MX2009009948A - Derivados de piridazinona utiles como inhibidores de glucano sintasa. - Google Patents
Derivados de piridazinona utiles como inhibidores de glucano sintasa.Info
- Publication number
- MX2009009948A MX2009009948A MX2009009948A MX2009009948A MX2009009948A MX 2009009948 A MX2009009948 A MX 2009009948A MX 2009009948 A MX2009009948 A MX 2009009948A MX 2009009948 A MX2009009948 A MX 2009009948A MX 2009009948 A MX2009009948 A MX 2009009948A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- glucan synthase
- synthase inhibitors
- derivatives useful
- methods
- Prior art date
Links
- AAILEWXSEQLMNI-UHFFFAOYSA-N 1h-pyridazin-6-one Chemical class OC1=CC=CN=N1 AAILEWXSEQLMNI-UHFFFAOYSA-N 0.000 title abstract 2
- 229940127488 Glucan Synthase Inhibitors Drugs 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 5
- 238000000034 method Methods 0.000 abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 206010017533 Fungal infection Diseases 0.000 abstract 1
- 208000031888 Mycoses Diseases 0.000 abstract 1
- 229940121375 antifungal agent Drugs 0.000 abstract 1
- 239000003429 antifungal agent Substances 0.000 abstract 1
- 108010052221 glucan synthase Proteins 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91817107P | 2007-03-15 | 2007-03-15 | |
| PCT/US2008/003257 WO2008115381A1 (en) | 2007-03-15 | 2008-03-12 | Pyridazinone derivatives useful as glucan synthase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009009948A true MX2009009948A (es) | 2009-09-24 |
Family
ID=39525788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009009948A MX2009009948A (es) | 2007-03-15 | 2008-03-12 | Derivados de piridazinona utiles como inhibidores de glucano sintasa. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8232274B2 (enExample) |
| EP (2) | EP2586778A3 (enExample) |
| JP (3) | JP5147866B2 (enExample) |
| KR (1) | KR20100049500A (enExample) |
| CN (1) | CN101730692A (enExample) |
| AR (1) | AR065721A1 (enExample) |
| AU (1) | AU2008227100B2 (enExample) |
| BR (1) | BRPI0809238A2 (enExample) |
| CA (1) | CA2680583A1 (enExample) |
| CL (1) | CL2008000725A1 (enExample) |
| CO (1) | CO6220966A2 (enExample) |
| EC (1) | ECSP099634A (enExample) |
| IL (1) | IL200906A0 (enExample) |
| MX (1) | MX2009009948A (enExample) |
| PE (1) | PE20081882A1 (enExample) |
| RU (1) | RU2009137946A (enExample) |
| TW (1) | TW200902516A (enExample) |
| WO (1) | WO2008115381A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ579402A (en) | 2007-03-15 | 2012-03-30 | Novartis Ag | Organic compounds for diagnosis and treatment of pathologies relating to the Hedgehog pathway |
| CA2680587A1 (en) * | 2007-03-15 | 2008-09-25 | Schering Corporation | Piperazine-substituted pyridazinone derivatives useful as glucan synthase inhibitors |
| JP5465177B2 (ja) * | 2007-09-20 | 2014-04-09 | アイアールエム・リミテッド・ライアビリティ・カンパニー | Ｇｐｒ１１９活性のモジュレーターとしての化合物および組成物 |
| US8304413B2 (en) | 2008-06-03 | 2012-11-06 | Intermune, Inc. | Compounds and methods for treating inflammatory and fibrotic disorders |
| US20100041663A1 (en) | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
| MX2013003954A (es) * | 2010-10-11 | 2013-08-01 | Axikin Pharmaceuticals Inc | Sales de arilsulfonamida antagonistas de ccr3. |
| FI20115234A0 (fi) * | 2011-03-08 | 2011-03-08 | Biotie Therapies Corp | Uusia pyridatsinoni- ja pyridoniyhdisteitä |
| GB201111704D0 (en) | 2011-07-07 | 2011-08-24 | Takeda Pharmaceutical | Novel compounds |
| GB201111705D0 (en) | 2011-07-07 | 2011-08-24 | Takeda Pharmaceutical | Compounds and their use |
| JO3115B1 (ar) | 2011-08-22 | 2017-09-20 | Takeda Pharmaceuticals Co | مركبات بيريدازينون واستخدامها كمثبطات daao |
| PE20141361A1 (es) | 2011-11-15 | 2014-10-13 | Takeda Pharmaceutical | Compuesto heterociclico dihidroxi aromatico |
| US20150087628A1 (en) * | 2012-04-10 | 2015-03-26 | The Regents Of The University Of California | Compositions and methods for treating cancer |
| AU2013203000B9 (en) | 2012-08-10 | 2017-02-02 | Lantheus Medical Imaging, Inc. | Compositions, methods, and systems for the synthesis and use of imaging agents |
| CN103664795B (zh) * | 2012-09-06 | 2017-10-03 | 华东理工大学 | 哒嗪酮类化合物及其用途 |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| JP6310464B2 (ja) | 2012-10-05 | 2018-04-11 | コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． | 改善されたｘ線画像を供する医療撮像システム及び方法 |
| GB201222711D0 (en) * | 2012-12-17 | 2013-01-30 | Takeda Pharmaceutical | Novel compounds |
| US10070649B2 (en) | 2013-01-30 | 2018-09-11 | Agrofresh Inc. | Volatile applications against pathogens |
| US11039617B2 (en) | 2013-01-30 | 2021-06-22 | Agrofresh Inc. | Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness |
| EP3039019B1 (en) * | 2013-08-26 | 2020-04-22 | Purdue Pharma L.P. | Azaspiro[4.5]decane derivatives and use thereof |
| WO2015153683A1 (en) | 2014-04-02 | 2015-10-08 | Intermune, Inc. | Anti-fibrotic pyridinones |
| CA2946163A1 (en) * | 2014-04-24 | 2015-10-29 | Hexima Limited | Agents and methods of treatment |
| RS64770B1 (sr) | 2016-03-07 | 2023-11-30 | Agrofresh Inc | Sinergistički postupci upotrebe jedinjenja benzoksaborola i gasova za prezerviranje kao antimikrobnih agenasa za useve |
| JP7104134B2 (ja) | 2017-03-15 | 2022-07-20 | ルネラ・バイオテック・インコーポレーテッド | ミトリボシン：癌細胞、細菌、及び病原性酵母を標的とした、ミトコンドリアベースの治療薬 |
| BR112019020693B1 (pt) | 2017-04-03 | 2023-11-28 | Syngenta Participations Ag | Compostos derivados de oxadiazol microbiocidas, suas composições, método para controlar ou prevenir a infestação de plantas úteis por microrganismos fitopatogênicos utilizando tais compostos e seus usos |
| WO2019055966A2 (en) | 2017-09-18 | 2019-03-21 | Goldfinch Bio, Inc. | PYRIDAZINONES AND METHODS OF USE |
| CN109912476A (zh) * | 2019-03-27 | 2019-06-21 | 南通宝凯化工有限公司 | 一种异丙氨基磺酰氯的生产工艺 |
| CN112513029B (zh) * | 2019-06-21 | 2023-10-24 | 上海翰森生物医药科技有限公司 | 含氮芳基磷氧化物类衍生物、其制备方法和应用 |
| US12509444B2 (en) * | 2019-12-06 | 2025-12-30 | Plexxikon Inc. | Compounds and methods for CD73 modulation and indications therefor |
| EP4143189A1 (en) | 2020-04-30 | 2023-03-08 | Gilead Sciences, Inc. | Macrocyclic inhibitors of peptidylarginine deiminases |
| WO2023204124A1 (ja) * | 2022-04-20 | 2023-10-26 | 日本曹達株式会社 | ピリダジノン化合物並びに農園芸用殺菌剤、殺線虫剤、および医療用・動物用抗真菌剤 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS565734B2 (enExample) * | 1973-02-28 | 1981-02-06 | ||
| DE3048487A1 (de) * | 1980-12-22 | 1982-07-29 | Cassella Ag, 6000 Frankfurt | Basisch substituierte pyridazine, ihre herstellung und ihre verwendung |
| ES540813A0 (es) | 1985-02-28 | 1985-11-16 | Abello Quimicos Farma Prod Sa | Procedimiento de obtencion de 1,2-diazin-3 (2h)-onas con interes farmaceutico |
| JPH04235975A (ja) * | 1991-01-21 | 1992-08-25 | Nissan Chem Ind Ltd | ピリダジノン誘導体および害虫防除剤 |
| GB2256587A (en) | 1991-06-11 | 1992-12-16 | American Cyanamid Co | Acetazolamide in sustained release form |
| HU227237B1 (en) * | 2001-09-27 | 2010-12-28 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Substituted alkylpyridazinone derivatives, process for their preparation, pharmaceutical compositions containing them |
| CN1633434A (zh) * | 2002-01-31 | 2005-06-29 | 第一制药株式会社 | 咪唑并[1,2－a]吡啶衍生物 |
| DE10216144A1 (de) * | 2002-04-12 | 2003-11-06 | Bayer Ag | Substituierte 2-Phenyl-3(2H)-Pyridazinone |
| US20050209278A1 (en) * | 2002-04-25 | 2005-09-22 | Mcdonald Joseph J | Piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors |
| UA77526C2 (en) * | 2002-06-07 | 2006-12-15 | Sanofi Aventis | Substituted derivatives of 1-piperazineacylpiperidine, a method for the preparation thereof and their use in therapy |
| CN1905873A (zh) * | 2003-11-19 | 2007-01-31 | 阵列生物制药公司 | Mek的杂环抑制剂及其使用方法 |
| AU2005249380C1 (en) * | 2004-04-23 | 2012-09-20 | Exelixis, Inc. | Kinase modulators and methods of use |
| GB0524991D0 (en) * | 2005-12-08 | 2006-01-18 | Ge Healthcare Ltd | Novel imaging agents for fibrosis |
| WO2007130383A2 (en) * | 2006-04-28 | 2007-11-15 | Northwestern University | Compositions and treatments using pyridazine compounds and secretases |
| CA2680587A1 (en) * | 2007-03-15 | 2008-09-25 | Schering Corporation | Piperazine-substituted pyridazinone derivatives useful as glucan synthase inhibitors |
-
2008
- 2008-03-12 US US12/046,755 patent/US8232274B2/en active Active
- 2008-03-12 KR KR1020097021457A patent/KR20100049500A/ko not_active Withdrawn
- 2008-03-12 EP EP12196756.6A patent/EP2586778A3/en not_active Withdrawn
- 2008-03-12 CN CN200880016155A patent/CN101730692A/zh active Pending
- 2008-03-12 PE PE2008000469A patent/PE20081882A1/es not_active Application Discontinuation
- 2008-03-12 BR BRPI0809238-9A patent/BRPI0809238A2/pt not_active IP Right Cessation
- 2008-03-12 CA CA002680583A patent/CA2680583A1/en not_active Abandoned
- 2008-03-12 MX MX2009009948A patent/MX2009009948A/es not_active Application Discontinuation
- 2008-03-12 CL CL2008000725A patent/CL2008000725A1/es unknown
- 2008-03-12 EP EP08726734.0A patent/EP2137179B1/en active Active
- 2008-03-12 JP JP2009553612A patent/JP5147866B2/ja not_active Expired - Fee Related
- 2008-03-12 WO PCT/US2008/003257 patent/WO2008115381A1/en not_active Ceased
- 2008-03-12 RU RU2009137946/04A patent/RU2009137946A/ru not_active Application Discontinuation
- 2008-03-12 AU AU2008227100A patent/AU2008227100B2/en not_active Ceased
- 2008-03-13 TW TW097108919A patent/TW200902516A/zh unknown
- 2008-03-13 AR ARP080101033A patent/AR065721A1/es not_active Application Discontinuation
-
2009
- 2009-09-13 IL IL200906A patent/IL200906A0/en unknown
- 2009-09-14 CO CO09098894A patent/CO6220966A2/es not_active Application Discontinuation
- 2009-09-14 EC EC2009009634A patent/ECSP099634A/es unknown
-
2012
- 2012-10-18 JP JP2012230565A patent/JP2013014622A/ja active Pending
-
2013
- 2013-12-16 JP JP2013259117A patent/JP2014051529A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US8232274B2 (en) | 2012-07-31 |
| BRPI0809238A2 (pt) | 2014-09-09 |
| CO6220966A2 (es) | 2010-11-19 |
| PE20081882A1 (es) | 2008-12-27 |
| IL200906A0 (en) | 2010-05-17 |
| US20090170861A1 (en) | 2009-07-02 |
| AU2008227100B2 (en) | 2014-01-09 |
| JP2010521461A (ja) | 2010-06-24 |
| EP2586778A3 (en) | 2013-07-31 |
| WO2008115381A1 (en) | 2008-09-25 |
| JP2014051529A (ja) | 2014-03-20 |
| JP5147866B2 (ja) | 2013-02-20 |
| AR065721A1 (es) | 2009-06-24 |
| KR20100049500A (ko) | 2010-05-12 |
| RU2009137946A (ru) | 2011-04-20 |
| AU2008227100A1 (en) | 2008-09-25 |
| JP2013014622A (ja) | 2013-01-24 |
| EP2586778A2 (en) | 2013-05-01 |
| EP2137179A1 (en) | 2009-12-30 |
| ECSP099634A (es) | 2009-10-30 |
| CN101730692A (zh) | 2010-06-09 |
| CL2008000725A1 (es) | 2008-11-14 |
| EP2137179B1 (en) | 2015-09-02 |
| CA2680583A1 (en) | 2008-09-25 |
| TW200902516A (en) | 2009-01-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HH | Correction or change in general | ||
| FA | Abandonment or withdrawal |