RU2007117372A - Процесс получения гидрохлорида 2-амино-2[2-[4(3-бензилоксифенилтио)-2-хлорфенил]этил]-1,3-пропандиола] и его гидратов, а также промежуточные продукты их получения - Google Patents
Процесс получения гидрохлорида 2-амино-2[2-[4(3-бензилоксифенилтио)-2-хлорфенил]этил]-1,3-пропандиола] и его гидратов, а также промежуточные продукты их получения Download PDFInfo
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- RU2007117372A RU2007117372A RU2007117372/04A RU2007117372A RU2007117372A RU 2007117372 A RU2007117372 A RU 2007117372A RU 2007117372/04 A RU2007117372/04 A RU 2007117372/04A RU 2007117372 A RU2007117372 A RU 2007117372A RU 2007117372 A RU2007117372 A RU 2007117372A
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- ethyl
- benzyloxyphenylthio
- chlorophenyl
- amino
- hydrate
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
- C07C319/12—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols by reactions not involving the formation of mercapto groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/01—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton
- C07C323/02—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/07—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
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- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (4)
1. Процесс получения гидрохлорида 2-амино-2-[2-[4-(3-бензилокси-фенилтио)-2-хлорфенил]этил]-1,3-пропандиола или его гидрата, включающий стадии
взаимодействия 4-(3-бензилоксифенилтио)-2-хлорбензальдегида и диэтилфосфоноацетата этила в растворителе в присутствии основания с получением этил 3-[4-(3-бензилоксифенилтио)-2-хлорфенил]акрилата;
восстановления образовавшегося этил 3-[4-(3-бензилоксифенилтио)-2-хлорфенил]акрилата при последующих мезилировании, иодинировании и нитровании с получением 1-бензилокси-3-[3-хлор-4-(3-нитропропил-фенилтио]бензола;
гидроксиметилирования образовавшегося 1-бензилокси-3-[3-хлор-4-(3-нитропропилфенилтио]бензола формальдегидом с получением 2-[2-[4-(3-бензилоксифенилтио)-2-хлорфенил]этил]-2-нитро-1,3-пропандиола; а также
восстановления образовавшегося 2-[2-[4-(3-бензилоксифенилтио)-2-хлорфенил]этил]-2-нитро-1,3-пропандиола с получением целевого продукта.
2. Промежуточный продукт получения гидрохлорида 2-амино-2-[2-[4-(3-бензилоксифенилтио)-2-хлорфенил]этил]-1,3-пропандиола или его гидрата, содержащий новое соединение - этил 3-[4-(3-бензилоксифенилтио)-2-хлорфенил]акрилат или его гидрат.
3. Промежуточный продукт получения гидрохлорида 2-амино-2-[2-[4-(3-бензилоксифенилтио)-2-хлорфенил]этил]-1,3-пропандиола или его гидрата, содержащий новое соединение - 1-бензилокси-3-[3-хлор-4-(3-нитропропилфенилтио)]бензол или его гидрат.
4. Промежуточный продукт получения гидрохлорида 2-амино-2-[2-[4-(3-бензилоксифенилтио)-2-хлорфенил]этил]-1,3-пропандиола или его гидрата, содержащий новое соединение-2-[2-[4-(3-бензилоксифенилтио)-2-хлорфенил]этил]-2-нитро-1,3-пропандиол или его гидрат.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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JP2004-297651 | 2004-10-12 | ||
JP2004297651 | 2004-10-12 |
Publications (2)
Publication Number | Publication Date |
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RU2007117372A true RU2007117372A (ru) | 2008-11-20 |
RU2376285C2 RU2376285C2 (ru) | 2009-12-20 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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RU2007117372/04A RU2376285C2 (ru) | 2004-10-12 | 2005-10-07 | Процесс получения гидрохлорида 2-амино-2-[2-[4-(3-бензилоксифенилтио)-2-хлорфенилэтил]-1,3-пропандиола] и его гидратов, а также промежуточные продукты их получения |
Country Status (14)
Country | Link |
---|---|
US (1) | US7795472B2 (ru) |
EP (2) | EP1806338B1 (ru) |
JP (1) | JP4792400B2 (ru) |
KR (1) | KR101181090B1 (ru) |
CN (2) | CN101880250B (ru) |
AU (1) | AU2005292984B2 (ru) |
BR (1) | BRPI0516337A (ru) |
CA (1) | CA2583846C (ru) |
ES (2) | ES2563034T3 (ru) |
MX (1) | MX2007004319A (ru) |
PL (2) | PL2511262T3 (ru) |
PT (1) | PT2511262T (ru) |
RU (1) | RU2376285C2 (ru) |
WO (1) | WO2006041019A1 (ru) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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RU2482110C2 (ru) * | 2008-03-24 | 2013-05-20 | Керин Фармасьютикал Ко., Лтд. | Способ кристаллизации гидрохлорида 2-амино-2-[2-[4-(3-бензилоксифенилтио)-2-хлорфенил]этил]-1,3-пропандиола |
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2005
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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RU2482110C2 (ru) * | 2008-03-24 | 2013-05-20 | Керин Фармасьютикал Ко., Лтд. | Способ кристаллизации гидрохлорида 2-амино-2-[2-[4-(3-бензилоксифенилтио)-2-хлорфенил]этил]-1,3-пропандиола |
US9493410B2 (en) | 2008-03-24 | 2016-11-15 | Kyorin Pharmaceutical Co., Ltd. | Method for crystallization of 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]-ethyl]-1,3-propanediol hydrochloride |
US9920005B2 (en) | 2008-03-24 | 2018-03-20 | Kyorin Pharmaceutical Co., Ltd. | Method for crystallization of 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]ethyl]-1,3-propanediol hydrochloride |
Also Published As
Publication number | Publication date |
---|---|
EP1806338A4 (en) | 2009-12-16 |
CN101880250B (zh) | 2013-04-03 |
PL1806338T3 (pl) | 2016-07-29 |
WO2006041019A1 (ja) | 2006-04-20 |
ES2615498T3 (es) | 2017-06-07 |
KR20070073895A (ko) | 2007-07-10 |
RU2376285C2 (ru) | 2009-12-20 |
CA2583846A1 (en) | 2006-04-20 |
US7795472B2 (en) | 2010-09-14 |
AU2005292984A1 (en) | 2006-04-20 |
EP1806338A1 (en) | 2007-07-11 |
ES2563034T3 (es) | 2016-03-10 |
AU2005292984B2 (en) | 2011-01-20 |
PT2511262T (pt) | 2017-03-30 |
US20080207941A1 (en) | 2008-08-28 |
PL2511262T3 (pl) | 2017-08-31 |
MX2007004319A (es) | 2007-06-15 |
JPWO2006041019A1 (ja) | 2008-05-15 |
JP4792400B2 (ja) | 2011-10-12 |
CN101072752A (zh) | 2007-11-14 |
CN101880250A (zh) | 2010-11-10 |
BRPI0516337A (pt) | 2008-04-29 |
EP2511262B1 (en) | 2017-02-01 |
CN101072752B (zh) | 2010-12-08 |
CA2583846C (en) | 2013-10-01 |
KR101181090B1 (ko) | 2012-09-07 |
EP1806338B1 (en) | 2016-01-20 |
EP2511262A1 (en) | 2012-10-17 |
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