RU2015111258A - Слабительные композиции и способы лечения запора и связанных с ним желудочно-кишечных заболеваний и состояний - Google Patents
Слабительные композиции и способы лечения запора и связанных с ним желудочно-кишечных заболеваний и состояний Download PDFInfo
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- RU2015111258A RU2015111258A RU2015111258A RU2015111258A RU2015111258A RU 2015111258 A RU2015111258 A RU 2015111258A RU 2015111258 A RU2015111258 A RU 2015111258A RU 2015111258 A RU2015111258 A RU 2015111258A RU 2015111258 A RU2015111258 A RU 2015111258A
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- Prior art keywords
- salt
- acetate
- cellulose
- composition
- bisoxatin
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- 239000000203 mixture Substances 0.000 title claims abstract 34
- 206010010774 Constipation Diseases 0.000 title claims 8
- 238000000034 method Methods 0.000 title claims 6
- 206010017943 Gastrointestinal conditions Diseases 0.000 title 1
- 208000018522 Gastrointestinal disease Diseases 0.000 title 1
- BPKUDUSVDVLOPY-UHFFFAOYSA-N bisoxatin Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C(=O)NC2=CC=CC=C2O1 BPKUDUSVDVLOPY-UHFFFAOYSA-N 0.000 claims abstract 15
- ZCBJDQBSLZREAA-UHFFFAOYSA-N Bisoxatin acetate Chemical compound C1=CC(OC(=O)C)=CC=C1C1(C=2C=CC(OC(C)=O)=CC=2)C(=O)NC2=CC=CC=C2O1 ZCBJDQBSLZREAA-UHFFFAOYSA-N 0.000 claims abstract 11
- 229960002875 bisoxatin Drugs 0.000 claims abstract 11
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- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims abstract 3
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- PTHCMJGKKRQCBF-UHFFFAOYSA-N Cellulose, microcrystalline Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC)C(CO)O1 PTHCMJGKKRQCBF-UHFFFAOYSA-N 0.000 claims abstract 2
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- 125000001453 quaternary ammonium group Chemical group 0.000 claims abstract 2
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- 150000003839 salts Chemical class 0.000 claims 8
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- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims 2
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- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 claims 2
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- 239000005019 zein Substances 0.000 claims 2
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- AEQDJSLRWYMAQI-UHFFFAOYSA-N 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline Chemical compound C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 claims 1
- XMIIGOLPHOKFCH-UHFFFAOYSA-N 3-phenylpropionic acid Chemical class OC(=O)CCC1=CC=CC=C1 XMIIGOLPHOKFCH-UHFFFAOYSA-N 0.000 claims 1
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 1
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- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims 1
- 239000000176 sodium gluconate Substances 0.000 claims 1
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- 229940005574 sodium gluconate Drugs 0.000 claims 1
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- 229910052938 sodium sulfate Inorganic materials 0.000 claims 1
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- WTWSHHITWMVLBX-DKWTVANSSA-M sodium;(2s)-2-aminobutanedioate;hydron Chemical compound [Na+].[O-]C(=O)[C@@H](N)CC(O)=O WTWSHHITWMVLBX-DKWTVANSSA-M 0.000 claims 1
- 230000001148 spastic effect Effects 0.000 claims 1
- 239000008117 stearic acid Substances 0.000 claims 1
- 150000003890 succinate salts Chemical class 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 150000003892 tartrate salts Chemical class 0.000 claims 1
- 150000003567 thiocyanates Chemical class 0.000 claims 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical class CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 1
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 claims 1
- 229940001496 tribasic sodium phosphate Drugs 0.000 claims 1
- 235000013337 tricalcium citrate Nutrition 0.000 claims 1
- PLSARIKBYIPYPF-UHFFFAOYSA-H trimagnesium dicitrate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O PLSARIKBYIPYPF-UHFFFAOYSA-H 0.000 claims 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims 1
- 230000008673 vomiting Effects 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- YBCVMFKXIKNREZ-UHFFFAOYSA-N acoh acetic acid Chemical compound CC(O)=O.CC(O)=O YBCVMFKXIKNREZ-UHFFFAOYSA-N 0.000 abstract 1
- 229920001727 cellulose butyrate Polymers 0.000 abstract 1
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Landscapes
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261694672P | 2012-08-29 | 2012-08-29 | |
| US61/694,672 | 2012-08-29 | ||
| US201261723027P | 2012-11-06 | 2012-11-06 | |
| US61/723,027 | 2012-11-06 | ||
| PCT/AU2013/000973 WO2014032108A1 (en) | 2012-08-29 | 2013-08-29 | Laxative compositions and methods for treating constipation and related gastrointestinal diseases and conditions |
Publications (1)
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| RU2015111258A true RU2015111258A (ru) | 2016-10-20 |
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| RU2015111258A RU2015111258A (ru) | 2012-08-29 | 2013-08-29 | Слабительные композиции и способы лечения запора и связанных с ним желудочно-кишечных заболеваний и состояний |
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| US (1) | US20150216806A1 (https=) |
| EP (1) | EP2890367A4 (https=) |
| JP (1) | JP2015531770A (https=) |
| KR (1) | KR20150046310A (https=) |
| CN (1) | CN104936581A (https=) |
| AU (1) | AU2013308403B2 (https=) |
| BR (1) | BR112015004165A2 (https=) |
| CA (1) | CA2882316A1 (https=) |
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| IL (1) | IL237276A0 (https=) |
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| MX (1) | MX2015002210A (https=) |
| PH (1) | PH12015500435A1 (https=) |
| RU (1) | RU2015111258A (https=) |
| WO (1) | WO2014032108A1 (https=) |
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| GB201112091D0 (en) | 2011-07-14 | 2011-08-31 | Gt Biolog Ltd | Bacterial strains isolated from pigs |
| GB201117313D0 (en) | 2011-10-07 | 2011-11-16 | Gt Biolog Ltd | Bacterium for use in medicine |
| WO2013139861A1 (en) | 2012-03-20 | 2013-09-26 | Luc Montagnier | Methods and pharmaceutical compositions of the treatment of autistic syndrome disorders |
| PT2877163T (pt) | 2012-07-27 | 2019-05-24 | Redhill Biopharma Ltd | Formulações e métodos de fabrico de formulações para utilização na evacuação colónica |
| WO2014144407A1 (en) | 2013-03-15 | 2014-09-18 | Braintree Laboratories, Inc. | Dual use oral pharmaceutical composition tablets of sulfate saltes and methods of use thereof |
| GB201306536D0 (en) | 2013-04-10 | 2013-05-22 | Gt Biolog Ltd | Polypeptide and immune modulation |
| WO2014176632A1 (en) * | 2013-04-30 | 2014-11-06 | Borody Thomas J | Compositions and methods for treating microbiota-related psychotropic conditions and diseases |
| WO2015084158A1 (en) * | 2013-12-06 | 2015-06-11 | N.V. Nutricia | A pyrimidine derivative and a fatty acid source for use in the treatment of constipation |
| US9456986B2 (en) | 2013-12-11 | 2016-10-04 | Develco Pharma Schweiz Ag | Naloxone mono preparation and multilayer tablet |
| US10105360B2 (en) * | 2013-12-11 | 2018-10-23 | Develco Pharma Schweiz Ag | Method and composition for the treatment of opioid induced constipation |
| KR101420315B1 (ko) | 2014-03-19 | 2014-07-17 | 남봉길 | 약학적 액제 조성물 |
| RO130546B1 (ro) * | 2014-04-28 | 2019-03-29 | Mariana Lisinschi | Unguent pentru tratamentul bolii hemoroidale |
| CA2947434A1 (en) | 2014-04-29 | 2015-11-05 | Colonaryconcepts Llc | Foods, systems, methods, and kits for providing electrolyte replacement |
| EP3400953A1 (en) | 2014-12-23 | 2018-11-14 | 4D Pharma Research Limited | Pirin polypeptide and immune modulation |
| AR103260A1 (es) | 2014-12-23 | 2017-04-26 | 4D Pharma Res Ltd | Modulación inmunitaria |
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| US20170042806A1 (en) | 2015-04-29 | 2017-02-16 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions |
| WO2016178578A1 (en) * | 2015-05-06 | 2016-11-10 | Polyvation B.V. | Antimicrobial compositions and methods for reducing microbial contamination |
| MA41060B1 (fr) | 2015-06-15 | 2019-11-29 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| WO2016203221A1 (en) | 2015-06-15 | 2016-12-22 | 4D Pharma Research Limited | Compositions comprising bacterial strains |
| MA41010B1 (fr) | 2015-06-15 | 2020-01-31 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
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| SMT201900588T1 (it) | 2015-06-15 | 2019-11-13 | 4D Pharma Res Limited | Blautia stercoris e wexlerae per uso nel trattamento di malattie infiammatorie ed autoimmuni |
| WO2017031121A1 (en) | 2015-08-17 | 2017-02-23 | Liang Alfred Chi-Yeh | Liquid formulations containing picosulfate and magnesium citrate |
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| CN108513545B (zh) | 2015-11-20 | 2020-11-03 | 4D制药研究有限公司 | 包含细菌菌株的组合物 |
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| WO2017131461A1 (ko) * | 2016-01-28 | 2017-08-03 | 주식회사 씨티씨바이오 | 하제 조성물 |
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| US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
| US11207307B2 (en) | 2016-06-16 | 2021-12-28 | Azurity Pharmaceuticals, Inc. | Composition and method for proton pump inhibitor suspension |
| TW201804996A (zh) | 2016-07-08 | 2018-02-16 | 輝凌責任有限公司 | 含有匹可硫酸鹽(picosulfate)之安定液體調配物 |
| WO2018009789A1 (en) * | 2016-07-08 | 2018-01-11 | Vanderbilt University | Treatment and prevention of clostridium difficile colitis using misoprostol |
| TWI802545B (zh) | 2016-07-13 | 2023-05-21 | 英商４Ｄ製藥有限公司 | 包含細菌菌株之組合物 |
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| IT201600122310A1 (it) | 2016-12-01 | 2018-06-01 | Sofar Spa | Composizione per uso nella terapia di alterazioni dell'intestino |
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| CN106830417B (zh) * | 2017-01-12 | 2021-05-11 | 新宇药业股份有限公司 | 一种高效降解废水中林可霉素的处理方法 |
| CN107616983A (zh) * | 2017-01-13 | 2018-01-23 | 江苏西宏生物医药有限公司 | 一种抗腹泻的经肠营养组合物 |
| CN107616984A (zh) * | 2017-01-13 | 2018-01-23 | 江苏西宏生物医药有限公司 | 一种抗腹泻的经肠营养组合物 |
| CN107518411A (zh) * | 2017-01-13 | 2017-12-29 | 江苏西宏生物医药有限公司 | 一种抗腹泻的经肠营养组合物 |
| GB201704909D0 (en) * | 2017-03-28 | 2017-05-10 | Ldn Pharma Ltd | Cancer therapy |
| DK3630136T3 (da) | 2017-05-22 | 2021-05-25 | 4D Pharma Res Ltd | Sammensætninger, der omfatter bakteriestammer |
| EP3630942B1 (en) | 2017-05-24 | 2022-11-30 | 4D Pharma Research Limited | Compositions comprising bacterial strain |
| SMT202000555T1 (it) | 2017-06-14 | 2020-11-10 | 4D Pharma Res Limited | Composizioni comprendenti un ceppo batterico del genere megaspaera e loro usi |
| CA3066189A1 (en) | 2017-06-14 | 2018-12-20 | 4D Pharma Research Limited | Compositions comprising bacterial strains |
| SMT202000695T1 (it) | 2017-06-14 | 2021-01-05 | 4D Pharma Res Limited | Composizioni comprendenti ceppi batterici |
| WO2019140316A1 (en) * | 2018-01-12 | 2019-07-18 | Colonaryconcepts Llc | Solid concentrated constipation treatment formulations |
| WO2019140319A1 (en) * | 2018-01-12 | 2019-07-18 | Colonaryconcepts Llc | Constipation specific treatment formulations |
| EA202092190A1 (ru) * | 2018-03-16 | 2020-11-19 | Анджи Фармасьютикалз Инк. | Композиции и способы для лечения сильного запора |
| CN110403945B (zh) * | 2018-04-28 | 2022-11-18 | 上海泽生科技开发股份有限公司 | 促进胃肠系统动力的复合维生素组合物及其制备方法 |
| CN115581699A (zh) * | 2018-04-28 | 2023-01-10 | 上海泽生科技开发股份有限公司 | 促进胃肠系统动力的复合维生素组合物及其制备方法 |
| CN108819052A (zh) * | 2018-05-04 | 2018-11-16 | 苏州捷德瑞精密机械有限公司 | 一种树脂基体系用脱模剂及其制备方法 |
| AU2019278927A1 (en) * | 2018-06-01 | 2020-12-24 | Bt Bidco, Inc. | Devices and systems for gastrointestinal microbiome detection and manipulation |
| JP6661712B2 (ja) * | 2018-08-15 | 2020-03-11 | 旭化成ワッカーシリコーン株式会社 | シリコーン消泡剤組成物、および、シリコーン消泡剤組成物の製造方法。 |
| CN109394711A (zh) * | 2018-11-06 | 2019-03-01 | 威海贯标信息科技有限公司 | 一种酒石酸西尼必利片组合物 |
| CN109337098B (zh) * | 2018-11-23 | 2021-02-02 | 哈尔滨工程大学 | 一种酶响应型结肠靶向载药凝胶的制备方法 |
| CN109749960B (zh) * | 2019-01-31 | 2020-05-26 | 上海宝藤生物医药科技股份有限公司 | 基于多种肠道细菌含量评估便秘风险及便秘程度的方法及装置 |
| US10857092B2 (en) * | 2019-03-14 | 2020-12-08 | Glen D Lindbo | Avoiding gag reflex to enable swallowing pills |
| CA3132400A1 (en) * | 2019-03-18 | 2020-09-24 | Cedars-Sinai Medical Center | Compositions and methods to treat gastrointestinal diseases and disorders |
| CN110051655A (zh) * | 2019-03-19 | 2019-07-26 | 吉林省盛赛医药实业有限公司 | 一种治疗便秘的复方制剂的制备方法 |
| US12053447B2 (en) | 2019-06-25 | 2024-08-06 | NuBioPharma, LLC | Oral solution and powder to liquid compositions of balsalazide |
| CN114364391B (zh) * | 2019-07-08 | 2023-08-11 | 吉亚生技控股股份有限公司 | 改善或抑制胃肠道不适的组合物及方法 |
| US11633478B2 (en) | 2019-07-16 | 2023-04-25 | Azurity Pharmaceuticals, Inc. | Compositions and kits for Omeprazole suspension |
| US10751333B1 (en) | 2019-07-16 | 2020-08-25 | Cutispharma, Inc. | Compositions and kits for omeprazole suspension |
| CN112386577B (zh) * | 2019-08-16 | 2024-01-23 | 北京天衡药物研究院有限公司 | 一种治疗便秘的组合物 |
| RU2716144C1 (ru) * | 2019-09-23 | 2020-03-06 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Казанский Государственный медицинский университет" Министерства здравоохранения Российской Федерации | Способ консервативного лечения послеоперационного пареза кишечника у новорожденных детей |
| CN110833537B (zh) * | 2019-11-15 | 2021-04-13 | 三峡大学 | 药物缓释材料及其在制备治疗直肠炎的缓释材料上的应用 |
| CN111920798A (zh) * | 2020-06-24 | 2020-11-13 | 首都医科大学附属北京同仁医院 | 一种硝呋酚酰肼在制备药物中的应用 |
| CN112843077A (zh) * | 2020-09-08 | 2021-05-28 | 天津国际生物医药联合研究院 | 表柔比星或者硫酸博来霉素在抗分枝杆菌感染中的潜在应用 |
| CN112189761A (zh) * | 2020-10-30 | 2021-01-08 | 安佑生物科技集团股份有限公司 | 一种防治动物便秘的饲料添加剂及其制备方法和应用 |
| CN114869879B (zh) * | 2022-05-09 | 2024-06-25 | 南方医科大学珠江医院 | 一种具备活性氧和炎症双重抑制作用的小分子水凝胶及其制备方法 |
| CN114965764B (zh) * | 2022-05-18 | 2024-12-31 | 陕西安宁云生生物技术有限公司 | 便秘的诊断和治疗 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA761927A (en) * | 1967-06-27 | Seeger Ernst | Benzoxazine derivatives | |
| MXPA01003197A (es) * | 1998-09-28 | 2004-04-21 | Warner Lambert Co | Suministro enterico y colonico utilizando capsulas de chpm. |
| CN1288730A (zh) * | 1999-09-07 | 2001-03-28 | 麦克内尔-Ppc股份有限公司 | 轻泻组合物 |
| ES2226933T3 (es) * | 1999-11-01 | 2005-04-01 | John Rhodes | Composicion para tratar el estreñimiento y el sindrome del intestino irritable. |
| US6541025B1 (en) * | 1999-12-30 | 2003-04-01 | Shear/Kershman Laboratories, Inc. | Method for preparing solid delivery system for encapsulated and non-encapsulated pharmaceuticals |
| EP1589951B1 (en) * | 2003-01-03 | 2017-08-09 | Supernus Pharmaceuticals, Inc. | Use of a mixture of two or more enteric materials to regulate drug release via membrane or matrix for systemic therapeutics |
| US20060222709A1 (en) * | 2005-03-18 | 2006-10-05 | Agi Therapeutics Research Ltd. | Metformin methods and formulations for treating chronic constipation |
| US20060229261A1 (en) * | 2005-04-12 | 2006-10-12 | John Devane | Acarbose methods and formulations for treating chronic constipation |
| US9161918B2 (en) * | 2005-05-02 | 2015-10-20 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
| US8158152B2 (en) * | 2005-11-18 | 2012-04-17 | Scidose Llc | Lyophilization process and products obtained thereby |
| US20070185145A1 (en) * | 2006-02-03 | 2007-08-09 | Royds Robert B | Pharmaceutical composition containing a central opioid agonist, a central opioid antagonist, and a peripheral opioid antagonist, and method for making the same |
| WO2008027442A2 (en) * | 2006-08-30 | 2008-03-06 | Theraquest Biosciences, Llc | Abuse deterrent oral pharmaceutical formulations of opioid agonists and method of use |
| AU2011342368B2 (en) * | 2010-12-13 | 2016-11-17 | Rite-Prep Pty Ltd | Gastric and colonic formulations and methods for making and using them |
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