IN2012DN02968A - - Google Patents
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- Publication number
- IN2012DN02968A IN2012DN02968A IN2968DEN2012A IN2012DN02968A IN 2012DN02968 A IN2012DN02968 A IN 2012DN02968A IN 2968DEN2012 A IN2968DEN2012 A IN 2968DEN2012A IN 2012DN02968 A IN2012DN02968 A IN 2012DN02968A
- Authority
- IN
- India
- Prior art keywords
- present
- relates
- heterocyclic
- schizophrenia
- solvate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
The present invention relates to a heterocyclic derivative of formula (I) wherein the variables are as defined in the specification or to a pharmaceutically acceptable salt or solvate thereof. The present invention further relates to pharmaceutical compositions comprising said heterocyclic derivatives and to their use in therapy, for instance in the treatment or prevention of disorders mediated by nicotinic acetylcholine receptors, such as schizophrenia and Alzheimer's disease.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25110109P | 2009-10-13 | 2009-10-13 | |
EP09172872 | 2009-10-13 | ||
PCT/EP2010/065160 WO2011045258A1 (en) | 2009-10-13 | 2010-10-11 | Condensed azine - derivatives for the treatment of diseases related to the acetylcholine receptor |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2012DN02968A true IN2012DN02968A (en) | 2015-07-31 |
Family
ID=42040651
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN2968DEN2012 IN2012DN02968A (en) | 2009-10-13 | 2010-10-11 |
Country Status (12)
Country | Link |
---|---|
US (1) | US8841289B2 (en) |
EP (1) | EP2488520B1 (en) |
JP (1) | JP2013507417A (en) |
KR (1) | KR20120100913A (en) |
CN (1) | CN102666540A (en) |
AU (1) | AU2010305825A1 (en) |
BR (1) | BR112012008518A2 (en) |
CA (1) | CA2776835A1 (en) |
IN (1) | IN2012DN02968A (en) |
MX (1) | MX2012004289A (en) |
RU (1) | RU2012119488A (en) |
WO (1) | WO2011045258A1 (en) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013018735A1 (en) | 2011-07-29 | 2013-02-07 | 大正製薬株式会社 | Amidine compound or salt thereof |
AU2013229229B2 (en) | 2012-03-07 | 2017-10-19 | Institute Of Cancer Research: Royal Cancer Hospital (The) | 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use |
US20150164858A1 (en) * | 2012-05-22 | 2015-06-18 | King Abdullah University Of Science And Technology | Combination comprising parthenolide for use in the treatment of alzheimer's disease and other neurodegenerative disorders |
NO3044221T3 (en) | 2013-09-11 | 2018-07-21 | ||
US9617226B2 (en) | 2014-09-05 | 2017-04-11 | AbbVie Deutschland GmbH & Co. KG | Fused heterocyclic or carbocyclic compounds carrying a substituted cycloaliphatic radical and use thereof for treating vasopressin-related diseases |
EP3623371A1 (en) | 2014-12-16 | 2020-03-18 | Axovant Sciences GmbH | Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors |
TWI698436B (en) | 2014-12-30 | 2020-07-11 | 美商佛瑪治療公司 | Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors |
MA41291A (en) | 2014-12-30 | 2017-11-07 | Forma Therapeutics Inc | PYRROLOTRIAZINONE AND IMIDAZOTRIAZINONE DERIVATIVES AS UBIQUE-SPECIFIC PROTEASE INHIBITORS No. 7 (USP7) FOR THE TREATMENT OF CANCER |
US9932351B2 (en) | 2015-02-05 | 2018-04-03 | Forma Therapeutics, Inc. | Thienopyrimidinones as ubiquitin-specific protease 7 inhibitors |
US9840491B2 (en) | 2015-02-05 | 2017-12-12 | Forma Therapeutics, Inc. | Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors |
WO2016126935A1 (en) | 2015-02-05 | 2016-08-11 | Forma Therapeutics, Inc. | Isothiazolopyrimidinones, pyrazolopyrimidinones, and pyrrolopyrimidinones as ubiquitin-specific protease 7 inhibitors |
CN106146410B (en) * | 2015-04-03 | 2018-10-12 | 中南大学 | 6- amino -4 (3H)-Quinazol derivative and its preparation method and use |
CN106279211B (en) | 2015-06-03 | 2020-09-15 | 北京大学 | Thiazolopyrimidinone compound and preparation method and application thereof |
WO2016201096A1 (en) | 2015-06-10 | 2016-12-15 | Forum Pharmaceuticals, Inc. | Aminobenzisoxazole compounds as agonists of a7-nicotinic acetylcholine receptors |
US10428062B2 (en) | 2015-08-12 | 2019-10-01 | Axovant Sciences Gmbh | Geminal substituted aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors |
LT3386591T (en) | 2015-12-09 | 2020-10-12 | Cadent Therapeutics, Inc. | Heteroaromatic nmda receptor modulators and uses thereof |
ES2950348T3 (en) | 2015-12-09 | 2023-10-09 | Novartis Ag | Thienopyrimidinone NMDA receptor modulators and uses thereof |
WO2018119374A1 (en) | 2016-12-22 | 2018-06-28 | Cadent Therapeutics | Nmda receptor modulators and uses thereof |
WO2020004594A1 (en) * | 2018-06-27 | 2020-01-02 | 株式会社リボルナバイオサイエンス | Prophylactic or therapeutic agent for spinal muscular atrophy |
HU231414B1 (en) * | 2018-07-13 | 2023-08-28 | Richter Gedeon Nyrt. | Thiadiazine derivatives |
KR20210039368A (en) | 2018-07-26 | 2021-04-09 | 도메인 테라퓨틱스 | Substituted quinazolinone derivatives and their use as positive allosteric modulators of mGluR4 |
LT3830092T (en) | 2018-08-03 | 2023-09-11 | Novartis Ag | Heteroaromatic nmda receptor modulators and uses thereof |
WO2021198188A1 (en) | 2020-03-30 | 2021-10-07 | Enyo Pharma | Quinazolinone derivatives and uses thereof for treating a cancer |
WO2021198191A1 (en) | 2020-03-30 | 2021-10-07 | Enyo Pharma | Quinazolinone derivatives and uses thereof for treating a cancer |
CN112898290B (en) * | 2021-01-29 | 2022-08-05 | 中南大学 | Isoxazole formamido-4 (3H) -quinazolinone derivative and synthesis method and application thereof |
WO2024054591A1 (en) | 2022-09-07 | 2024-03-14 | Arvinas Operations, Inc. | Rapidly accelerated fibrosarcoma (raf) degrading compounds and associated methods of use |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0000540D0 (en) | 2000-02-18 | 2000-02-18 | Astrazeneca Ab | New compounds |
MXPA03009650A (en) * | 2001-04-20 | 2005-03-07 | Vertex Pharma | 9-deazaguanine derivatives as inhibitors of gsk-3. |
US7148236B2 (en) | 2002-01-17 | 2006-12-12 | Merck & Co., Inc. | Modulators of acetylcholine receptors |
GB0220581D0 (en) | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
TW200536830A (en) * | 2004-02-06 | 2005-11-16 | Chugai Pharmaceutical Co Ltd | 1-(2H)-isoquinolone derivative |
AU2006274245B2 (en) * | 2005-07-26 | 2011-11-24 | Sanofi-Aventis | Piperidinyl-substituted isoquinolone derivatives as Rho-kinase inhibitors |
CA2663161C (en) * | 2006-09-11 | 2014-10-28 | N.V. Organon | Quinazolinone and isoquinolinone acetamide derivatives |
BRPI0720909A2 (en) | 2006-12-27 | 2016-11-01 | Sanofi Aventis | substituted isoquinoline and isoquinolinone derivatives |
JP2010229035A (en) * | 2007-08-01 | 2010-10-14 | Taisho Pharmaceutical Co Ltd | Pyridopyrimidin-4-one derivative |
MX2010005040A (en) * | 2007-11-14 | 2010-05-21 | Neurosearch As | Novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their medical use. |
KR20100114123A (en) | 2008-02-29 | 2010-10-22 | 테크노 코어 인터내셔널 가부시키가이샤 | Charging device and quality judging device of pack cell |
-
2010
- 2010-10-11 CA CA2776835A patent/CA2776835A1/en not_active Abandoned
- 2010-10-11 BR BR112012008518A patent/BR112012008518A2/en not_active Application Discontinuation
- 2010-10-11 RU RU2012119488/04A patent/RU2012119488A/en unknown
- 2010-10-11 US US13/501,587 patent/US8841289B2/en active Active
- 2010-10-11 CN CN2010800465507A patent/CN102666540A/en active Pending
- 2010-10-11 JP JP2012533593A patent/JP2013507417A/en active Pending
- 2010-10-11 MX MX2012004289A patent/MX2012004289A/en not_active Application Discontinuation
- 2010-10-11 KR KR1020127009340A patent/KR20120100913A/en not_active Application Discontinuation
- 2010-10-11 IN IN2968DEN2012 patent/IN2012DN02968A/en unknown
- 2010-10-11 AU AU2010305825A patent/AU2010305825A1/en not_active Abandoned
- 2010-10-11 EP EP10771062.6A patent/EP2488520B1/en active Active
- 2010-10-11 WO PCT/EP2010/065160 patent/WO2011045258A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
KR20120100913A (en) | 2012-09-12 |
US20120208796A1 (en) | 2012-08-16 |
RU2012119488A (en) | 2013-11-20 |
US8841289B2 (en) | 2014-09-23 |
EP2488520A1 (en) | 2012-08-22 |
AU2010305825A1 (en) | 2012-04-19 |
WO2011045258A1 (en) | 2011-04-21 |
MX2012004289A (en) | 2012-06-12 |
CA2776835A1 (en) | 2011-04-21 |
BR112012008518A2 (en) | 2016-04-05 |
CN102666540A (en) | 2012-09-12 |
EP2488520B1 (en) | 2015-09-02 |
JP2013507417A (en) | 2013-03-04 |
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