WO2009104051A3 - Combinational therapeutics for treatment of prostate cancer using epoxy encapsulated magnetic particles and rnai medicine - Google Patents
Combinational therapeutics for treatment of prostate cancer using epoxy encapsulated magnetic particles and rnai medicine Download PDFInfo
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- WO2009104051A3 WO2009104051A3 PCT/IB2008/003661 IB2008003661W WO2009104051A3 WO 2009104051 A3 WO2009104051 A3 WO 2009104051A3 IB 2008003661 W IB2008003661 W IB 2008003661W WO 2009104051 A3 WO2009104051 A3 WO 2009104051A3
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- sirna
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- therapeutics
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- prostate cancer
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24024—Gelatinase A (3.4.24.24), i.e. matrix metalloproteinase 2 or MMP2
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- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24035—Gelatinase B (3.4.24.35), i.e. matrix metalloprotease 9 or MMP9
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- C12N2320/00—Applications; Uses
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- C12N2320/32—Special delivery means, e.g. tissue-specific
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Abstract
The present invention provides compositions and methods for treatment of prostate cancer using siRNA cocktail sequences targeting multiple disease causing genes, and a combined regimen with both RNAi therapeutics and EEMP encapsulated magnetic nanoparticle therapeutics. The invention includes: 1) The algorithm for designing siRNA drug API (active pharmaceutical ingredient); 2)The compositions of multiple siRNA inhibiting expression of the multiple cancer causing genes; 3) The methods of designing siRNA duplexes with different lengths, different ends and to target the same genes from both human and mouse cells; 4) The methods of formulating various siRNA cocktail which are able to inhibit tumorigenic and angiogenesis; 5) The methods of using histidine-lysine copolymer (HKP), PAMAM dendrimer and Liposomal (DOTAP) carrier to enhance siRNA delivery into the cutaneous tissue; and 6) The methods of using two disease relevant mouse xenograft models to validate the siRNA cocktail for its efficacy on controlling tumor growth.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US623107P | 2007-12-31 | 2007-12-31 | |
US60/006,231 | 2007-12-31 |
Publications (2)
Publication Number | Publication Date |
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WO2009104051A2 WO2009104051A2 (en) | 2009-08-27 |
WO2009104051A3 true WO2009104051A3 (en) | 2010-06-10 |
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ID=40985986
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/IB2008/003661 WO2009104051A2 (en) | 2007-12-31 | 2008-12-31 | Combinational therapeutics for treatment of prostate cancer using epoxy encapsulated magnetic particles and rnai medicine |
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WO (1) | WO2009104051A2 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8491914B2 (en) * | 2004-02-13 | 2013-07-23 | Ibc Pharmaceuticals, Inc. | Dock-and-lock (DNL) complexes for delivery of interference RNA |
EP2475372B2 (en) | 2009-09-10 | 2020-10-21 | Velin-Pharma A/S | Method for the preparation of micro-rna and its therapeutic application |
US9642873B2 (en) * | 2010-05-04 | 2017-05-09 | Sirnaomics, Inc. | Combinations of TGFβ and COX-2 inhibitors and methods for their therapeutic application |
CA2801535C (en) | 2010-06-04 | 2017-05-30 | Hough Ear Institute | Composition and method for inner ear sensory hair cell regeneration or replacement |
DE102011100581A1 (en) * | 2011-05-04 | 2012-11-08 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Treatment of hyperproliferative diseases of the genitourinary tract |
CN105363042B (en) * | 2015-10-21 | 2022-05-06 | 圣诺生物医药技术(苏州)有限公司 | Pharmaceutical composition and application thereof |
WO2020144583A1 (en) * | 2019-01-08 | 2020-07-16 | Olix Pharmaceuticals, Inc. | Cell-penetrating tripodal interfering rna |
CN113209043B (en) * | 2020-01-19 | 2023-12-15 | 中山大学孙逸仙纪念医院 | Intracellular response nanoparticle loaded with target gene siRNA and preparation method thereof |
CN111693619B (en) * | 2020-05-18 | 2021-09-17 | 中国石油大学(北京) | P-mercaptobenzoic acid modified magnetic PAMAM dendritic polymer material |
AU2022315530A1 (en) | 2021-07-20 | 2024-01-18 | Ags Therapeutics Sas | Extracellular vesicles from microalgae, their preparation, and uses |
WO2023144127A1 (en) | 2022-01-31 | 2023-08-03 | Ags Therapeutics Sas | Extracellular vesicles from microalgae, their biodistribution upon administration, and uses |
WO2023232976A1 (en) | 2022-06-03 | 2023-12-07 | Ags Therapeutics Sas | Extracellular vesicles from genetically-modified microalgae containing endogenously-loaded cargo, their preparation, and uses |
WO2024088808A1 (en) | 2022-10-24 | 2024-05-02 | Ags Therapeutics Sas | Extracellular vesicles from microalgae, their biodistribution upon intranasal administration, and uses thereof |
Citations (5)
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US20050026172A1 (en) * | 2003-02-11 | 2005-02-03 | Immusol, Inc. | siRNA libraries optimized for predetermined protein families |
US20070190055A1 (en) * | 2006-02-16 | 2007-08-16 | Jayakrishna Ambati | CCR3 inhibition for ocular angiogenesis and macular degeneration |
US20070248535A1 (en) * | 2005-02-07 | 2007-10-25 | The Trustees Of Columbia University In The City Of New York | Methods to treat or prevent hormone-resistant prostate cancer using siRNA specific for protocadherin-PC, or other inhibitors of protocadherin-PC expression or activity |
US20070264199A1 (en) * | 2005-09-26 | 2007-11-15 | Labhasetwar Vinod D | Magnetic nanoparticle composition and methods for using the same |
US20070275923A1 (en) * | 2006-05-25 | 2007-11-29 | Nastech Pharmaceutical Company Inc. | CATIONIC PEPTIDES FOR siRNA INTRACELLULAR DELIVERY |
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2008
- 2008-12-31 WO PCT/IB2008/003661 patent/WO2009104051A2/en active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050026172A1 (en) * | 2003-02-11 | 2005-02-03 | Immusol, Inc. | siRNA libraries optimized for predetermined protein families |
US20070248535A1 (en) * | 2005-02-07 | 2007-10-25 | The Trustees Of Columbia University In The City Of New York | Methods to treat or prevent hormone-resistant prostate cancer using siRNA specific for protocadherin-PC, or other inhibitors of protocadherin-PC expression or activity |
US20070264199A1 (en) * | 2005-09-26 | 2007-11-15 | Labhasetwar Vinod D | Magnetic nanoparticle composition and methods for using the same |
US20070190055A1 (en) * | 2006-02-16 | 2007-08-16 | Jayakrishna Ambati | CCR3 inhibition for ocular angiogenesis and macular degeneration |
US20070275923A1 (en) * | 2006-05-25 | 2007-11-29 | Nastech Pharmaceutical Company Inc. | CATIONIC PEPTIDES FOR siRNA INTRACELLULAR DELIVERY |
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