CN102282131B - 作为钙离子通道阻断剂的新的苯磺酰胺 - Google Patents

作为钙离子通道阻断剂的新的苯磺酰胺 Download PDF

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Publication number
CN102282131B
CN102282131B CN201080004675.3A CN201080004675A CN102282131B CN 102282131 B CN102282131 B CN 102282131B CN 201080004675 A CN201080004675 A CN 201080004675A CN 102282131 B CN102282131 B CN 102282131B
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ylcarbonyl
benzenesulfonamide
pyrazin
hexahydropyrrolo
formula
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Expired - Fee Related
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Chinese (zh)
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CN102282131A (zh
Inventor
张庆伟
A.O.斯图尔特
夏之仁
M.F.贾维斯
V.E.斯科特
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Abbott Laboratories Ltd
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Abbott Laboratories
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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CN201080004675.3A 2009-01-15 2010-01-14 作为钙离子通道阻断剂的新的苯磺酰胺 Expired - Fee Related CN102282131B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14489909P 2009-01-15 2009-01-15
US61/144899 2009-01-15
PCT/US2010/020964 WO2010083264A1 (en) 2009-01-15 2010-01-14 Novel benzenesulfonamides as calcium channel blockers

Publications (2)

Publication Number Publication Date
CN102282131A CN102282131A (zh) 2011-12-14
CN102282131B true CN102282131B (zh) 2015-08-26

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Country Link
US (3) US8101614B2 (https=)
EP (1) EP2382191B1 (https=)
JP (1) JP5619773B2 (https=)
KR (1) KR20110110299A (https=)
CN (1) CN102282131B (https=)
AR (1) AR077440A1 (https=)
AU (1) AU2010204753A1 (https=)
BR (1) BRPI1005675A2 (https=)
CA (1) CA2747752A1 (https=)
CL (1) CL2011001714A1 (https=)
CO (1) CO6400194A2 (https=)
DO (1) DOP2011000217A (https=)
ES (1) ES2527467T3 (https=)
IL (1) IL213500A0 (https=)
MX (1) MX337190B (https=)
PE (1) PE20120126A1 (https=)
RU (1) RU2011134052A (https=)
SG (1) SG172308A1 (https=)
TW (1) TW201028421A (https=)
UY (1) UY32384A (https=)
WO (1) WO2010083264A1 (https=)
ZA (1) ZA201104715B (https=)

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TW201028421A (en) * 2009-01-15 2010-08-01 Abbott Lab Novel benzenesulfonamides as calcium channel blockers
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UY34349A (es) 2011-09-29 2013-04-05 Abb Vie Inc OCTAHIDROPIRROLO[1,2-a]PIRAZINA SULFONAMIDAS SUSTITUIDAS COMO BLOQUEADORES DE CANALES DE CALCIO
US20130178477A1 (en) * 2012-01-05 2013-07-11 Abbvie Inc. Methods of treating diabetic neuropathy using benzenesulfonamides
JP2016503007A (ja) 2012-12-12 2016-02-01 アッヴィ・インコーポレイテッド 疼痛治療におけるカルシウムチャネル遮断薬として有用なジアゼピン誘導体
KR102300576B1 (ko) * 2013-09-10 2021-09-08 보드 오브 리전츠 더 유니버시티 오브 텍사스 시스템 절단된 선종성 결장 폴립증 (ａｐｃ) 단백질을 타겟화하는 치료제
US9700549B2 (en) 2013-10-03 2017-07-11 David Wise Compositions and methods for treating pelvic pain and other conditions
US10082496B2 (en) 2014-09-10 2018-09-25 Board Of Regents Of The University Of Texas System Targeting emopamil binding protein (EBP) with small molecules that induce an abnormal feedback response by lowering endogenous cholesterol biosynthesis
DK3364993T3 (da) 2015-10-22 2023-01-09 Cavion Inc Fremgangsmåder til behandling af angelman syndrom
CN110545806A (zh) 2017-02-15 2019-12-06 卡维昂公司 钙通道抑制剂
CN110770221B (zh) 2017-04-26 2023-09-08 卡维昂公司 用于改善记忆和认知以及用于治疗记忆和认知障碍的方法
TW202406538A (zh) 2018-01-10 2024-02-16 美商克拉治療有限責任公司 包含苯基磺醯胺之醫藥組合物及其治療應用
WO2020038435A1 (en) 2018-08-24 2020-02-27 Sunshine Lake Pharma Co., Ltd. Pyridinylmethylenepiperidine derivatives and uses thereof
TWI879741B (zh) 2018-10-03 2025-04-11 美商卡凡恩公司 以(r)-2-(4-異丙基苯基)-n-(1-(5-(2,2,2-三氟乙氧基)吡啶-2-基)乙基)乙醯胺治療自發性震顫
AR116898A1 (es) * 2018-10-30 2021-06-23 H Lundbeck As DERIVADOS DE ARILSULFONILPIRROLCARBOXAMIDA COMO ACTIVADORES DE CANALES DE POTASIO Kv3
EP3996746A4 (en) 2019-07-11 2023-08-23 Praxis Precision Medicines, Inc. T-TYPE CALCIUM CHANNEL MODULATOR FORMULATIONS AND METHODS OF USE THEREOF
AU2020311404A1 (en) * 2019-07-11 2022-03-03 Cura Therapeutics, Llc Sulfone compounds and pharmaceutical compositions thereof, and their therapeutic applications for the treatment of neurodegenerative diseases
CN117229257B (zh) * 2022-06-06 2026-01-30 中国药科大学 间氨磺酰苯甲酰胺类化合物及制法、药物组合物和应用
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US20130210827A1 (en) 2013-08-15
CN102282131A (zh) 2011-12-14
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US20100197693A1 (en) 2010-08-05
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