacter tandoii; Acinetobacter tjernbergiae; Acinetobacter towneri; Acinetobacter ursingii; Acinetobacter venetianus; Moraxella atlantae; Moraxella boevrei; Moraxella bovis; Moraxella bovoculi; Moraxella canis; Moraxella caprae; Moraxella catarrhalis; Moraxella caviae; Moraxella cuniculi; Moraxella equi; Moraxella lacunata; Moraxella lincolnii; Moraxella macacae; Moraxella nonliquefaciens; Moraxella oblonga; Moraxella osloensis; Moraxella ovis; Moraxella phenylpyruvica; Moraxella pluranimalium; Moraxella porci. -- Moritellaceae:- Moritella abyssi; Moritella dasanensis; Moritella japonica; Moritella marina; Moritella pro-funda; Moritella viscosa; Moritella yayanosii. -- Neisseriaceae: - Chromobacterium violaceum; Eikenella corrodens; Kingella denitrificans, Kingella kingae, Kingella oralis, Kingella potus; Neisseria cinerea; Neisseria elongate; Neisseria flavescens; Neisseria gonorrhoeae; Neisseria lactamica; Neisseria meningitidis; Neisseria mucosa; Neisseria polysaccharea; Neisseria sicca; Neisseria subflava; Neisseria weaver; Vitreoscilla spp. --Nitrosomonadaceae: - Nitrosomonas eutropha; Nitrosomonas halophila; Nitrosomonas oligotropha. -- Pasteurellaceae: - Actinobacillus actinomycetemcomitans; Actinobacillus equuli; Actinobacillus lignieresii; Actinobacillus pleuropneumoniae; Actinobacillus seminis; Actinobacillus succinogenes; Actinobacillus ureae; Aggregatibacter actinomycetemcomitans, Aggregatibacter segnis, Aggregatibacter aphrophilus; Avibacterium avium; Avibacterium endocarditidis; Avibacterium gallinarum; Avibacterium paragallinarum; Avibacterium volantium; Bibersteinia trehalose; Gallibacterium anatis; Gallibacterium геномный вид 1; Gallibacterium геномный вид 2; Gallibacterium геномный вид 3; Gallibacterium группа V; Gallibacterium melopsittaci; Gallibacterium salpingitidis; Gallibacterium trehalosifermentans; Haemophilus aegyptius; Haemophilus avium; Haemophilus ducreyi; Haemophilus haemolyticus; Haemophilus influenzae; Haemophilus parahaemolyticus; Haemophilus parainfluenzas; Haemophilus parasuis; Histophilus somni; Mannheimia caviae; Mannheimia glucosida; Mannheimia granulomatis; Mannheimia haemolytica; Mannheimia ruminalis; Mannheimia varigena; Nicoletella semolina; Pasteurella aerogenes; Pasteurella bettyae; Pasteurella caballi; Pasteurella canis; Pasteurella dagmatis; Pasteurella multocida (подвиды multocida, septicum, gallicida); Pasteurella pneumotropica; Pasteurella stomatis; Pasteurella trehalosi. -- Piscirickettsiaceae: - Piscirickettsia salmonis. -- Plesiomonadaceae: - Plesiomonas shigelloides. -- Polyangiaceae: - Sorangium cellulosum. -- Porphyromonadaceae: - Dysgonomonas capnocytophagoides; Dysgonomonas gadei; Dysgonomonas hofstadii; Dysgonomonas mossii; Dysgonomonas oryzarvi; Dysgonomonas wimpennyi; Porphyromonas gingivalis. -- Prevotellaceae: - Prevotella spp., в том числе Prevotella intermedia, Prevotella melaninogenica. -- Pseudomonadaceae: - Chryseomonas luteola; Pseudomonas aeruginosa; Pseudomonas luteola; Pseudomonas fluorescens; Pseudomonas putida; Pseudomonas stutzeri; Pseudomonas oryzihabitans. -- Rhizobiaceae: - Agrobacterium tumefaciens; Rhizobium radiobacter. -- Rickettsiaceae: - Orientia chuto; Orientia tsutsugamushi; Rickettsia aeschlimannii; Rickettsia africae; Rickettsia akari; Rickettsia argasii; Rickettsia asiatica; Rickettsia australis; Rickettsia bellii; Rickettsia canadensis; Rickettsia conorii; Rickettsia cooleyi; Rickettsia felis; Rickettsia heilongjiangensis; Rickettsia helvetica; Rickettsia honei; Rickettsia hoogstraalii; Rickettsia hulinensis; Rickettsia hulinii; Rickettsia japonica; Rickettsia marmionii; Rickettsia martinet; Rickettsia massiliae; Rickettsia monacensis; Rickettsia montanensis; Rickettsia monteiroi; Rickettsia moreli; Rickettsia parkeri; Rickettsia peacockii; Rickettsia philipii; Rickettsia prowazekii; Rickettsia raoultii; Rickettsia rhipicephali; Rickettsia lickettsii; Rickettsia sibirica subgroup; Rickettsia slovaca; Rickettsia tamurae; Rickettsia typhi. -- Shewanellaceae:- Shewanella putrefaciens. -- Sphingomonadaceae: - Sphingobacterium multivorum; Sphingobacterium spiritivorum; Sphingomonas paucimobilis. -- Spirillaceae: - Spirillum minus; Spirillum volutans; Spirillum winogradskyi. -- Spirochaetaceae: - Borrelia afzelii; Borrelia anserine; Borrelia bissettii; Borrelia burgdorferi; Borrelia coriaceae; Borrelia duttonii; Borrelia garinii; Borrelia hermsii; Borrelia hispanica; Borrelia japonica; Borrelia lonestari; Borrelia lusitaniae; Borrelia miyamotoi; Borrelia parkeri; Borrelia persica; Borrelia recurrentis; Borrelia spielmanii; Borrelia turicatae; Borrelia turicatae; Borrelia valaisiana; Treponema carateum; Treponema pallidum ssp. endemicum; Treponema pallidum ssp. pallidum; Treponema pallidum ssp. pertenue. -- Succinivibrionaceae: - Anaerobiospirillum spp. -- Sutterellaceae: - Sutterella spp including Sutterella wadsworthia. -- Thermaceae: - Meiothermus spp. -- Thermotogaceae: - Thermotoga neapolitana. -- Veillonellaceae: - Dialister spp; Megamonas spp; Megasphaera spp; Pectinatus spp; Pelosinus spp; Propionispora spp; Sporomusa spp; Veillonella spp.; Zymophilus spp. -- Vibrionaceae: - Photobacterium damselae; Vibrio adaptatus; Vibrio alginolyticus; Vibrio azasii; Vibrio campbellii; Vibrio cholera; Vibrio damsel; Vibrio fluvialis; Vibrio furnisii; Vibrio hollisae; Vibrio metchnikovii; Vibrio mimicus; Vibrio parahaemolyticus; Vibrio vulnificus. -- Wolbachieae: - Wolbachia spp. -- Xanthomonadaceae: - Luteimonas aestuarii; Luteimonas aquatica; Luteimonas composti; Luteimonas lutimaris; Luteimonas marina; Luteimonas mephitis; Luteimonas vadosa; Pseudoxanthomonas broegbemensis; Pseudoxanthomonas japonensis; Stenotrophomonas maltophilia и Stenotrophomonas nitritireducens.
9. Способ по п. 8, отличающийся тем, что бактериальный агент выбран из группы, включающей: виды Aeromonas hydrophila, виды Citrobacter, виды Enterobacter, Escherichia coli, Klebsiella pneumoniae, Morganella morganii, Pseudomonas aeruginosa и Stenotrophomonas maltophilia.
10. Способ по любому из пп. 1-3, 5, 6, 8 и 9, отличающийся тем, что робенидин вводят вместе с соединением, которое уменьшает целостность клеточной стенки бактериального агента.
11. Способ по любому из пп. 1-3, отличающийся тем, что бактериальный агент не имеет клеточной стенки.
12. Способ по п. 11, отличающийся тем, что бактериальный агент выбран из группы, включающей: Mycoplasma spp, Mycoplasma agalactiae, Mycoplasma alkalescens, Mycoplasma amphoriforme, Mycoplasma arginini, Mycoplasma bovigenitalum, Mycoplasma bovirhinis, Mycoplasma bovis, Mycoplasma bovoculi, Mycoplasma buccale, Mycoplasma californicum, Mycoplasma canadense, Mycoplasma capricolum subsp.capricolum, Mycoplasma capricolum subsp.capripneumoniae, Mycoplasma conjunctivae, Mycoplasma cynos, Mycoplasma dispar, Mycoplasma equigenitalium, Mycoplasma faucium, Mycoplasma felis, Mycoplasma fermentans (incognitus str.), Mycoplasma gallisepticum (MG), Mycoplasma gateae, Mycoplasma genitalium, Mycoplasma haemocanis, Mycoplasma haemofelis, Mycoplasma haemosuis (ранее Eperythrozoon suis), Mycoplasma hominis, Mycoplasma hyopneumoniae, Mycoplasma hyorhinis, Mycoplasma hyosynoviae, Mycoplasma iowae meleagridis (MM), Mycoplasma iowae, Mycoplasma leachii, Mycoplasma lipophilum, Mycoplasma meleagridis, Mycoplasma mycoides subsp capri, Mycoplasma mycoides subsp mycoides, Mycoplasma mycoides subsp.mycoides (например, возбудитель контагиозной плевропневмонии крупного рогатого скота, СВРР), Mycoplasma orale, Mycoplasma ovipneumoniae, Mycoplasma ovis, Mycoplasma penetrans, Mycoplasma pirum, Mycoplasma pneumoniae, Mycoplasma primatum, Mycoplasma putrefaciens, Mycoplasma salivarium, Mycoplasma spermatophilum, Mycoplasma suis, Mycoplasma synoviae (MS), Mycoplasma wenyonii, Mycoplasma, Ureaplasma spp, Ureaplasma parvum, Ureaplasma urealyticum, Ureaplasma и Ureoplasma diversum.
13. Способ по любому из пп. 1-3, 5, 6, 8, 9 и 12, отличающийся тем, что бактериальный агент является грамположительным, грамотрицательным или не имеет клеточной стенки, и указанный бактериальный агент выбран из группы, включающей, но не ограниченной перечисленными, следующие патогены домашнего скота: Actinobaculum suis, Actinomyces bovis, Arcanobacterium pyogenes, Bacillus anthracis, cereus, licheniformis, pumilus, melaninogenicus, subtilis, Clostridium botulinum, chauvoei, haemolyticum, novyi, perfringens, septicum, sordellii, tetani, colinum, Corynebacterium pseudotuberculosis, renale, Dermatophilus congolensis, Enterococcus spp (тате как E. faecalis, E. faecium, E. durans, E. avium, E. hirae), Erysipelothrix rhusiopathiae, Listeria ivanovii, grayi, innocua, seeligeri, welshimeri, monocytogenes, Mycobacterium avium, bovis, paratuberculosis (болезнь Джона), Mycoplasma (такие как capricolum subsp.capripneumoniae, subsp.capricolum, M. mycoides subsp mycoides, M. agalactiae, M. ovipneumoniae, M. conjunctivae, M. arginini, M. bovis и M. putrefaciens) Mycoplasma bovis, dispar, mycoides subsp. mycoides (например, возбудитель контагиозной плевропневмонии крупного рогатого скота, СВРР) Mycoplasma gallisepticum (MG), iowae meleagridis (MM), synoviae (MS) Mycoplasma haemosuis (ранее Eperythrozoon suis), alkalescens, bovigenitalum, bovirhinis, bovoculi, californicum, canadense, cynos, equigenitalium, gateae, haemocanis, haemofelis, hyopneumoniae, hyorhinis, hyosynoviae, iowae, leachii, meleagridis, mycoides subsp capri, wenyonii, suis, Rhodococcus equi, Staphylococcus epidermidis, Staphylococcus simulans, Staphylococcus felis, Staphylococcus xylosus, Staphylococcus chromogenes, Staphylococcus warneri, Staphylococcus haemolyticus, Staphylococcus sciuri, Staphylococcus saprophyticus, Staphylococcus hominis, Staphylococcus caprae, Staphylococcus cohnii subsp. cohnii, Staphylococcus cohnii subsp.urealyticus, Staphylococcus capitis subsp.capitis, Staphylococcus capitis subsp.urealyticus, Staphylococcus hyicus, Staphylococcus aureus, Staphylococcus pseudintermedius, Staphylococcus delphini, Staphylococcus schleiferi subsp.coagulans, Staphylococcus aureus subsp.anaerobius, Streptococcus uberis, Streptococcus canis, Streptococcus agalactiae, Streptococcus dysgalactiae, Streptococcus pyogenes, Streptococcus bovis, Streptococcus equi subsp.Zooepidemicus, Streptococcus equinus, Streptococcus equi (Streptococcus equi subsp equi), Streptococcus equisimilis (Streptococcus dysgalactiae subsp equisimilis), porcinus, suis, zooepidemicus, Streptococcus zooepidemicus (Streptococcus equi subsp zooepidemicus), Streptococcus dysgalactiae subsp.equisimilis, Propionibacterium acnes, Propionibacterium granulosum, Eubacterium, Peptococcus indolicus и Peptostreptococcus anaerobius; Actinobacillus, Aeromonas, Anaplasma, Arcobacter, Avibacterium, Bacteroides, Bartonella, Bordetella, Borrelia, Brachyspira, Brucella, Campylobacter, Capnocytophaga, Chlamydia, Chlamydophila, Chryseobacterium, Coxiella, Cytophaga, Dichelobacter, Edwardsiella, Ehrlichia, Escherichia, Flavobacterium, Francisella, Fusobacterium, Gallibacterium, Haemophilus, Histophilus, Klebsiella, Lawsonia, Leptospira, Mannheimia, Megasphaera, Moraxella, Neorickettsia, Ornithobactehum, Pasteurella, Photobacterium, Piscichlamydia, Piscirickettsia, Porphyromonas, Prevotella, Proteus, Pseudomonas, Rickettsia, Riemerella, Salmonella, Streptobacillus, Tenacibaculum, Vibrio и Yersinia.
14. Способ по любому из пп. 1-3, 5, 6, 8, 9 и 12, отличающийся тем, что инфекция или колонизация вызвана смесью по меньшей мере двух бактериальных агентов, выбранных из группы, включающей: грамотрицательные бактерии, грамположительные бактерии и бактерии, не имеющие клеточной стенки.
15. Способ по любому из пп. 1-3, 5, 6, 8, 9 и 12, отличающийся тем, что бактериальный агент устойчив к одному или более соединению, выбранному из группы, включающей: пенициллины, цефалоспорины, карбапенемы, монобактамы и другие В-лактамные антибиотики, фузиданы, аминогликозиды, фторхинолоны, стрептограмины, тетрациклины, глицилциклины, хлорамфеникол и другие фениколы, макролиды и кетолиды, линкозамиды, оксазолидиноны, аминоциклитоли, полимиксины, гликопептиды, липопептиды, бацитрацин, мупирицин, плевромутилины, рифамицины, сульфаниламиды и триметоприм.
16. Способ по п. 15, отличающийся тем, что бактериальный агент устойчив к одному или более соединению, выбранному из группы, включающей: В-лактамы, гликопептиды, липопептиды, макролиды, оксазолидиноны и тетрациклины.
17. Способ по п. 15, отличающийся тем, что бактериальный агент устойчив к указанному соединению, если соединение находится в диапазоне концентраций, выбранном из следующих: 0,001-10000 мкг/мл; 0,01-1000 мкг/мл; 0,10-100 мкг/мл и 1-50 мкг/мл.
18. Способ по любому из пп. 1-3, 5, 6, 8, 9, 12, 16 и 17, отличающийся тем, что бактериальная инфекция или колонизация у субъекта по существу вызывает симптом, выбранный из группы, включающей: внутрибольничную пневмонию, вызванную Staphylococcus aureus или Streptococcus pneumoniae; осложненные инфекции кожи и подкожной клетчатки, вызванные Staphylococcus aureus, Streptococcus pyogenes или Streptococcus agalactiae; инвазивные пневмококковые заболевания, такие как пневмония, бронхит, острый синусит, отит среднего уха, конъюнктивит, менингит, бактериемия, сепсис, остеомиелит, септический артрит, эндокардит, перитонит, перикардит, подкожная флегмона и абсцесс головного мозга, вызванный Streptococcus pneumoniae; неосложненные инфекции кожи и подкожной клетчатки, вызванные Staphylococcus aureus или Streptococcus pyogenes; внебольничную пневмонию, вызванную Streptococcus pneumoniae, Staphylococcus aureus или Staphylococcus aureus; инфекции кровотока (бактериемия), вызванные метициллин-чувствительными и метициллин-устойчивыми изолятами; ванкомицин-устойчивые инфекции, вызванные Enterococcus; ассоциированная с Clostridium difficile диарея (CDAD); а также вызванные грамотрицательными, грамположительными бактериями или смешанные инфекции костей и суставов; инфекции центральной нервной системы; глазные инфекции; инфекции желудочно-кишечного тракта; генитальные инфекции; инфекции брюшной полости; инфекции дыхательных путей; отит наружного уха; отит среднего уха; сепсис; системные инфекции; инфекции брюшной полости (ИБП); инфекции мочевыводящих путей (ИМП) и бактериемию.
19. Способ по любому из пп. 1-3, 5, 6, 8, 9, 12, 16 и 17, отличающийся тем, что терапевтически эффективное количество робенидина или его терапевтически приемлемой соли вводят субъекту путем перорального введения.
20. Способ по любому из пп. 1-3, 5, 6, 8, 9, 12, 16 и 17, отличающийся тем, что терапевтически эффективное количество робенидина или его терапевтически приемлемой соли вводят субъекту путем парентерального введения.
21. Способ по любому из пп. 1-3, 5, 6, 8, 9, 12, 16 и 17, отличающийся тем, что терапевтически эффективное количество робенидина или его терапевтически приемлемой соли вводят субъекту путем местного введения.
22. Антибактериальная фармацевтическая композиция, содержащая терапевтически эффективное количество робенидина или его терапевтически приемлемой соли и, необязательно, фармацевтически приемлемое вспомогательное вещество или носитель.
23. Антибактериальная ветеринарная композиция, содержащая терапевтически эффективное количество робенидина или его терапевтически приемлемой соль и, необязательно, ветеринарно приемлемое вспомогательное вещество или носитель.
24. Композиция по любому из пп. 22 или 23, отличающаяся тем, что указанная композиция содержит дополнительный противомикробный агент, выбранный из группы, включающей: антибактериальные и противогрибковые агенты.
25. Композиция по любому из пп. 22 или 23, отличающаяся тем, что указанная композиция адаптирована для перорального введения.
26. Композиция по любому из пп. 22 или 23, отличающаяся тем, что указанная композиция адаптирована для парентерального введения.
27. Композиция по любому из пп. 22 или 23, отличающаяся тем, что указанная композиция адаптирована для местного введения.
28. Применение робенидина или его терапевтически приемлемой соли в производстве лекарственного средства для лечения бактериальной колонизации или инфекции у субъекта.
29. Применение по п. 28, отличающееся тем, что указанное применение включает введение субъекту терапевтически эффективного количества робенидина или его терапевтически приемлемой соли.
30. Применение по п. 29, отличающееся тем, что робенидин вводят субъекту в дозе в диапазоне от 0,1 до 250 мг на кг массы тела.
31. Применение по любому из пп. 28-30, отличающееся тем, что лекарственное средство вводят субъекту путем перорального введения.
32. Применение по любому из пп. 28-30, отличающееся тем, что лекарственное средство вводят субъекту путем парентерального введения.
33. Применение по любому из пп. 28-30, отличающееся тем, что лекарственное средство вводят субъекту путем местного введения.
34. Медицинское устройство, применяемое в способе лечения или профилактики бактериальной колонизации или инфекции у субъекта, причем указанное медицинское устройство содержит композицию по любому из пп. 24-27.
35. Медицинское устройство по п. 34, отличающееся тем, что указанное медицинское устройство представлено в форме, выбранной из группы, включающей: пластырь, бинт, повязку или имплантат, применимые при бактериальной колонизации или инфекции у субъекта.
36. Способ элиминации бактерий, включающий стадию приведения бактерий в контакт с робенидином или его терапевтически приемлемой солью.
37. Применение робенидина или его терапевтически приемлемой соли для элиминации бактерий, причем указанное применение включает стадию приведения бактерий в контакт с робенидином или его терапевтически приемлемой солью.
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| CA2910752A1 (en) | 2014-11-06 |
| US20170071884A1 (en) | 2017-03-16 |
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