BR112014013250A2 - compostos com enzima alvo e usos dos mesmos - Google Patents
compostos com enzima alvo e usos dos mesmosInfo
- Publication number
- BR112014013250A2 BR112014013250A2 BR112014013250A BR112014013250A BR112014013250A2 BR 112014013250 A2 BR112014013250 A2 BR 112014013250A2 BR 112014013250 A BR112014013250 A BR 112014013250A BR 112014013250 A BR112014013250 A BR 112014013250A BR 112014013250 A2 BR112014013250 A2 BR 112014013250A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- enzyme
- compound
- target
- iduronate
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/06—Sulfuric ester hydrolases (3.1.6)
- C12Y301/06013—Iduronate-2-sulfatase (3.1.6.13)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
targeted enzyme compounds and uses thereof abstract of the disclosure the present invention is related to a compound that includes a lysosomal enzyme and a targeting moiety, for example, where compound is a fusion protein including iduronate-2-sulfatase and angiopep-2. in certain embodiments, these compounds, owning to the presence of the targeting moiety can crossing the blood-brain barrier or accumulate in the lysosome more effectively than the enzyme alone. the invention also features methods for treating lysosomal storage disorders (e.g., mucopolysaccharidosis type ii) using such compounds. ____________________________ tradução do resumo resumo patente de invenção: "compostos com enzima alvo e usos dos mesmos". a presente invenção refere-se a um composto que inclui uma enzima lisossomal e uma porção alvo, por exemplo, onde o com-posto é uma proteína de fusão incluindo iduronato-2-sulfatase e angi-opep-2. em certas modalidades, esses compostos, devido à presença da porção alvo, podem cruzar a barreira cérebro-sangue ou acumular no lisossoma mais eficazmente do que a enzima sozinha. a invenção refere-se também a métodos para tratamento de distúrbios de arma-zenamento lisossomal (por exemplo, mucopolissacaridose tipo ii) u-sando tais compostos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161565764P | 2011-12-01 | 2011-12-01 | |
US201261596516P | 2012-02-08 | 2012-02-08 | |
PCT/CA2012/050865 WO2013078562A2 (en) | 2011-12-01 | 2012-11-30 | Targeted enzyme compounds and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112014013250A2 true BR112014013250A2 (pt) | 2019-09-24 |
Family
ID=48536182
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014013250A BR112014013250A2 (pt) | 2011-12-01 | 2012-11-30 | compostos com enzima alvo e usos dos mesmos |
Country Status (10)
Country | Link |
---|---|
US (1) | US20140335163A1 (pt) |
EP (1) | EP2785837A4 (pt) |
JP (1) | JP2015500800A (pt) |
CN (1) | CN104136606A (pt) |
AU (1) | AU2012344700A1 (pt) |
BR (1) | BR112014013250A2 (pt) |
CA (1) | CA2857548A1 (pt) |
HK (1) | HK1200190A1 (pt) |
RU (1) | RU2014126482A (pt) |
WO (1) | WO2013078562A2 (pt) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1583562T3 (da) | 2003-01-06 | 2011-09-19 | Angiochem Inc | Angiopep-1, beslægtede forbindelser og anvendelser deraf |
ES2424242T3 (es) | 2005-07-15 | 2013-09-30 | Angiochem Inc. | Uso de polipéptidos de aprotinina como portadores en conjugados farmacéuticos |
US9365634B2 (en) | 2007-05-29 | 2016-06-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
BRPI0920209A2 (pt) | 2008-10-15 | 2015-12-22 | Angiochem Inc | conjugados de agonistas de glp-1 e usos dos mesmos |
RU2531591C2 (ru) | 2008-10-15 | 2014-10-20 | Ангиокем Инк. | Конъюгаты этопозида и доксорубицина для доставки лекарственных средств |
MX2011006685A (es) | 2008-12-17 | 2011-09-27 | Angiochem Inc | Inhibidores de metaloproteinas de matriz de membrana tipo-1 y sus usos. |
ES2729261T3 (es) | 2009-04-20 | 2019-10-31 | Angiochem Inc | Tratamiento del cáncer de ovario utilizando un agente anticancerígeno conjugado con un análogo de Angiopep-2 |
IN2012DN00248A (pt) | 2009-07-02 | 2015-05-01 | Angiochem Inc | |
AU2012344702A1 (en) * | 2011-12-01 | 2014-06-19 | Angiochem Inc. | Targeted lysosomal enzyme compounds |
WO2013181697A1 (en) * | 2012-06-05 | 2013-12-12 | The University Of Melbourne | Bicyclo[6.1.0]non-4-yne compounds suitable for use as linkers in biological applications |
WO2013185235A1 (en) * | 2012-06-15 | 2013-12-19 | Angiochem Inc. | Targeted iduronidase compounds |
EP2885318A4 (en) | 2012-08-14 | 2016-03-30 | Angiochem Inc | PEPTIDE-DENDRIMER CONJUGATES AND USES THEREOF |
WO2014082184A1 (en) * | 2012-11-30 | 2014-06-05 | Angiochem Inc. | Targeted iduronate-2-sulfatase compounds |
GB201300707D0 (en) * | 2013-01-15 | 2013-02-27 | Novartis Ag | Compounds and processes |
WO2014194427A1 (en) * | 2013-06-06 | 2014-12-11 | Angiochem Inc. | Targeted iduronate-2-sulfatase fusion proteins |
ES2826827T3 (es) | 2015-06-15 | 2021-05-19 | Angiochem Inc | Métodos para el tratamiento de carcinomatosis leptomeníngea |
KR102368068B1 (ko) | 2015-08-24 | 2022-02-25 | 삼성전자주식회사 | 반도체 소자 제조용 조성물 및 이를 이용하는 반도체 소자의 제조 방법 |
GB201603296D0 (en) | 2016-02-25 | 2016-04-13 | Ucl Business Plc | Chemotactic,drug-containing polymersomes |
GB201604553D0 (en) | 2016-03-17 | 2016-05-04 | Ucl Business Plc | Fumarate polymersomes |
JP6993814B2 (ja) * | 2016-08-25 | 2022-01-14 | Jcrファーマ株式会社 | 抗体融合蛋白質の製造方法 |
GB201701968D0 (en) | 2017-02-07 | 2017-03-22 | Univ Manchester | Gene therapy |
JOP20190245A1 (ar) | 2017-04-20 | 2019-10-15 | Novartis Ag | أنظمة توصيل إطلاق مستدام تتضمن روابط بلا أثر لنقطة الربط |
CA3076369A1 (en) | 2017-10-02 | 2019-04-11 | Denali Therapeutics Inc. | Fusion proteins comprising enzyme replacement therapy enzymes |
AR116566A1 (es) | 2018-10-03 | 2021-05-19 | Novartis Ag | Administración sostenida de polipéptidos similares a la angiopoyetina 3 |
WO2020144467A1 (en) | 2019-01-07 | 2020-07-16 | Ucl Business Ltd | Polymersomes functionalised with multiple ligands |
CA3238273A1 (en) | 2021-11-24 | 2023-06-01 | Giuseppe Battaglia | Polymersomes for clearance of amyloid beta and/or tau proteins |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2487815A1 (en) * | 2002-05-29 | 2003-12-11 | Symbiontics, Inc. | Targeted therapeutic proteins |
WO2004108071A2 (en) * | 2003-06-05 | 2004-12-16 | Salk Institute For Biological Studies | Targeting polypeptides to the central nervous system |
WO2006108052A2 (en) * | 2005-04-06 | 2006-10-12 | Genzyme Corporation | Peg and polysialic lysosomal enzyme conjugates via acid labile linkers for therapeutic targeting |
CN101946001A (zh) * | 2007-12-20 | 2011-01-12 | 安吉奥开米公司 | 多肽-核酸结合物及其应用 |
US9914754B2 (en) * | 2008-12-05 | 2018-03-13 | Angiochem Inc. | Conjugates of neurotensin or neurotensin analogs and uses thereof |
CN102348723A (zh) * | 2008-12-05 | 2012-02-08 | 安吉奥开米公司 | 肽治疗剂轭合物及其应用 |
JP2013506697A (ja) * | 2009-10-06 | 2013-02-28 | アンジオケム インコーポレーテッド | 治療薬を輸送するための組成物と方法 |
EP2333074A1 (en) * | 2009-12-14 | 2011-06-15 | Robert Steinfeld | Substances and methods for the treatment of lysosmal storage diseases |
-
2012
- 2012-11-30 CA CA2857548A patent/CA2857548A1/en not_active Abandoned
- 2012-11-30 AU AU2012344700A patent/AU2012344700A1/en not_active Abandoned
- 2012-11-30 EP EP12853573.9A patent/EP2785837A4/en not_active Withdrawn
- 2012-11-30 RU RU2014126482A patent/RU2014126482A/ru not_active Application Discontinuation
- 2012-11-30 JP JP2014543736A patent/JP2015500800A/ja active Pending
- 2012-11-30 CN CN201280068452.2A patent/CN104136606A/zh active Pending
- 2012-11-30 US US14/362,063 patent/US20140335163A1/en not_active Abandoned
- 2012-11-30 WO PCT/CA2012/050865 patent/WO2013078562A2/en active Application Filing
- 2012-11-30 BR BR112014013250A patent/BR112014013250A2/pt not_active IP Right Cessation
-
2015
- 2015-01-16 HK HK15100521.1A patent/HK1200190A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP2785837A2 (en) | 2014-10-08 |
EP2785837A4 (en) | 2015-07-01 |
CA2857548A1 (en) | 2013-06-06 |
WO2013078562A2 (en) | 2013-06-06 |
HK1200190A1 (en) | 2015-07-31 |
WO2013078562A3 (en) | 2013-09-06 |
US20140335163A1 (en) | 2014-11-13 |
RU2014126482A (ru) | 2016-01-27 |
AU2012344700A1 (en) | 2014-06-19 |
CN104136606A (zh) | 2014-11-05 |
JP2015500800A (ja) | 2015-01-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |