JP2007119479A5 - - Google Patents
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- Publication number
- JP2007119479A5 JP2007119479A5 JP2006315261A JP2006315261A JP2007119479A5 JP 2007119479 A5 JP2007119479 A5 JP 2007119479A5 JP 2006315261 A JP2006315261 A JP 2006315261A JP 2006315261 A JP2006315261 A JP 2006315261A JP 2007119479 A5 JP2007119479 A5 JP 2007119479A5
- Authority
- JP
- Japan
- Prior art keywords
- oral
- hours
- plasma concentration
- methylphenidate
- formulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000009472 formulation Methods 0.000 claims 21
- 239000000203 mixture Substances 0.000 claims 21
- 230000036470 plasma concentration Effects 0.000 claims 17
- DUGOZIWVEXMGBE-UHFFFAOYSA-N Methylphenidate Chemical compound C=1C=CC=CC=1C(C(=O)OC)C1CCCCN1 DUGOZIWVEXMGBE-UHFFFAOYSA-N 0.000 claims 16
- 229960001344 methylphenidate Drugs 0.000 claims 16
- 230000001419 dependent effect Effects 0.000 claims 11
- 239000002702 enteric coating Substances 0.000 claims 9
- 238000009505 enteric coating Methods 0.000 claims 9
- 239000000758 substrate Substances 0.000 claims 9
- 238000002360 preparation method Methods 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 7
- 235000020937 fasting conditions Nutrition 0.000 claims 6
- 239000006186 oral dosage form Substances 0.000 claims 6
- 102000004190 Enzymes Human genes 0.000 claims 4
- 108090000790 Enzymes Proteins 0.000 claims 4
- 238000013270 controlled release Methods 0.000 claims 4
- 239000011159 matrix material Substances 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 229920000623 Cellulose acetate phthalate Polymers 0.000 claims 2
- 239000011324 bead Substances 0.000 claims 2
- 229940081734 cellulose acetate phthalate Drugs 0.000 claims 2
- 229920001577 copolymer Polymers 0.000 claims 2
- 238000004090 dissolution Methods 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000012530 fluid Substances 0.000 claims 2
- 210000004051 gastric juice Anatomy 0.000 claims 2
- 230000000968 intestinal effect Effects 0.000 claims 2
- 229940100467 polyvinyl acetate phthalate Drugs 0.000 claims 2
- 229920001800 Shellac Polymers 0.000 claims 1
- 229920002494 Zein Polymers 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000001125 extrusion Methods 0.000 claims 1
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 claims 1
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 claims 1
- 238000007909 melt granulation Methods 0.000 claims 1
- 229920002744 polyvinyl acetate phthalate Polymers 0.000 claims 1
- 229940113147 shellac Drugs 0.000 claims 1
- 239000004208 shellac Substances 0.000 claims 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 claims 1
- 235000013874 shellac Nutrition 0.000 claims 1
- 239000005019 zein Substances 0.000 claims 1
- 229940093612 zein Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11266798P | 1998-12-17 | 1998-12-17 | |
| US60/112,667 | 1998-12-17 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000587770A Division JP4663880B2 (ja) | 1998-12-17 | 1999-12-17 | 制御／調整放出型メチルフェニデート経口製剤 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012095985A Division JP5844676B2 (ja) | 1998-12-17 | 2012-04-19 | 制御／調整放出型メチルフェニデート経口製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007119479A JP2007119479A (ja) | 2007-05-17 |
| JP2007119479A5 true JP2007119479A5 (https=) | 2007-08-16 |
| JP5186100B2 JP5186100B2 (ja) | 2013-04-17 |
Family
ID=22345214
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000587770A Expired - Lifetime JP4663880B2 (ja) | 1998-12-17 | 1999-12-17 | 制御／調整放出型メチルフェニデート経口製剤 |
| JP2006315261A Expired - Lifetime JP5186100B2 (ja) | 1998-12-17 | 2006-11-22 | 制御／調整放出型メチルフェニデート経口製剤 |
| JP2012095985A Expired - Lifetime JP5844676B2 (ja) | 1998-12-17 | 2012-04-19 | 制御／調整放出型メチルフェニデート経口製剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000587770A Expired - Lifetime JP4663880B2 (ja) | 1998-12-17 | 1999-12-17 | 制御／調整放出型メチルフェニデート経口製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012095985A Expired - Lifetime JP5844676B2 (ja) | 1998-12-17 | 2012-04-19 | 制御／調整放出型メチルフェニデート経口製剤 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6673367B1 (https=) |
| EP (2) | EP1967191B8 (https=) |
| JP (3) | JP4663880B2 (https=) |
| AT (1) | ATE395916T1 (https=) |
| AU (1) | AU2371200A (https=) |
| CA (1) | CA2355644C (https=) |
| CY (2) | CY1108253T1 (https=) |
| DE (1) | DE69938791D1 (https=) |
| DK (2) | DK1967191T3 (https=) |
| ES (2) | ES2586611T3 (https=) |
| LT (1) | LT1967191T (https=) |
| PT (2) | PT1967191T (https=) |
| SI (2) | SI1967191T1 (https=) |
| WO (1) | WO2000035450A1 (https=) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004200325B2 (en) * | 1998-10-21 | 2006-09-28 | Shire Llc | Oral Pulsed Dose Drug Delivery System |
| US20010055613A1 (en) * | 1998-10-21 | 2001-12-27 | Beth A. Burnside | Oral pulsed dose drug delivery system |
| US6419960B1 (en) * | 1998-12-17 | 2002-07-16 | Euro-Celtique S.A. | Controlled release formulations having rapid onset and rapid decline of effective plasma drug concentrations |
| US7083808B2 (en) * | 1998-12-17 | 2006-08-01 | Euro-Celtique S.A. | Controlled/modified release oral methylphenidate formulations |
| US6673367B1 (en) * | 1998-12-17 | 2004-01-06 | Euro-Celtique, S.A. | Controlled/modified release oral methylphenidate formulations |
| US7674480B2 (en) * | 2000-06-23 | 2010-03-09 | Teva Pharmaceutical Industries Ltd. | Rapidly expanding composition for gastric retention and controlled release of therapeutic agents, and dosage forms including the composition |
| US6344215B1 (en) * | 2000-10-27 | 2002-02-05 | Eurand America, Inc. | Methylphenidate modified release formulations |
| CA2428971A1 (en) * | 2000-11-14 | 2003-05-01 | New River Pharmaceuticals Inc. | Conjugates of a therapeutic agent and a peptide carrier |
| FR2818552B1 (fr) * | 2000-12-26 | 2003-02-07 | Servier Lab | Compositions pharmaceutique solide thermoformable pour la liberation controlee d'ivabradine |
| US20020187192A1 (en) * | 2001-04-30 | 2002-12-12 | Yatindra Joshi | Pharmaceutical composition which reduces or eliminates drug abuse potential |
| DE10208344A1 (de) | 2002-02-27 | 2003-09-04 | Roehm Gmbh | Schmelzextrusion von Wirkstoffsalzen |
| CA2395819A1 (en) * | 2002-08-13 | 2004-02-13 | Bernard Charles Sherman | Dual-spike release formulation for oral drug delivery |
| US6913768B2 (en) | 2002-09-24 | 2005-07-05 | Shire Laboratories, Inc. | Sustained release delivery of amphetamine salts |
| US7988993B2 (en) | 2002-12-09 | 2011-08-02 | Andrx Pharmaceuticals, Inc. | Oral controlled release dosage form |
| JP2007516220A (ja) * | 2003-05-06 | 2007-06-21 | ビーピーエスアイ ホールディングス，インコーポレーテッド | アクリルポリマー接着剤を含有する熱成形組成物の製造方法、医薬製剤および該製剤の製造方法 |
| US8802139B2 (en) | 2003-06-26 | 2014-08-12 | Intellipharmaceutics Corp. | Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient |
| WO2005044238A1 (en) * | 2003-11-07 | 2005-05-19 | Ranbaxy Laboratories Limited | Modified release solid dosage form of amphetamine salts |
| US7387793B2 (en) * | 2003-11-14 | 2008-06-17 | Eurand, Inc. | Modified release dosage forms of skeletal muscle relaxants |
| US8394409B2 (en) * | 2004-07-01 | 2013-03-12 | Intellipharmaceutics Corp. | Controlled extended drug release technology |
| US20060024361A1 (en) * | 2004-07-28 | 2006-02-02 | Isa Odidi | Disintegrant assisted controlled release technology |
| DK2036546T3 (en) | 2004-08-23 | 2018-12-17 | Pejo Iserlohn Heilmittel Und Diaet Gmbh & Co Kg | Psychostimulants containing a pharmaceutical composition |
| US10624858B2 (en) * | 2004-08-23 | 2020-04-21 | Intellipharmaceutics Corp | Controlled release composition using transition coating, and method of preparing same |
| US10064828B1 (en) | 2005-12-23 | 2018-09-04 | Intellipharmaceutics Corp. | Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems |
| CA2645855C (en) | 2006-03-16 | 2015-02-03 | Tris Pharma, Inc. | Modified release formulations containing drug-ion exchange resin complexes |
| CN101453996B (zh) * | 2006-04-03 | 2016-05-11 | 伊萨·奥迪迪 | 药物递送组合物 |
| JP5457830B2 (ja) * | 2006-04-03 | 2014-04-02 | オディディ，イサ | オルガノゾル被膜を含む制御放出送達デバイス |
| MX350380B (es) * | 2006-05-09 | 2017-09-05 | SpecGx LLC | Formas de dosificacion solida de liberacion modificada en el orden de cero. |
| US10960077B2 (en) * | 2006-05-12 | 2021-03-30 | Intellipharmaceutics Corp. | Abuse and alcohol resistant drug composition |
| US8846100B2 (en) | 2006-05-12 | 2014-09-30 | Shire Llc | Controlled dose drug delivery system |
| US20080075768A1 (en) * | 2006-07-21 | 2008-03-27 | Vaughn Jason M | Hydrophobic opioid abuse deterrent delivery system using opioid antagonists |
| DE102007009242A1 (de) | 2007-02-22 | 2008-09-18 | Evonik Röhm Gmbh | Pellets mit magensaftresistenter Wirkstoff-Matix |
| ATE476176T1 (de) * | 2007-03-02 | 2010-08-15 | Farnam Co Inc | Wachsähnliches material enthaltende tabletten mit verzögerter freisetzung |
| EP2197448A4 (en) * | 2007-09-12 | 2010-11-17 | Elan Pharma Int Ltd | dosing schedule |
| CA2627198A1 (en) * | 2008-03-27 | 2009-09-27 | Pharmascience Inc. | Methylphenidate extended release therapeutic drug delivery system |
| MX2011001384A (es) | 2008-08-06 | 2011-09-27 | Gosforth Ct Holdings Pty Ltd | Composiciones y metodos para tratar trastornos psiquiatricos. |
| WO2010053306A2 (ko) * | 2008-11-07 | 2010-05-14 | 주식회사 삼양사 | 메칠페니데이트의 방출 제어용 약제학적 조성물 |
| US8287903B2 (en) | 2011-02-15 | 2012-10-16 | Tris Pharma Inc | Orally effective methylphenidate extended release powder and aqueous suspension product |
| US9561241B1 (en) * | 2011-06-28 | 2017-02-07 | Medicis Pharmaceutical Corporation | Gastroretentive dosage forms for minocycline |
| GB201111712D0 (en) | 2011-07-08 | 2011-08-24 | Gosforth Ct Holdings Pty Ltd | Pharmaceutical compositions |
| US8951996B2 (en) * | 2011-07-28 | 2015-02-10 | Lipocine Inc. | 17-hydroxyprogesterone ester-containing oral compositions and related methods |
| CN105025883A (zh) * | 2013-03-29 | 2015-11-04 | 沃克哈特有限公司 | 右哌甲酯或其盐的调节释放的药物组合物 |
| CA2936740C (en) * | 2014-10-31 | 2017-10-10 | Purdue Pharma | Methods and compositions particularly for treatment of attention deficit disorder |
| US11590228B1 (en) | 2015-09-08 | 2023-02-28 | Tris Pharma, Inc | Extended release amphetamine compositions |
| EP3372225A1 (en) * | 2017-03-09 | 2018-09-12 | Develco Pharma Schweiz AG | Novel dosage form |
| US12458592B1 (en) | 2017-09-24 | 2025-11-04 | Tris Pharma, Inc. | Extended release amphetamine tablets |
| US11590081B1 (en) | 2017-09-24 | 2023-02-28 | Tris Pharma, Inc | Extended release amphetamine tablets |
| US10722473B2 (en) | 2018-11-19 | 2020-07-28 | Purdue Pharma L.P. | Methods and compositions particularly for treatment of attention deficit disorder |
| KR20210119458A (ko) * | 2019-01-25 | 2021-10-05 | 아이언쇼어 파마슈티컬즈 앤드 디벨롭먼트, 인크. | 주의력 결핍 과잉행동 장애의 치료를 위한 메틸페니데이트 조성물 |
| CN114022146A (zh) * | 2021-11-03 | 2022-02-08 | 杭州每刻科技有限公司 | 基于Jasper的网银付款文件的生成方法及系统 |
| JP7817300B2 (ja) * | 2023-02-14 | 2026-02-18 | 沢井製薬株式会社 | コーティング顆粒、コーティング顆粒を含む製剤及びそれらの製造方法 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| JPS55149211A (en) * | 1979-05-10 | 1980-11-20 | Takeda Chem Ind Ltd | Production of gradually releasable preparation |
| GB2186485B (en) * | 1986-02-13 | 1988-09-07 | Ethical Pharma Ltd | Slow release formulation |
| AU591248B2 (en) | 1986-03-27 | 1989-11-30 | Kinaform Technology, Inc. | Sustained-release pharaceutical preparation |
| GB8613689D0 (en) * | 1986-06-05 | 1986-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| IT1213080B (it) * | 1986-06-17 | 1989-12-07 | Recordati Chem Pharm | Sistemi terapeutico per la cessione controllata di farmaci. |
| EP0325086A3 (en) * | 1987-11-23 | 1990-10-31 | Jago Research Ag | Novel methods for obtaining therapeutic systems with controlled release of the drug |
| DE3827214A1 (de) * | 1988-08-11 | 1990-02-15 | Roehm Gmbh | Retardierte arzneiform und verfahren zu ihrer herstellung |
| US5133974A (en) | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
| AU1992592A (en) | 1991-05-24 | 1993-01-08 | Pharmavene, Inc. | Treatment of drug withdrawal symptoms and drug craving with type b monoamine oxidase inhibitors |
| EP0520119A1 (de) | 1991-06-17 | 1992-12-30 | Spirig Ag Pharmazeutische Präparate | Neue orale Diclofenaczubereitung |
| US5326570A (en) | 1991-07-23 | 1994-07-05 | Pharmavene, Inc. | Advanced drug delivery system and method of treating psychiatric, neurological and other disorders with carbamazepine |
| US5286493A (en) | 1992-01-27 | 1994-02-15 | Euroceltique, S.A. | Stabilized controlled release formulations having acrylic polymer coating |
| US5273760A (en) | 1991-12-24 | 1993-12-28 | Euroceltigue, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer |
| US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| US6077533A (en) | 1994-05-25 | 2000-06-20 | Purdue Pharma L.P. | Powder-layered oral dosage forms |
| GB9514451D0 (en) | 1995-07-14 | 1995-09-13 | Chiroscience Ltd | Sustained-release formulation |
| AU702801B2 (en) | 1995-07-14 | 1999-03-04 | Darwin Discovery Limited | Therapeutic use of D-threo-methylphenidate |
| US5922736A (en) * | 1995-12-04 | 1999-07-13 | Celegene Corporation | Chronic, bolus administration of D-threo methylphenidate |
| US5837284A (en) * | 1995-12-04 | 1998-11-17 | Mehta; Atul M. | Delivery of multiple doses of medications |
| MX9801835A (es) | 1996-07-08 | 1998-08-30 | Mendell Co Inc Edward | Matriz de liberacion sostenida para medicamentos insolubles de dosis altas. |
| AU3909597A (en) * | 1996-08-16 | 1998-03-06 | Alza Corporation | Dosage form for providing ascending dose of drug |
| CA2264852C (en) * | 1996-09-30 | 2005-11-01 | Alza Corporation | Use of methylphenidate or a pharmaceutically acceptable salt thereof |
| PT946151E (pt) | 1996-11-25 | 2006-07-31 | Alza Corp | Forma de dosagem de dose crescente |
| US5945123A (en) * | 1998-04-02 | 1999-08-31 | K-V Pharmaceutical Company | Maximizing effectiveness of substances used to improve health and well being |
| ATE277594T1 (de) | 1998-06-03 | 2004-10-15 | Alza Corp | Vorrichtungen um eine verlängerte medikamententherapie zu erreichen |
| MXPA01004381A (es) | 1998-11-02 | 2005-09-08 | Elan Corp Plc | Composicion de multiparticulado de liberacion modificada. |
| US6419960B1 (en) | 1998-12-17 | 2002-07-16 | Euro-Celtique S.A. | Controlled release formulations having rapid onset and rapid decline of effective plasma drug concentrations |
| US6673367B1 (en) * | 1998-12-17 | 2004-01-06 | Euro-Celtique, S.A. | Controlled/modified release oral methylphenidate formulations |
-
1999
- 1999-12-16 US US09/465,158 patent/US6673367B1/en not_active Expired - Lifetime
- 1999-12-17 CA CA002355644A patent/CA2355644C/en not_active Expired - Lifetime
- 1999-12-17 PT PT81563975T patent/PT1967191T/pt unknown
- 1999-12-17 DE DE69938791T patent/DE69938791D1/de not_active Expired - Lifetime
- 1999-12-17 JP JP2000587770A patent/JP4663880B2/ja not_active Expired - Lifetime
- 1999-12-17 WO PCT/US1999/030305 patent/WO2000035450A1/en not_active Ceased
- 1999-12-17 DK DK08156397.5T patent/DK1967191T3/en active
- 1999-12-17 EP EP08156397.5A patent/EP1967191B8/en not_active Expired - Lifetime
- 1999-12-17 DK DK99967438T patent/DK1140088T3/da active
- 1999-12-17 ES ES08156397.5T patent/ES2586611T3/es not_active Expired - Lifetime
- 1999-12-17 AU AU23712/00A patent/AU2371200A/en not_active Abandoned
- 1999-12-17 ES ES99967438T patent/ES2306535T3/es not_active Expired - Lifetime
- 1999-12-17 SI SI9931081A patent/SI1967191T1/sl unknown
- 1999-12-17 EP EP99967438A patent/EP1140088B1/en not_active Revoked
- 1999-12-17 PT PT99967438T patent/PT1140088E/pt unknown
- 1999-12-17 SI SI9931015T patent/SI1140088T1/sl unknown
- 1999-12-17 LT LTEP08156397.5T patent/LT1967191T/lt unknown
- 1999-12-17 AT AT99967438T patent/ATE395916T1/de active
-
2006
- 2006-11-22 JP JP2006315261A patent/JP5186100B2/ja not_active Expired - Lifetime
-
2008
- 2008-08-12 CY CY20081100849T patent/CY1108253T1/el unknown
-
2012
- 2012-04-19 JP JP2012095985A patent/JP5844676B2/ja not_active Expired - Lifetime
-
2016
- 2016-07-27 CY CY20161100738T patent/CY1117845T1/el unknown
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