RU2012119488A - Конденсированные азиновые производные для лечения заболеваний, связанных с ацетилхолиновым рецептором - Google Patents
Конденсированные азиновые производные для лечения заболеваний, связанных с ацетилхолиновым рецептором Download PDFInfo
- Publication number
- RU2012119488A RU2012119488A RU2012119488/04A RU2012119488A RU2012119488A RU 2012119488 A RU2012119488 A RU 2012119488A RU 2012119488/04 A RU2012119488/04 A RU 2012119488/04A RU 2012119488 A RU2012119488 A RU 2012119488A RU 2012119488 A RU2012119488 A RU 2012119488A
- Authority
- RU
- Russia
- Prior art keywords
- alkyl
- cycloalkyl
- heterocyclic derivative
- optionally substituted
- group
- Prior art date
Links
- 0 *C(N(*)*=C1C(*)=CC=CC=C/C=C1)=* Chemical compound *C(N(*)*=C1C(*)=CC=CC=C/C=C1)=* 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25110109P | 2009-10-13 | 2009-10-13 | |
EP09172872.5 | 2009-10-13 | ||
EP09172872 | 2009-10-13 | ||
US61/251,101 | 2009-10-13 | ||
PCT/EP2010/065160 WO2011045258A1 (en) | 2009-10-13 | 2010-10-11 | Condensed azine - derivatives for the treatment of diseases related to the acetylcholine receptor |
Publications (1)
Publication Number | Publication Date |
---|---|
RU2012119488A true RU2012119488A (ru) | 2013-11-20 |
Family
ID=42040651
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2012119488/04A RU2012119488A (ru) | 2009-10-13 | 2010-10-11 | Конденсированные азиновые производные для лечения заболеваний, связанных с ацетилхолиновым рецептором |
Country Status (12)
Country | Link |
---|---|
US (1) | US8841289B2 (es) |
EP (1) | EP2488520B1 (es) |
JP (1) | JP2013507417A (es) |
KR (1) | KR20120100913A (es) |
CN (1) | CN102666540A (es) |
AU (1) | AU2010305825A1 (es) |
BR (1) | BR112012008518A2 (es) |
CA (1) | CA2776835A1 (es) |
IN (1) | IN2012DN02968A (es) |
MX (1) | MX2012004289A (es) |
RU (1) | RU2012119488A (es) |
WO (1) | WO2011045258A1 (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPWO2013018735A1 (ja) | 2011-07-29 | 2015-03-05 | 大正製薬株式会社 | アミジン化合物又はその塩 |
CN104302358B (zh) | 2012-03-07 | 2017-12-05 | 癌症研究协会:皇家癌症医院 | 3‑芳基‑5‑取代的异喹啉‑1‑酮化合物和它们的治疗用途 |
AU2013264943B2 (en) * | 2012-05-22 | 2018-02-01 | King Abdullah University Of Science And Technology | Combination comprising parthenolide for use in the treatment of Alzheimer's Disease and other neurodegenerative disorders |
CN105722835B (zh) | 2013-09-11 | 2018-07-31 | 癌症研究协会:皇家癌症医院 | 3-芳基-5-取代的-异喹啉-1-酮化合物及它们的疗法应用 |
US9617226B2 (en) | 2014-09-05 | 2017-04-11 | AbbVie Deutschland GmbH & Co. KG | Fused heterocyclic or carbocyclic compounds carrying a substituted cycloaliphatic radical and use thereof for treating vasopressin-related diseases |
EP3233087B1 (en) | 2014-12-16 | 2019-10-02 | Axovant Sciences GmbH | Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors |
TWI770525B (zh) | 2014-12-30 | 2022-07-11 | 美商瓦洛健康公司 | 作為泛素特異性蛋白酶7抑制劑之吡咯并及吡唑并嘧啶 |
MA41291A (fr) | 2014-12-30 | 2017-11-07 | Forma Therapeutics Inc | Dérivés de la pyrrolotriazinone et de l'imidazotriazinone en tant qu'inhibiteurs de la protéase spécifique de l'ubiquitine n° 7 (usp7) pour le traitement d'un cancer |
JP2018504432A (ja) | 2015-02-05 | 2018-02-15 | フォーマ セラピューティクス,インコーポレイテッド | ユビキチン特異的プロテアーゼ7阻害物質としてのイソチアゾロピリミジノン、ピラゾロピリミジノン及びピロロピリミジノン |
WO2016126926A1 (en) | 2015-02-05 | 2016-08-11 | Forma Therapeutics, Inc. | Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors |
WO2016126929A1 (en) | 2015-02-05 | 2016-08-11 | Forma Therapeutics, Inc. | Thienopyrimidinones as ubiquitin-specific protease 7 inhibitors |
CN106146410B (zh) * | 2015-04-03 | 2018-10-12 | 中南大学 | 6-氨基-4(3h)-喹唑啉酮衍生物及其合成方法和用途 |
CN106279211B (zh) * | 2015-06-03 | 2020-09-15 | 北京大学 | 一种噻唑并嘧啶酮化合物及其制备方法和应用 |
AU2016274694A1 (en) | 2015-06-10 | 2018-01-18 | Axovant Sciences Gmbh | Aminobenzisoxazole compounds as agonists of A7-nicotinic acetylcholine receptors |
JP2018523707A (ja) | 2015-08-12 | 2018-08-23 | アクソバント サイエンシズ ゲーエムベーハー | α7−ニコチン性アセチルコリン受容体のアゴニストとしてのジェミナル置換アミノベンゾイソオキサゾール化合物 |
DK3386591T3 (da) | 2015-12-09 | 2020-09-28 | Cadent Therapeutics Inc | Heteroaromatic nmda receptor modulators and uses thereof |
ES2950348T3 (es) | 2015-12-09 | 2023-10-09 | Novartis Ag | Moduladores de receptores NMDA de tienopirimidinona y usos de los mismos |
AU2017382339B2 (en) | 2016-12-22 | 2024-02-15 | Novartis Ag | NMDA receptor modulators and uses thereof |
WO2020004594A1 (ja) * | 2018-06-27 | 2020-01-02 | 株式会社リボルナバイオサイエンス | 脊髄性筋萎縮症の予防または治療剤 |
HU231414B1 (hu) * | 2018-07-13 | 2023-08-28 | Richter Gedeon Nyrt. | Tiadiazin származékok |
MX2021000841A (es) | 2018-07-26 | 2021-03-26 | Domain Therapeutics | Derivados de quinazolinona sustituidos y su uso como moduladores alostericos positivos de mglur4. |
DK3830092T3 (en) | 2018-08-03 | 2023-08-07 | Novartis Ag | Heteroaromatic nmda receptor modulators and uses thereof |
WO2021198191A1 (en) | 2020-03-30 | 2021-10-07 | Enyo Pharma | Quinazolinone derivatives and uses thereof for treating a cancer |
EP4126847A1 (en) | 2020-03-30 | 2023-02-08 | ENYO Pharma | Quinazolinone derivatives and uses thereof for treating a cancer |
CN112898290B (zh) * | 2021-01-29 | 2022-08-05 | 中南大学 | 异噁唑甲酰胺基-4(3h)-喹唑啉酮衍生物及其合成方法和用途 |
US11957759B1 (en) | 2022-09-07 | 2024-04-16 | Arvinas Operations, Inc. | Rapidly accelerated fibrosarcoma (RAF) degrading compounds and associated methods of use |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0000540D0 (sv) | 2000-02-18 | 2000-02-18 | Astrazeneca Ab | New compounds |
JP2005504730A (ja) * | 2001-04-20 | 2005-02-17 | バーテックス ファーマシューティカルズ インコーポレイテッド | Gsk−3インヒビターとして有用な組成物 |
EP1472248A1 (en) * | 2002-01-17 | 2004-11-03 | Eli Lilly And Company | Modulators of acetylcholine receptors |
GB0220581D0 (en) | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
TW200536830A (en) * | 2004-02-06 | 2005-11-16 | Chugai Pharmaceutical Co Ltd | 1-(2H)-isoquinolone derivative |
KR101373535B1 (ko) * | 2005-07-26 | 2014-03-12 | 사노피 | Rho-키나제 억제제로서의 피페리디닐-치환된 이소퀴놀론유도체 |
KR20090107994A (ko) * | 2006-09-11 | 2009-10-14 | 엔.브이.오가논 | 퀴나졸리논 및 이소퀴놀리논 아세트아미드 유도체 |
RU2009128690A (ru) | 2006-12-27 | 2011-02-10 | Санофи-Авентис (Fr) | Новые замещенные производные изохинолина и изохинолинона |
JP2010229035A (ja) * | 2007-08-01 | 2010-10-14 | Taisho Pharmaceutical Co Ltd | ピリドピリミジン−4−オン誘導体 |
JP2011503145A (ja) * | 2007-11-14 | 2011-01-27 | ノイロサーチ アクティーゼルスカブ | 新規な1,4−ジアザ−ビシクロ[3.2.2]ノニルピリミジン誘導体及びその医学的使用 |
KR20100114123A (ko) | 2008-02-29 | 2010-10-22 | 테크노 코어 인터내셔널 가부시키가이샤 | 팩 전지의 충전 장치 및 팩 전지의 품질 판정 장치 |
-
2010
- 2010-10-11 RU RU2012119488/04A patent/RU2012119488A/ru unknown
- 2010-10-11 CA CA2776835A patent/CA2776835A1/en not_active Abandoned
- 2010-10-11 MX MX2012004289A patent/MX2012004289A/es not_active Application Discontinuation
- 2010-10-11 BR BR112012008518A patent/BR112012008518A2/pt not_active Application Discontinuation
- 2010-10-11 WO PCT/EP2010/065160 patent/WO2011045258A1/en active Application Filing
- 2010-10-11 IN IN2968DEN2012 patent/IN2012DN02968A/en unknown
- 2010-10-11 AU AU2010305825A patent/AU2010305825A1/en not_active Abandoned
- 2010-10-11 CN CN2010800465507A patent/CN102666540A/zh active Pending
- 2010-10-11 EP EP10771062.6A patent/EP2488520B1/en active Active
- 2010-10-11 JP JP2012533593A patent/JP2013507417A/ja active Pending
- 2010-10-11 KR KR1020127009340A patent/KR20120100913A/ko not_active Application Discontinuation
- 2010-10-11 US US13/501,587 patent/US8841289B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US20120208796A1 (en) | 2012-08-16 |
BR112012008518A2 (pt) | 2016-04-05 |
JP2013507417A (ja) | 2013-03-04 |
CN102666540A (zh) | 2012-09-12 |
WO2011045258A1 (en) | 2011-04-21 |
EP2488520B1 (en) | 2015-09-02 |
MX2012004289A (es) | 2012-06-12 |
AU2010305825A1 (en) | 2012-04-19 |
KR20120100913A (ko) | 2012-09-12 |
US8841289B2 (en) | 2014-09-23 |
CA2776835A1 (en) | 2011-04-21 |
IN2012DN02968A (es) | 2015-07-31 |
EP2488520A1 (en) | 2012-08-22 |
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