AU2001241140A1 - Novel crystal of stilbene derivative and process for producing the same - Google Patents

Novel crystal of stilbene derivative and process for producing the same

Info

Publication number
AU2001241140A1
AU2001241140A1 AU2001241140A AU4114001A AU2001241140A1 AU 2001241140 A1 AU2001241140 A1 AU 2001241140A1 AU 2001241140 A AU2001241140 A AU 2001241140A AU 4114001 A AU4114001 A AU 4114001A AU 2001241140 A1 AU2001241140 A1 AU 2001241140A1
Authority
AU
Australia
Prior art keywords
crystal
producing
same
stilbene derivative
novel crystal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001241140A
Inventor
Hiroyuki Matsueda
Yoko Sugawara
Shinichiro Takahashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of AU2001241140A1 publication Critical patent/AU2001241140A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms

Abstract

A Type IV crystal of (Z)-N-Ä2-methoxy-5-Ä2-(3,4,5-trimethoxyphenyl)vinylÜphenylÜ-L-serinamide hydrochloride, which can be produced at a crystallization step using a solvent containing water at 2 % by weight at the maximum and which has a X ray powder diffraction pattern with peaks containing at least those at 13.4 DEG , 18.7 DEG , 19.4 DEG and 22.5 DEG (2θ) is provided. This compound is useful as an effective ingredient for a carcinostatic agent. In accordance with the present invention, a crystal is obtained, which has excellent properties desirable from the standpoint of the production of medicinal products, i.e. exceedingly less water adsorption and extremely high stability to water. Also provided are a method for producing the Type IV crystal thereof and a method for use of the crystal. <IMAGE>
AU2001241140A 2000-03-17 2001-03-14 Novel crystal of stilbene derivative and process for producing the same Abandoned AU2001241140A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000076887 2000-03-17
JP2000-76887 2000-03-17
PCT/JP2001/002028 WO2001068587A1 (en) 2000-03-17 2001-03-14 Novel crystal of stilbene derivative and process for producing the same

Publications (1)

Publication Number Publication Date
AU2001241140A1 true AU2001241140A1 (en) 2001-09-24

Family

ID=18594552

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001241140A Abandoned AU2001241140A1 (en) 2000-03-17 2001-03-14 Novel crystal of stilbene derivative and process for producing the same

Country Status (13)

Country Link
US (1) US6784315B2 (en)
EP (1) EP1264821B1 (en)
JP (1) JP4826051B2 (en)
CN (1) CN1221527C (en)
AT (1) ATE395325T1 (en)
AU (1) AU2001241140A1 (en)
DE (1) DE60133995D1 (en)
DK (1) DK1264821T3 (en)
ES (1) ES2306705T3 (en)
PT (1) PT1264821E (en)
SI (1) SI1264821T1 (en)
TW (1) TWI291459B (en)
WO (1) WO2001068587A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007254292A (en) * 2006-03-20 2007-10-04 Nippon Polyurethane Ind Co Ltd Method for producing diphenyl sulfone diisocyanate
FR2953518B1 (en) 2009-12-03 2012-01-20 Sanofi Aventis PROCESS FOR PREPARING A COMBRETASTATIN DERIVATIVE
WO2013084150A1 (en) * 2011-12-06 2013-06-13 Sanofi Novel crystal form of (2s)-2-amino-3-hydroxy-n-[2-methoxy-2-[(1z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl]propanamide and method of preparation thereof
EP2805705B1 (en) 2013-05-23 2016-11-09 IP Gesellschaft für Management mbH Packaging with one or more administration units comprising a sodium salt of (R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1 H-imidazol-4-yl)-propionic acid

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW334418B (en) 1995-03-07 1998-06-21 Ajinomoto Kk Stilbene derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
WO2001068587A1 (en) 2001-09-20
SI1264821T1 (en) 2008-10-31
CN1221527C (en) 2005-10-05
EP1264821B1 (en) 2008-05-14
EP1264821A1 (en) 2002-12-11
TWI291459B (en) 2007-12-21
EP1264821A4 (en) 2005-06-08
CN1418186A (en) 2003-05-14
US6784315B2 (en) 2004-08-31
DE60133995D1 (en) 2008-06-26
PT1264821E (en) 2008-08-12
US20030065035A1 (en) 2003-04-03
JP4826051B2 (en) 2011-11-30
ATE395325T1 (en) 2008-05-15
DK1264821T3 (en) 2008-09-08
ES2306705T3 (en) 2008-11-16

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