RU2012150728A - Устройство доставки лекарственного средства, применяемого при ревматоидном артрите - Google Patents

Устройство доставки лекарственного средства, применяемого при ревматоидном артрите Download PDF

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RU2012150728A
RU2012150728A RU2012150728/14A RU2012150728A RU2012150728A RU 2012150728 A RU2012150728 A RU 2012150728A RU 2012150728/14 A RU2012150728/14 A RU 2012150728/14A RU 2012150728 A RU2012150728 A RU 2012150728A RU 2012150728 A RU2012150728 A RU 2012150728A
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rheumatoid arthritis
drug
nanostructures
microneedle
nanometers
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Расселл Фредерик РОСС
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Кимберли-Кларк Ворлдвайд, Инк.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture

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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
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  • Hematology (AREA)
  • Dermatology (AREA)
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  • Vascular Medicine (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Moulds For Moulding Plastics Or The Like (AREA)

Abstract

1. Устройство для доставки лекарственного средства при ревматоидном артрите через дермальный барьер, содержащее:микроиглу и множество наноструктур, изготовленных на поверхности микроиглы, наноструктуры образуют заранее определенный узор; илекарственное средство при ревматоидном артрите, сообщающееся по потоку текучей среды с микроиглой.2. Устройство по п.1, в котором узор дополнительно содержит микроструктуры, причем наноструктуры обладают размером в сечении меньше, чем микроструктуры.3. Устройство по п.2, дополнительно содержащее вторые наноструктуры с размером в сечении меньше размера в сечении микроструктур и больше размера в сечении первых наноструктур.4. Медицинское устройство по п.1 или 2, в котором по меньшей мере участок наноструктур обладает размером в сечении меньше примерно 500 нанометров и больше примерно 5 нанометров.5. Медицинское устройство по п.1 или 2, в котором по меньшей мере участок наноструктур обладает промежутком между центрами наноструктур от примерно 50 нанометров до примерно 1 микрометра.6. Медицинское устройство по п.1 или 2, в котором по меньшей мере участок наноструктур обладает высотой от примерно 10 нанометров до примерно 20 микрометров.7. Медицинское устройство по п.1 или 2, в котором по меньшей мере на некотором участке наноструктуры обладают отношением размеров от примерно 0,15 до примерно 30.8. Устройство по п.1 или 2, в котором лекарственное средство при ревматоидном артрите представляет собой смягчающее заболевание противоревматическое лекарственное средство.9. Устройство по п.8, в котором лекарственным средством при ревматоидном артрите является белковое терапевтическое лекарстве�

Claims (20)

1. Устройство для доставки лекарственного средства при ревматоидном артрите через дермальный барьер, содержащее:
микроиглу и множество наноструктур, изготовленных на поверхности микроиглы, наноструктуры образуют заранее определенный узор; и
лекарственное средство при ревматоидном артрите, сообщающееся по потоку текучей среды с микроиглой.
2. Устройство по п.1, в котором узор дополнительно содержит микроструктуры, причем наноструктуры обладают размером в сечении меньше, чем микроструктуры.
3. Устройство по п.2, дополнительно содержащее вторые наноструктуры с размером в сечении меньше размера в сечении микроструктур и больше размера в сечении первых наноструктур.
4. Медицинское устройство по п.1 или 2, в котором по меньшей мере участок наноструктур обладает размером в сечении меньше примерно 500 нанометров и больше примерно 5 нанометров.
5. Медицинское устройство по п.1 или 2, в котором по меньшей мере участок наноструктур обладает промежутком между центрами наноструктур от примерно 50 нанометров до примерно 1 микрометра.
6. Медицинское устройство по п.1 или 2, в котором по меньшей мере участок наноструктур обладает высотой от примерно 10 нанометров до примерно 20 микрометров.
7. Медицинское устройство по п.1 или 2, в котором по меньшей мере на некотором участке наноструктуры обладают отношением размеров от примерно 0,15 до примерно 30.
8. Устройство по п.1 или 2, в котором лекарственное средство при ревматоидном артрите представляет собой смягчающее заболевание противоревматическое лекарственное средство.
9. Устройство по п.8, в котором лекарственным средством при ревматоидном артрите является белковое терапевтическое лекарственное средство.
10. Устройство по п.9, в котором лекарственным средством при ревматоидном артрите является TNF-α блокатор или IL-1 блокатор.
11. Устройство по п.1 или 2, в котором лекарственным средством при ревматоидном артрите является противовоспалительное лекарственное средство.
12. Устройство по п.1 или 2, в котором лекарственным средство при ревматоидном артрите является анальгетик.
13. Способ доставки лекарственного средства при ревматоидном артрите через дермальный барьер, способ включает:
проникновение через роговой слой микроиглы, микроигла содержит множество наноструктур, сформированных на поверхности микроиглы и скомпонованных в узор, лекарственное средство при ревматоидном артрите сообщается по потоку текучей среды с микроиглой, лекарственное средство при ревматоидном артрите транспортируется через роговой слой после проникновения в роговой слой микроиглы.
14. Способ по п.13, в котором лекарственное средство при ревматоидном артрите транспортируется через роговой слой внутри круглого канала или канала микроиглы.
15. Способ по п.13 или 14, в котором лекарственное средство при ревматоидном артрите транспортируется через роговой слой при неизменной концентрации в течение некоторого периода времени.
16. Способ по п.13 или 14, в котором лекарственное средство при ревматоидном артрите обладает молекулярной массой более примерно 100 кДа.
17. Способ формирования устройства для доставки лекарственного средства при ревматоидном артрите через дермальный барьер, способ включает:
изготовление массива микроигл;
изготовление узора из наноструктур на поверхности по меньшей мере одной го микроигл;
присоединение лекарственного средства при ревматоидном артрите к микроиглам, чтобы лекарственное средство при ревматоидном артрите сообщалось по потоку текучей среды с микроиглами.
18. Способ по п.17, способ дополнительно включает удержание лекарственного средства при ревматоидном артрите внутри емкости, которая сообщается по потоку текучей среды с массивом микроигл.
19. Способ по п.18, в котором емкость присоединена к подложке, на которой расположен массив микроигл.
20. Способ по п.18, в котором емкость съемно присоединена к массиву микроигл.
RU2012150728/14A 2010-04-28 2011-04-27 Устройство доставки лекарственного средства, применяемого при ревматоидном артрите RU2585159C2 (ru)

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US32872310P 2010-04-28 2010-04-28
US61/328,723 2010-04-28
US41110110P 2010-11-08 2010-11-08
US61/411,101 2010-11-08
US201161435973P 2011-01-25 2011-01-25
US61/435,973 2011-01-25
PCT/IB2011/051861 WO2011135530A2 (en) 2010-04-28 2011-04-27 Device for delivery of rheumatoid arthritis medication

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CN (1) CN102971037B (ru)
AU (1) AU2011246879C1 (ru)
CA (1) CA2797204C (ru)
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US20130144257A1 (en) 2013-06-06
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US20230137871A1 (en) 2023-05-04
US10709884B2 (en) 2020-07-14
CN102971037A (zh) 2013-03-13
US20190209818A1 (en) 2019-07-11
AU2011246879A1 (en) 2012-11-08
CA2797204A1 (en) 2011-11-03
US20170157380A1 (en) 2017-06-08
RU2585159C2 (ru) 2016-05-27
KR20130058704A (ko) 2013-06-04
CN102971037B (zh) 2016-05-25
US10029082B2 (en) 2018-07-24
US20200297986A1 (en) 2020-09-24
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WO2011135530A3 (en) 2012-03-15
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WO2011135530A2 (en) 2011-11-03
US9522263B2 (en) 2016-12-20
JP5860032B2 (ja) 2016-02-16
EP2563450A4 (en) 2013-10-23
MX345837B (es) 2017-02-16
KR101799612B1 (ko) 2017-11-20
DK2563450T3 (da) 2017-11-13
EP2563450B1 (en) 2017-07-26
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PT2563450T (pt) 2017-08-28
US11565098B2 (en) 2023-01-31

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