RU2009137946A - Производные пиридазинона для применения в качестве ингибиторов глюкансинтазы - Google Patents
Производные пиридазинона для применения в качестве ингибиторов глюкансинтазы Download PDFInfo
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- RU2009137946A RU2009137946A RU2009137946/04A RU2009137946A RU2009137946A RU 2009137946 A RU2009137946 A RU 2009137946A RU 2009137946/04 A RU2009137946/04 A RU 2009137946/04A RU 2009137946 A RU2009137946 A RU 2009137946A RU 2009137946 A RU2009137946 A RU 2009137946A
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- alkyl
- alkenyl
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- candida
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- AAILEWXSEQLMNI-UHFFFAOYSA-N 1h-pyridazin-6-one Chemical class OC1=CC=CN=N1 AAILEWXSEQLMNI-UHFFFAOYSA-N 0.000 title 1
- 229940127488 Glucan Synthase Inhibitors Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims abstract 46
- 150000001875 compounds Chemical class 0.000 claims abstract 30
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 25
- 125000003710 aryl alkyl group Chemical group 0.000 claims abstract 24
- 125000003118 aryl group Chemical group 0.000 claims abstract 24
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims abstract 23
- 125000003342 alkenyl group Chemical group 0.000 claims abstract 21
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims abstract 19
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract 18
- 125000005018 aryl alkenyl group Chemical group 0.000 claims abstract 16
- 125000005356 cycloalkylalkenyl group Chemical group 0.000 claims abstract 13
- 125000004447 heteroarylalkenyl group Chemical group 0.000 claims abstract 13
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract 13
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims abstract 12
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 11
- 229910052799 carbon Inorganic materials 0.000 claims abstract 5
- 150000002148 esters Chemical class 0.000 claims abstract 4
- 239000000651 prodrug Substances 0.000 claims abstract 4
- 229940002612 prodrug Drugs 0.000 claims abstract 4
- 150000003839 salts Chemical class 0.000 claims abstract 4
- 239000012453 solvate Substances 0.000 claims abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000001257 hydrogen Substances 0.000 claims abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 2
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 2
- 229910052717 sulfur Inorganic materials 0.000 claims abstract 2
- -1 alkenyl-O-alkyl Chemical group 0.000 claims 28
- 239000012634 fragment Substances 0.000 claims 17
- 238000000034 method Methods 0.000 claims 14
- 125000001424 substituent group Chemical group 0.000 claims 10
- 125000004982 dihaloalkyl group Chemical group 0.000 claims 9
- 125000006682 monohaloalkyl group Chemical group 0.000 claims 9
- 125000004385 trihaloalkyl group Chemical group 0.000 claims 9
- 206010017533 Fungal infection Diseases 0.000 claims 8
- 208000031888 Mycoses Diseases 0.000 claims 8
- 125000005020 hydroxyalkenyl group Chemical group 0.000 claims 8
- 241001465754 Metazoa Species 0.000 claims 7
- 125000000304 alkynyl group Chemical group 0.000 claims 7
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 150000002367 halogens Chemical class 0.000 claims 7
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 238000011282 treatment Methods 0.000 claims 7
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
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- 229940121375 antifungal agent Drugs 0.000 claims 5
- 239000003429 antifungal agent Substances 0.000 claims 5
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- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 4
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- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 claims 3
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 claims 2
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- IIUZTXTZRGLYTI-UHFFFAOYSA-N Dihydrogriseofulvin Natural products COC1CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 IIUZTXTZRGLYTI-UHFFFAOYSA-N 0.000 claims 2
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- UXWOXTQWVMFRSE-UHFFFAOYSA-N Griseoviridin Natural products O=C1OC(C)CC=C(C(NCC=CC=CC(O)CC(O)C2)=O)SCC1NC(=O)C1=COC2=N1 UXWOXTQWVMFRSE-UHFFFAOYSA-N 0.000 claims 2
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- DDUHZTYCFQRHIY-UHFFFAOYSA-N Negwer: 6874 Natural products COC1=CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-UHFFFAOYSA-N 0.000 claims 2
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- 125000004171 alkoxy aryl group Chemical group 0.000 claims 2
- 125000005082 alkoxyalkenyl group Chemical group 0.000 claims 2
- 125000005081 alkoxyalkoxyalkyl group Chemical group 0.000 claims 2
- 125000002877 alkyl aryl group Chemical group 0.000 claims 2
- 125000005120 alkyl cycloalkyl alkyl group Chemical group 0.000 claims 2
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 claims 2
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 claims 2
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- HQABUPZFAYXKJW-UHFFFAOYSA-N butan-1-amine Chemical compound CCCCN HQABUPZFAYXKJW-UHFFFAOYSA-N 0.000 claims 2
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 2
- 125000005112 cycloalkylalkoxy group Chemical group 0.000 claims 2
- 244000053095 fungal pathogen Species 0.000 claims 2
- DDUHZTYCFQRHIY-RBHXEPJQSA-N griseofulvin Chemical compound COC1=CC(=O)C[C@@H](C)[C@@]11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-RBHXEPJQSA-N 0.000 claims 2
- 229960002867 griseofulvin Drugs 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 125000004404 heteroalkyl group Chemical group 0.000 claims 2
- 125000004449 heterocyclylalkenyl group Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 claims 1
- 241001019659 Acremonium <Plectosphaerellaceae> Species 0.000 claims 1
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- APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 claims 1
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- BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 claims 1
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- 229960001589 posaconazole Drugs 0.000 claims 1
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- 238000002360 preparation method Methods 0.000 claims 1
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- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 1
- 150000003558 thiocarbamic acid derivatives Chemical class 0.000 claims 1
- FUSNMLFNXJSCDI-UHFFFAOYSA-N tolnaftate Chemical compound C=1C=C2C=CC=CC2=CC=1OC(=S)N(C)C1=CC=CC(C)=C1 FUSNMLFNXJSCDI-UHFFFAOYSA-N 0.000 claims 1
- 229960004880 tolnaftate Drugs 0.000 claims 1
- 229940055035 trichophyton verrucosum Drugs 0.000 claims 1
- 125000004952 trihaloalkoxy group Chemical group 0.000 claims 1
- BCEHBSKCWLPMDN-MGPLVRAMSA-N voriconazole Chemical compound C1([C@H](C)[C@](O)(CN2N=CN=C2)C=2C(=CC(F)=CC=2)F)=NC=NC=C1F BCEHBSKCWLPMDN-MGPLVRAMSA-N 0.000 claims 1
- 229960004740 voriconazole Drugs 0.000 claims 1
- 0 CCCCCCC(C(C)CC=CCCCC=C)C1C*CC1 Chemical compound CCCCCCC(C(C)CC=CCCCC=C)C1C*CC1 0.000 description 8
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- QYHMHGZURIRWSF-AIJKMKQJSA-N C/C=C\C=C(/C=C)\Cl Chemical compound C/C=C\C=C(/C=C)\Cl QYHMHGZURIRWSF-AIJKMKQJSA-N 0.000 description 1
- JGUUEXDKOJKWAK-IZHYLOQSSA-P C=C/C(/N(CC1)CCN1[S+](Cc1ccccc1)(O)=O)=C(\C(Nc1ccccc1)=O)/OCC1CC1 Chemical compound C=C/C(/N(CC1)CCN1[S+](Cc1ccccc1)(O)=O)=C(\C(Nc1ccccc1)=O)/OCC1CC1 JGUUEXDKOJKWAK-IZHYLOQSSA-P 0.000 description 1
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- SBNSCWXFTVHEEY-IDJMTWOOSA-N CC(CC1)C1O/C(/C(Nc1cc(F)cc(F)c1)=O)=C(/C=N)\NCN(CI)S(Cc1ccccc1)(=O)=O Chemical compound CC(CC1)C1O/C(/C(Nc1cc(F)cc(F)c1)=O)=C(/C=N)\NCN(CI)S(Cc1ccccc1)(=O)=O SBNSCWXFTVHEEY-IDJMTWOOSA-N 0.000 description 1
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- VVKZMEJWMORYLF-RGMCHMAOSA-N CCN(CN)/C(/C=N)=C(/C(Nc1cc(F)cc(F)c1)=O)\OC(Cc1ccccc1C1)C1F Chemical compound CCN(CN)/C(/C=N)=C(/C(Nc1cc(F)cc(F)c1)=O)\OC(Cc1ccccc1C1)C1F VVKZMEJWMORYLF-RGMCHMAOSA-N 0.000 description 1
- SZMAWHVUXSTECB-FKGPLHHQSA-N CCN(CN)/C(/C=N)=C(/C(Nc1cccc(Cl)c1)=O)\OCC1(C)CC1 Chemical compound CCN(CN)/C(/C=N)=C(/C(Nc1cccc(Cl)c1)=O)\OCC1(C)CC1 SZMAWHVUXSTECB-FKGPLHHQSA-N 0.000 description 1
- SOPVWOCOOOLPLI-XDAAAEPZSA-N CCN(CNSCc(cc1)cc(N)c1OC)/C(/C=N)=C(/C(Nc1cc(F)cc(F)c1)=O)\OCC1(C)CC1 Chemical compound CCN(CNSCc(cc1)cc(N)c1OC)/C(/C=N)=C(/C(Nc1cc(F)cc(F)c1)=O)\OCC1(C)CC1 SOPVWOCOOOLPLI-XDAAAEPZSA-N 0.000 description 1
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- QBPCSMQLQMGIAM-UHFFFAOYSA-N N=CC(N(CC1)CCN1S(=O)=O)=C(C(Nc1cc(Cl)ccc1)=O)OC1Cc2ccccc2CC1 Chemical compound N=CC(N(CC1)CCN1S(=O)=O)=C(C(Nc1cc(Cl)ccc1)=O)OC1Cc2ccccc2CC1 QBPCSMQLQMGIAM-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
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| US60/918,171 | 2007-03-15 |
Publications (1)
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| RU2009137946A true RU2009137946A (ru) | 2011-04-20 |
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| JP2010521463A (ja) * | 2007-03-15 | 2010-06-24 | シェーリング コーポレイション | グルカンシンターゼの阻害剤として有用なピペラジン置換ビリダジノン誘導体 |
| EP2137162B1 (en) | 2007-03-15 | 2018-08-01 | Novartis AG | Organic compounds and their uses |
| CA2697551C (en) * | 2007-09-20 | 2013-03-12 | Irm Llc | Piperidine derivatives as modulators of gpr119 activity |
| JP5627574B2 (ja) | 2008-06-03 | 2014-11-19 | インターミューン， インコーポレイテッド | 炎症性および線維性疾患を治療するための化合物および方法 |
| US20100041663A1 (en) | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
| US20120088769A1 (en) * | 2010-10-11 | 2012-04-12 | Axikin Pharmaceuticals, Inc. | Salts of arylsulfonamide ccr3 antagonists |
| FI20115234A0 (fi) | 2011-03-08 | 2011-03-08 | Biotie Therapies Corp | Uusia pyridatsinoni- ja pyridoniyhdisteitä |
| GB201111705D0 (en) | 2011-07-07 | 2011-08-24 | Takeda Pharmaceutical | Compounds and their use |
| GB201111704D0 (en) | 2011-07-07 | 2011-08-24 | Takeda Pharmaceutical | Novel compounds |
| JO3115B1 (ar) * | 2011-08-22 | 2017-09-20 | Takeda Pharmaceuticals Co | مركبات بيريدازينون واستخدامها كمثبطات daao |
| AP2014007637A0 (en) | 2011-11-15 | 2014-05-31 | Takeda Pharmaceutical | Dihydroxy aromatic heterocyclic compound |
| CN104379563B (zh) * | 2012-04-10 | 2018-12-21 | 加利福尼亚大学董事会 | 用于治疗癌症的组合物和方法 |
| AU2013203000B9 (en) | 2012-08-10 | 2017-02-02 | Lantheus Medical Imaging, Inc. | Compositions, methods, and systems for the synthesis and use of imaging agents |
| CN103664795B (zh) * | 2012-09-06 | 2017-10-03 | 华东理工大学 | 哒嗪酮类化合物及其用途 |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| JP6310464B2 (ja) | 2012-10-05 | 2018-04-11 | コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． | 改善されたｘ線画像を供する医療撮像システム及び方法 |
| GB201222711D0 (en) * | 2012-12-17 | 2013-01-30 | Takeda Pharmaceutical | Novel compounds |
| US10070649B2 (en) | 2013-01-30 | 2018-09-11 | Agrofresh Inc. | Volatile applications against pathogens |
| US11039617B2 (en) | 2013-01-30 | 2021-06-22 | Agrofresh Inc. | Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness |
| CA2922567A1 (en) * | 2013-08-26 | 2015-03-05 | Purdue Pharma L.P. | Azaspiro[4.5]decane derivatives and use thereof |
| US10233195B2 (en) | 2014-04-02 | 2019-03-19 | Intermune, Inc. | Anti-fibrotic pyridinones |
| CA2946163A1 (en) * | 2014-04-24 | 2015-10-29 | Hexima Limited | Agents and methods of treatment |
| NZ745681A (en) | 2016-03-07 | 2022-05-27 | Agrofresh Inc | Synergistic methods of using benzoxaborole compounds and preservative gases as an antimicrobial for crops |
| EP3596043B1 (en) | 2017-03-15 | 2025-12-03 | Lunella Biotech, Inc. | Mitoriboscins: mitochondrial-based therapeutics targeting cancer cells, bacteria, and pathogenic yeast |
| US20210101874A1 (en) | 2017-04-03 | 2021-04-08 | Syngenta Participations Ag | Microbiocidal oxadiazole derivatives |
| AU2018334290A1 (en) | 2017-09-18 | 2020-04-02 | Goldfinch Bio, Inc. | Pyridazinones and methods of use thereof |
| CN109912476A (zh) * | 2019-03-27 | 2019-06-21 | 南通宝凯化工有限公司 | 一种异丙氨基磺酰氯的生产工艺 |
| TW202115042A (zh) * | 2019-06-21 | 2021-04-16 | 大陸商江蘇豪森藥業集團有限公司 | 芳基磷氧化物類衍生物抑制劑、其製備方法和應用 |
| US12509444B2 (en) * | 2019-12-06 | 2025-12-30 | Plexxikon Inc. | Compounds and methods for CD73 modulation and indications therefor |
| CN115551862B (zh) | 2020-04-30 | 2024-04-12 | 吉利德科学公司 | 肽基精氨酸脱亚胺酶的大环抑制剂 |
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| JPS565734B2 (enExample) * | 1973-02-28 | 1981-02-06 | ||
| DE3048487A1 (de) * | 1980-12-22 | 1982-07-29 | Cassella Ag, 6000 Frankfurt | Basisch substituierte pyridazine, ihre herstellung und ihre verwendung |
| ES8601972A1 (es) | 1985-02-28 | 1985-11-16 | Abello Quimicos Farma Prod Sa | Procedimiento de obtencion de 1,2-diazin-3 (2h)-onas con interes farmaceutico |
| JPH04235975A (ja) * | 1991-01-21 | 1992-08-25 | Nissan Chem Ind Ltd | ピリダジノン誘導体および害虫防除剤 |
| GB2256587A (en) | 1991-06-11 | 1992-12-16 | American Cyanamid Co | Acetazolamide in sustained release form |
| HU227237B1 (en) * | 2001-09-27 | 2010-12-28 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Substituted alkylpyridazinone derivatives, process for their preparation, pharmaceutical compositions containing them |
| EP1479681A4 (en) * | 2002-01-31 | 2006-05-10 | Daiichi Seiyaku Co | IMIDAZO (1,2-a) pyridine |
| DE10216144A1 (de) * | 2002-04-12 | 2003-11-06 | Bayer Ag | Substituierte 2-Phenyl-3(2H)-Pyridazinone |
| US20050209278A1 (en) * | 2002-04-25 | 2005-09-22 | Mcdonald Joseph J | Piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors |
| UA77526C2 (en) * | 2002-06-07 | 2006-12-15 | Sanofi Aventis | Substituted derivatives of 1-piperazineacylpiperidine, a method for the preparation thereof and their use in therapy |
| NZ547481A (en) * | 2003-11-19 | 2009-12-24 | Array Biopharma Inc | Heterocyclic inhibitors of mek and methods of use thereof |
| WO2005117909A2 (en) * | 2004-04-23 | 2005-12-15 | Exelixis, Inc. | Kinase modulators and methods of use |
| GB0524991D0 (en) * | 2005-12-08 | 2006-01-18 | Ge Healthcare Ltd | Novel imaging agents for fibrosis |
| WO2007130383A2 (en) * | 2006-04-28 | 2007-11-15 | Northwestern University | Compositions and treatments using pyridazine compounds and secretases |
| JP2010521463A (ja) * | 2007-03-15 | 2010-06-24 | シェーリング コーポレイション | グルカンシンターゼの阻害剤として有用なピペラジン置換ビリダジノン誘導体 |
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- 2008-03-12 EP EP08726734.0A patent/EP2137179B1/en active Active
- 2008-03-12 MX MX2009009948A patent/MX2009009948A/es not_active Application Discontinuation
- 2008-03-12 WO PCT/US2008/003257 patent/WO2008115381A1/en not_active Ceased
- 2008-03-12 CA CA002680583A patent/CA2680583A1/en not_active Abandoned
- 2008-03-12 PE PE2008000469A patent/PE20081882A1/es not_active Application Discontinuation
- 2008-03-12 BR BRPI0809238-9A patent/BRPI0809238A2/pt not_active IP Right Cessation
- 2008-03-13 AR ARP080101033A patent/AR065721A1/es not_active Application Discontinuation
- 2008-03-13 TW TW097108919A patent/TW200902516A/zh unknown
-
2009
- 2009-09-13 IL IL200906A patent/IL200906A0/en unknown
- 2009-09-14 CO CO09098894A patent/CO6220966A2/es not_active Application Discontinuation
- 2009-09-14 EC EC2009009634A patent/ECSP099634A/es unknown
-
2012
- 2012-10-18 JP JP2012230565A patent/JP2013014622A/ja active Pending
-
2013
- 2013-12-16 JP JP2013259117A patent/JP2014051529A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP2586778A3 (en) | 2013-07-31 |
| JP5147866B2 (ja) | 2013-02-20 |
| EP2586778A2 (en) | 2013-05-01 |
| US20090170861A1 (en) | 2009-07-02 |
| TW200902516A (en) | 2009-01-16 |
| JP2014051529A (ja) | 2014-03-20 |
| MX2009009948A (es) | 2009-09-24 |
| WO2008115381A1 (en) | 2008-09-25 |
| JP2013014622A (ja) | 2013-01-24 |
| EP2137179A1 (en) | 2009-12-30 |
| ECSP099634A (es) | 2009-10-30 |
| CN101730692A (zh) | 2010-06-09 |
| CA2680583A1 (en) | 2008-09-25 |
| CO6220966A2 (es) | 2010-11-19 |
| KR20100049500A (ko) | 2010-05-12 |
| AU2008227100A1 (en) | 2008-09-25 |
| BRPI0809238A2 (pt) | 2014-09-09 |
| AR065721A1 (es) | 2009-06-24 |
| IL200906A0 (en) | 2010-05-17 |
| AU2008227100B2 (en) | 2014-01-09 |
| US8232274B2 (en) | 2012-07-31 |
| CL2008000725A1 (es) | 2008-11-14 |
| EP2137179B1 (en) | 2015-09-02 |
| JP2010521461A (ja) | 2010-06-24 |
| PE20081882A1 (es) | 2008-12-27 |
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Legal Events
| Date | Code | Title | Description |
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| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20110527 |