MXPA05011581A - Derivados de acido 3-(1-naftil)-2-cianopropanoico como ligandos receptores de estrogenos. - Google Patents

Derivados de acido 3-(1-naftil)-2-cianopropanoico como ligandos receptores de estrogenos.

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Publication number
MXPA05011581A
MXPA05011581A MXPA05011581A MXPA05011581A MXPA05011581A MX PA05011581 A MXPA05011581 A MX PA05011581A MX PA05011581 A MXPA05011581 A MX PA05011581A MX PA05011581 A MXPA05011581 A MX PA05011581A MX PA05011581 A MXPA05011581 A MX PA05011581A
Authority
MX
Mexico
Prior art keywords
methods
acid amide
ester derivatives
cyanopropanoic acid
arthritis
Prior art date
Application number
MXPA05011581A
Other languages
English (en)
Inventor
Callain Younghee Kim
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of MXPA05011581A publication Critical patent/MXPA05011581A/es

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    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
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    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
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    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
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Abstract

La invencion describe compuestos de la formula (I) (ver formula (I)) o una sal farmaceuticamente aceptable de los mismos que es util para el tratamiento del componente inflamatorio de enfermedades y que son particularmente utiles en el tratamiento de la arteriosclerosis, infarto de miocardio, enfermedad inflamatoria del intestino, artritis, diabetes de tipo II, y enfermedades autoinmunes tales como esclerosis multiple y artritis reumatoide.
MXPA05011581A 2003-04-30 2004-04-30 Derivados de acido 3-(1-naftil)-2-cianopropanoico como ligandos receptores de estrogenos. MXPA05011581A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46656703P 2003-04-30 2003-04-30
US10/833,678 US20050004164A1 (en) 2003-04-30 2004-04-28 2-Cyanopropanoic acid amide and ester derivatives and methods of their use
PCT/US2004/013360 WO2004099150A2 (en) 2003-04-30 2004-04-30 3-(1-naphthyl)-2-cyanopropanoic acid derivatives as estrogen receptor ligands

Publications (1)

Publication Number Publication Date
MXPA05011581A true MXPA05011581A (es) 2005-12-14

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MXPA05011581A MXPA05011581A (es) 2003-04-30 2004-04-30 Derivados de acido 3-(1-naftil)-2-cianopropanoico como ligandos receptores de estrogenos.

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US (2) US20050004164A1 (es)
EP (1) EP1620102B1 (es)
JP (1) JP2006526630A (es)
KR (1) KR20060015556A (es)
AR (1) AR044762A1 (es)
AT (1) ATE418335T1 (es)
AU (1) AU2004236216A1 (es)
BR (1) BRPI0409921A (es)
CA (1) CA2523235A1 (es)
CO (1) CO5700755A2 (es)
CR (1) CR8041A (es)
DE (1) DE602004018629D1 (es)
MX (1) MXPA05011581A (es)
NO (1) NO20054969L (es)
RU (1) RU2005137175A (es)
TW (1) TW200508217A (es)
WO (1) WO2004099150A2 (es)

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USRE46117E1 (en) 1999-12-22 2016-08-23 Teva Pharmaceuticals International Gmbh Modulators of dopamine neurotransmission
SE9904723D0 (sv) 1999-12-22 1999-12-22 Carlsson A Research Ab New modulators of dopamine neurotransmission II
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