RU2012150729A - Медицинские устройства для доставки кирнк - Google Patents

Медицинские устройства для доставки кирнк Download PDF

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RU2012150729A
RU2012150729A RU2012150729/14A RU2012150729A RU2012150729A RU 2012150729 A RU2012150729 A RU 2012150729A RU 2012150729/14 A RU2012150729/14 A RU 2012150729/14A RU 2012150729 A RU2012150729 A RU 2012150729A RU 2012150729 A RU2012150729 A RU 2012150729A
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nanostructures
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Расселл Фредерик РОСС
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Кимберли-Кларк Ворлдвайд, Инк.
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    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
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    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface
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    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
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    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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Abstract

1. Устройство для доставки конструкции киРНК через дермальный барьер, содержащеемикроиглу и множество наноструктур, изготовленных на поверхности микроиглы, где наноструктуры образуют заранее определенный узор;и конструкцию киРНК, сообщающуюся по потоку текучей среды с микроиглой.2. Устройство по п.1, в котором узор дополнительно включает микроструктуры, причем наноструктуры обладают меньшим размером в сечении, чем микроструктуры.3. Устройство по п.2, дополнительно содержащее вторые наноструктуры с размером в сечении меньше размера в сечении микроструктур и больше размера в сечении первых наноструктур.4. Медицинское устройство по п.1 или 2, в котором по меньшей мере участок наноструктур обладает размером в сечении меньше примерно 500 и больше примерно 5 нанометров.5. Медицинское устройство по п.1 или 2, в котором по меньшей мере участок наноструктур обладает промежутком между центрами от примерно 50 нанометров до примерно 1 микрометра.6. Медицинское устройство по п.1 или 2, в котором по меньшей мере участок наноструктур обладает высотой от примерно 10 нанометров до примерно 20 микрометров.7. Медицинское устройство по п.1 или 2, в котором по меньшей мере на некотором участке наноструктуры обладают отношением размеров от примерно 0,15 до примерно 30.8. Устройство по п.1 или 2, в котором киРНК-препарат включает дуплексный участок от примерно 20 до примерно 30 пар.9. Устройство по п.1 или 2, в котором по меньшей мере одна цепь киРНК содержит 3'-липкий конец из двух или трех нуклеотидов.10. Устройство по п.1 или 2, киРНК-препарат содержит дополнительные нуклеотиды или аналоги нуклеотидов.11. Устройство по п.1 или 2, в котором киРНК-препарат соде�

Claims (23)

1. Устройство для доставки конструкции киРНК через дермальный барьер, содержащее
микроиглу и множество наноструктур, изготовленных на поверхности микроиглы, где наноструктуры образуют заранее определенный узор;
и конструкцию киРНК, сообщающуюся по потоку текучей среды с микроиглой.
2. Устройство по п.1, в котором узор дополнительно включает микроструктуры, причем наноструктуры обладают меньшим размером в сечении, чем микроструктуры.
3. Устройство по п.2, дополнительно содержащее вторые наноструктуры с размером в сечении меньше размера в сечении микроструктур и больше размера в сечении первых наноструктур.
4. Медицинское устройство по п.1 или 2, в котором по меньшей мере участок наноструктур обладает размером в сечении меньше примерно 500 и больше примерно 5 нанометров.
5. Медицинское устройство по п.1 или 2, в котором по меньшей мере участок наноструктур обладает промежутком между центрами от примерно 50 нанометров до примерно 1 микрометра.
6. Медицинское устройство по п.1 или 2, в котором по меньшей мере участок наноструктур обладает высотой от примерно 10 нанометров до примерно 20 микрометров.
7. Медицинское устройство по п.1 или 2, в котором по меньшей мере на некотором участке наноструктуры обладают отношением размеров от примерно 0,15 до примерно 30.
8. Устройство по п.1 или 2, в котором киРНК-препарат включает дуплексный участок от примерно 20 до примерно 30 пар.
9. Устройство по п.1 или 2, в котором по меньшей мере одна цепь киРНК содержит 3'-липкий конец из двух или трех нуклеотидов.
10. Устройство по п.1 или 2, киРНК-препарат содержит дополнительные нуклеотиды или аналоги нуклеотидов.
11. Устройство по п.1 или 2, в котором киРНК-препарат содержит нуклеотидную последовательность, идентичную участку гена-мишени.
12. Устройство по п.1 или 2, в котором киРНК-препарат содержит вставки, делеции или одноточечные мутации по сравнению с участком гена-мишени.
13. Устройство по п.1 или 2, в котором киРНК-препарат представляет собой одноцепочечную киРНК.
14. Устройство по п.1 или 2, в котором киРНК содержит лиганд, связанный с киРНК, например модификатор терапевтического средства, диагностическое соединение, "репортерную" группу, перекрестно-сшитый препарат, нуклеотидное основание, липофильную молекулу или белок.
15. Устройство по п.1 или 2, в котором киРНК-препарат внедрен в носитель для доставки, например, в липосому.
16. Устройство по п.1 или 2, в котором конструкция киРНК содержит вектор, например вирусный вектор.
17. Способ доставки конструкции киРНК через дермальный барьер, где способ включает:
проникновение через роговой слой микроиглы, микроигла содержит множество наноструктур, сформированных на поверхности микроиглы и скомпонованных в узор, конструкция киРНК сообщается по потоку текучей среды с микроиглой, конструкция киРНК транспортируется через роговой слой после проникновения в роговой слой микроиглы.
18. Способ по п.17, в котором конструкция киРНК транспортируется через роговой слой внутри круглого канала или канала микроиглы.
19. Способ по п.17 или 18, в котором конструкция киРНК транспортируется через роговой слой при стабильной концентрации в течение некоторого периода времени.
20. Способ формирования устройства для доставки конструкции РНК через дермальный барьер, где способ включает:
изготовление массива микроигл;
изготовление узора из наноструктур на поверхности по меньшей мере одной из микроигл;
присоединение конструкции киРНК к микроиглам, чтобы конструкция киРНК сообщалась по потоку текучей среды с микроиглами.
21. Способ по п.20, способ дополнительно включает удержание конструкции киРНК внутри емкости, которая сообщается по потоку текучей среды с массивом микроигл.
22. Способ по п.21, в котором емкость присоединена к подложке, на которой расположен массив микроигл.
23. Способ по п.21, в котором емкость съемно присоединяется к массиву микроигл.
RU2012150729/14A 2010-04-28 2011-04-27 Медицинские устройства для доставки кирнк RU2585138C2 (ru)

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US41605710P 2010-11-22 2010-11-22
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PCT/IB2011/051862 WO2011135531A2 (en) 2010-04-28 2011-04-27 MEDICAL DEVICES FOR DELIVERY OF siRNA

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US20200345993A1 (en) 2020-11-05
CN102985131A (zh) 2013-03-20
US20170157381A1 (en) 2017-06-08
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US20130158505A1 (en) 2013-06-20
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US20210393934A1 (en) 2021-12-23
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