RU2004113111A - Производные индола в качестве ингибиторов сох 11 - Google Patents
Производные индола в качестве ингибиторов сох 11 Download PDFInfo
- Publication number
- RU2004113111A RU2004113111A RU2004113111/04A RU2004113111A RU2004113111A RU 2004113111 A RU2004113111 A RU 2004113111A RU 2004113111/04 A RU2004113111/04 A RU 2004113111/04A RU 2004113111 A RU2004113111 A RU 2004113111A RU 2004113111 A RU2004113111 A RU 2004113111A
- Authority
- RU
- Russia
- Prior art keywords
- alkyl
- compound according
- hydroxy
- compound
- cyano
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title claims 2
- 150000002475 indoles Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 23
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 16
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 125000004093 cyano group Chemical group *C#N 0.000 claims 7
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 239000011593 sulfur Substances 0.000 claims 2
- GVUYJYPBPIQKHW-UHFFFAOYSA-N (6-methylsulfonyl-3-phenylsulfanyl-1h-indol-2-yl)methanol Chemical compound OCC=1NC2=CC(S(=O)(=O)C)=CC=C2C=1SC1=CC=CC=C1 GVUYJYPBPIQKHW-UHFFFAOYSA-N 0.000 claims 1
- XAOIOAYWZAVEIW-UHFFFAOYSA-N 3-(2,4-difluorophenyl)sulfanyl-6-methylsulfonyl-1h-indole-2-carbonitrile Chemical compound N#CC=1NC2=CC(S(=O)(=O)C)=CC=C2C=1SC1=CC=C(F)C=C1F XAOIOAYWZAVEIW-UHFFFAOYSA-N 0.000 claims 1
- VHSYYXRBWBHMNB-UHFFFAOYSA-N 3-(4-fluorophenoxy)-2-methyl-6-methylsulfonyl-1h-indole Chemical compound CC=1NC2=CC(S(C)(=O)=O)=CC=C2C=1OC1=CC=C(F)C=C1 VHSYYXRBWBHMNB-UHFFFAOYSA-N 0.000 claims 1
- OHVHHRUUBCGBLX-UHFFFAOYSA-N 3-(4-fluorophenyl)sulfanyl-6-methylsulfonyl-1h-indole-2-carbonitrile Chemical compound N#CC=1NC2=CC(S(=O)(=O)C)=CC=C2C=1SC1=CC=C(F)C=C1 OHVHHRUUBCGBLX-UHFFFAOYSA-N 0.000 claims 1
- VNYCGFXZOQHLEM-UHFFFAOYSA-N 3-(4-fluorophenyl)sulfinyl-2-methyl-6-methylsulfonyl-1h-indole Chemical compound CC=1NC2=CC(S(C)(=O)=O)=CC=C2C=1S(=O)C1=CC=C(F)C=C1 VNYCGFXZOQHLEM-UHFFFAOYSA-N 0.000 claims 1
- JGGHRZWTRXUNBK-UHFFFAOYSA-N 3-[(2-chlorophenyl)methyl]-2-methyl-6-methylsulfonyl-1h-indole Chemical compound CC=1NC2=CC(S(C)(=O)=O)=CC=C2C=1CC1=CC=CC=C1Cl JGGHRZWTRXUNBK-UHFFFAOYSA-N 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- 208000025978 Athletic injury Diseases 0.000 claims 1
- 208000008035 Back Pain Diseases 0.000 claims 1
- 206010006811 Bursitis Diseases 0.000 claims 1
- 208000032170 Congenital Abnormalities Diseases 0.000 claims 1
- 208000005171 Dysmenorrhea Diseases 0.000 claims 1
- 206010013935 Dysmenorrhoea Diseases 0.000 claims 1
- 201000005569 Gout Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 201000002481 Myositis Diseases 0.000 claims 1
- 208000005107 Premature Birth Diseases 0.000 claims 1
- 206010036590 Premature baby Diseases 0.000 claims 1
- 208000010040 Sprains and Strains Diseases 0.000 claims 1
- 208000000491 Tendinopathy Diseases 0.000 claims 1
- 206010043255 Tendonitis Diseases 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 201000004595 synovitis Diseases 0.000 claims 1
- 201000004415 tendinitis Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 208000004371 toothache Diseases 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32538901P | 2001-09-27 | 2001-09-27 | |
| US60/325,389 | 2001-09-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2004113111A true RU2004113111A (ru) | 2005-06-27 |
Family
ID=23267681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2004113111/04A RU2004113111A (ru) | 2001-09-27 | 2002-09-20 | Производные индола в качестве ингибиторов сох 11 |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US6872744B2 (enExample) |
| EP (1) | EP1438289B1 (enExample) |
| JP (1) | JP4141954B2 (enExample) |
| KR (1) | KR20040047862A (enExample) |
| CN (1) | CN1261412C (enExample) |
| AR (1) | AR036624A1 (enExample) |
| AT (1) | ATE292115T1 (enExample) |
| BR (1) | BR0212925A (enExample) |
| CA (1) | CA2461670A1 (enExample) |
| CO (1) | CO5560557A2 (enExample) |
| DE (1) | DE60203529T2 (enExample) |
| DK (1) | DK1438289T3 (enExample) |
| ES (1) | ES2238616T3 (enExample) |
| HR (1) | HRPK20040271B3 (enExample) |
| HU (1) | HUP0401499A3 (enExample) |
| IL (1) | IL160752A0 (enExample) |
| MX (1) | MXPA04002824A (enExample) |
| NO (1) | NO20041237L (enExample) |
| NZ (1) | NZ531577A (enExample) |
| PL (1) | PL370342A1 (enExample) |
| PT (1) | PT1438289E (enExample) |
| RU (1) | RU2004113111A (enExample) |
| SI (1) | SI1438289T1 (enExample) |
| WO (1) | WO2003029212A1 (enExample) |
| ZA (1) | ZA200402360B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60203529T2 (de) * | 2001-09-27 | 2006-03-16 | F. Hoffmann-La Roche Ag | Indolderivate als cox-ii-inhibitoren |
| SE0202241D0 (sv) * | 2002-07-17 | 2002-07-17 | Astrazeneca Ab | Novel Compounds |
| US7365090B2 (en) * | 2002-08-07 | 2008-04-29 | Idenix Pharmaceuticals, Inc. | Substituted phenylindoles for the treatment of HIV |
| US20050250794A1 (en) * | 2003-12-19 | 2005-11-10 | Andrew Napper | Methods of treating a disorder |
| US7119214B2 (en) | 2004-04-13 | 2006-10-10 | Cephalon France | Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives |
| US7423176B2 (en) | 2004-04-13 | 2008-09-09 | Cephalon, Inc. | Bicyclic aromatic sulfinyl derivatives |
| EP1589016A1 (en) * | 2004-04-13 | 2005-10-26 | Cephalon France | Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives |
| CN101006053A (zh) | 2004-06-18 | 2007-07-25 | 比奥里波克斯公司 | 用于治疗炎症的吲哚 |
| WO2006041961A1 (en) * | 2004-10-05 | 2006-04-20 | GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTHAND HUMAN SERVICES | Arylthioindole tubulin polymerization inhibitors and methods of treating or preventing cancer using same |
| AU2005325497A1 (en) | 2005-01-19 | 2006-07-27 | Biolipox Ab | Indoles useful in the treatment of inflammation |
| US7622495B2 (en) * | 2006-10-03 | 2009-11-24 | Neurim Pharmaceuticals (1991) Ltd. | Substituted aryl-indole compounds and their kynurenine/kynuramine-like metabolites as therapeutic agents |
| CA2668959A1 (en) | 2006-11-09 | 2008-05-15 | F. Hoffmann-La Roche Ag | Indole and benzofuran 2-carboxamide derivatives |
| JP2013536200A (ja) | 2010-08-20 | 2013-09-19 | アミラ ファーマシューティカルス，インコーポレーテッド | オートタキシン阻害剤およびその使用 |
| EP2714680B1 (en) | 2011-05-27 | 2015-11-25 | Amira Pharmaceuticals, Inc. | Heterocyclic autotaxin inhibitors and uses thereof |
| WO2015042053A1 (en) | 2013-09-17 | 2015-03-26 | Pharmakea, Inc. | Vinyl autotaxin inhibitor compounds |
| US9951026B2 (en) | 2013-09-17 | 2018-04-24 | Pharmakea, Inc. | Heterocyclic vinyl autotaxin inhibitor compounds |
| US9850203B2 (en) | 2013-09-26 | 2017-12-26 | Pharmakea, Inc. | Autotaxin inhibitor compounds |
| WO2015077503A1 (en) | 2013-11-22 | 2015-05-28 | Pharmakea, Inc. | Autotaxin inhibitor compounds |
| AU2016268250B2 (en) | 2015-05-27 | 2020-08-27 | Sabre Therapeutics Llc | Autotaxin inhibitors and uses thereof |
| KR102241064B1 (ko) | 2019-07-30 | 2021-04-16 | 부산대학교 산학협력단 | 신규한 인돌 유도체 및 이를 포함하는 염증성 질환 예방 또는 치료용 조성물 |
| CN113004187B (zh) * | 2021-03-16 | 2022-09-20 | 沈阳药科大学 | 一种具有抑制有机阴离子转运体1活性的化合物及制备方法和应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4654360A (en) * | 1984-06-01 | 1987-03-31 | Syntex (U.S.A.) Inc. | 1,2,3-trisubstituted indoles for treatment of inflammation |
| JPH0347123A (ja) | 1989-05-05 | 1991-02-28 | G D Searle & Co | インドール―２―カルボキシレート化合物類を含有するｃｎｓ疾患治療用組成物 |
| DE4338770A1 (de) | 1993-11-12 | 1995-05-18 | Matthias Dr Lehr | Indol-2-alkansäuren und ihre Derivate als Hemmstoffe der Phospholipase A¶2¶ |
| WO1998008818A1 (en) | 1996-08-26 | 1998-03-05 | Genetics Institute, Inc. | Inhibitors of phospholipase enzymes |
| WO1998051667A1 (en) * | 1997-05-16 | 1998-11-19 | Chugai Seiyaku Kabushiki Kaisha | Indole derivatives and mono- and diazaindole derivatives |
| EP1062216A1 (en) | 1998-02-25 | 2000-12-27 | Genetics Institute, Inc. | Inhibitors of phospholipase a2 |
| MXPA00006605A (es) * | 1999-07-02 | 2004-12-09 | Pfizer | Compuestos de carbonil-indol biciclicos como agentes antiinflamatorios/analgesicos. |
| US6306890B1 (en) * | 1999-08-30 | 2001-10-23 | Vanderbilt University | Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors |
| US6376708B1 (en) * | 2000-04-11 | 2002-04-23 | Monsanto Technology Llc | Process and catalyst for dehydrogenating primary alcohols to make carboxylic acid salts |
| DE60203529T2 (de) * | 2001-09-27 | 2006-03-16 | F. Hoffmann-La Roche Ag | Indolderivate als cox-ii-inhibitoren |
| TW200400177A (en) * | 2002-06-04 | 2004-01-01 | Wyeth Corp | 1-(Aminoalkyl)-3-sulfonylindole and-indazole derivatives as 5-hydroxytryptamine-6 ligands |
-
2002
- 2002-09-20 DE DE60203529T patent/DE60203529T2/de not_active Expired - Fee Related
- 2002-09-20 PL PL02370342A patent/PL370342A1/xx not_active Application Discontinuation
- 2002-09-20 EP EP02779382A patent/EP1438289B1/en not_active Expired - Lifetime
- 2002-09-20 SI SI200230116T patent/SI1438289T1/xx unknown
- 2002-09-20 RU RU2004113111/04A patent/RU2004113111A/ru not_active Application Discontinuation
- 2002-09-20 HU HU0401499A patent/HUP0401499A3/hu unknown
- 2002-09-20 AT AT02779382T patent/ATE292115T1/de not_active IP Right Cessation
- 2002-09-20 PT PT02779382T patent/PT1438289E/pt unknown
- 2002-09-20 HR HR20040271A patent/HRPK20040271B3/xx not_active IP Right Cessation
- 2002-09-20 JP JP2003532462A patent/JP4141954B2/ja not_active Expired - Fee Related
- 2002-09-20 DK DK02779382T patent/DK1438289T3/da active
- 2002-09-20 CN CNB028191900A patent/CN1261412C/zh not_active Expired - Fee Related
- 2002-09-20 CA CA002461670A patent/CA2461670A1/en not_active Abandoned
- 2002-09-20 IL IL16075202A patent/IL160752A0/xx unknown
- 2002-09-20 BR BR0212925-6A patent/BR0212925A/pt not_active IP Right Cessation
- 2002-09-20 MX MXPA04002824A patent/MXPA04002824A/es unknown
- 2002-09-20 ES ES02779382T patent/ES2238616T3/es not_active Expired - Lifetime
- 2002-09-20 KR KR10-2004-7004428A patent/KR20040047862A/ko not_active Ceased
- 2002-09-20 WO PCT/EP2002/010557 patent/WO2003029212A1/en not_active Ceased
- 2002-09-20 NZ NZ531577A patent/NZ531577A/en unknown
- 2002-09-25 AR ARP020103595A patent/AR036624A1/es not_active Application Discontinuation
- 2002-09-26 US US10/255,891 patent/US6872744B2/en not_active Expired - Fee Related
-
2004
- 2004-03-24 CO CO04027740A patent/CO5560557A2/es not_active Application Discontinuation
- 2004-03-24 NO NO20041237A patent/NO20041237L/no unknown
- 2004-03-25 ZA ZA200402360A patent/ZA200402360B/en unknown
-
2005
- 2005-02-25 US US11/065,841 patent/US7074939B2/en not_active Expired - Fee Related
-
2006
- 2006-03-02 US US11/391,655 patent/US7410994B2/en not_active Expired - Fee Related
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