CO6220966A2 - Derivados de piridazinona utiles como inhibidores de glucano sintasa - Google Patents
Derivados de piridazinona utiles como inhibidores de glucano sintasaInfo
- Publication number
- CO6220966A2 CO6220966A2 CO09098894A CO09098894A CO6220966A2 CO 6220966 A2 CO6220966 A2 CO 6220966A2 CO 09098894 A CO09098894 A CO 09098894A CO 09098894 A CO09098894 A CO 09098894A CO 6220966 A2 CO6220966 A2 CO 6220966A2
- Authority
- CO
- Colombia
- Prior art keywords
- alkenyl
- alkyl
- heterocyclylalkyl
- cycloalkyl
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
1.- Un compuesto de Fórmula I: o una sal, solvato, éster o profármaco aceptables desde el punto de vista farmacéutico de los anteriores, en el cual:- - - - - - representa un enlace doble o un enlace simple, según lo permita el requerimiento de valencias, con la salvedad de que cuando E es N, el enlace doble está presente y R6 está ausente; A es O, o S; D y E son en forma independiente C o N, siempre que cuando D es carbono, D está sustituido con hidrógeno, alquilo, -Oalquilo, -Nalquilo o -Salquilo; R3 es un resto seleccionado del grupo que consiste en alquilo, alquenilo, arilo, arilalquilo, arilalquenilo, heteroarilo, heteroarilalquilo, heteroarilalquenilo, cicloalquilo, cicloalquilalquilo, cicloalquilalquenilo, ciclenilo, ciclenilalquilo, ciclenilalquenilo, heterociclilo, heterociclilalquilo, heterociclilalquenilo, heterociclenilo, heterociclenilalquilo, heterociclenilalquenilo, arilalcoxilalquilo, arilalcoxilalquenilo, cicloalcoxilalquilo, cicloalcoxilalquenilo, cicloalquenoxilalquilo, y cicloalquenioxilalquenilo, donde cada uno de dicho alquilo, alquenilo, arilo, arilalquilo, arilalquenilo, heteroarilo, heteroarilalquilo, heteroarilalquenilo, cicloalquilo, cicloalquilalquilo, cicloalquilalquenilo, ciclenilo, ciclenilalquilo, ciclenilalquenilo, heterociclilo, heterociclilalquilo, heterociclilalquenilo, heterociclenilo, heterociclenilalquilo, heterociclenilalquenilo, arilalcoxilalquilo, arilalcoxilalquenilo, cicloalcoxilalquilo, cicloalcoxilalquenilo, cicloalquenoxilalquilo, cicloalquenioxilalquenilo puede no estar sustituido o estar sustituido con uno o más restos, que pueden ser iguales o diferentes, cada resto se selecciona en forma independiente del grupo que consiste en alquilo, alquenilo, alquinilo, cicloalquilo, halógeno, trihaloalquilo, dihaloalquilo, monohaloalquilo, -NR92, -OR9, -SR9, -NO2, -CN, -NR16COR9, -NR16SO2R9, -COR9, -CO2R9, -SO2R9, -CONR9R16, y N=C=O; Y puede estar presente o ausente; o siempre que cuando Y es O, ...
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91817107P | 2007-03-15 | 2007-03-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6220966A2 true CO6220966A2 (es) | 2010-11-19 |
Family
ID=39525788
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO09098894A CO6220966A2 (es) | 2007-03-15 | 2009-09-14 | Derivados de piridazinona utiles como inhibidores de glucano sintasa |
Country Status (18)
Country | Link |
---|---|
US (1) | US8232274B2 (es) |
EP (2) | EP2586778A3 (es) |
JP (3) | JP5147866B2 (es) |
KR (1) | KR20100049500A (es) |
CN (1) | CN101730692A (es) |
AR (1) | AR065721A1 (es) |
AU (1) | AU2008227100B2 (es) |
BR (1) | BRPI0809238A2 (es) |
CA (1) | CA2680583A1 (es) |
CL (1) | CL2008000725A1 (es) |
CO (1) | CO6220966A2 (es) |
EC (1) | ECSP099634A (es) |
IL (1) | IL200906A0 (es) |
MX (1) | MX2009009948A (es) |
PE (1) | PE20081882A1 (es) |
RU (1) | RU2009137946A (es) |
TW (1) | TW200902516A (es) |
WO (1) | WO2008115381A1 (es) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101668529A (zh) * | 2007-03-15 | 2010-03-10 | 先灵公司 | 用作葡聚糖合成酶抑制剂的哌嗪取代的哒嗪酮衍生物 |
PE20090188A1 (es) | 2007-03-15 | 2009-03-20 | Novartis Ag | Compuestos heterociclicos como moduladores de la senda de hedgehog |
MX2010003117A (es) * | 2007-09-20 | 2010-04-01 | Irm Llc | Compuestos y composiciones como moduladores de la actividad de gpr119. |
CN102099036B (zh) | 2008-06-03 | 2015-05-27 | 英特芒尼公司 | 用于治疗炎性疾患和纤维化疾患的化合物和方法 |
US20100041663A1 (en) | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
CN103298786B (zh) * | 2010-10-11 | 2016-01-20 | 埃克希金医药品有限公司 | 芳基磺酰胺盐ccr3拮抗剂 |
FI20115234A0 (fi) | 2011-03-08 | 2011-03-08 | Biotie Therapies Corp | Uusia pyridatsinoni- ja pyridoniyhdisteitä |
GB201111704D0 (en) | 2011-07-07 | 2011-08-24 | Takeda Pharmaceutical | Novel compounds |
GB201111705D0 (en) | 2011-07-07 | 2011-08-24 | Takeda Pharmaceutical | Compounds and their use |
JO3115B1 (ar) * | 2011-08-22 | 2017-09-20 | Takeda Pharmaceuticals Co | مركبات بيريدازينون واستخدامها كمثبطات daao |
US9212147B2 (en) | 2011-11-15 | 2015-12-15 | Takeda Pharmaceutical Company Limited | Dihydroxy aromatic heterocyclic compound |
CN104379563B (zh) * | 2012-04-10 | 2018-12-21 | 加利福尼亚大学董事会 | 用于治疗癌症的组合物和方法 |
AU2013203000B9 (en) | 2012-08-10 | 2017-02-02 | Lantheus Medical Imaging, Inc. | Compositions, methods, and systems for the synthesis and use of imaging agents |
CN103664795B (zh) * | 2012-09-06 | 2017-10-03 | 华东理工大学 | 哒嗪酮类化合物及其用途 |
AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
JP6310464B2 (ja) | 2012-10-05 | 2018-04-11 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | 改善されたx線画像を供する医療撮像システム及び方法 |
GB201222711D0 (en) * | 2012-12-17 | 2013-01-30 | Takeda Pharmaceutical | Novel compounds |
US11039617B2 (en) | 2013-01-30 | 2021-06-22 | Agrofresh Inc. | Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness |
US10070649B2 (en) | 2013-01-30 | 2018-09-11 | Agrofresh Inc. | Volatile applications against pathogens |
US9884865B2 (en) * | 2013-08-26 | 2018-02-06 | Purdue Pharma L.P. | Azaspiro[4.5] decane derivatives and use thereof |
CN110452216B (zh) | 2014-04-02 | 2022-08-26 | 英特穆恩公司 | 抗纤维化吡啶酮类 |
RS64770B1 (sr) | 2016-03-07 | 2023-11-30 | Agrofresh Inc | Sinergistički postupci upotrebe jedinjenja benzoksaborola i gasova za prezerviranje kao antimikrobnih agenasa za useve |
IL305316B1 (en) * | 2017-03-15 | 2024-05-01 | Lunella Biotech Inc | Mitoriboscines: Mitochondrial-Based Therapies Targeting Cancer Cells, Bacteria, and Pathogenic Yeasts |
WO2018185013A1 (en) | 2017-04-03 | 2018-10-11 | Syngenta Participations Ag | Microbiocidal oxadiazole derivatives |
CN109912476A (zh) * | 2019-03-27 | 2019-06-21 | 南通宝凯化工有限公司 | 一种异丙氨基磺酰氯的生产工艺 |
CN112469713B (zh) * | 2019-06-21 | 2023-09-01 | 江苏豪森药业集团有限公司 | 芳基磷氧化物类衍生物抑制剂、其制备方法和应用 |
WO2021113625A1 (en) * | 2019-12-06 | 2021-06-10 | Plexxikon Inc. | Compounds and methods for cd73 modulation and indications therefor |
CA3177532A1 (en) | 2020-04-30 | 2021-11-04 | Gilead Sciences, Inc. | Macrocyclic inhibitors of peptidylarginine deiminases |
WO2023204124A1 (ja) * | 2022-04-20 | 2023-10-26 | 日本曹達株式会社 | ピリダジノン化合物並びに農園芸用殺菌剤、殺線虫剤、および医療用・動物用抗真菌剤 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS565734B2 (es) * | 1973-02-28 | 1981-02-06 | ||
DE3048487A1 (de) * | 1980-12-22 | 1982-07-29 | Cassella Ag, 6000 Frankfurt | Basisch substituierte pyridazine, ihre herstellung und ihre verwendung |
ES540813A0 (es) | 1985-02-28 | 1985-11-16 | Abello Quimicos Farma Prod Sa | Procedimiento de obtencion de 1,2-diazin-3 (2h)-onas con interes farmaceutico |
JPH04235975A (ja) * | 1991-01-21 | 1992-08-25 | Nissan Chem Ind Ltd | ピリダジノン誘導体および害虫防除剤 |
GB2256587A (en) | 1991-06-11 | 1992-12-16 | American Cyanamid Co | Acetazolamide in sustained release form |
HU227237B1 (en) * | 2001-09-27 | 2010-12-28 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Substituted alkylpyridazinone derivatives, process for their preparation, pharmaceutical compositions containing them |
RU2004126320A (ru) | 2002-01-31 | 2005-04-10 | Дайити Фармасьютикал Ко., Лтд. (JP) | Производные имидазо [1,2-а]пиридина |
DE10216144A1 (de) * | 2002-04-12 | 2003-11-06 | Bayer Ag | Substituierte 2-Phenyl-3(2H)-Pyridazinone |
US20050209278A1 (en) * | 2002-04-25 | 2005-09-22 | Mcdonald Joseph J | Piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors |
UA77526C2 (en) * | 2002-06-07 | 2006-12-15 | Sanofi Aventis | Substituted derivatives of 1-piperazineacylpiperidine, a method for the preparation thereof and their use in therapy |
SI1682138T1 (sl) * | 2003-11-19 | 2011-04-29 | Array Biopharma Inc | HETEROCIKLIÄŚNI INHIBITORJI MEK-a |
WO2005117909A2 (en) * | 2004-04-23 | 2005-12-15 | Exelixis, Inc. | Kinase modulators and methods of use |
GB0524991D0 (en) * | 2005-12-08 | 2006-01-18 | Ge Healthcare Ltd | Novel imaging agents for fibrosis |
WO2007130383A2 (en) * | 2006-04-28 | 2007-11-15 | Northwestern University | Compositions and treatments using pyridazine compounds and secretases |
CN101668529A (zh) * | 2007-03-15 | 2010-03-10 | 先灵公司 | 用作葡聚糖合成酶抑制剂的哌嗪取代的哒嗪酮衍生物 |
-
2008
- 2008-03-12 AU AU2008227100A patent/AU2008227100B2/en not_active Ceased
- 2008-03-12 MX MX2009009948A patent/MX2009009948A/es not_active Application Discontinuation
- 2008-03-12 EP EP12196756.6A patent/EP2586778A3/en not_active Withdrawn
- 2008-03-12 CN CN200880016155A patent/CN101730692A/zh active Pending
- 2008-03-12 PE PE2008000469A patent/PE20081882A1/es not_active Application Discontinuation
- 2008-03-12 RU RU2009137946/04A patent/RU2009137946A/ru not_active Application Discontinuation
- 2008-03-12 KR KR1020097021457A patent/KR20100049500A/ko not_active Application Discontinuation
- 2008-03-12 JP JP2009553612A patent/JP5147866B2/ja not_active Expired - Fee Related
- 2008-03-12 CA CA002680583A patent/CA2680583A1/en not_active Abandoned
- 2008-03-12 BR BRPI0809238-9A patent/BRPI0809238A2/pt not_active IP Right Cessation
- 2008-03-12 WO PCT/US2008/003257 patent/WO2008115381A1/en active Application Filing
- 2008-03-12 EP EP08726734.0A patent/EP2137179B1/en active Active
- 2008-03-12 US US12/046,755 patent/US8232274B2/en active Active
- 2008-03-12 CL CL2008000725A patent/CL2008000725A1/es unknown
- 2008-03-13 TW TW097108919A patent/TW200902516A/zh unknown
- 2008-03-13 AR ARP080101033A patent/AR065721A1/es not_active Application Discontinuation
-
2009
- 2009-09-13 IL IL200906A patent/IL200906A0/en unknown
- 2009-09-14 EC EC2009009634A patent/ECSP099634A/es unknown
- 2009-09-14 CO CO09098894A patent/CO6220966A2/es not_active Application Discontinuation
-
2012
- 2012-10-18 JP JP2012230565A patent/JP2013014622A/ja active Pending
-
2013
- 2013-12-16 JP JP2013259117A patent/JP2014051529A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP2586778A2 (en) | 2013-05-01 |
US20090170861A1 (en) | 2009-07-02 |
EP2137179B1 (en) | 2015-09-02 |
EP2586778A3 (en) | 2013-07-31 |
PE20081882A1 (es) | 2008-12-27 |
CN101730692A (zh) | 2010-06-09 |
CA2680583A1 (en) | 2008-09-25 |
KR20100049500A (ko) | 2010-05-12 |
EP2137179A1 (en) | 2009-12-30 |
JP5147866B2 (ja) | 2013-02-20 |
RU2009137946A (ru) | 2011-04-20 |
ECSP099634A (es) | 2009-10-30 |
JP2013014622A (ja) | 2013-01-24 |
AU2008227100B2 (en) | 2014-01-09 |
AU2008227100A1 (en) | 2008-09-25 |
TW200902516A (en) | 2009-01-16 |
AR065721A1 (es) | 2009-06-24 |
IL200906A0 (en) | 2010-05-17 |
CL2008000725A1 (es) | 2008-11-14 |
WO2008115381A1 (en) | 2008-09-25 |
JP2014051529A (ja) | 2014-03-20 |
MX2009009948A (es) | 2009-09-24 |
BRPI0809238A2 (pt) | 2014-09-09 |
US8232274B2 (en) | 2012-07-31 |
JP2010521461A (ja) | 2010-06-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Application withdrawn |