JP5619773B2 - カルシウムチャンネル遮断薬としての新規なベンゼンスルホンアミド類 - Google Patents
カルシウムチャンネル遮断薬としての新規なベンゼンスルホンアミド類 Download PDFInfo
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- JP5619773B2 JP5619773B2 JP2011546319A JP2011546319A JP5619773B2 JP 5619773 B2 JP5619773 B2 JP 5619773B2 JP 2011546319 A JP2011546319 A JP 2011546319A JP 2011546319 A JP2011546319 A JP 2011546319A JP 5619773 B2 JP5619773 B2 JP 5619773B2
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- Prior art keywords
- ylcarbonyl
- pyrazin
- hexahydropyrrolo
- benzenesulfonamide
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229940127291 Calcium channel antagonist Drugs 0.000 title description 22
- 239000000480 calcium channel blocker Substances 0.000 title description 21
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- -1 2,3-difluorophenyl Chemical group 0.000 claims description 145
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 108
- 125000003118 aryl group Chemical group 0.000 claims description 67
- 229910052739 hydrogen Inorganic materials 0.000 claims description 63
- 239000001257 hydrogen Substances 0.000 claims description 62
- 125000000217 alkyl group Chemical group 0.000 claims description 59
- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 claims description 58
- 150000003839 salts Chemical class 0.000 claims description 49
- 229910052736 halogen Inorganic materials 0.000 claims description 45
- 150000002367 halogens Chemical class 0.000 claims description 45
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 36
- 125000001072 heteroaryl group Chemical group 0.000 claims description 32
- 125000003545 alkoxy group Chemical group 0.000 claims description 31
- 125000001424 substituent group Chemical group 0.000 claims description 31
- 125000001188 haloalkyl group Chemical group 0.000 claims description 28
- 229910052757 nitrogen Inorganic materials 0.000 claims description 27
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- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 20
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- 125000000579 2,2-diphenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])* 0.000 claims description 10
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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| US14489909P | 2009-01-15 | 2009-01-15 | |
| US61/144,899 | 2009-01-15 | ||
| PCT/US2010/020964 WO2010083264A1 (en) | 2009-01-15 | 2010-01-14 | Novel benzenesulfonamides as calcium channel blockers |
Publications (3)
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| JP2012515209A JP2012515209A (ja) | 2012-07-05 |
| JP2012515209A5 JP2012515209A5 (https=) | 2013-02-28 |
| JP5619773B2 true JP5619773B2 (ja) | 2014-11-05 |
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| JP2011546319A Expired - Fee Related JP5619773B2 (ja) | 2009-01-15 | 2010-01-14 | カルシウムチャンネル遮断薬としての新規なベンゼンスルホンアミド類 |
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| US (3) | US8101614B2 (https=) |
| EP (1) | EP2382191B1 (https=) |
| JP (1) | JP5619773B2 (https=) |
| KR (1) | KR20110110299A (https=) |
| CN (1) | CN102282131B (https=) |
| AR (1) | AR077440A1 (https=) |
| AU (1) | AU2010204753A1 (https=) |
| BR (1) | BRPI1005675A2 (https=) |
| CA (1) | CA2747752A1 (https=) |
| CL (1) | CL2011001714A1 (https=) |
| CO (1) | CO6400194A2 (https=) |
| DO (1) | DOP2011000217A (https=) |
| ES (1) | ES2527467T3 (https=) |
| IL (1) | IL213500A0 (https=) |
| MX (1) | MX337190B (https=) |
| PE (1) | PE20120126A1 (https=) |
| RU (1) | RU2011134052A (https=) |
| SG (1) | SG172308A1 (https=) |
| TW (1) | TW201028421A (https=) |
| UY (1) | UY32384A (https=) |
| WO (1) | WO2010083264A1 (https=) |
| ZA (1) | ZA201104715B (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
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| ES2527589T3 (es) | 2008-04-24 | 2015-01-27 | Msd K.K. | Inhibidor de la enzima de elongación de ácidos grasos de cadena larga que comprende un derivado de arilsulfonilo como principio activo |
| TW201028421A (en) * | 2009-01-15 | 2010-08-01 | Abbott Lab | Novel benzenesulfonamides as calcium channel blockers |
| US9296692B2 (en) * | 2011-09-15 | 2016-03-29 | Taipei Medical University | Use of indolyl and indolinyl hydroxamates for treating heart failure of neuronal injury |
| WO2013049164A1 (en) | 2011-09-29 | 2013-04-04 | Abbvie Inc. | SUBSTITUTED OCTAHYDROPYRROLO[1,2-a]PYRAZINES AS CALCIUM CHANNEL BLOCKERS |
| UY34349A (es) | 2011-09-29 | 2013-04-05 | Abb Vie Inc | OCTAHIDROPIRROLO[1,2-a]PIRAZINA SULFONAMIDAS SUSTITUIDAS COMO BLOQUEADORES DE CANALES DE CALCIO |
| US20130178477A1 (en) * | 2012-01-05 | 2013-07-11 | Abbvie Inc. | Methods of treating diabetic neuropathy using benzenesulfonamides |
| JP2016503007A (ja) | 2012-12-12 | 2016-02-01 | アッヴィ・インコーポレイテッド | 疼痛治療におけるカルシウムチャネル遮断薬として有用なジアゼピン誘導体 |
| KR102300576B1 (ko) * | 2013-09-10 | 2021-09-08 | 보드 오브 리전츠 더 유니버시티 오브 텍사스 시스템 | 절단된 선종성 결장 폴립증 (ａｐｃ) 단백질을 타겟화하는 치료제 |
| US9700549B2 (en) | 2013-10-03 | 2017-07-11 | David Wise | Compositions and methods for treating pelvic pain and other conditions |
| US10082496B2 (en) | 2014-09-10 | 2018-09-25 | Board Of Regents Of The University Of Texas System | Targeting emopamil binding protein (EBP) with small molecules that induce an abnormal feedback response by lowering endogenous cholesterol biosynthesis |
| DK3364993T3 (da) | 2015-10-22 | 2023-01-09 | Cavion Inc | Fremgangsmåder til behandling af angelman syndrom |
| CN110545806A (zh) | 2017-02-15 | 2019-12-06 | 卡维昂公司 | 钙通道抑制剂 |
| CN110770221B (zh) | 2017-04-26 | 2023-09-08 | 卡维昂公司 | 用于改善记忆和认知以及用于治疗记忆和认知障碍的方法 |
| TW202406538A (zh) | 2018-01-10 | 2024-02-16 | 美商克拉治療有限責任公司 | 包含苯基磺醯胺之醫藥組合物及其治療應用 |
| WO2020038435A1 (en) | 2018-08-24 | 2020-02-27 | Sunshine Lake Pharma Co., Ltd. | Pyridinylmethylenepiperidine derivatives and uses thereof |
| TWI879741B (zh) | 2018-10-03 | 2025-04-11 | 美商卡凡恩公司 | 以(r)-2-(4-異丙基苯基)-n-(1-(5-(2,2,2-三氟乙氧基)吡啶-2-基)乙基)乙醯胺治療自發性震顫 |
| AR116898A1 (es) * | 2018-10-30 | 2021-06-23 | H Lundbeck As | DERIVADOS DE ARILSULFONILPIRROLCARBOXAMIDA COMO ACTIVADORES DE CANALES DE POTASIO Kv3 |
| EP3996746A4 (en) | 2019-07-11 | 2023-08-23 | Praxis Precision Medicines, Inc. | T-TYPE CALCIUM CHANNEL MODULATOR FORMULATIONS AND METHODS OF USE THEREOF |
| AU2020311404A1 (en) * | 2019-07-11 | 2022-03-03 | Cura Therapeutics, Llc | Sulfone compounds and pharmaceutical compositions thereof, and their therapeutic applications for the treatment of neurodegenerative diseases |
| CN117229257B (zh) * | 2022-06-06 | 2026-01-30 | 中国药科大学 | 间氨磺酰苯甲酰胺类化合物及制法、药物组合物和应用 |
| WO2025255502A1 (en) | 2024-06-07 | 2025-12-11 | Cavion, Inc. | PYRIDYL AMIDE Cav3 CHANNEL MODULATORS |
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| EP1165508B1 (en) | 1999-04-07 | 2004-06-23 | The University of Virginia Patent Foundation | Anticancer calcium channel blockers |
| TW200503994A (en) | 2003-01-24 | 2005-02-01 | Novartis Ag | Organic compounds |
| US7223754B2 (en) | 2003-03-10 | 2007-05-29 | Dynogen Pharmaceuticals, Inc. | Thiazolidinone, oxazolidinone, and imidazolone derivatives for treating lower urinary tract and related disorders |
| ATE482747T1 (de) * | 2003-04-11 | 2010-10-15 | High Point Pharmaceuticals Llc | Neue amide derivate und deren pharmazeutische verwendungen |
| DE602004012083T2 (de) * | 2003-04-15 | 2009-04-23 | Astrazeneca Ab | Neue Verbindungen, die als Verstärker von Glutamatrezeptoren dienen |
| EP1866298A2 (en) * | 2005-03-31 | 2007-12-19 | Takeda San Diego, Inc. | Hydroxysteroid dehydrogenase inhibitors |
| WO2007052843A1 (ja) * | 2005-11-04 | 2007-05-10 | Takeda Pharmaceutical Company Limited | 複素環アミド化合物およびその用途 |
| WO2008043183A1 (en) * | 2006-10-13 | 2008-04-17 | Neuromed Pharmaceuticals Ltd. | Cyclopropyl-piperazine compounds as calcium channel blockers |
| KR20100033981A (ko) * | 2007-06-03 | 2010-03-31 | 벤더르빌트 유니버시티 | 벤즈아미드 대사성 글루타민산염 수용체5 양성 알로스테릭 조절자 및 이의 제조 및 사용방법 |
| ES2527589T3 (es) | 2008-04-24 | 2015-01-27 | Msd K.K. | Inhibidor de la enzima de elongación de ácidos grasos de cadena larga que comprende un derivado de arilsulfonilo como principio activo |
| TW201028421A (en) * | 2009-01-15 | 2010-08-01 | Abbott Lab | Novel benzenesulfonamides as calcium channel blockers |
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| US8404719B2 (en) | 2013-03-26 |
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| US20130210827A1 (en) | 2013-08-15 |
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| MX337190B (es) | 2016-02-16 |
| SG172308A1 (en) | 2011-07-28 |
| RU2011134052A (ru) | 2013-02-20 |
| US20100197693A1 (en) | 2010-08-05 |
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| EP2382191A1 (en) | 2011-11-02 |
| BRPI1005675A2 (pt) | 2017-06-13 |
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| CL2011001714A1 (es) | 2011-11-11 |
| AR077440A1 (es) | 2011-08-31 |
| KR20110110299A (ko) | 2011-10-06 |
| EP2382191B1 (en) | 2014-11-12 |
| MX2011007496A (es) | 2011-08-04 |
| CA2747752A1 (en) | 2010-07-22 |
| WO2010083264A1 (en) | 2010-07-22 |
| US20120083499A1 (en) | 2012-04-05 |
| US8101614B2 (en) | 2012-01-24 |
| TW201028421A (en) | 2010-08-01 |
| DOP2011000217A (es) | 2011-07-31 |
| CO6400194A2 (es) | 2012-03-15 |
| CN102282131B (zh) | 2015-08-26 |
| ZA201104715B (en) | 2014-01-29 |
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