RU2012119488A - Конденсированные азиновые производные для лечения заболеваний, связанных с ацетилхолиновым рецептором - Google Patents
Конденсированные азиновые производные для лечения заболеваний, связанных с ацетилхолиновым рецептором Download PDFInfo
- Publication number
- RU2012119488A RU2012119488A RU2012119488/04A RU2012119488A RU2012119488A RU 2012119488 A RU2012119488 A RU 2012119488A RU 2012119488/04 A RU2012119488/04 A RU 2012119488/04A RU 2012119488 A RU2012119488 A RU 2012119488A RU 2012119488 A RU2012119488 A RU 2012119488A
- Authority
- RU
- Russia
- Prior art keywords
- alkyl
- cycloalkyl
- heterocyclic derivative
- optionally substituted
- group
- Prior art date
Links
- 0 *C(N(*)*=C1C(*)=CC=CC=C/C=C1)=* Chemical compound *C(N(*)*=C1C(*)=CC=CC=C/C=C1)=* 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25110109P | 2009-10-13 | 2009-10-13 | |
| EP09172872.5 | 2009-10-13 | ||
| US61/251,101 | 2009-10-13 | ||
| EP09172872 | 2009-10-13 | ||
| PCT/EP2010/065160 WO2011045258A1 (en) | 2009-10-13 | 2010-10-11 | Condensed azine - derivatives for the treatment of diseases related to the acetylcholine receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012119488A true RU2012119488A (ru) | 2013-11-20 |
Family
ID=42040651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012119488/04A RU2012119488A (ru) | 2009-10-13 | 2010-10-11 | Конденсированные азиновые производные для лечения заболеваний, связанных с ацетилхолиновым рецептором |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8841289B2 (es) |
| EP (1) | EP2488520B1 (es) |
| JP (1) | JP2013507417A (es) |
| KR (1) | KR20120100913A (es) |
| CN (1) | CN102666540A (es) |
| AU (1) | AU2010305825A1 (es) |
| BR (1) | BR112012008518A2 (es) |
| CA (1) | CA2776835A1 (es) |
| IN (1) | IN2012DN02968A (es) |
| MX (1) | MX2012004289A (es) |
| RU (1) | RU2012119488A (es) |
| WO (1) | WO2011045258A1 (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20140045511A (ko) | 2011-07-29 | 2014-04-16 | 다이쇼 세이야꾸 가부시끼가이샤 | 아미딘 화합물 또는 그의 염 |
| KR102104144B1 (ko) | 2012-03-07 | 2020-04-23 | 디 인스티튜트 오브 캔서 리서치:로얄 캔서 하스피틀 | 3-아릴-5-치환-이소퀴놀린-1-온 화합물 및 그의 치료적 용도 |
| AU2013264943B2 (en) * | 2012-05-22 | 2018-02-01 | King Abdullah University Of Science And Technology | Combination comprising parthenolide for use in the treatment of Alzheimer's Disease and other neurodegenerative disorders |
| DK3044221T3 (en) | 2013-09-11 | 2018-04-23 | Institute Of Cancer Res Royal Cancer Hospital The | 3-ARYL-5-SUBSTITUTED-ISOQUINOLIN-1-ON COMPOUNDS AND THERAPEUTIC APPLICATION THEREOF |
| US9617226B2 (en) | 2014-09-05 | 2017-04-11 | AbbVie Deutschland GmbH & Co. KG | Fused heterocyclic or carbocyclic compounds carrying a substituted cycloaliphatic radical and use thereof for treating vasopressin-related diseases |
| EP3623371A1 (en) | 2014-12-16 | 2020-03-18 | Axovant Sciences GmbH | Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors |
| MA41291A (fr) | 2014-12-30 | 2017-11-07 | Forma Therapeutics Inc | Dérivés de la pyrrolotriazinone et de l'imidazotriazinone en tant qu'inhibiteurs de la protéase spécifique de l'ubiquitine n° 7 (usp7) pour le traitement d'un cancer |
| AR103297A1 (es) | 2014-12-30 | 2017-05-03 | Forma Therapeutics Inc | Pirrolo y pirazolopirimidinas como inhibidores de la proteasa 7 específica de ubiquitina |
| JP2018504431A (ja) | 2015-02-05 | 2018-02-15 | フォーマ セラピューティクス，インコーポレイテッド | ユビキチン特異的プロテアーゼ７阻害物質としてのチエノピリミジノン |
| WO2016126926A1 (en) | 2015-02-05 | 2016-08-11 | Forma Therapeutics, Inc. | Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors |
| US9938300B2 (en) | 2015-02-05 | 2018-04-10 | Forma Therapeutics, Inc. | Isothiazolopyrimidinones, pyrazolopyrimidinones, and pyrrolopyrimidinones as ubiquitin-specific protease 7 inhibitors |
| CN106146410B (zh) * | 2015-04-03 | 2018-10-12 | 中南大学 | 6-氨基-4(3h)-喹唑啉酮衍生物及其合成方法和用途 |
| CN106279211B (zh) * | 2015-06-03 | 2020-09-15 | 北京大学 | 一种噻唑并嘧啶酮化合物及其制备方法和应用 |
| RU2017145964A (ru) | 2015-06-10 | 2019-07-10 | Аксовант Сайенсиз Гмбх | Аминобензизоксазольные соединения в качестве агонистов α7-никотиновых ацетилхолиновых рецепторов |
| WO2017027600A1 (en) | 2015-08-12 | 2017-02-16 | Forum Pharmaceuticals, Inc. | GEMINAL SUBSTITUTED AMINOBENZISOXAZOLE COMPOUNDS AS AGONISTS OF α7-NICOTINIC ACETYLCHOLINE RECEPTORS |
| EP4006038A1 (en) | 2015-12-09 | 2022-06-01 | Cadent Therapeutics, Inc. | Thienopyrimidinone nmda receptor modulators and uses thereof |
| RS60834B1 (sr) | 2015-12-09 | 2020-10-30 | Cadent Therapeutics Inc | Modulatori heteroaromatskog nmda receptora i njihove upotrebe |
| WO2018119374A1 (en) | 2016-12-22 | 2018-06-28 | Cadent Therapeutics | Nmda receptor modulators and uses thereof |
| KR20210025625A (ko) * | 2018-06-27 | 2021-03-09 | 리보르나 바이오사이언시스, 아이엔씨. | 척수성 근위축증 예방제 또는 치료제 |
| HU231414B1 (hu) * | 2018-07-13 | 2023-08-28 | Richter Gedeon Nyrt. | Tiadiazin származékok |
| EP3827001A1 (en) | 2018-07-26 | 2021-06-02 | Domain Therapeutics | Substituted quinazolinone derivatives and their use as positive allosteric modulators of mglur4 |
| CR20210125A (es) | 2018-08-03 | 2021-06-30 | Cadent Therapeutics Inc | Moduladores del receptor nmda heteroaromático y usos de los mismos |
| WO2021198191A1 (en) | 2020-03-30 | 2021-10-07 | Enyo Pharma | Quinazolinone derivatives and uses thereof for treating a cancer |
| WO2021198188A1 (en) | 2020-03-30 | 2021-10-07 | Enyo Pharma | Quinazolinone derivatives and uses thereof for treating a cancer |
| CN112898290B (zh) * | 2021-01-29 | 2022-08-05 | 中南大学 | 异噁唑甲酰胺基-4(3h)-喹唑啉酮衍生物及其合成方法和用途 |
| US11957759B1 (en) | 2022-09-07 | 2024-04-16 | Arvinas Operations, Inc. | Rapidly accelerated fibrosarcoma (RAF) degrading compounds and associated methods of use |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0000540D0 (sv) | 2000-02-18 | 2000-02-18 | Astrazeneca Ab | New compounds |
| MXPA03009650A (es) * | 2001-04-20 | 2005-03-07 | Vertex Pharma | Derivados de 9-deazoguanidina como inhibidores de gsk-3. |
| WO2003062235A1 (en) | 2002-01-17 | 2003-07-31 | Eli Lilly And Company | Modulators of acetylcholine receptors |
| GB0220581D0 (en) | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
| TW200536830A (en) * | 2004-02-06 | 2005-11-16 | Chugai Pharmaceutical Co Ltd | 1-(2H)-isoquinolone derivative |
| NI200800025A (es) * | 2005-07-26 | 2009-03-03 | Derivados de isoquinolona sustituidos con piperidinilo en calidad de inhibidores de rho-quinasa | |
| KR20090107994A (ko) | 2006-09-11 | 2009-10-14 | 엔.브이.오가논 | 퀴나졸리논 및 이소퀴놀리논 아세트아미드 유도체 |
| MX2009005862A (es) * | 2006-12-27 | 2009-06-17 | Sanofi Aventis | Nuevos derivados de isoquinolina e isoquinolinona sustituidos. |
| JP2010229035A (ja) * | 2007-08-01 | 2010-10-14 | Taisho Pharmaceutical Co Ltd | ピリドピリミジン−４−オン誘導体 |
| BRPI0820259A2 (pt) * | 2007-11-14 | 2015-06-16 | Neurosearch As | Derivado de 1,4-diaza-biciclo[3.2.2] nonil pirimidina, composição farmacêutica, uso do derivado de 1,4-diaza-biciclo[3.2.2] nonil pirimidina, e, método de tratamento, prevenção ou alívio de uma doença ou uma desordem ou uma condição de um corpo de animal vivo |
| KR20100114123A (ko) | 2008-02-29 | 2010-10-22 | 테크노 코어 인터내셔널 가부시키가이샤 | 팩 전지의 충전 장치 및 팩 전지의 품질 판정 장치 |
-
2010
- 2010-10-11 JP JP2012533593A patent/JP2013507417A/ja active Pending
- 2010-10-11 US US13/501,587 patent/US8841289B2/en active Active
- 2010-10-11 MX MX2012004289A patent/MX2012004289A/es not_active Application Discontinuation
- 2010-10-11 CA CA2776835A patent/CA2776835A1/en not_active Abandoned
- 2010-10-11 CN CN2010800465507A patent/CN102666540A/zh active Pending
- 2010-10-11 IN IN2968DEN2012 patent/IN2012DN02968A/en unknown
- 2010-10-11 WO PCT/EP2010/065160 patent/WO2011045258A1/en active Application Filing
- 2010-10-11 EP EP10771062.6A patent/EP2488520B1/en active Active
- 2010-10-11 RU RU2012119488/04A patent/RU2012119488A/ru unknown
- 2010-10-11 KR KR1020127009340A patent/KR20120100913A/ko not_active Application Discontinuation
- 2010-10-11 AU AU2010305825A patent/AU2010305825A1/en not_active Abandoned
- 2010-10-11 BR BR112012008518A patent/BR112012008518A2/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP2488520A1 (en) | 2012-08-22 |
| WO2011045258A1 (en) | 2011-04-21 |
| CA2776835A1 (en) | 2011-04-21 |
| AU2010305825A1 (en) | 2012-04-19 |
| CN102666540A (zh) | 2012-09-12 |
| KR20120100913A (ko) | 2012-09-12 |
| US20120208796A1 (en) | 2012-08-16 |
| US8841289B2 (en) | 2014-09-23 |
| MX2012004289A (es) | 2012-06-12 |
| IN2012DN02968A (es) | 2015-07-31 |
| JP2013507417A (ja) | 2013-03-04 |
| BR112012008518A2 (pt) | 2016-04-05 |
| EP2488520B1 (en) | 2015-09-02 |
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