TW200902516A - Pyridazinone derivatives useful as glucan synthase inhibitors - Google Patents

Info

Publication number

TW200902516A

TW200902516A TW097108919A TW97108919A TW200902516A TW 200902516 A TW200902516 A TW 200902516A TW 097108919 A TW097108919 A TW 097108919A TW 97108919 A TW97108919 A TW 97108919A TW 200902516 A TW200902516 A TW 200902516A

Authority

TW

Taiwan

Prior art keywords

alkyl

group

alkenyl

quot

compound

Prior art date

2007-03-15

Links

• Espacenet
• Global Dossier
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• AAILEWXSEQLMNI-UHFFFAOYSA-N 1h-pyridazin-6-one Chemical class OC1=CC=CN=N1 AAILEWXSEQLMNI-UHFFFAOYSA-N 0.000 title abstract description 12
• 229940127488 Glucan Synthase Inhibitors Drugs 0.000 title abstract 2
• 150000001875 compounds Chemical class 0.000 claims abstract description 386
• 238000000034 method Methods 0.000 claims abstract description 90
• 229940121375 antifungal agent Drugs 0.000 claims abstract description 19
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• 239000003429 antifungal agent Substances 0.000 claims abstract description 15
• 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 15
• 230000002265 prevention Effects 0.000 claims abstract description 7
• 125000000217 alkyl group Chemical group 0.000 claims description 212
• -1 aralkenyl Chemical group 0.000 claims description 147
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 108
• 229910052757 nitrogen Inorganic materials 0.000 claims description 104
• 125000003118 aryl group Chemical group 0.000 claims description 102
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• 125000001072 heteroaryl group Chemical group 0.000 claims description 73
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• 125000000623 heterocyclic group Chemical group 0.000 claims description 71
• OAKJQQAXSVQMHS-UHFFFAOYSA-N hydrazine group Chemical group NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims description 59
• 125000003710 aryl alkyl group Chemical group 0.000 claims description 51
• 150000003839 salts Chemical class 0.000 claims description 42
• 125000001424 substituent group Chemical group 0.000 claims description 42
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• 229910052717 sulfur Inorganic materials 0.000 claims description 35
• 239000012453 solvate Substances 0.000 claims description 31
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 30
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• APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 claims description 4
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