RU2014121390A - Новые дизамещенные соединения 3,4-диамино-3-циклобутен-1,2-диона для использования при лечении опосредованных цитокинами заболеваний - Google Patents

Новые дизамещенные соединения 3,4-диамино-3-циклобутен-1,2-диона для использования при лечении опосредованных цитокинами заболеваний Download PDF

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RU2014121390A
RU2014121390A RU2014121390/04A RU2014121390A RU2014121390A RU 2014121390 A RU2014121390 A RU 2014121390A RU 2014121390/04 A RU2014121390/04 A RU 2014121390/04A RU 2014121390 A RU2014121390 A RU 2014121390A RU 2014121390 A RU2014121390 A RU 2014121390A
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methyl
atom
hydrogen atom
carbon atoms
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Жером ОБЕР
Жан-Ги БУАТО
Лоранс КЛАРИ
Бранислав МУСИЦКИ
Патрисия РОССИО
Марлен ШЮППЛИ-НОЛЛЕ
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Галдерма Ресерч Энд Девелопмент
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    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/341Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
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    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/14Radicals substituted by nitrogen atoms not forming part of a nitro radical
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/16Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
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  • Chemical & Material Sciences (AREA)
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
RU2014121390/04A 2011-10-28 2012-10-26 Новые дизамещенные соединения 3,4-диамино-3-циклобутен-1,2-диона для использования при лечении опосредованных цитокинами заболеваний RU2014121390A (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161552940P 2011-10-28 2011-10-28
US61/552,940 2011-10-28
FR1159833A FR2981935B1 (fr) 2011-10-28 2011-10-28 Nouveaux composes di-substitues de la diamino-3,4-cyclobutene-3-dione-1,2 utiles dans le traitement de pathologies mediees par des chimiokines.
FR1159833 2011-10-28
PCT/FR2012/052478 WO2013061004A1 (fr) 2011-10-28 2012-10-26 Nouveaux composés di-substitués de la diamino-3,4-cyclobutène-3-dione-1,2 utiles dans le traitement de pathologies médiées par des chimiokines

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RU2014121390A true RU2014121390A (ru) 2015-12-10

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Country Link
US (2) US9388149B2 (enExample)
EP (1) EP2771329B1 (enExample)
JP (1) JP6068486B2 (enExample)
KR (1) KR20140090168A (enExample)
CN (1) CN103906738B (enExample)
AU (1) AU2012328198A1 (enExample)
BR (1) BR112014009889A2 (enExample)
CA (1) CA2848263A1 (enExample)
CY (1) CY1117705T1 (enExample)
DK (1) DK2771329T3 (enExample)
ES (1) ES2569053T3 (enExample)
FR (1) FR2981935B1 (enExample)
HR (1) HRP20160608T1 (enExample)
HU (1) HUE029128T2 (enExample)
IN (1) IN2014CN02273A (enExample)
MX (1) MX342924B (enExample)
PL (1) PL2771329T3 (enExample)
PT (1) PT2771329E (enExample)
RS (1) RS54775B1 (enExample)
RU (1) RU2014121390A (enExample)
SI (1) SI2771329T1 (enExample)
SM (1) SMT201600151B (enExample)
WO (1) WO2013061004A1 (enExample)
ZA (1) ZA201401678B (enExample)

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Publication number Priority date Publication date Assignee Title
AU2014360743C1 (en) 2013-12-02 2021-01-28 Chemocentryx, Inc. CCR6 compounds
FR3030515B1 (fr) 2014-12-23 2017-01-20 Galderma Res & Dev Nouveaux composes antagonistes des recepteurs cxcr1 et cxcr2 aux chimiokines, et leur utilisation dans le traitement de pathologies mediees par des chimiokines
TWI734715B (zh) 2015-11-19 2021-08-01 美商卡默森屈有限公司 趨化因子受體調節劑
TWI724056B (zh) 2015-11-19 2021-04-11 美商卡默森屈有限公司 Cxcr2抑制劑
US10660909B2 (en) 2016-11-17 2020-05-26 Syntrix Biosystems Inc. Method for treating cancer using chemokine antagonists
RU2020106383A (ru) 2017-08-14 2021-09-16 Аллерган, Инк. 3,4-двузамещенные 3-циклобутен-1,2-дионы и их применение
IL275839B2 (en) * 2018-01-08 2024-02-01 Chemocentryx Inc Methods for the treatment of generalized abscess psoriasis using a CCR6 or CXCR2 antagonist
WO2019165315A1 (en) 2018-02-23 2019-08-29 Syntrix Biosystems Inc. Method for treating cancer using chemokine antagonists alone or in combination
GEP20237476B (en) 2018-09-21 2023-03-27 Pfizer N-substituted-dioxocyclobutenylamino-3-hydroxypicolinamides useful as ccr6 inhibitors
IL297675A (en) 2020-04-30 2022-12-01 Idorsia Pharmaceuticals Ltd History of aztidine-3-ylmethanol as ccr6 receptor modulators
WO2023057548A1 (en) 2021-10-07 2023-04-13 Idorsia Pharmaceuticals Ltd Ccr6 receptor modulators
JP2024539987A (ja) 2021-10-26 2024-10-31 イドルシア・ファーマシューティカルズ・リミテッド Ccr6受容体調節剤
CA3236396A1 (en) 2021-10-28 2023-05-04 Oliver Allemann Ccr6 receptor modulators
WO2024222865A1 (zh) * 2023-04-28 2024-10-31 武汉朗来科技发展有限公司 作为ccr6拮抗剂的化合物、其药物组合物和用途
WO2025092968A1 (zh) * 2023-11-03 2025-05-08 武汉朗来科技发展有限公司 作为ccr6拮抗剂的化合物、其药物组合物和用途

Family Cites Families (7)

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Publication number Priority date Publication date Assignee Title
US6652737B2 (en) * 2000-07-21 2003-11-25 Exxonmobil Research And Engineering Company Production of naphtha and light olefins
CZ20032831A3 (cs) * 2001-04-16 2004-03-17 Schering Corporation 3,4-Disubstituované cyklobuten-1,2-diony
MX2009013276A (es) * 2007-06-06 2010-01-25 Novartis Ag Compuestos anti-inflamatorios de ciclobutenodiona sustituida.
UA103198C2 (en) * 2008-08-04 2013-09-25 Новартис Аг Squaramide derivatives as cxcr2 antagonists
KR200444641Y1 (ko) * 2008-12-03 2009-05-27 강민수 헤드작동형 다기능 스패너
WO2010063802A1 (en) * 2008-12-05 2010-06-10 Novartis Ag 3, 4-di-substituted cyclobutene- 1, 2 -diones as cxcr2 receptor antagonists
WO2010131147A1 (en) * 2009-05-12 2010-11-18 Pfizer Limited Cyclobutenedione derivatives

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RS54775B1 (sr) 2016-10-31
US9388149B2 (en) 2016-07-12
CY1117705T1 (el) 2017-05-17
CN103906738B (zh) 2016-09-07
US20140296254A1 (en) 2014-10-02
US20160362403A1 (en) 2016-12-15
JP6068486B2 (ja) 2017-01-25
EP2771329B1 (fr) 2016-03-16
MX2014003958A (es) 2014-08-27
PT2771329E (pt) 2016-06-17
CN103906738A (zh) 2014-07-02
MX342924B (es) 2016-10-19
ES2569053T3 (es) 2016-05-06
IN2014CN02273A (enExample) 2015-06-19
KR20140090168A (ko) 2014-07-16
SMT201600151B (it) 2016-07-01
BR112014009889A2 (pt) 2017-04-25
AU2012328198A1 (en) 2014-04-03
WO2013061004A1 (fr) 2013-05-02
FR2981935B1 (fr) 2015-08-07
FR2981935A1 (fr) 2013-05-03
CA2848263A1 (fr) 2013-05-02
US9580412B2 (en) 2017-02-28
WO2013061004A8 (fr) 2014-04-17
DK2771329T3 (en) 2016-06-06
JP2014530894A (ja) 2014-11-20
SI2771329T1 (sl) 2016-07-29
HRP20160608T1 (hr) 2016-07-01
HUE029128T2 (en) 2017-02-28
ZA201401678B (en) 2015-04-29
EP2771329A1 (fr) 2014-09-03
PL2771329T3 (pl) 2016-09-30

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