RU2004119547A - Кристаллы производных таксана и способ их получения - Google Patents
Кристаллы производных таксана и способ их получения Download PDFInfo
- Publication number
- RU2004119547A RU2004119547A RU2004119547/04A RU2004119547A RU2004119547A RU 2004119547 A RU2004119547 A RU 2004119547A RU 2004119547/04 A RU2004119547/04 A RU 2004119547/04A RU 2004119547 A RU2004119547 A RU 2004119547A RU 2004119547 A RU2004119547 A RU 2004119547A
- Authority
- RU
- Russia
- Prior art keywords
- mixture
- water
- organic solvent
- crystals
- group
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (8)
1. Кристаллы (1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-ацетокси-2-бензоилокси-9,10-[(1S)-2-(диметиламино)этилидендиокси]-5,20-эпокси-1-гидрокситакс-11-ен-13-ил(2R,3S)-3-(трет-бутоксикарбониламино)-3-(3-фтор-2-пиридил)-2-гидроксипропионата, которые демонстрируют картину дифракции рентгеновских лучей в порошке с характеристическими пиками при углах дифракции (2θ) равных 6,2°, 10,3°, 10,7°, 11,4° и 12,0°.
2. Способ получения кристаллов по п.1, который включает этап проведения кристаллизации с использованием органического растворителя, выбранного из группы, состоящей из растворителя типа кетона, растворителя типа нитрила и их смеси или смеси указанного органического растворителя и воды.
3. Способ по п. 2, в котором органический растворитель, который выбирают из группы, состоящей из растворителя типа кетона, растворителя типа нитрила и их смеси является органическим растворителем, выбранным из группы, состоящей из ацетона, ацетонитрила, и их смеси.
4. Способ по п. 2, в котором кристаллизацию проводят с использованием смеси ацетона и воды или смеси ацетонитрила и воды.
5. Способ по п. 4, в котором смесь ацетона и воды, или смесь ацетонитрила и воды содержит от 40 до 50% воды по массе.
6. Способ по любому из пп. 2-5, дополнительно включающий стадию сушки кристаллов, полученных кристаллизацией при температуре от 30 до 60°С.
7. Противоопухолевый агент, включающий в качестве активного ингредиента кристалл по п.1.
8. Кристалл по п.1, используемый для получения лекарственного средства, содержащего (1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-ацетокси-2-бензоилокси-9,10-[(1S)-2-(диметиламино)этилидендиокси]-5,20-эпокси-1-гидрокситакс-11-ен-13-ил(2R,3S)-3-(трет-бутоксикарбониламино)-3-(3-фтор-2-пиридил)-2-гидроксипропионат, в качестве активного ингредиента.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001363681 | 2001-11-29 | ||
| JP2001-363681 | 2001-11-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2004119547A true RU2004119547A (ru) | 2005-03-27 |
| RU2284328C2 RU2284328C2 (ru) | 2006-09-27 |
Family
ID=19173983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2004119547/04A RU2284328C2 (ru) | 2001-11-29 | 2002-11-29 | Кристаллы производных таксана и способ их получения |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7410980B2 (ru) |
| EP (1) | EP1457492B1 (ru) |
| JP (1) | JP4310191B2 (ru) |
| KR (1) | KR100886805B1 (ru) |
| CN (1) | CN1295229C (ru) |
| AT (1) | ATE382624T1 (ru) |
| AU (1) | AU2002354126A1 (ru) |
| CA (1) | CA2468953C (ru) |
| DE (1) | DE60224440T2 (ru) |
| DK (1) | DK1457492T3 (ru) |
| ES (1) | ES2299612T3 (ru) |
| HK (1) | HK1065547A1 (ru) |
| MX (1) | MXPA04005192A (ru) |
| NO (1) | NO328559B1 (ru) |
| PT (1) | PT1457492E (ru) |
| RU (1) | RU2284328C2 (ru) |
| TW (1) | TWI333856B (ru) |
| WO (1) | WO2003045953A1 (ru) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2859996B1 (fr) * | 2003-09-19 | 2006-02-03 | Aventis Pharma Sa | Solvat acetonique du dimethoxy docetaxel et son procede de preparation |
| WO2005105807A1 (ja) * | 2004-04-30 | 2005-11-10 | Daiichi Pharmaceutical Co., Ltd. | 五環性タキサンの製造方法 |
| WO2007005829A2 (en) * | 2005-07-01 | 2007-01-11 | Nec Laboratories America, Inc. | Operating system-based memory compression for embedded systems |
| US8697892B2 (en) | 2010-06-30 | 2014-04-15 | Gfv, Llc | Taxane compounds, compositions and methods |
| US8785669B2 (en) | 2010-06-30 | 2014-07-22 | Gfv, Llc | Taxane compounds, compositions and methods |
| EP2447268A1 (en) * | 2010-10-29 | 2012-05-02 | INDENA S.p.A. | Crystalline form of 13-[(N-tert-butoxycarbonyl)-2'-O-hexanoyl-3-phenylisoserinyl]-10-deacetylbaccatin III |
| JP5909089B2 (ja) * | 2011-02-01 | 2016-04-26 | アークレイ株式会社 | 光学結晶、テラヘルツ波発生装置及び方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW480262B (en) | 1995-04-28 | 2002-03-21 | Daiichi Seiyaku Co | A taxol derivative having an antitumor activity and a pharmaceutical composition comprising the same |
| JP2000159757A (ja) | 1998-12-01 | 2000-06-13 | Dai Ichi Seiyaku Co Ltd | ７−デオキシタキソール誘導体の製造方法 |
| JP2002544269A (ja) * | 1999-05-17 | 2002-12-24 | ブリストル−マイヤーズ スクイブ カンパニー | パクリタキセルおよびパクリタキセル類似体の製造におけるシリルエーテルの切断のための新規反応条件 |
| US6677456B2 (en) | 1999-10-15 | 2004-01-13 | Daiichi Pharmaceutical Co., Ltd. | Pentacyclic taxan compound |
| MY125378A (en) | 1999-10-15 | 2006-07-31 | Daiichi Sankyo Co Ltd | Pentacyclic taxan compound |
| US7126003B2 (en) | 2001-03-07 | 2006-10-24 | Daiichi Pharmaceutical Co., Ltd. | Method for producing 2-azetidinone derivative |
-
2002
- 2002-11-29 EP EP02785977A patent/EP1457492B1/en not_active Expired - Lifetime
- 2002-11-29 TW TW091134817A patent/TWI333856B/zh not_active IP Right Cessation
- 2002-11-29 KR KR1020047008200A patent/KR100886805B1/ko not_active IP Right Cessation
- 2002-11-29 DE DE60224440T patent/DE60224440T2/de not_active Expired - Lifetime
- 2002-11-29 AU AU2002354126A patent/AU2002354126A1/en not_active Abandoned
- 2002-11-29 ES ES02785977T patent/ES2299612T3/es not_active Expired - Lifetime
- 2002-11-29 DK DK02785977T patent/DK1457492T3/da active
- 2002-11-29 JP JP2003547403A patent/JP4310191B2/ja not_active Expired - Fee Related
- 2002-11-29 CA CA2468953A patent/CA2468953C/en not_active Expired - Lifetime
- 2002-11-29 AT AT02785977T patent/ATE382624T1/de active
- 2002-11-29 CN CNB02823815XA patent/CN1295229C/zh not_active Expired - Fee Related
- 2002-11-29 RU RU2004119547/04A patent/RU2284328C2/ru active IP Right Revival
- 2002-11-29 PT PT02785977T patent/PT1457492E/pt unknown
- 2002-11-29 WO PCT/JP2002/012506 patent/WO2003045953A1/ja active IP Right Grant
- 2002-11-29 US US10/495,437 patent/US7410980B2/en not_active Expired - Lifetime
- 2002-11-29 MX MXPA04005192A patent/MXPA04005192A/es active IP Right Grant
-
2004
- 2004-06-28 NO NO20042723A patent/NO328559B1/no not_active IP Right Cessation
- 2004-10-28 HK HK04108450A patent/HK1065547A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60224440D1 (de) | 2008-02-14 |
| DE60224440T2 (de) | 2009-01-02 |
| CN1295229C (zh) | 2007-01-17 |
| CN1596259A (zh) | 2005-03-16 |
| KR100886805B1 (ko) | 2009-03-05 |
| CA2468953C (en) | 2010-05-11 |
| KR20040081426A (ko) | 2004-09-21 |
| NO20042723L (no) | 2004-06-28 |
| US20050070579A1 (en) | 2005-03-31 |
| EP1457492A4 (en) | 2005-03-23 |
| DK1457492T3 (da) | 2008-05-13 |
| JP4310191B2 (ja) | 2009-08-05 |
| JPWO2003045953A1 (ja) | 2005-04-07 |
| HK1065547A1 (en) | 2005-02-25 |
| ES2299612T3 (es) | 2008-06-01 |
| AU2002354126A1 (en) | 2003-06-10 |
| MXPA04005192A (es) | 2005-02-22 |
| EP1457492B1 (en) | 2008-01-02 |
| ATE382624T1 (de) | 2008-01-15 |
| EP1457492A1 (en) | 2004-09-15 |
| WO2003045953A1 (fr) | 2003-06-05 |
| CA2468953A1 (en) | 2003-06-05 |
| NO328559B1 (no) | 2010-03-22 |
| RU2284328C2 (ru) | 2006-09-27 |
| TW200301114A (en) | 2003-07-01 |
| US7410980B2 (en) | 2008-08-12 |
| PT1457492E (pt) | 2008-02-28 |
| TWI333856B (en) | 2010-12-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20151130 |
|
| NF4A | Reinstatement of patent |
Effective date: 20171023 |