RU2012103240A - Мультимерные пептидные конъюгаты и их применение - Google Patents
Мультимерные пептидные конъюгаты и их применение Download PDFInfo
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- RU2012103240A RU2012103240A RU2012103240/10A RU2012103240A RU2012103240A RU 2012103240 A RU2012103240 A RU 2012103240A RU 2012103240/10 A RU2012103240/10 A RU 2012103240/10A RU 2012103240 A RU2012103240 A RU 2012103240A RU 2012103240 A RU2012103240 A RU 2012103240A
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- 239000000863 peptide conjugate Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 30
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract 14
- 239000013598 vector Substances 0.000 claims abstract 14
- 239000003795 chemical substances by application Substances 0.000 claims abstract 7
- 239000012634 fragment Substances 0.000 claims abstract 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims abstract 3
- 238000000034 method Methods 0.000 claims 18
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 9
- 238000011321 prophylaxis Methods 0.000 claims 8
- 238000011282 treatment Methods 0.000 claims 8
- 208000035475 disorder Diseases 0.000 claims 7
- 230000001965 increasing effect Effects 0.000 claims 4
- 208000011580 syndromic disease Diseases 0.000 claims 3
- 206010012335 Dependence Diseases 0.000 claims 2
- 102000007446 Glucagon-Like Peptide-1 Receptor Human genes 0.000 claims 2
- 108010086246 Glucagon-Like Peptide-1 Receptor Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000028017 Psychotic disease Diseases 0.000 claims 2
- 206010051379 Systemic Inflammatory Response Syndrome Diseases 0.000 claims 2
- 210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 claims 2
- 230000036760 body temperature Effects 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 206010013663 drug dependence Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000037406 food intake Effects 0.000 claims 2
- 235000012631 food intake Nutrition 0.000 claims 2
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 2
- 210000005240 left ventricle Anatomy 0.000 claims 2
- 208000010125 myocardial infarction Diseases 0.000 claims 2
- 235000016709 nutrition Nutrition 0.000 claims 2
- 230000002980 postoperative effect Effects 0.000 claims 2
- 201000000980 schizophrenia Diseases 0.000 claims 2
- 208000011117 substance-related disease Diseases 0.000 claims 2
- 210000002700 urine Anatomy 0.000 claims 2
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 claims 1
- 208000004476 Acute Coronary Syndrome Diseases 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 102000013455 Amyloid beta-Peptides Human genes 0.000 claims 1
- 108010090849 Amyloid beta-Peptides Proteins 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 206010010904 Convulsion Diseases 0.000 claims 1
- 208000032781 Diabetic cardiomyopathy Diseases 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 208000008279 Dumping Syndrome Diseases 0.000 claims 1
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 206010020919 Hypervolaemia Diseases 0.000 claims 1
- 208000004356 Hysteria Diseases 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 208000016285 Movement disease Diseases 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 206010033664 Panic attack Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000032395 Post gastric surgery syndrome Diseases 0.000 claims 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- 206010037423 Pulmonary oedema Diseases 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 206010038687 Respiratory distress Diseases 0.000 claims 1
- 206010071436 Systolic dysfunction Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 230000016571 aggressive behavior Effects 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 230000036528 appetite Effects 0.000 claims 1
- 235000019789 appetite Nutrition 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000017531 blood circulation Effects 0.000 claims 1
- 230000001925 catabolic effect Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000005779 cell damage Effects 0.000 claims 1
- 208000037887 cell injury Diseases 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 230000007882 cirrhosis Effects 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 230000008828 contractile function Effects 0.000 claims 1
- 208000012839 conversion disease Diseases 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 230000029142 excretion Effects 0.000 claims 1
- 208000019622 heart disease Diseases 0.000 claims 1
- 210000003897 hepatic stem cell Anatomy 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 230000000297 inotrophic effect Effects 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 230000000302 ischemic effect Effects 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 230000000116 mitigating effect Effects 0.000 claims 1
- 210000004165 myocardium Anatomy 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 229960002748 norepinephrine Drugs 0.000 claims 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 claims 1
- 230000035764 nutrition Effects 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 208000019906 panic disease Diseases 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 201000010065 polycystic ovary syndrome Diseases 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 239000011591 potassium Substances 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 238000009101 premedication Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 208000005333 pulmonary edema Diseases 0.000 claims 1
- 208000002815 pulmonary hypertension Diseases 0.000 claims 1
- 230000010410 reperfusion Effects 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 208000037816 tissue injury Diseases 0.000 claims 1
- 231100000331 toxic Toxicity 0.000 claims 1
- 230000002588 toxic effect Effects 0.000 claims 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 1
Classifications
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22278509P | 2009-07-02 | 2009-07-02 | |
| US61/222,785 | 2009-07-02 | ||
| US25202409P | 2009-10-15 | 2009-10-15 | |
| US61/252,024 | 2009-10-15 | ||
| PCT/CA2010/001014 WO2011000095A1 (en) | 2009-07-02 | 2010-06-30 | Multimeric peptide conjugates and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012103240A true RU2012103240A (ru) | 2013-08-10 |
Family
ID=43410407
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012103240/10A RU2012103240A (ru) | 2009-07-02 | 2010-06-30 | Мультимерные пептидные конъюгаты и их применение |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9161988B2 (https=) |
| EP (1) | EP2448965A4 (https=) |
| JP (1) | JP5932642B2 (https=) |
| CN (1) | CN102596993A (https=) |
| AU (1) | AU2010268726A1 (https=) |
| BR (1) | BRPI1015918A2 (https=) |
| CA (1) | CA2766537A1 (https=) |
| IN (1) | IN2012DN00248A (https=) |
| MX (1) | MX2012000016A (https=) |
| RU (1) | RU2012103240A (https=) |
| WO (1) | WO2011000095A1 (https=) |
| ZA (1) | ZA201109324B (https=) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004060403A2 (en) | 2003-01-06 | 2004-07-22 | Angiochem Inc. | Aprotinin and anglos as carriers across the blood-brain barrier |
| US20090016959A1 (en) * | 2005-02-18 | 2009-01-15 | Richard Beliveau | Delivery of antibodies to the central nervous system |
| ES2744225T3 (es) | 2005-07-15 | 2020-02-24 | Angiochem Inc | Uso de polipéptidos de aprotinina como portadores en conjugados farmacéuticos |
| JP2010506860A (ja) | 2006-10-19 | 2010-03-04 | アンジオケム，インコーポレーテッド | Ｐ−糖タンパク質機能を刺激するための化合物およびその使用 |
| US9365634B2 (en) | 2007-05-29 | 2016-06-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
| CA2740316A1 (en) | 2008-10-15 | 2010-04-22 | Angiochem Inc. | Conjugates of glp-1 agonists and uses thereof |
| CA2745524C (en) | 2008-12-05 | 2020-06-09 | Angiochem Inc. | Conjugates of neurotensin or neurotensin analogs and uses thereof |
| US8853353B2 (en) | 2008-12-17 | 2014-10-07 | Angiochem, Inc. | Membrane type-1 matrix metalloprotein inhibitors and uses thereof |
| MX2011011023A (es) | 2009-04-20 | 2012-01-20 | Angiochem Inc | Tratamiento de cancer de ovarios usando un agente anti-cancer conjugado con un analogo de angiopep-2. |
| RU2012103240A (ru) | 2009-07-02 | 2013-08-10 | Ангиокем Инк. | Мультимерные пептидные конъюгаты и их применение |
| JP2015526434A (ja) | 2012-08-14 | 2015-09-10 | アンジオケム インコーポレーテッド | ペプチド−デンドリマーコンジュゲート及びその使用 |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| AU2013366692B2 (en) | 2012-12-21 | 2017-11-23 | Sanofi | Dual GLP1/GIP or trigonal GLP1/GIP/Glucagon agonists |
| ES2670995T3 (es) * | 2013-03-12 | 2018-06-04 | Cephalon, Inc. | Formulaciones de nanopartículas y macropartículas |
| WO2014194429A1 (en) * | 2013-06-06 | 2014-12-11 | Angiochem Inc. | Targeted enzyme compounds and uses thereof |
| WO2015086733A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/glucagon receptor agonists |
| EP3080154B1 (en) | 2013-12-13 | 2018-02-07 | Sanofi | Dual glp-1/gip receptor agonists |
| WO2015086728A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
| EP3080152A1 (en) | 2013-12-13 | 2016-10-19 | Sanofi | Non-acylated exendin-4 peptide analogues |
| SG11201606824VA (en) * | 2014-02-19 | 2016-09-29 | Hoffmann La Roche | Blood brain barrier shuttle |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑 |
| TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物 |
| TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑 |
| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| EP3294753A1 (en) * | 2015-05-11 | 2018-03-21 | Janssen Vaccines & Prevention B.V. | Influenza virus neutralizing peptidomimetic compounds |
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- 2010-06-30 MX MX2012000016A patent/MX2012000016A/es unknown
- 2010-06-30 JP JP2012518704A patent/JP5932642B2/ja not_active Expired - Fee Related
- 2010-06-30 CA CA2766537A patent/CA2766537A1/en not_active Abandoned
- 2010-06-30 EP EP10793472.1A patent/EP2448965A4/en not_active Withdrawn
- 2010-06-30 US US13/382,069 patent/US9161988B2/en active Active
- 2010-06-30 WO PCT/CA2010/001014 patent/WO2011000095A1/en not_active Ceased
- 2010-06-30 CN CN2010800387423A patent/CN102596993A/zh active Pending
- 2010-06-30 BR BRPI1015918A patent/BRPI1015918A2/pt not_active IP Right Cessation
- 2010-06-30 AU AU2010268726A patent/AU2010268726A1/en not_active Abandoned
- 2010-06-30 IN IN248DEN2012 patent/IN2012DN00248A/en unknown
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|---|---|
| WO2011000095A1 (en) | 2011-01-06 |
| US9161988B2 (en) | 2015-10-20 |
| JP2012531467A (ja) | 2012-12-10 |
| JP5932642B2 (ja) | 2016-06-08 |
| AU2010268726A1 (en) | 2012-01-19 |
| BRPI1015918A2 (pt) | 2019-09-24 |
| CN102596993A (zh) | 2012-07-18 |
| CA2766537A1 (en) | 2011-01-06 |
| EP2448965A4 (en) | 2015-02-11 |
| US20120141416A1 (en) | 2012-06-07 |
| EP2448965A1 (en) | 2012-05-09 |
| MX2012000016A (es) | 2012-03-26 |
| IN2012DN00248A (https=) | 2015-05-01 |
| ZA201109324B (en) | 2013-02-27 |
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