RU2011134052A - Новые бензолсульфонамиды в качестве блокаторов кальциевых каналов - Google Patents
Новые бензолсульфонамиды в качестве блокаторов кальциевых каналов Download PDFInfo
- Publication number
- RU2011134052A RU2011134052A RU2011134052/04A RU2011134052A RU2011134052A RU 2011134052 A RU2011134052 A RU 2011134052A RU 2011134052/04 A RU2011134052/04 A RU 2011134052/04A RU 2011134052 A RU2011134052 A RU 2011134052A RU 2011134052 A RU2011134052 A RU 2011134052A
- Authority
- RU
- Russia
- Prior art keywords
- pyrazin
- pyrrolo
- hexahydro
- benzenesulfonamide
- alkylcarbonyl
- Prior art date
Links
- 108090000312 Calcium Channels Proteins 0.000 title 1
- 102000003922 Calcium Channels Human genes 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 claims abstract 31
- 150000001875 compounds Chemical class 0.000 claims abstract 29
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 27
- 239000001257 hydrogen Substances 0.000 claims abstract 27
- 125000000217 alkyl group Chemical group 0.000 claims abstract 24
- 229910052736 halogen Inorganic materials 0.000 claims abstract 22
- 150000002367 halogens Chemical class 0.000 claims abstract 22
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 21
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 14
- 125000001188 haloalkyl group Chemical group 0.000 claims abstract 12
- 125000001424 substituent group Chemical group 0.000 claims abstract 12
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract 11
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract 10
- 150000003839 salts Chemical class 0.000 claims abstract 10
- 125000003386 piperidinyl group Chemical group 0.000 claims abstract 7
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims abstract 7
- 125000002393 azetidinyl group Chemical group 0.000 claims abstract 6
- 150000002431 hydrogen Chemical class 0.000 claims abstract 6
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims abstract 6
- 125000002757 morpholinyl group Chemical group 0.000 claims abstract 6
- 239000000651 prodrug Chemical class 0.000 claims abstract 6
- 229940002612 prodrug Drugs 0.000 claims abstract 6
- 125000004568 thiomorpholinyl group Chemical group 0.000 claims abstract 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 4
- 125000003725 azepanyl group Chemical group 0.000 claims abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract 3
- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 claims 26
- -1 2,6-difluorophenyl Chemical group 0.000 claims 15
- 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 5
- 208000002193 Pain Diseases 0.000 claims 5
- 125000000579 2,2-diphenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])* 0.000 claims 4
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 3
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 3
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 125000004215 2,4-difluorophenyl group Chemical group [H]C1=C([H])C(*)=C(F)C([H])=C1F 0.000 claims 2
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims 2
- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims 2
- 208000020925 Bipolar disease Diseases 0.000 claims 2
- 208000019695 Migraine disease Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 206010027599 migraine Diseases 0.000 claims 2
- NTGHBMWKKZCQJX-UHFFFAOYSA-N 3-(1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazine-2-carbonyl)-n-[3-(trifluoromethyl)phenyl]benzenesulfonamide Chemical compound FC(F)(F)C1=CC=CC(NS(=O)(=O)C=2C=C(C=CC=2)C(=O)N2CC3CCCCN3CC2)=C1 NTGHBMWKKZCQJX-UHFFFAOYSA-N 0.000 claims 1
- YKRLUOZLOMRDJR-UHFFFAOYSA-N 3-(1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazine-2-carbonyl)-n-[4-(trifluoromethyl)phenyl]benzenesulfonamide Chemical compound C1=CC(C(F)(F)F)=CC=C1NS(=O)(=O)C1=CC=CC(C(=O)N2CC3CCCCN3CC2)=C1 YKRLUOZLOMRDJR-UHFFFAOYSA-N 0.000 claims 1
- SZDJXSZWBRYRNN-CQSZACIVSA-N 5-[(8ar)-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazine-2-carbonyl]-4-chloro-2-fluoro-n-(2-fluorophenyl)-n-methylbenzenesulfonamide Chemical compound C=1C(C(=O)N2C[C@H]3CCCN3CC2)=C(Cl)C=C(F)C=1S(=O)(=O)N(C)C1=CC=CC=C1F SZDJXSZWBRYRNN-CQSZACIVSA-N 0.000 claims 1
- 206010065040 AIDS dementia complex Diseases 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 206010002388 Angina unstable Diseases 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000008035 Back Pain Diseases 0.000 claims 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 206010012434 Dermatitis allergic Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 206010019196 Head injury Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 208000004454 Hyperalgesia Diseases 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010020853 Hypertonic bladder Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 208000005615 Interstitial Cystitis Diseases 0.000 claims 1
- 208000009722 Overactive Urinary Bladder Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 1
- 208000003251 Pruritus Diseases 0.000 claims 1
- 208000028017 Psychotic disease Diseases 0.000 claims 1
- 208000008765 Sciatica Diseases 0.000 claims 1
- 201000001880 Sexual dysfunction Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 claims 1
- 208000007814 Unstable Angina Diseases 0.000 claims 1
- FZLDXPOFLGONMF-LJQANCHMSA-N [(8ar)-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl]-[2-chloro-4-fluoro-5-[4-(4-fluorophenyl)piperazin-1-yl]sulfonylphenyl]methanone Chemical compound C1=CC(F)=CC=C1N1CCN(S(=O)(=O)C=2C(=CC(Cl)=C(C(=O)N3C[C@H]4CCCN4CC3)C=2)F)CC1 FZLDXPOFLGONMF-LJQANCHMSA-N 0.000 claims 1
- GAGSUTMMGKVUCP-MRXNPFEDSA-N [(8ar)-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl]-[2-chloro-5-(2,3-dihydroindol-1-ylsulfonyl)-4-fluorophenyl]methanone Chemical compound C1CN2CCC[C@@H]2CN1C(=O)C1=C(Cl)C=C(F)C(S(=O)(=O)N2C3=CC=CC=C3CC2)=C1 GAGSUTMMGKVUCP-MRXNPFEDSA-N 0.000 claims 1
- HRCAYCQDIMSMJS-MUUNZHRXSA-N [(8ar)-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl]-[3-(4-benzhydrylpiperazin-1-yl)sulfonylphenyl]methanone Chemical compound C([C@H]1CCCN1CC1)N1C(=O)C(C=1)=CC=CC=1S(=O)(=O)N(CC1)CCN1C(C=1C=CC=CC=1)C1=CC=CC=C1 HRCAYCQDIMSMJS-MUUNZHRXSA-N 0.000 claims 1
- ZDPSZHMSLVWWKX-MUUNZHRXSA-N [(8ar)-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl]-[3-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]sulfonylphenyl]methanone Chemical compound C1=CC(F)=CC=C1C(C=1C=CC(F)=CC=1)N1CCN(S(=O)(=O)C=2C=C(C=CC=2)C(=O)N2C[C@H]3CCCN3CC2)CC1 ZDPSZHMSLVWWKX-MUUNZHRXSA-N 0.000 claims 1
- HRCAYCQDIMSMJS-NDEPHWFRSA-N [(8as)-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl]-[3-(4-benzhydrylpiperazin-1-yl)sulfonylphenyl]methanone Chemical compound C([C@@H]1CCCN1CC1)N1C(=O)C(C=1)=CC=CC=1S(=O)(=O)N(CC1)CCN1C(C=1C=CC=CC=1)C1=CC=CC=C1 HRCAYCQDIMSMJS-NDEPHWFRSA-N 0.000 claims 1
- GQMHURPKRZFOJV-QFIPXVFZSA-N [(8as)-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl]-[3-[4-(4-fluorophenyl)piperazin-1-yl]sulfonylphenyl]methanone Chemical compound C1=CC(F)=CC=C1N1CCN(S(=O)(=O)C=2C=C(C=CC=2)C(=O)N2C[C@@H]3CCCN3CC2)CC1 GQMHURPKRZFOJV-QFIPXVFZSA-N 0.000 claims 1
- ZDPSZHMSLVWWKX-NDEPHWFRSA-N [(8as)-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl]-[3-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]sulfonylphenyl]methanone Chemical compound C1=CC(F)=CC=C1C(C=1C=CC(F)=CC=1)N1CCN(S(=O)(=O)C=2C=C(C=CC=2)C(=O)N2C[C@@H]3CCCN3CC2)CC1 ZDPSZHMSLVWWKX-NDEPHWFRSA-N 0.000 claims 1
- FMJDPDFOYAFJHW-MUUNZHRXSA-N [3-[[(8ar)-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl]sulfonyl]phenyl]-(4-benzhydrylpiperazin-1-yl)methanone Chemical compound C=1C=CC(S(=O)(=O)N2C[C@H]3CCCN3CC2)=CC=1C(=O)N(CC1)CCN1C(C=1C=CC=CC=1)C1=CC=CC=C1 FMJDPDFOYAFJHW-MUUNZHRXSA-N 0.000 claims 1
- OUYFGDJNIFQCCM-MUUNZHRXSA-N [3-[[(8ar)-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl]sulfonyl]phenyl]-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]methanone Chemical compound C1=CC(F)=CC=C1C(C=1C=CC(F)=CC=1)N1CCN(C(=O)C=2C=C(C=CC=2)S(=O)(=O)N2C[C@H]3CCCN3CC2)CC1 OUYFGDJNIFQCCM-MUUNZHRXSA-N 0.000 claims 1
- FMJDPDFOYAFJHW-NDEPHWFRSA-N [3-[[(8as)-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl]sulfonyl]phenyl]-(4-benzhydrylpiperazin-1-yl)methanone Chemical compound C=1C=CC(S(=O)(=O)N2C[C@@H]3CCCN3CC2)=CC=1C(=O)N(CC1)CCN1C(C=1C=CC=CC=1)C1=CC=CC=C1 FMJDPDFOYAFJHW-NDEPHWFRSA-N 0.000 claims 1
- OUYFGDJNIFQCCM-NDEPHWFRSA-N [3-[[(8as)-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl]sulfonyl]phenyl]-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]methanone Chemical compound C1=CC(F)=CC=C1C(C=1C=CC(F)=CC=1)N1CCN(C(=O)C=2C=C(C=CC=2)S(=O)(=O)N2C[C@@H]3CCCN3CC2)CC1 OUYFGDJNIFQCCM-NDEPHWFRSA-N 0.000 claims 1
- 208000005298 acute pain Diseases 0.000 claims 1
- 208000029650 alcohol withdrawal Diseases 0.000 claims 1
- 206010053552 allodynia Diseases 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 208000028683 bipolar I disease Diseases 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 208000015114 central nervous system disease Diseases 0.000 claims 1
- 208000026106 cerebrovascular disease Diseases 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 206010013663 drug dependence Diseases 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 208000000509 infertility Diseases 0.000 claims 1
- 230000036512 infertility Effects 0.000 claims 1
- 231100000535 infertility Toxicity 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 claims 1
- 201000004332 intermediate coronary syndrome Diseases 0.000 claims 1
- PGTKRXNTBSUGKM-UHFFFAOYSA-N n-(4-fluorophenyl)-3-(4-piperidin-1-ylpiperidine-1-carbonyl)benzenesulfonamide Chemical compound C1=CC(F)=CC=C1NS(=O)(=O)C1=CC=CC(C(=O)N2CCC(CC2)N2CCCCC2)=C1 PGTKRXNTBSUGKM-UHFFFAOYSA-N 0.000 claims 1
- TYCVFQIHNMKHJV-UHFFFAOYSA-N n-(4-fluorophenyl)-3-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)benzenesulfonamide Chemical compound C1=CC(F)=CC=C1NS(=O)(=O)C1=CC=CC(C(=O)N2CCC(CC2)N2CCCC2)=C1 TYCVFQIHNMKHJV-UHFFFAOYSA-N 0.000 claims 1
- WYKKYPQOAAYHTB-HSZRJFAPSA-N n-[4-[(8ar)-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazine-2-carbonyl]-2-chlorophenyl]-2,2-diphenylacetamide Chemical compound ClC1=CC(C(=O)N2C[C@H]3CCCN3CC2)=CC=C1NC(=O)C(C=1C=CC=CC=1)C1=CC=CC=C1 WYKKYPQOAAYHTB-HSZRJFAPSA-N 0.000 claims 1
- BBRCLJMUOZNGJS-QGZVFWFLSA-N n-[4-[(8ar)-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazine-2-carbonyl]-2-chlorophenyl]-4-fluorobenzamide Chemical compound C1=CC(F)=CC=C1C(=O)NC1=CC=C(C(=O)N2C[C@H]3CCCN3CC2)C=C1Cl BBRCLJMUOZNGJS-QGZVFWFLSA-N 0.000 claims 1
- MHCUFMBGRRJYKY-OAQYLSRUSA-N n-[4-[(8ar)-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazine-2-carbonyl]-2-chlorophenyl]naphthalene-2-carboxamide Chemical compound C1CN2CCC[C@@H]2CN1C(=O)C1=CC=C(NC(=O)C=2C=C3C=CC=CC3=CC=2)C(Cl)=C1 MHCUFMBGRRJYKY-OAQYLSRUSA-N 0.000 claims 1
- RAGZMQXBGQELKC-HSZRJFAPSA-N n-[5-[(8ar)-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazine-2-carbonyl]-2-chlorophenyl]-2,2-diphenylacetamide Chemical compound ClC1=CC=C(C(=O)N2C[C@H]3CCCN3CC2)C=C1NC(=O)C(C=1C=CC=CC=1)C1=CC=CC=C1 RAGZMQXBGQELKC-HSZRJFAPSA-N 0.000 claims 1
- BLPCUCQQGPCUAP-QGZVFWFLSA-N n-[5-[(8ar)-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazine-2-carbonyl]-2-chlorophenyl]-4-fluorobenzamide Chemical compound C1=CC(F)=CC=C1C(=O)NC1=CC(C(=O)N2C[C@H]3CCCN3CC2)=CC=C1Cl BLPCUCQQGPCUAP-QGZVFWFLSA-N 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
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- 208000020629 overactive bladder Diseases 0.000 claims 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/10—Drugs for disorders of the urinary system of the bladder
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
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| US10577344B2 (en) | 2013-09-10 | 2020-03-03 | The Board Of Regents Of The University Of Texas System | Therapeutics targeting truncated adenomatous polyposis coli (APC) proteins |
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| WO2009131065A1 (ja) | 2008-04-24 | 2009-10-29 | 萬有製薬株式会社 | アリールスルホニル誘導体を有効成分とする長鎖脂肪酸伸長酵素阻害剤 |
| TW201028421A (en) * | 2009-01-15 | 2010-08-01 | Abbott Lab | Novel benzenesulfonamides as calcium channel blockers |
| CA2848877A1 (en) * | 2011-09-15 | 2013-03-21 | Taipei Medical University | Use of indolyl and indolinvl hvdroxamates for treating heart failure or neuronal injury |
| WO2013049164A1 (en) | 2011-09-29 | 2013-04-04 | Abbvie Inc. | SUBSTITUTED OCTAHYDROPYRROLO[1,2-a]PYRAZINES AS CALCIUM CHANNEL BLOCKERS |
| WO2013049174A1 (en) * | 2011-09-29 | 2013-04-04 | Abbvie Inc. | Substituted octahydropyrrolo[1,2-a]pyrazine sulfonamides as calcium channel blockers |
| US20130178477A1 (en) * | 2012-01-05 | 2013-07-11 | Abbvie Inc. | Methods of treating diabetic neuropathy using benzenesulfonamides |
| WO2014093337A1 (en) * | 2012-12-12 | 2014-06-19 | Abbvie, Inc. | Diazepine derivatives useful as calcium channel blockers in the treatment of pain |
| US9700549B2 (en) | 2013-10-03 | 2017-07-11 | David Wise | Compositions and methods for treating pelvic pain and other conditions |
| US10082496B2 (en) | 2014-09-10 | 2018-09-25 | Board Of Regents Of The University Of Texas System | Targeting emopamil binding protein (EBP) with small molecules that induce an abnormal feedback response by lowering endogenous cholesterol biosynthesis |
| JP6957460B2 (ja) | 2015-10-22 | 2021-11-02 | カビオン・インコーポレイテッドＣａｖｉｏｎ， Ｉｎｃ． | アンジェルマン症候群および関連する障害の処置方法 |
| AU2018221722B2 (en) | 2017-02-15 | 2022-02-03 | Cavion, Inc. | Calcium channel inhibitors |
| JP7321097B2 (ja) | 2017-04-26 | 2023-08-04 | カビオン・インコーポレイテッド | 記憶および認知を改善する、ならびに記憶および認知障害を処置するための方法 |
| JP7395480B2 (ja) | 2018-01-10 | 2023-12-11 | クラ セラピューティクス， エルエルシー | フェニルスルホンアミドを含む薬学的組成物、及びそれらの治療的適用 |
| WO2020038435A1 (en) | 2018-08-24 | 2020-02-27 | Sunshine Lake Pharma Co., Ltd. | Pyridinylmethylenepiperidine derivatives and uses thereof |
| IL300798B2 (en) | 2018-10-03 | 2025-09-01 | Cavion Inc | Treatment of skeletal tremor with (r)–2-(4–isopropylphenyl)–n-(1-(5-(2,2,2–trifluoroethoxy)pyridin-2-yl)ethyl)acetamide |
| AR116898A1 (es) * | 2018-10-30 | 2021-06-23 | H Lundbeck As | DERIVADOS DE ARILSULFONILPIRROLCARBOXAMIDA COMO ACTIVADORES DE CANALES DE POTASIO Kv3 |
| CN114340670B (zh) | 2019-07-11 | 2026-02-17 | 普拉克西斯精密药物股份有限公司 | T-型钙通道调节剂的制剂及其使用方法 |
| EP3997068A1 (en) * | 2019-07-11 | 2022-05-18 | Cura Therapeutics, LLC | Sulfone compounds and pharmaceutical compositions thereof, and their therapeutic applications for the treatment of neurodegenerative diseases |
| CN117229257B (zh) * | 2022-06-06 | 2026-01-30 | 中国药科大学 | 间氨磺酰苯甲酰胺类化合物及制法、药物组合物和应用 |
| WO2025255502A1 (en) | 2024-06-07 | 2025-12-11 | Cavion, Inc. | PYRIDYL AMIDE Cav3 CHANNEL MODULATORS |
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| JP4932994B2 (ja) | 1999-04-07 | 2012-05-16 | ユニバーシテイ・オブ・バージニア・パテント・フアウンデーシヨン | 抗癌性カルシウムチャンネル遮断薬 |
| TW200503994A (en) * | 2003-01-24 | 2005-02-01 | Novartis Ag | Organic compounds |
| US7223754B2 (en) * | 2003-03-10 | 2007-05-29 | Dynogen Pharmaceuticals, Inc. | Thiazolidinone, oxazolidinone, and imidazolone derivatives for treating lower urinary tract and related disorders |
| ATE467616T1 (de) * | 2003-04-11 | 2010-05-15 | High Point Pharmaceuticals Llc | Verbindungen mit aktivität an der 11beta- hydroxasteroiddehydrogenase |
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| CA2666275A1 (en) * | 2006-10-13 | 2008-04-17 | Neuromed Pharmaceuticals Ltd. | Cyclopropyl-piperazine compounds as calcium channel blockers |
| SG185285A1 (en) * | 2007-06-03 | 2012-11-29 | Univ Vanderbilt | Benzamide mglur5 positive allosteric modulators and methods of making and using same |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10577344B2 (en) | 2013-09-10 | 2020-03-03 | The Board Of Regents Of The University Of Texas System | Therapeutics targeting truncated adenomatous polyposis coli (APC) proteins |
| RU2727516C2 (ru) * | 2013-09-10 | 2020-07-22 | Борд Оф Риджентс Оф Дзе Юниверсити Оф Техас Систем | Терапевтические средства, нацеленные на укороченные белки аденоматозного полипоза толстого кишечника (арс) |
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