CN101730692A - 用作葡聚糖合成酶抑制剂的哒嗪酮衍生物 - Google Patents

用作葡聚糖合成酶抑制剂的哒嗪酮衍生物 Download PDF

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Publication number
CN101730692A
CN101730692A CN200880016155A CN200880016155A CN101730692A CN 101730692 A CN101730692 A CN 101730692A CN 200880016155 A CN200880016155 A CN 200880016155A CN 200880016155 A CN200880016155 A CN 200880016155A CN 101730692 A CN101730692 A CN 101730692A
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CN
China
Prior art keywords
alkyl
alkenyl
mmol
compound
candida
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Pending
Application number
CN200880016155A
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English (en)
Chinese (zh)
Inventor
P·C·丁
R·G·艾斯兰安
寇佳华
D·W.-S·金
关若泽
G·周
R·J·希尔
A·J·兹克
J·杨
H·吴
N·朱恩
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Curia Global Inc
Original Assignee
Albany Molecular Research Inc
Schering Corp
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Publication date
Application filed by Albany Molecular Research Inc, Schering Corp filed Critical Albany Molecular Research Inc
Publication of CN101730692A publication Critical patent/CN101730692A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN200880016155A 2007-03-15 2008-03-12 用作葡聚糖合成酶抑制剂的哒嗪酮衍生物 Pending CN101730692A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91817107P 2007-03-15 2007-03-15
US60/918,171 2007-03-15
PCT/US2008/003257 WO2008115381A1 (en) 2007-03-15 2008-03-12 Pyridazinone derivatives useful as glucan synthase inhibitors

Publications (1)

Publication Number Publication Date
CN101730692A true CN101730692A (zh) 2010-06-09

Family

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Family Applications (1)

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CN200880016155A Pending CN101730692A (zh) 2007-03-15 2008-03-12 用作葡聚糖合成酶抑制剂的哒嗪酮衍生物

Country Status (18)

Country Link
US (1) US8232274B2 (enExample)
EP (2) EP2586778A3 (enExample)
JP (3) JP5147866B2 (enExample)
KR (1) KR20100049500A (enExample)
CN (1) CN101730692A (enExample)
AR (1) AR065721A1 (enExample)
AU (1) AU2008227100B2 (enExample)
BR (1) BRPI0809238A2 (enExample)
CA (1) CA2680583A1 (enExample)
CL (1) CL2008000725A1 (enExample)
CO (1) CO6220966A2 (enExample)
EC (1) ECSP099634A (enExample)
IL (1) IL200906A0 (enExample)
MX (1) MX2009009948A (enExample)
PE (1) PE20081882A1 (enExample)
RU (1) RU2009137946A (enExample)
TW (1) TW200902516A (enExample)
WO (1) WO2008115381A1 (enExample)

Cited By (4)

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WO2014036952A1 (zh) * 2012-09-06 2014-03-13 华东理工大学 哒嗪酮类化合物及其用途
CN103748079A (zh) * 2011-08-22 2014-04-23 武田药品工业株式会社 哒嗪酮混合物及其作为daao抑制剂的用途
CN109912476A (zh) * 2019-03-27 2019-06-21 南通宝凯化工有限公司 一种异丙氨基磺酰氯的生产工艺
WO2020253860A1 (zh) * 2019-06-21 2020-12-24 江苏豪森药业集团有限公司 芳基磷氧化物类衍生物抑制剂、其制备方法和应用

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DK2137162T3 (en) 2007-03-15 2018-11-26 Novartis Ag Organic compounds and their applications
EP2136808A2 (en) * 2007-03-15 2009-12-30 Schering Corporation Piperazine-substituted pyridazinone derivatives useful as glucan synthase inhibitors
MX2010003117A (es) * 2007-09-20 2010-04-01 Irm Llc Compuestos y composiciones como moduladores de la actividad de gpr119.
EP2296653B1 (en) 2008-06-03 2016-01-27 Intermune, Inc. Compounds and methods for treating inflammatory and fibrotic disorders
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
AU2011313906B2 (en) * 2010-10-11 2015-08-13 Axikin Pharmaceuticals, Inc. Salts of arylsulfonamide CCR3 antagonists
FI20115234A0 (fi) 2011-03-08 2011-03-08 Biotie Therapies Corp Uusia pyridatsinoni- ja pyridoniyhdisteitä
GB201111704D0 (en) 2011-07-07 2011-08-24 Takeda Pharmaceutical Novel compounds
GB201111705D0 (en) 2011-07-07 2011-08-24 Takeda Pharmaceutical Compounds and their use
AP2014007637A0 (en) 2011-11-15 2014-05-31 Takeda Pharmaceutical Dihydroxy aromatic heterocyclic compound
EP2836482B1 (en) * 2012-04-10 2019-12-25 The Regents of The University of California Compositions and methods for treating cancer
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
WO2014053973A2 (en) 2012-10-05 2014-04-10 Koninklijke Philips N.V. Medical imaging system and method for providing an enhanced x-ray image
GB201222711D0 (en) 2012-12-17 2013-01-30 Takeda Pharmaceutical Novel compounds
US11039617B2 (en) 2013-01-30 2021-06-22 Agrofresh Inc. Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness
US10070649B2 (en) 2013-01-30 2018-09-11 Agrofresh Inc. Volatile applications against pathogens
WO2015031036A1 (en) * 2013-08-26 2015-03-05 Purdue Pharma L.P. Azaspiro[4.5] decane derivatives and use thereof
RU2692485C2 (ru) 2014-04-02 2019-06-25 Интермьюн, Инк. Противофиброзные пиридиноны
CN106456708A (zh) * 2014-04-24 2017-02-22 赫希玛有限公司 治疗的试剂和方法
EP3426029B1 (en) 2016-03-07 2023-08-30 AgroFresh Inc. Synergistic methods of using benzoxaborole compounds and preservative gases as an antimicrobial for crops
RU2019132396A (ru) * 2017-03-15 2021-04-15 Лунелла Байотек, Инк. Миторибосцины: терапевтические средства на основе митохондрий, направленные на раковые клетки, бактерии и патогенные дрожжи
BR112019020693B1 (pt) 2017-04-03 2023-11-28 Syngenta Participations Ag Compostos derivados de oxadiazol microbiocidas, suas composições, método para controlar ou prevenir a infestação de plantas úteis por microrganismos fitopatogênicos utilizando tais compostos e seus usos
EP3684364A4 (en) 2017-09-18 2021-06-02 Goldfinch Bio, Inc. PYRIDAZINONE AND METHOD OF USE THEREOF
WO2021113625A1 (en) * 2019-12-06 2021-06-10 Plexxikon Inc. Compounds and methods for cd73 modulation and indications therefor
WO2021222353A1 (en) 2020-04-30 2021-11-04 Gilead Sciences, Inc. Macrocyclic inhibitors of peptidylarginine deiminases
WO2023204124A1 (ja) * 2022-04-20 2023-10-26 日本曹達株式会社 ピリダジノン化合物並びに農園芸用殺菌剤、殺線虫剤、および医療用・動物用抗真菌剤

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103748079A (zh) * 2011-08-22 2014-04-23 武田药品工业株式会社 哒嗪酮混合物及其作为daao抑制剂的用途
CN103748079B (zh) * 2011-08-22 2016-03-16 武田药品工业株式会社 哒嗪酮混合物及其作为daao抑制剂的用途
WO2014036952A1 (zh) * 2012-09-06 2014-03-13 华东理工大学 哒嗪酮类化合物及其用途
CN103664795A (zh) * 2012-09-06 2014-03-26 华东理工大学 哒嗪酮类化合物及其用途
CN103664795B (zh) * 2012-09-06 2017-10-03 华东理工大学 哒嗪酮类化合物及其用途
CN109912476A (zh) * 2019-03-27 2019-06-21 南通宝凯化工有限公司 一种异丙氨基磺酰氯的生产工艺
WO2020253860A1 (zh) * 2019-06-21 2020-12-24 江苏豪森药业集团有限公司 芳基磷氧化物类衍生物抑制剂、其制备方法和应用
CN112469713A (zh) * 2019-06-21 2021-03-09 江苏豪森药业集团有限公司 芳基磷氧化物类衍生物抑制剂、其制备方法和应用
CN112469713B (zh) * 2019-06-21 2023-09-01 江苏豪森药业集团有限公司 芳基磷氧化物类衍生物抑制剂、其制备方法和应用

Also Published As

Publication number Publication date
AU2008227100A1 (en) 2008-09-25
CA2680583A1 (en) 2008-09-25
EP2137179B1 (en) 2015-09-02
CO6220966A2 (es) 2010-11-19
MX2009009948A (es) 2009-09-24
KR20100049500A (ko) 2010-05-12
US8232274B2 (en) 2012-07-31
JP2013014622A (ja) 2013-01-24
PE20081882A1 (es) 2008-12-27
ECSP099634A (es) 2009-10-30
EP2586778A3 (en) 2013-07-31
AU2008227100B2 (en) 2014-01-09
WO2008115381A1 (en) 2008-09-25
IL200906A0 (en) 2010-05-17
CL2008000725A1 (es) 2008-11-14
AR065721A1 (es) 2009-06-24
EP2586778A2 (en) 2013-05-01
JP5147866B2 (ja) 2013-02-20
JP2014051529A (ja) 2014-03-20
JP2010521461A (ja) 2010-06-24
BRPI0809238A2 (pt) 2014-09-09
TW200902516A (en) 2009-01-16
US20090170861A1 (en) 2009-07-02
EP2137179A1 (en) 2009-12-30
RU2009137946A (ru) 2011-04-20

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Application publication date: 20100609