AR044762A1 - Derivados de ester y amida del acido 2-cianopropanoico, un proceso para su preparacion y el uso de dichos derivados para la preparacion de un medicamento - Google Patents

Derivados de ester y amida del acido 2-cianopropanoico, un proceso para su preparacion y el uso de dichos derivados para la preparacion de un medicamento

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Publication number
AR044762A1
AR044762A1 ARP040101492A ARP040101492A AR044762A1 AR 044762 A1 AR044762 A1 AR 044762A1 AR P040101492 A ARP040101492 A AR P040101492A AR P040101492 A ARP040101492 A AR P040101492A AR 044762 A1 AR044762 A1 AR 044762A1
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AR
Argentina
Prior art keywords
alkyl
het
aryl
ring
preparation
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Application number
ARP040101492A
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English (en)
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Wyeth Corp
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Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR044762A1 publication Critical patent/AR044762A1/es

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    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
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    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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  • Anesthesiology (AREA)

Abstract

Un compuesto de fórmula (1), que tiene la estructura, en donde: B y D independientemente CH o N, con la condición de que B y D no sean ambos N; R1, R1a, R2 son cada uno, independientemente, hidrógeno, halógeno, alquilo C1-6, alcoxi C1-6, nitro, ciano, tioalquilo C1-6, arilo, alquiltio C1-6, CF3, -OCF3, -NR5R6, o hidroxi; o R1 y R2 junto con los átomos de carbono a los cuales están unidos forman un anillo de benceno fusionado, estando el anillo de naftaleno así formado opcionalmente sustituido con halógeno, alquilo C1-6, alcoxi C1-6, nitro, ciano, tioalquilo C1-6, arilo, alquiltio C1-6, CF3, -OCF3, -NR5R6, o hidroxi; R3 es hidrógeno, alquilo C1-6, arilalquilo C1-6 en la porción alquilo, alquenilo C2-7, cicloalquilmetilo C3-8 en la porción cicloalquilo, arilalcoxialquilo, alcoxialquilo, dialquilaminoalquilo C1-6 en las porciones alquilo, o Het-alquilo (C1-6) en la porción alquilo; R4 es -NR5R6, -OR6, o un resto de grupo de fórmula (2), o A, en donde todo anillo de fenilo en R4 está opcionalmente sustituido con R7; R5 y R6 son cada uno, independientemente, hidrógeno, alquilo C1-6, arilo, arilalquilo C1-6 en la porción alquilo, Het-alquilo (C1-6) en la porción alquilo, hidroxialquilo C1-6, dihidroxialquilo C1-6, o cicloalquilo C3-8; R7 es alquilo C1-6, alcoxi C1-6, halógeno, nitro, ciano, alquiltio C1-6, tioalquilo C1-6, CF3, o -OCF3; R8 es alquilo C1-8; A es hidrógeno, cicloalquilo C3-8, alcoxialquilo C1-6 en las porciones alquilo y alcoxi, dialquilaminoalquilo C1-6 en las porciones alquilo, arilo, Het, hidroxialquilo C1-6, dihidroxialquilo C1-6, Het-alquilo C1-6 en la porción alquilo, arilalquilo C1-6 en la porción alquilo, o una fórmula (3); W es arilo, -Y-arilo, o Het o -Y-Het; Y es -O- o NH-; Z es O o S; Het es un anillo o sistema de anillo heterocíclico, saturado, insaturado o parcialmente insaturado con 4-12 átomos en el anillo y 1-3 heteroátomos seleccionados a partir de N, O, o S, que puede estar opcionalmente sustituido con 1-3 grupos R7; arilo es un anillo o sistema de anillos aromático con C6-14 en el anillo o sistema de anillo, que puede estar opcionalmente sustituido con 1-3 grupos R7; con la condición de que por lo menos uno de los grupos R1, R1a, o R2 no sea hidrógeno; o una sal farmacéuticamente aceptable de los mismos; un proceso para su preparación, y el uso de dichos compuestos para la preparación de medicamentos que son útiles para el tratamiento del componente inflamatorio de enfermedades y que son particularmente útiles en el tratamiento de la arteriosclerosis, infarto de miocardio, enfermedad inflamatoria del intestino, artritis, diabetes de tipo II, y enfermedades autoinmunes tales como esclerosis múltiple y artritis reumatoide.
ARP040101492A 2003-04-30 2004-04-30 Derivados de ester y amida del acido 2-cianopropanoico, un proceso para su preparacion y el uso de dichos derivados para la preparacion de un medicamento AR044762A1 (es)

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AU2004236216A1 (en) 2004-11-18
CO5700755A2 (es) 2006-11-30
WO2004099150A3 (en) 2004-12-23
RU2005137175A (ru) 2006-05-27
EP1620102B1 (en) 2008-12-24
EP1620102A2 (en) 2006-02-01
US20050004164A1 (en) 2005-01-06
KR20060015556A (ko) 2006-02-17
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NO20054969L (no) 2005-11-22
TW200508217A (en) 2005-03-01
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