RU2005137175A - Производные сложного эфира и амида 2-цианопропановой кислоты и способы их применения - Google Patents
Производные сложного эфира и амида 2-цианопропановой кислоты и способы их применения Download PDFInfo
- Publication number
- RU2005137175A RU2005137175A RU2005137175/04A RU2005137175A RU2005137175A RU 2005137175 A RU2005137175 A RU 2005137175A RU 2005137175/04 A RU2005137175/04 A RU 2005137175/04A RU 2005137175 A RU2005137175 A RU 2005137175A RU 2005137175 A RU2005137175 A RU 2005137175A
- Authority
- RU
- Russia
- Prior art keywords
- methyl
- naphthyl
- methoxyphenyl
- cyano
- propanoate
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title claims 24
- JDEFPFLTCXIVDH-UHFFFAOYSA-N 2-cyanopropanoic acid Chemical compound N#CC(C)C(O)=O JDEFPFLTCXIVDH-UHFFFAOYSA-N 0.000 title 1
- 150000001408 amides Chemical class 0.000 title 1
- 125000004204 2-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C([H])=C1[H] 0.000 claims 47
- 125000004432 carbon atom Chemical group C* 0.000 claims 34
- -1 Het Chemical group 0.000 claims 23
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims 21
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 20
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 18
- 125000000217 alkyl group Chemical group 0.000 claims 17
- 229910052739 hydrogen Inorganic materials 0.000 claims 16
- 239000001257 hydrogen Substances 0.000 claims 16
- 125000001325 propanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 claims 13
- 150000002431 hydrogen Chemical group 0.000 claims 11
- 125000003118 aryl group Chemical group 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 9
- 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 7
- RFIOZSIHFNEKFF-UHFFFAOYSA-M piperazine-1-carboxylate Chemical compound [O-]C(=O)N1CCNCC1 RFIOZSIHFNEKFF-UHFFFAOYSA-M 0.000 claims 6
- PHRABVHYUHIYGY-UHFFFAOYSA-N 1-methylnaphthalene Chemical group C1=CC=C2C([CH2])=CC=CC2=C1 PHRABVHYUHIYGY-UHFFFAOYSA-N 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 claims 4
- ITWQRJZKAATYDR-CQTOTRCISA-N (2s,3s)-2-[4-(4-chlorophenyl)-3,6-dihydro-2h-pyridine-1-carbonyl]-3-(2-methoxyphenyl)-2-methyl-3-naphthalen-1-ylpropanenitrile Chemical compound COC1=CC=CC=C1[C@@H]([C@@](C)(C#N)C(=O)N1CC=C(CC1)C=1C=CC(Cl)=CC=1)C1=CC=CC2=CC=CC=C12 ITWQRJZKAATYDR-CQTOTRCISA-N 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical group C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 125000004414 alkyl thio group Chemical group 0.000 claims 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 125000004122 cyclic group Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 3
- 125000004001 thioalkyl group Chemical group 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Chemical compound CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- 235000010290 biphenyl Nutrition 0.000 claims 2
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 claims 2
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 claims 2
- 125000004990 dihydroxyalkyl group Chemical group 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 229960002179 ephedrine Drugs 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 2
- IVXQBCUBSIPQGU-UHFFFAOYSA-N piperazine-1-carboxamide Chemical compound NC(=O)N1CCNCC1 IVXQBCUBSIPQGU-UHFFFAOYSA-N 0.000 claims 2
- FVSKHRXBFJPNKK-UHFFFAOYSA-N propionitrile Chemical compound CCC#N FVSKHRXBFJPNKK-UHFFFAOYSA-N 0.000 claims 2
- LOUPRKONTZGTKE-LHHVKLHASA-N quinidine Chemical class C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@H]2[C@@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-LHHVKLHASA-N 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- DCCPNFFQPPRMAK-BHDXBOSCSA-N (2s,3s)-2-[4-(2,3-dichlorophenyl)piperazine-1-carbonyl]-3-(2-methoxyphenyl)-2-methyl-3-naphthalen-1-ylpropanenitrile Chemical compound COC1=CC=CC=C1[C@@H]([C@@](C)(C#N)C(=O)N1CCN(CC1)C=1C(=C(Cl)C=CC=1)Cl)C1=CC=CC2=CC=CC=C12 DCCPNFFQPPRMAK-BHDXBOSCSA-N 0.000 claims 1
- ZUEWWCPREOHWEN-QWOOXDRHSA-N (2s,3s)-2-[4-(2,3-dihydro-1h-inden-4-yl)piperazine-1-carbonyl]-3-(2-methoxyphenyl)-2-methyl-3-naphthalen-1-ylpropanenitrile Chemical compound COC1=CC=CC=C1[C@@H]([C@@](C)(C#N)C(=O)N1CCN(CC1)C=1C=2CCCC=2C=CC=1)C1=CC=CC2=CC=CC=C12 ZUEWWCPREOHWEN-QWOOXDRHSA-N 0.000 claims 1
- SSHPWBDOIDZSCP-UZNNEEJFSA-N (2s,3s)-2-[4-(2,3-dimethylphenyl)piperazine-1-carbonyl]-3-(2-methoxyphenyl)-2-methyl-3-naphthalen-1-ylpropanenitrile Chemical compound COC1=CC=CC=C1[C@@H]([C@@](C)(C#N)C(=O)N1CCN(CC1)C=1C(=C(C)C=CC=1)C)C1=CC=CC2=CC=CC=C12 SSHPWBDOIDZSCP-UZNNEEJFSA-N 0.000 claims 1
- DUAHHJADGMHDAK-XDFJSJKPSA-N (2s,3s)-2-[4-(2-chlorophenyl)piperazine-1-carbonyl]-3-(2-methoxyphenyl)-2-methyl-3-naphthalen-1-ylpropanenitrile Chemical compound COC1=CC=CC=C1[C@@H]([C@@](C)(C#N)C(=O)N1CCN(CC1)C=1C(=CC=CC=1)Cl)C1=CC=CC2=CC=CC=C12 DUAHHJADGMHDAK-XDFJSJKPSA-N 0.000 claims 1
- YDPHVMLWKVJBQE-XDFJSJKPSA-N (2s,3s)-2-[4-(2-fluorophenyl)piperazine-1-carbonyl]-3-(2-methoxyphenyl)-2-methyl-3-naphthalen-1-ylpropanenitrile Chemical compound COC1=CC=CC=C1[C@@H]([C@@](C)(C#N)C(=O)N1CCN(CC1)C=1C(=CC=CC=1)F)C1=CC=CC2=CC=CC=C12 YDPHVMLWKVJBQE-XDFJSJKPSA-N 0.000 claims 1
- JKPJSOHGSKFXIK-UZNNEEJFSA-N (2s,3s)-2-[4-(3,4-dimethylphenyl)piperazine-1-carbonyl]-3-(2-methoxyphenyl)-2-methyl-3-naphthalen-1-ylpropanenitrile Chemical compound COC1=CC=CC=C1[C@@H]([C@@](C)(C#N)C(=O)N1CCN(CC1)C=1C=C(C)C(C)=CC=1)C1=CC=CC2=CC=CC=C12 JKPJSOHGSKFXIK-UZNNEEJFSA-N 0.000 claims 1
- RDYVLJXNUNCGGT-UZNNEEJFSA-N (2s,3s)-2-[4-(3,5-dimethoxyphenyl)piperazine-1-carbonyl]-3-(2-methoxyphenyl)-2-methyl-3-naphthalen-1-ylpropanenitrile Chemical compound COC1=CC(OC)=CC(N2CCN(CC2)C(=O)[C@](C)(C#N)[C@H](C=2C(=CC=CC=2)OC)C=2C3=CC=CC=C3C=CC=2)=C1 RDYVLJXNUNCGGT-UZNNEEJFSA-N 0.000 claims 1
- LUIUWFWPBAGLHR-XDFJSJKPSA-N (2s,3s)-2-[4-(3-chlorophenyl)piperazine-1-carbonyl]-3-(2-methoxyphenyl)-2-methyl-3-naphthalen-1-ylpropanenitrile Chemical compound COC1=CC=CC=C1[C@@H]([C@@](C)(C#N)C(=O)N1CCN(CC1)C=1C=C(Cl)C=CC=1)C1=CC=CC2=CC=CC=C12 LUIUWFWPBAGLHR-XDFJSJKPSA-N 0.000 claims 1
- NEYGOQHEACXZQW-XDFJSJKPSA-N (2s,3s)-2-[4-(4-chlorophenyl)piperazine-1-carbonyl]-3-(2-methoxyphenyl)-2-methyl-3-naphthalen-1-ylpropanenitrile Chemical compound COC1=CC=CC=C1[C@@H]([C@@](C)(C#N)C(=O)N1CCN(CC1)C=1C=CC(Cl)=CC=1)C1=CC=CC2=CC=CC=C12 NEYGOQHEACXZQW-XDFJSJKPSA-N 0.000 claims 1
- UBVIGVSCRZJWOE-CQTOTRCISA-N (2s,3s)-2-[4-[4-chloro-3-(trifluoromethyl)phenyl]-3,6-dihydro-2h-pyridine-1-carbonyl]-3-(2-methoxyphenyl)-2-methyl-3-naphthalen-1-ylpropanenitrile Chemical compound COC1=CC=CC=C1[C@@H]([C@@](C)(C#N)C(=O)N1CC=C(CC1)C=1C=C(C(Cl)=CC=1)C(F)(F)F)C1=CC=CC2=CC=CC=C12 UBVIGVSCRZJWOE-CQTOTRCISA-N 0.000 claims 1
- QLYQQJLNIFDUNH-CQTOTRCISA-N (2s,3s)-2-[4-[4-chloro-3-(trifluoromethyl)phenyl]piperidine-1-carbonyl]-3-(2-methoxyphenyl)-2-methyl-3-naphthalen-1-ylpropanenitrile Chemical compound COC1=CC=CC=C1[C@@H]([C@@](C)(C#N)C(=O)N1CCC(CC1)C=1C=C(C(Cl)=CC=1)C(F)(F)F)C1=CC=CC2=CC=CC=C12 QLYQQJLNIFDUNH-CQTOTRCISA-N 0.000 claims 1
- IIWQXKLEVDCXJI-UHFFFAOYSA-N 2-[(2-methoxyphenyl)-quinolin-3-ylmethyl]-2-methyl-3-oxo-3-[4-[3-(trifluoromethyl)phenyl]piperidin-1-yl]propanenitrile Chemical compound COC1=CC=CC=C1C(C(C)(C#N)C(=O)N1CCC(CC1)C=1C=C(C=CC=1)C(F)(F)F)C1=CN=C(C=CC=C2)C2=C1 IIWQXKLEVDCXJI-UHFFFAOYSA-N 0.000 claims 1
- PYUXCEVGIQTTRI-UHFFFAOYSA-N 2-[4-(3-chloro-2-methylphenyl)piperazine-1-carbonyl]-3-(2-methoxyphenyl)-2-methyl-3-naphthalen-1-ylpropanenitrile Chemical compound COC1=CC=CC=C1C(C(C)(C#N)C(=O)N1CCN(CC1)C=1C(=C(Cl)C=CC=1)C)C1=CC=CC2=CC=CC=C12 PYUXCEVGIQTTRI-UHFFFAOYSA-N 0.000 claims 1
- 125000006280 2-bromobenzyl group Chemical group [H]C1=C([H])C(Br)=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000006276 2-bromophenyl group Chemical group [H]C1=C([H])C(Br)=C(*)C([H])=C1[H] 0.000 claims 1
- 125000006282 2-chlorobenzyl group Chemical group [H]C1=C([H])C(Cl)=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000003852 3-chlorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C(Cl)=C1[H])C([H])([H])* 0.000 claims 1
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 1
- 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims 1
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- ZUSWDTWYONAOPH-UHFFFAOYSA-N [2-(trifluoromethyl)phenyl]hydrazine;hydrochloride Chemical group [Cl-].[NH3+]NC1=CC=CC=C1C(F)(F)F ZUSWDTWYONAOPH-UHFFFAOYSA-N 0.000 claims 1
- QLDHWVVRQCGZLE-UHFFFAOYSA-N acetyl cyanide Chemical compound CC(=O)C#N QLDHWVVRQCGZLE-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 229940100198 alkylating agent Drugs 0.000 claims 1
- 239000002168 alkylating agent Substances 0.000 claims 1
- 230000029936 alkylation Effects 0.000 claims 1
- 238000005804 alkylation reaction Methods 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 125000005127 aryl alkoxy alkyl group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- KMPWYEUPVWOPIM-KODHJQJWSA-N cinchonidine Chemical compound C1=CC=C2C([C@H]([C@H]3[N@]4CC[C@H]([C@H](C4)C=C)C3)O)=CC=NC2=C1 KMPWYEUPVWOPIM-KODHJQJWSA-N 0.000 claims 1
- KMPWYEUPVWOPIM-UHFFFAOYSA-N cinchonidine Natural products C1=CC=C2C(C(C3N4CCC(C(C4)C=C)C3)O)=CC=NC2=C1 KMPWYEUPVWOPIM-UHFFFAOYSA-N 0.000 claims 1
- 125000004981 cycloalkylmethyl group Chemical group 0.000 claims 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- CNKCDDUMEAKBMY-UHFFFAOYSA-N ethyl 2-cyano-3-(2,4-dimethoxyphenyl)-3-naphthalen-1-ylpropanoate Chemical compound C=1C=CC2=CC=CC=C2C=1C(C(C#N)C(=O)OCC)C1=CC=C(OC)C=C1OC CNKCDDUMEAKBMY-UHFFFAOYSA-N 0.000 claims 1
- HAWZLUYUKKDNQT-UHFFFAOYSA-N ethyl 2-cyano-3-(2,6-dichlorophenyl)-3-naphthalen-1-ylpropanoate Chemical compound C=1C=CC2=CC=CC=C2C=1C(C(C#N)C(=O)OCC)C1=C(Cl)C=CC=C1Cl HAWZLUYUKKDNQT-UHFFFAOYSA-N 0.000 claims 1
- FTSXTKLDGMGCEN-UHFFFAOYSA-N ethyl 2-cyano-3-(2,6-dimethoxyphenyl)-3-naphthalen-1-ylpropanoate Chemical compound C=1C=CC2=CC=CC=C2C=1C(C(C#N)C(=O)OCC)C1=C(OC)C=CC=C1OC FTSXTKLDGMGCEN-UHFFFAOYSA-N 0.000 claims 1
- BCMHUBAKWXCWES-UHFFFAOYSA-N ethyl 2-cyano-3-(2-methoxyphenyl)-3-naphthalen-1-ylpropanoate Chemical compound C=1C=CC2=CC=CC=C2C=1C(C(C#N)C(=O)OCC)C1=CC=CC=C1OC BCMHUBAKWXCWES-UHFFFAOYSA-N 0.000 claims 1
- XEJUPNISYVEWOR-UHFFFAOYSA-N ethyl 2-cyano-3-naphthalen-1-yl-3-(2-propan-2-ylphenyl)propanoate Chemical compound C=1C=CC2=CC=CC=C2C=1C(C(C#N)C(=O)OCC)C1=CC=CC=C1C(C)C XEJUPNISYVEWOR-UHFFFAOYSA-N 0.000 claims 1
- QSQIOLZIBXSXMS-UHFFFAOYSA-N ethyl 2-cyano-3-naphthalen-1-yl-3-[2-(trifluoromethyl)phenyl]propanoate Chemical compound C=1C=CC2=CC=CC=C2C=1C(C(C#N)C(=O)OCC)C1=CC=CC=C1C(F)(F)F QSQIOLZIBXSXMS-UHFFFAOYSA-N 0.000 claims 1
- 150000004820 halides Chemical class 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- NOFLSPNCSWNKMK-UHFFFAOYSA-N tert-butyl 2-cyano-3-(2,6-dimethylphenyl)-3-naphthalen-1-ylpropanoate Chemical compound CC1=CC=CC(C)=C1C(C(C#N)C(=O)OC(C)(C)C)C1=CC=CC2=CC=CC=C12 NOFLSPNCSWNKMK-UHFFFAOYSA-N 0.000 claims 1
- FNNBTMYOIIUTFI-UHFFFAOYSA-N tert-butyl 2-cyano-3-(2-methoxyphenyl)-3-naphthalen-1-ylpropanoate Chemical compound COC1=CC=CC=C1C(C(C#N)C(=O)OC(C)(C)C)C1=CC=CC2=CC=CC=C12 FNNBTMYOIIUTFI-UHFFFAOYSA-N 0.000 claims 1
- IYZKSQINJIJKKF-UHFFFAOYSA-N tert-butyl 2-cyano-3-naphthalen-1-yl-3-(2-propan-2-ylphenyl)propanoate Chemical compound CC(C)C1=CC=CC=C1C(C(C#N)C(=O)OC(C)(C)C)C1=CC=CC2=CC=CC=C12 IYZKSQINJIJKKF-UHFFFAOYSA-N 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 0 CC(C(C(O*)=O)C#N)[Al] Chemical compound CC(C(C(O*)=O)C#N)[Al] 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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| US6271199B2 (en) * | 1997-02-15 | 2001-08-07 | Millennium Pharmaceuticals, Inc. | Treatment of infarcts |
| CA2298651A1 (en) * | 1997-08-07 | 1999-02-18 | Jeffrey Alan Dodge | 1-¬4-(substituted alkoxy)benzyl|naphthalene compounds having estrogen inhibitory activity |
| JPH11295383A (ja) * | 1998-04-15 | 1999-10-29 | Mitsubishi Electric Corp | マイクロ波帯域用半導体トランジスタのバーンイン方法、バーンイン装置及びバーンインした半導体装置 |
| HUP0102782A3 (en) * | 1998-06-19 | 2002-12-28 | Smithkline Beecham Corp | Salycilanilide as inhibitors of transcription factor nf-kb |
| HK1047582B (zh) * | 1999-06-23 | 2005-03-04 | 萨诺费－阿文蒂斯德国有限公司 | 取代的苯並咪唑 |
| DE19951360A1 (de) * | 1999-10-26 | 2001-05-03 | Aventis Pharma Gmbh | Substituierte Indole |
| WO2005039583A1 (en) * | 2003-09-24 | 2005-05-06 | Wyeth | METHOD OF TREATING RHEUMATOID ARTHRITIS USING NF-kB INHIBITORS |
| AU2003272675A1 (en) * | 2003-09-24 | 2005-05-11 | Wyeth | Use of estrogen receptor ligands for the treatment of inflammatory bowel disease |
| WO2005039582A1 (en) * | 2003-09-24 | 2005-05-06 | Wyeth | METHODS OF TREATING ATHEROSCLEROSIS USING NF-kB INHIBITORS |
-
2004
- 2004-04-28 US US10/833,678 patent/US20050004164A1/en not_active Abandoned
- 2004-04-29 TW TW093111996A patent/TW200508217A/zh unknown
- 2004-04-30 EP EP04750987A patent/EP1620102B1/en not_active Expired - Lifetime
- 2004-04-30 AR ARP040101492A patent/AR044762A1/es unknown
- 2004-04-30 RU RU2005137175/04A patent/RU2005137175A/ru not_active Application Discontinuation
- 2004-04-30 AU AU2004236216A patent/AU2004236216A1/en not_active Abandoned
- 2004-04-30 AT AT04750987T patent/ATE418335T1/de not_active IP Right Cessation
- 2004-04-30 KR KR1020057020599A patent/KR20060015556A/ko not_active Withdrawn
- 2004-04-30 DE DE602004018629T patent/DE602004018629D1/de not_active Expired - Fee Related
- 2004-04-30 CA CA002523235A patent/CA2523235A1/en not_active Abandoned
- 2004-04-30 WO PCT/US2004/013360 patent/WO2004099150A2/en not_active Ceased
- 2004-04-30 JP JP2006514164A patent/JP2006526630A/ja active Pending
- 2004-04-30 MX MXPA05011581A patent/MXPA05011581A/es not_active Application Discontinuation
- 2004-04-30 BR BRPI0409921-4A patent/BRPI0409921A/pt not_active IP Right Cessation
-
2005
- 2005-10-12 CR CR8041A patent/CR8041A/es not_active Application Discontinuation
- 2005-10-26 CO CO05109228A patent/CO5700755A2/es not_active Application Discontinuation
- 2005-10-26 NO NO20054969A patent/NO20054969L/no not_active Application Discontinuation
-
2007
- 2007-07-31 US US11/831,375 patent/US20070299105A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20070299105A1 (en) | 2007-12-27 |
| CR8041A (es) | 2006-05-30 |
| CA2523235A1 (en) | 2004-11-18 |
| DE602004018629D1 (de) | 2009-02-05 |
| TW200508217A (en) | 2005-03-01 |
| WO2004099150A3 (en) | 2004-12-23 |
| KR20060015556A (ko) | 2006-02-17 |
| AR044762A1 (es) | 2005-10-05 |
| AU2004236216A1 (en) | 2004-11-18 |
| ATE418335T1 (de) | 2009-01-15 |
| JP2006526630A (ja) | 2006-11-24 |
| EP1620102A2 (en) | 2006-02-01 |
| MXPA05011581A (es) | 2005-12-14 |
| EP1620102B1 (en) | 2008-12-24 |
| BRPI0409921A (pt) | 2006-04-25 |
| NO20054969L (no) | 2005-11-22 |
| WO2004099150A2 (en) | 2004-11-18 |
| CO5700755A2 (es) | 2006-11-30 |
| NO20054969D0 (no) | 2005-10-26 |
| US20050004164A1 (en) | 2005-01-06 |
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| FA93 | Acknowledgement of application withdrawn (no request for examination) |
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