AU2008227100B2 - Pyridazinone derivatives useful as glucan synthase inhibitors - Google Patents

Pyridazinone derivatives useful as glucan synthase inhibitors Download PDF

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Publication number
AU2008227100B2
AU2008227100B2 AU2008227100A AU2008227100A AU2008227100B2 AU 2008227100 B2 AU2008227100 B2 AU 2008227100B2 AU 2008227100 A AU2008227100 A AU 2008227100A AU 2008227100 A AU2008227100 A AU 2008227100A AU 2008227100 B2 AU2008227100 B2 AU 2008227100B2
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AU
Australia
Prior art keywords
compound
alkyl
candida
spp
pct
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2008227100A
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English (en)
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AU2008227100A1 (en
Inventor
Robert G. Aslanian
Jianhua Cao
Robert Jason Herr
David Won-Shik Kim
Rongze Kuang
Pauline C. Ting
Heping Wu
Jinhai Yang
Gang Zhou
Nicolas Zorn
Andrew John Zych
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp & Dohme LLC
Curia Global Inc
Original Assignee
Merck Sharp and Dohme Ltd
Albany Molecular Research Inc
Merck Sharp & Dohme LLC
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Application filed by Merck Sharp and Dohme Ltd, Albany Molecular Research Inc, Merck Sharp & Dohme LLC filed Critical Merck Sharp and Dohme Ltd
Publication of AU2008227100A1 publication Critical patent/AU2008227100A1/en
Assigned to MERCK SHARP & DOHME CORP., ALBANY MOLECULAR RESEARCH, INC. reassignment MERCK SHARP & DOHME CORP. Alteration of Name(s) of Applicant(s) under S113 Assignors: ALBANY MOLECULAR RESEARCH, INC., SCHERING CORPORATION
Application granted granted Critical
Publication of AU2008227100B2 publication Critical patent/AU2008227100B2/en
Priority to AU2014201996A priority Critical patent/AU2014201996A1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AU2008227100A 2007-03-15 2008-03-12 Pyridazinone derivatives useful as glucan synthase inhibitors Ceased AU2008227100B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2014201996A AU2014201996A1 (en) 2007-03-15 2014-04-08 Pyridazinone derivatives useful as glucan synthase inhibitors

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91817107P 2007-03-15 2007-03-15
US60/918,171 2007-03-15
PCT/US2008/003257 WO2008115381A1 (en) 2007-03-15 2008-03-12 Pyridazinone derivatives useful as glucan synthase inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2014201996A Division AU2014201996A1 (en) 2007-03-15 2014-04-08 Pyridazinone derivatives useful as glucan synthase inhibitors

Publications (2)

Publication Number Publication Date
AU2008227100A1 AU2008227100A1 (en) 2008-09-25
AU2008227100B2 true AU2008227100B2 (en) 2014-01-09

Family

ID=39525788

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008227100A Ceased AU2008227100B2 (en) 2007-03-15 2008-03-12 Pyridazinone derivatives useful as glucan synthase inhibitors

Country Status (18)

Country Link
US (1) US8232274B2 (enExample)
EP (2) EP2586778A3 (enExample)
JP (3) JP5147866B2 (enExample)
KR (1) KR20100049500A (enExample)
CN (1) CN101730692A (enExample)
AR (1) AR065721A1 (enExample)
AU (1) AU2008227100B2 (enExample)
BR (1) BRPI0809238A2 (enExample)
CA (1) CA2680583A1 (enExample)
CL (1) CL2008000725A1 (enExample)
CO (1) CO6220966A2 (enExample)
EC (1) ECSP099634A (enExample)
IL (1) IL200906A0 (enExample)
MX (1) MX2009009948A (enExample)
PE (1) PE20081882A1 (enExample)
RU (1) RU2009137946A (enExample)
TW (1) TW200902516A (enExample)
WO (1) WO2008115381A1 (enExample)

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US8536168B2 (en) 2007-03-15 2013-09-17 Novartis Ag Benzyl and pyridinyl derivatives as modulators of the hedgehog signaling pathway
MX2009009849A (es) * 2007-03-15 2009-09-24 Schering Corp Derivados de piridazinona sustituida con piperazina utiles como inhibidores de glucano sintasa.
ES2499018T3 (es) * 2007-09-20 2014-09-26 Irm Llc Compuestos y composiciones como moduladores de la actividad de GPR119
EP2296653B1 (en) 2008-06-03 2016-01-27 Intermune, Inc. Compounds and methods for treating inflammatory and fibrotic disorders
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
US20120088769A1 (en) * 2010-10-11 2012-04-12 Axikin Pharmaceuticals, Inc. Salts of arylsulfonamide ccr3 antagonists
FI20115234A0 (fi) 2011-03-08 2011-03-08 Biotie Therapies Corp Uusia pyridatsinoni- ja pyridoniyhdisteitä
GB201111705D0 (en) 2011-07-07 2011-08-24 Takeda Pharmaceutical Compounds and their use
GB201111704D0 (en) 2011-07-07 2011-08-24 Takeda Pharmaceutical Novel compounds
JO3115B1 (ar) 2011-08-22 2017-09-20 Takeda Pharmaceuticals Co مركبات بيريدازينون واستخدامها كمثبطات daao
AP2014007637A0 (en) 2011-11-15 2014-05-31 Takeda Pharmaceutical Dihydroxy aromatic heterocyclic compound
WO2013155223A1 (en) * 2012-04-10 2013-10-17 The Regents Of The University Of California Compositions and methods for treating cancer
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
CN103664795B (zh) * 2012-09-06 2017-10-03 华东理工大学 哒嗪酮类化合物及其用途
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
CN104717924A (zh) 2012-10-05 2015-06-17 皇家飞利浦有限公司 用于提供增强的x射线图像的医学成像系统及方法
GB201222711D0 (en) * 2012-12-17 2013-01-30 Takeda Pharmaceutical Novel compounds
US11039617B2 (en) 2013-01-30 2021-06-22 Agrofresh Inc. Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness
US10070649B2 (en) 2013-01-30 2018-09-11 Agrofresh Inc. Volatile applications against pathogens
WO2015031036A1 (en) * 2013-08-26 2015-03-05 Purdue Pharma L.P. Azaspiro[4.5] decane derivatives and use thereof
RU2692485C2 (ru) 2014-04-02 2019-06-25 Интермьюн, Инк. Противофиброзные пиридиноны
AU2015251501B2 (en) * 2014-04-24 2019-08-15 Hexima Limited Agents and methods of treatment
WO2017155879A1 (en) 2016-03-07 2017-09-14 Agrofresh Inc. Synergistic methods of using benzoxaborole compounds and preservative gases as an antimicrobial for crops
EP3596043B1 (en) * 2017-03-15 2025-12-03 Lunella Biotech, Inc. Mitoriboscins: mitochondrial-based therapeutics targeting cancer cells, bacteria, and pathogenic yeast
WO2018185013A1 (en) 2017-04-03 2018-10-11 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
US12435078B2 (en) 2017-09-18 2025-10-07 Gfb (Abc), Llc Pyridazinones and methods of use thereof
CN109912476A (zh) * 2019-03-27 2019-06-21 南通宝凯化工有限公司 一种异丙氨基磺酰氯的生产工艺
CN112469713B (zh) * 2019-06-21 2023-09-01 江苏豪森药业集团有限公司 芳基磷氧化物类衍生物抑制剂、其制备方法和应用
WO2021113625A1 (en) * 2019-12-06 2021-06-10 Plexxikon Inc. Compounds and methods for cd73 modulation and indications therefor
MX2022013615A (es) 2020-04-30 2022-11-16 Gilead Sciences Inc Inhibidores de macrociclo de peptidilarginina deiminasas.
WO2023204124A1 (ja) * 2022-04-20 2023-10-26 日本曹達株式会社 ピリダジノン化合物並びに農園芸用殺菌剤、殺線虫剤、および医療用・動物用抗真菌剤

Citations (2)

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JPH04235975A (ja) * 1991-01-21 1992-08-25 Nissan Chem Ind Ltd ピリダジノン誘導体および害虫防除剤
CA2482151A1 (en) * 2002-04-12 2003-11-27 Bayer Healthcare Ag Substituted 2-phenyl-3(2h)-pyridazinones

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ES8601972A1 (es) 1985-02-28 1985-11-16 Abello Quimicos Farma Prod Sa Procedimiento de obtencion de 1,2-diazin-3 (2h)-onas con interes farmaceutico
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UA77526C2 (en) * 2002-06-07 2006-12-15 Sanofi Aventis Substituted derivatives of 1-piperazineacylpiperidine, a method for the preparation thereof and their use in therapy
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JPH04235975A (ja) * 1991-01-21 1992-08-25 Nissan Chem Ind Ltd ピリダジノン誘導体および害虫防除剤
CA2482151A1 (en) * 2002-04-12 2003-11-27 Bayer Healthcare Ag Substituted 2-phenyl-3(2h)-pyridazinones

Also Published As

Publication number Publication date
KR20100049500A (ko) 2010-05-12
JP2014051529A (ja) 2014-03-20
PE20081882A1 (es) 2008-12-27
JP2010521461A (ja) 2010-06-24
US8232274B2 (en) 2012-07-31
CN101730692A (zh) 2010-06-09
BRPI0809238A2 (pt) 2014-09-09
US20090170861A1 (en) 2009-07-02
WO2008115381A1 (en) 2008-09-25
EP2586778A3 (en) 2013-07-31
JP2013014622A (ja) 2013-01-24
RU2009137946A (ru) 2011-04-20
IL200906A0 (en) 2010-05-17
AU2008227100A1 (en) 2008-09-25
CO6220966A2 (es) 2010-11-19
CL2008000725A1 (es) 2008-11-14
EP2137179B1 (en) 2015-09-02
MX2009009948A (es) 2009-09-24
AR065721A1 (es) 2009-06-24
CA2680583A1 (en) 2008-09-25
TW200902516A (en) 2009-01-16
EP2586778A2 (en) 2013-05-01
ECSP099634A (es) 2009-10-30
EP2137179A1 (en) 2009-12-30
JP5147866B2 (ja) 2013-02-20

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired